• 방사선산업학회지
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• 제17권2호
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• pp.173-181
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• 2023

3D printing is a technology that can transform and process computerized data obtained through modeling or 3D scanning via CAD. In the medical field, studies on customized 3D printing technology for clinical use or patients and diseases continue. The importance of research on filaments and molding methods is increasing, but research on manufacturing methods and available raw materials is not being actively conducted. In this study, we compare the characteristics of each material according to the manufacturing method of the phantom manufactured with 3D printing technology and evaluate its usefulness. We manufactured phantoms of the same size using poly methyl meta acrylate (PMMA), acrylonitrile butadiene styrene (ABS), and Poly Lactic Acid (PLA) based on the international standard phantom of aluminum step wedge. We used SITEC's radiation generator (DigiRAD-FPC R-1000-150) and compared the shielding rate and line attenuation coefficient through the average after shooting 10 times. As a result, in the case of the measured dose transmitted through each phantom, it was confirmed that the appearance of the dose measured for phantoms decreased linearly as the thickness increased under each condition. The sensitivity also decreased as the steps increased for each phantom and confirmed that it was different depending on the thickness and material. Through this study, we confirmed that 3D printing technology can be usefully used for phantom production in the medical field. If further development of printing technology and studies on various materials are conducted, it is believed that they will contribute to the development of the medical research environment.

• 한국염색가공학회지
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• 제20권6호
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• pp.1-7
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• 2008

The effects of $TiO_2$ contents and UV irradiation treatment on the surface properties of PLA films embedded with $TiO_2$ nanoparticle were investigated. Whereas UV irradiation decreased reflectance of the treated PLA films proportionally with increasing UV energy, the reflectance of PLA/$TiO_2$ films increased with increasing UV energy. The UV irradiation treatment caused PLA/$TiO_2$ blend films more polar as indicated in the generation of new carbonyl group and decrease in zeta potentials, which was more pronounced with the introduction of $TiO_2$. Upon UV irradiation, $TiO_2$ particles appeared on the film surface as observed in SEM images. The PLA/$TiO_2$ blend films showed photocatalytic properties such as photobleaching of methylene blue, deodorization of ammonia and antimicrobial activity in comparison with pure PLA films.

• 대한기계학회논문집A
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• 제41권7호
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• pp.607-612
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• 2017

최근 다양한 분야에 적용되고 있는 적층 가공 기술(AM)은 복잡한 형상 제조 및 재료 비용 절감으로 인해 혁신적인 제품 생산 방법으로 각광을 받고 있다. 그 중에서도 압출적층조형(Fused Deposition Modeling, FDM) 공정을 통한 친환경 부품 제조는 의료 분야산업에서 많은 주목을 받고 있다. 따라서, 본 논문에서는 친환경 생분해성 재료인 Poly Lactic Acid(PLA)를 사용한 FDM 공정 실험을 수행하고 제작된 적층 시편에 대한 인장 시험을 적용하여 주요 FDM 공정 변수인 적층 두께, 적층 방향, 적층 충진량이 인장 시편의 기계적 성질에 미치는 영향을 정량적 및 정성적으로 분석하고 이를 극대화하는 각 공정 변수의 최적값을 도출하였다.

• Journal of Pharmaceutical Investigation
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• 제34권5호
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• pp.401-406
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• 2004

To develop an intravenous delivery system of all-trans retinoic acid (ATRA) for the cancer therapy, poly(L-lactic acid) nanoparticles were prepared and characterized. Emulsification-solvent evaporation method was chosen to prepare submicron sized nanoparticles. Spherical nanoparticles less than 200 nm in diameter with narrow size distribution were prepared, and the entrapment efficiency of drug was more than 95%. The endothermic peak at $183^{\circ}C$ and X-ray crystallographic peak of ATRA appeared in the nanoparticle system, suggesting the inhibition of crystallization of ATRA by polymer adsorption during the precipitation process. ATRA was released at $37^{\circ}C$ for 60 days and the release rate was dependent on the concentration of drug incorporated in the nanoparticles. While ATRA was unstable in the light, it was very stable at $4^{\circ}C$. These results suggest the usefulness of PLA nanoparticles as a sustained and prolonged release carrier for ATRA.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.52-53
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• 2006

A new series of PEO-PPO-PEO and PPO-PEO-PPO copolymers having several hydroxyl groups on the PPO chain segment were synthesized, further modified with various poly(lactic acid) PLA oligomeric chains to confer physical stability after thermo-gelation in the body fluid. Gel stability was endowed by either increasing hydrophobic interaction between PLA chains or inducing stereocomplex formation between enatiomeric isomers of PLA chains. Macromolecular drugs were incorporated within the gels and their release patterns were investigated using Pluronic F127 as a control.

• Korean Chemical Engineering Research
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• 제48권3호
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• pp.342-349
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• 2010

젖산은 식품, 화학 및 의약 산업에서 널리 이용되며 생분해성 고분자인 폴리젖산(poly lactic acid)의 원료로서 요구량이 증대되고 있다. 합성에 의한 생산 방법에서 환경 친화적이고 경제적인 발효에 의한 생산 방법으로 바뀌는 추세이다. 그러나 발효에 의해 생성된 생산물은 과량의 물과 고비점 부산물을 포함하고 있다. 고비점 물질의 존재와 젖산의 비휘발성은 젖산 분리 및 정제를 어렵게 만든다. 또한 정제 및 분리 공정은 많은 투자 비용과 에너지 소모를 요구한다. 반응증류 공정은 기존 공정과 비교하여 높은 선택도와 수율을 얻을 수 있다. 분리벽형 반응 증류탑과 같이 새롭게 통합된 공정은 투자 비용과 에너지 비용을 줄일 수 있고 순수한 젖산을 회수할 수 있다. 본 연구에서는 젖산의 분리 및 정제를 위한 설계구조들을 제안하였다. 제안된 설계구조들은 SQP 방법에 의해 최적화되었으며 최적화된 설계 구조들 사이의 에너지 소모량 및 생산물 순도를 비교하였다. 그리고 공정 성능과 최적화된 공정에 대한 주요 공정 변수들의 영향을 조사하였다.

