• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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• pp.236-236
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• 2002

Pyruvate dehydrogenase phosphatase (PDP) is a mitochondrial protein serine/threonine phosphatase that catalyzes the dephosphorylation and concomitant reactivation of the pyruvate dehydrogenase componant of the pyruvate dehydrogenase complex (PDC). PDP consists of a Mg$\^$+2/ -dependent and Ca$\^$+2)-stimulated catalytic subunit (PDPc) of Mr 52,600 and a FAD-containing regulatory subunit (PDPr) of Mr 95.600. Catalytic subunit of pyruvate dehydrogenase phosphatase (PDPc) has been suggested to have three major functional domains such as dihydrolipoamide acetyltransferase(E$_2$)-binding domain, regulatory subunit of PDP(PDPr)-binding domain, and calcium-binding domain. In order to identify functional domains, recombinant catalytic subunit of pyruvate dehydrogenase phosphatase (rPDPc) was expressed in E. coli JM101 and purified to near homogeneity using the unique property of PDPc: PDPm binds to the inner lipoyl domain (L$_2$) of E$_2$ of pyruvate dehydrogenase complex (PDC) in the presence of Ca$\^$+2/, not under EGTA. PDPc was limited-proteolysed by trypsin, chymotrypsin, Arg-C, and elastase at pH7.0 and 30$^{\circ}C$ and N-terminal analysis of the fragment was done. Chymotrypsin, trypsin, and elastase made two major framents: N-terminal large fragment, approx. 50kD and C-terminal small fragment, approx. 0 kDa. Arg-C made three major fragments: N-terminal fragment, approx. 35 kD, and central fragment, approx. 15 kD, and C-terminal fragment, approx. 10 kD. This study strongly suggest that PDPc consists of three major functional domains. However, further study should be necessary to identify the functional role.

• 공업화학
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• 제23권3호
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• pp.271-278
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• 2012

본 연구에서는 마이카와 산화 아연을 이용하여 복합 재료를 제조하고, 이를 자외선 차단 크림에 응용하는 연구를 수행하였다. 먼저 마이카와 산화 아연을 각각 3-aminopropyltrimethoxysilane (APTMS)으로 처리하여 표면에 아민기를 생성시켰다. 아민기가 붙은 마이카를 1,4-phenylenediisothiocyanate (PDC)와 반응시켜 표면에 -N=C=S 작용기를 활성화시킨 후, 아민기가 붙어있는 산화 아연과 결합시켜 산화 아연으로 덮인 마이카 복합 재료를 합성하였다. 원소 분석, EDS 분석, 열 중량 분석, SEM 이미지 분석, 형광 이미지 분석, 제타 전위 측정, X-선 회절 분석, DRS UV/Vis 분석을 통하여 고체 생성물의 특성을 규명하였다. 최종적으로 표준 프로토콜로 제조된 자외선 차단 크림의 파장에 따른 투과도를 280~400 nm 범위에서 측정하여 자외선 차단 효과를 확인하였다.

• 한국지능시스템학회논문지
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• 제15권3호
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• pp.318-323
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• 2005

본 논문에서는 불확실성을 포함한 연속시간 비선형 동적 시스템에 대한 퍼지 모델 기반 제어기의 지능형 디지털 재설계를 위한 조직적인 방법을 제안한다. 불확실 비선형 시스템을 표현하기 위해 연속시간 불확실 TS 퍼지 모델이 구성된다. 그리고, 안정화와 추적을 위한 퍼지 모델 기반 제어기 설계를 위해 PDC 기법이 이용된다. 마지막으로, 설계된 연속시간 제어기는 지능형 디지털 재설계 기법을 이용함으로써 이산시간 제어기로 전환됨을 증명하는 방법을 제안한다. 이 새로운 설계 기법은 퍼지 모델 기반 제어 이론과 불확실성을 가진 비선형 동적 시스템에 대한 진보된 디지털 재설계 기법의 통합을 위한 조직적이고, 효과적인 틀을 제공한다 마지막으로, 단일 링크 유연 로봇 시스템의 모의 실험을 이용해 개발된 설계 방법의 효용성과 실행 가능성을 입증한다.

• 전자공학회논문지SC
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• 제42권1호
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• pp.13-21
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• 2005

본 논문에서는 시간지연과 입력포화를 갖는 카오스 시스템에 대한 퍼지 모텔 기반의 동기화 기법을 제안한다. 시간지연을 갖는 카오스 마스터 시스템과 슬레이브 시스템을 모델링하기 위해 Takagi-Sugeno(T-S) 퍼지 모델을 이용한다. 특히 슬레이브 시스템은 제어 입력이 제한되는 입력포화 특성을 갖는다고 가정한다. 선형 오차 피드백과 병렬 분상 보상(PDC) 방법에 따라 퍼지 카오스 동기화 시스템을 설계하고 동기화 오차 시스템의 국소 안정도 조건을 해석한다. 신호 전송 채널에는 시간지연이 항상 존재하므로 채널 시간지연 또한 고려한다. 입력포화와 시간지연을 갖는 퍼지 동기화 시스템의 국소 안정도에 대한 충분 조건은 Lyapunov-Krasovskii 이론을 적용하여 선형 행렬 부등식 (LMI) 문제의 해를 통해 얻어진다. 제안된 동기화 기법의 효과를 확인하기 위해서 모의 실험을 수행한다.

