• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.475-481
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• 2016

PICK1, a PDZ domain-containing protein, is known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface. Here, we report a direct and functional interaction between PICK1 and dopamine $D_3$ receptors ($D_3R$), which act as autoreceptors to negatively regulate dopaminergic neurons. PICK1 colocalized with both dopamine $D_2$ receptor ($D_2R$) and $D_3R$ in clusters but exerted different functional influences on them. The cell surface expression, agonist affinity, endocytosis, and signaling of $D_2R$ were unaffected by the coexpression of PICK1. On the other hand, the surface expression and tolerance of $D_3R$ were inhibited by the coexpression of PICK1. These findings show that PICK1 exerts multiple effects on $D_3R$ functions.

• Journal of Biosystems Engineering
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• v.42 no.1
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• pp.12-22
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• 2017

Purpose: This aim of this study was to develop a pick-up type pulse crop harvester for harvesting cut and dried pulse crop. Methods: The pick-up type pulse crop harvester was designed and constructed. Its specifications and operating performance were investigated. Results: Compared with conventional bean harvesters, the pick-up type pulse crop harvester adopted seven rows of chains with tines to pick-up the cut and dried pulse crop on a flat or ridged field, two transverse threshing drums with steel wire teeth to reduce the threshing speed, and a tilt plate and plastic bucket elevator for conveying clean grain to reduce damage. The threshing speed and the oscillating frequency of the separating and cleaning parts according to crop type and condition could be varied easily to efficiently use engine power and to improve harvesting performance. The harvester showed forward speed ranges of 0 ~ 1.5 m/s during harvesting operation, and 0 ~ 2.5 m/s during road travelling. The pick-up width of the harvester was about 1 m. Conclusions: The pick-up type self-propelled 51.5 kW harvester was designed and constructed to harvest cut and dried pulse crop. The effective field capacity of the harvester was predicted as above 40 a/h.

• Geomechanics and Engineering
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• v.13 no.1
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• pp.141-159
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• 2017

A pick cutter is a rock-cutting tool used in partial-face excavation machines such as roadheaders, and its quality is a key element influencing the excavation performance and efficiency of such machines. In this study, pick cutters with hardfacing deposits applied to a tungsten carbide insert were made with aim of increasing their durability and wear resistance. They were field-tested by being installed in a roadheader and compared with conventional pick cutters under the same excavation conditions for 24 hours. The hardfaced pick cutters showed much smaller weight loss after excavation, and therefore better excavation performance, than the conventional pick cutters. In particular, the damage to and detachment (loss) of tungsten carbide inserts was minimal in the hardfaced pick cutters. A detailed inspection using scanning electron microscope-energy dispersive X-ray spectrometry and three-dimensional X-ray computed tomography scanning revealed no macro- or micro-cracks in the pick cutters. The reason for the absence of cracks may be that the heads of pick cutters are mechanically worn after the tungsten carbide inserts have been worn and damaged. However, scanning revealed the presence of voids between tungsten carbide inserts and pick cutter heads. This discovery of voids indicates the need to improve production processes in order to guarantee a higher quality of pick cutters.

• Journal of Genetic Medicine
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• v.4 no.2
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• pp.200-203
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• 2007

Niemann-Pick type C is an inborn error of metabolism that affects lipid degradation and storage, which is characterized by hepatosplenomegaly and progressive neurological symptoms. A 7-month-old girl with jaundice was presented cholestasis and hepatosplenomegaly. Laboratory study showed elevated acid phosphatase, angiotensin converting enzyme and mild decrease of cholesterol. Characteristic foamy cell and sea-blue histiocytes in bone marrow biopsy consistent with Niemann-Pick disease. Niemann-Pick type C was suspected by past medical history and findings of physical examination. Therefore, molecular analysis was performed and found mutations of NPC1 gene. We report the first Korean case of type C Niemann-Pick disease confirmed by mutation analysis.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.05a
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• pp.191-194
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• 2002

In optical pick-up, optical components such as objective lens, collimator, mirror, laser diode and photo diode are mounted on the pick-up base. These components must keep their original position during operation for proper transmittance of information from laser diode to optical disk and back to photo diode. However, micro thermal deformation of pick-up base which is induced by thermal environment during operation can deteriorate the performance of optical pick-up. Therefore, it is important to measure and analyze the thermal deformation behavior of pick-up base under thermal environment. In the present study, a measurement system using holographic interferometry was designed to measure micro thermal deformation of pick up base. The measurement system was verified by using the deformation of cantilever with prescribed motion actuated by PZT with 1 nm resolution. Interferometric measurement was compared quantitatively with that induced by PZT actuator. Finally, micro thermal deformation of pick-up base under actual thermal environment was measured using the present holographic interferometry and the results were analysed.