• Advanced Composite Materials
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• 제16권4호
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• pp.361-376
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• 2007

Disposing of conventional fiber-reinforced polymers (FRPs) poses an environmentally challenging problem. Disposal of FRPs by combustion discharges carbon dioxide in the air because the resin of FRPs is made of fossil fuel. When they are disposed of in the ground, FRPs remain semipermanently without decomposing. In response to these problems, green composites are now being developed and are extensively studied as a material that produces a lower environmental burden. In this paper, green composites using kenaf fiber yarn bundles and PLA (poly(lactic acid)) are fabricated and their tensile properties are evaluated in the experiment. The tensile Young's modulus of all of the laminations is larger than that of PLA alone and the tensile strength of some laminations is larger than that of PLA alone. In particular, the value of UD composite of $0^{\circ$ shows double the tensile strength of PLA alone. Furthermore, the molding conditions for fabricating with a hot press are investigated and the heat resistant tensile properties of green composites are also reported.

• 멤브레인
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• 제34권1호
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• pp.20-29
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• 2024

분리막 기술은 해수담수화, 기체분리 등 산업용 분리 정제 공정을 비롯하여 우리 주변의 생활용품, 의료 및 헬스케어 제품 등에서 쉽게 찾아볼 수 있다. 최근 지속가능한 친환경 분리막 제조 기술 또한 환경오염을 줄이기 위해 연구되고 있으며, 특히 polylactic acid (PLA), polybutylene adipate terephthalate (PBAT), polybutylene succinate (PBS) 등 생분해성 소재를 활용한 분리막 제조기술이 보고되어 왔다. 기존 분리막 소재와 마찬가지로 생분해성 고분자 소재들 또한 상분리 공정을 통해 다공성 분리막을 제조하는 연구가 이루어지고 있다. 본 총설을 통해 대표적인 생분해성 고분자인 PLA 기반의 상분리 공정을 활용한 분리막 제조 기술 개발 동향을 살펴보고 향후 연구 개발 및 적용 가능성에 대해 고찰해보고자 한다.

• Journal of the Korean Wood Science and Technology
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• 제52권3호
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• pp.205-220
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• 2024

Various polylactic acid (PLA) blends were reinforced with untreated or silane-treated micro-sized cellulose fiber (MCF), successfully prepared as 3D printing filaments and then printed using a fused filament fabrication (FFF) 3D printer. In this study, we focused on developing 3D-printed MCF/PLA composites through silane treatment of MCF and investigating the effect of silane treatment on the various properties of FFF 3D-printed composites. Fourier transform infrared spectra confirmed the increase in hydrophobic properties of silane-treated MCF by showing the new absorption peaks at 1,100 cm^-1, 1,030 cm^-1, and 815 cm^-1 representing C-NH₂, Si-O-Si, and Si-CH₂ bonds, respectively. In scanning electron microscope images of silane-treated MCF filled PLA composites, the improved interfacial adhesion between MCF and PLA matrix was observed. The mechanical properties of the 3D-printed MCF/PLA composites with silane-treated MCF were improved compared to those of the 3D-printed MCF/PLA composites with untreated MCF. In particular, the highest tensile and flexural modulus values were observed for S-MCF10 (5,784.77 MPa) and S-MCF5 (2,441.67 MPa), respectively. The thermal stability of silane-treated MCF was enhanced by delaying the initial thermal decomposition temperature compared to untreated MCF. The thermal decomposition temperature difference at T₉₅ was around 26℃. This study suggests that the effect of silane treatment on the 3D-printed MCF/PLA composites is effective and promising.

• 한국콘텐츠학회논문지
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• 제15권1호
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• pp.308-315
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• 2015

본 연구는 3D 프린터를 이용하여 통풍이 원활하고 위생적이며 선명한 방사선영상을 구할 수 있는 그물형 손목 부목을 제작하고자 하였다. 스캐너는 의료용 다중단층영상장치(MDCT)를 이용했으며, 3D 프린터 기기는 용융 적층 조형술(fused deposition modeling, FDM)의 프린팅 방식을 이용했다. 소재는 분해성 플라스틱 (poly lactic acid, PLA)을 사용하였다. 손목의 3 차원 볼륨렌더링은 MDCT에서 획득된 단층영상으로 구현하였다. 구현된 손목 3 차원 영상을 바탕으로 가상의 그물형 부목 모형을 디자인하고 출력하였다. 그 결과 3D 프린터로 출력된 부목이 기존 부목보다도 우수한 방사선 손목영상을 획득할 수 있었으며 가려움증 및 비위생적인 단점을 개선하고 부목 해체 작업이 용이하였다. 결론적으로 본 연구에서 모델링된 3D 부목 모형은 향후 3D 프린팅 부목 제작에 기초자료로 활용할 수 있으며 환자들의 실생활에 도움을 줄 것으로 기대한다.