• Journal of Periodontal and Implant Science
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• v.34 no.3
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• pp.563-572
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• 2004

Since bacterial plaque is known as the major cause of every oral disease, it is necessary to control plaque to maintain periodontal health. Although tooth brushing has been the typical method of plaque control, additional use of plaque control devices are necessary for cleansing interdental areas. Dental floss has been used for a long time as the additional plaque control device and proved to be effective. The newly developed embossed new dental pick is composed of elastic plastic material in form with its tip longer than other toothpick. In addition, as thickness of the tip gradually increases, it can be adapted easily with minimal trauma to interdental gingiva. The embossed tip can remove dental plaque easily, and the opposite end can approach lingual and palatal areas through triple angulation. Therefore, the authors studied the effect of embossed new dental pick and dental floss on periodontally involved 15 patient. The following results were obtained. 1. For embossed new dental pick, probing depth at baseline, 1 week, 4 weeks were $3.6{\pm}0.6mm$, $3.4{\pm}0.5mm$, $3.2{\pm}0.5mm$, respectively, and $4.2{\pm}0.9mm$, $4.1{\pm}0.9mm$, $4.0{\pm}0.9mm$, respectivly for clinical attachment level. 2. In case of embossed new dental pick, bleeding on probing at baseline, 1 week, 4 weeks were $43.0{\pm}4.4%$, $28.5{\pm}5.1%$, $22.2{\pm}5.6%$, respectively, and, at 1 week and 4 weeks, they were significantly different from that of dental floss. 3. Gingival index of toαhpick at baseline, 1 week, 4 weeks were $1.7{\pm}0.5$, $1.0{\pm}0.3$, $0.9{\pm}0.2$, respectively, and, $1.7{\pm}0.5$, $1.1{\pm}0.4$, $1.0{\pm}0.4$, respectively for plaque index, and $3.0{\pm}0.5$, $1.7{\pm}0.5$, $1.4{\pm}0.4$, respectively for proximal plaque index. proximal plaque index at 4 weeks was significantly different from that of dental floss. 4. The result of questionnaire showed that the two types of device were both satisfactory, however, embossed new dental pick had higher preference as well as satisfaction. As a result, embossed new dental pick is thought to be clinically effective for its simplicity and good accessibility.

• Clinical and Experimental Pediatrics
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• v.49 no.12
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• pp.1358-1362
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• 2006

Niemann-Pick disease is a group of autosomal recessive disorders associated with hepatosplenomegaly, variable neurologic deficits, and the storage of sphingomyelin and other lipids. Seven cases have been reported in Korea. We report an additional case presenting with hypotonia, early neurodevelopmental delay, hepatosplenomegaly and death by persistent pneumonia and asphyxia at the age of 23 months. MRI of brain and fundoscopic findings of our case at 4 months of age were normal. However, abnormal intensity of the thalamus and atrophy of the right temporal lobe on the MRI and macular cherry red spots were noticed at the age of 17 months. A bone marrow biopsy showed large foamy cells, while hexosaminidase A and B levels were normal. Although biochemical or molecular workup was not done, these findings led to the diagnosis of infantile onset Niemann-Pick disease, probably type A. A brief review of the related literatures was made.

• Journal of Institute of Control, Robotics and Systems
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• v.20 no.5
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• pp.578-583
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• 2014

Optical pick-up is a core component for data read/write operations in optical disc drives, and an optical pick-up performance evaluator is an instrument used to analyze the overall performance of an optical pick-up. Due to inevitable errors in an analog measurement circuit, resultant evaluation data is not guaranteed to be accurate. In this paper, a calibration method for an optical pick-up performance evaluator is proposed to ensure evaluation accuracy. Measured data is corrected by a 1st order correction function, and a calibration process based on least-square method is utilized to obtain correction coefficients of the correction function. The proposed calibration method is applied to experiments, and enhanced accuracy is presented with resultant evaluation data.

• Journal of Institute of Control, Robotics and Systems
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• v.9 no.1
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• pp.30-36
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• 2003

Driving and pick-off using electromagnetic force for a cylindrical vibratory gyroscope is considered. A gyroscope consisting of thin cylindrical vibrating element and electromagnetic drive and pick-off element is designed, fabricated and tested. The results of the proposed pick-off method were compared with the results of the highly precise laser interferometer and eddy current sensor as it was used as the reference standard. Through the experiment, it is verified that the proposed electromagnetic driving and pick-off method can be an effective alternative to conventional electrostatic or piezo-electric methods.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.15 no.4
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• pp.1-7
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• 2016

The pick cutter, which directly contacts and crushes the rock, is the expendable part of a roadheader. The arrangement and angle of attachment of the pick cutter are important factors that determine excavator performance. It is necessary to numerically calculate the contact between the pick cutter and rock. The rock is defined as a set of particles using the discrete element method. The parallel bond model is used to define the bonds between particles. The properties of granite that are measured by the uniaxial compressive test are applied to the numerical rock model. The pick cutter is defined by the polygon elements. The linear cutting simulation is considered to simulate the contact between the pick cutter and rock. The results of the simulation show the rock breaking due to contact with the pick cutter.