• 한국지능시스템학회논문지
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• 제12권3호
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• pp.239-245
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• 2002

본 논문에서는 입력에 제한이 있는 시간지연 비선형 시스템에 대한 퍼지 $H_2/H_{\infty}$ 제어기 설계 방법을 제시한다. 포화입력을 갖는 시간지연 비선형 시스템을 시간지연과 포화입력을 갖는 Takagi-Sugeno 퍼지 모델로 표현하고 병렬분산보상(PDC)의 개념을 이용하여 제어기를 설계한다. Lyapunov 함수를 이용하여 시간지연과 포화입력을 갖는 $H_2/H_{\infty}$ 퍼지모델에 대한 폐루프 시스템의 안정성 조건과 LQ 성능을 최소화하는 조건을 유도하고, 퍼지 $H_2/H_{\infty}$ 제어기가 존재할 충분조건을 선형행렬부등식(LMI: liner matrix inequality)을 이용하여 구한다. 제어기는 선형행렬부등식의 해를 구하므로써 바로 구할 수 있으며, 설계된 퍼지 $H_2/H_{\infty}$ 제어기는 $H_{\infty}$ 노옴 한계값을 만족하면서 LQ성능의 상한값을 최소화한다. 마지막으로 포화압력으로 포화압력을 가지는 시간지연 비선형 시스템에 대해 퍼지 $H_2/H_{\infty}$ 제어기 설계 사례를 보인다.

• Asian-Australasian Journal of Animal Sciences
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• 제27권2호
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• pp.161-168
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• 2014

This study aimed to investigate dietary concentrate:forage ratios (C:F) and undegraded dietary protein (UDP) on nitrogen balance and urinary excretion of purine derivatives (PD) in lambs. Four Dorper${\times}$thin-tailed Han crossbred castrated lambs with $62.3{\pm}1.9$ kg body weight at 10 months of age were randomly assigned to four dietary treatments in a $2{\times}2$ factorial arrangement of two levels of C:F (40:60 and 60:40) and two levels of UDP (35% and 50% of CP), according to a complete $4{\times}4$ Latin-square design. Each experimental period lasted for 19 d. After a 7-d adaptation period, lambs were moved into individual metabolism crates for 12 d including 7 d of adaption and 5 d of metabolism trial. During the metabolism trial, total urine was collected for 24 h and spot urine samples were also collected at different times. Urinary PD was measured using a colorimetric method and creatinine was measured using an automated analyzer. Intake of dry matter (DM) (p<0.01) and organic matter (OM) (p<0.01) increased as the level of UDP decreased. Fecal N was not affected by dietary treatment (p>0.05) while urinary N increased as the level of UDP decreased (p<0.05), but decreased as dietary C:F increased (p<0.05). Nitrogen retention increased as dietary C:F increased (p<0.05). As dietary C:F increased, urinary excretion of PD increased (p<0.05), but was not affected by dietary UDP (p>0.05) or interaction between dietary treatments (p>0.05). Daily excretion of creatinine was not affected by dietary treatments (p<0.05), with an average value of $0.334{\times}0.005$ mmol/kg $BW^{0.75}$. A linear correlation was found between total PD excretion and PDC index ($R^2$ = 0.93). Concentrations of creatinine and PDC index in spot urine were unaffected by sampling time (p>0.05) and a good correlation was found between the PDC index (average value of three times) of spot urine and daily excretion of PD ($R^2$ = 0.88). These results suggest that for animals fed ad libitum, the PDC index in spot urine is effective to predict daily excretion of PD. In order to improve the accuracy of the spot sampling technique, an appropriate lag phase between the time of feeding and sampling should be determined so that the sampling time can coincide with the peak concentration of PD in the urine.

• 한국의류학회지
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• 제21권6호
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• pp.1041-1050
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• 1997

This study was carried out to improve the thermal insulation properties of wool and wool- like fabrics by treating the fabrics with polyethylene glycol, to evaluate the fabric hand of PEG treated wool and wool-like fabrics and to grade up the fabric hand of the treated fabrics by treating with softening agents. Wool and wool-like fabrics were treated with high molecular PEG-8,000 by PDC. The thermal release/storage properties were measured on a DSC. Hand of specimens were evaluated by KES-FB system. The results were as follows; 1. PEG-treated fabrics showed thermal storage and thermal release properties by DSC and the heat contents were generally proportional to the add-ons. 2. PEG-treated fabrics showed higher Koshi and lower Numeri and Sofutosa values due to lower tensile energy and recovery and higher bending rigidity and shear stiffness as the add- ons increased. 3. PEG-treated fabrics showed much lower bending rigidity after softening agents treatment.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.1500-1505
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• 2004

This paper presents the design and control of a small Brushless DC (BLDC) Motor for entertainment robots. In order to control the developed BLDC motor, Adaptive Fuzzy Control (AFC) scheme via Parallel distributed Compensation(PDC) is developed for the multi- input/multi-output plant model represented by the Takagi-Sugeno(TS) model. The alternative AFC scheme is proposed to provide asymptotic tracking of a reference signal for the systems with uncertain or slowly time-varying parameters. The developed control law and adaptive law guarantee the boundedness of all signals in the closed-loop system. In addition, the plant state tracks the state of the reference model asymptotically with time for any bounded reference input signal. The suggested design technique is applied to the velocity control of a developed small BLDC motor for entertainment robots.

• 한국지능시스템학회논문지
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• 제12권6호
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• pp.559-564
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• 2002

This Paper Proposes a design method of a fuzzy output feedback controller for the nonlinear systems with the unknown time- delay. Recently, Cao et ai. proposed a stabilization method for the nonlinear time-delay systems using a fuzzy controller when the time-delay is known. However, the time-delay is likely to be unknown in practical. We represent the nonlinear systems with the unknown time-delay by Takagi-Sugeno (T-5) fuzzy model and design the fuzzy observer and the parallel distributed compensation (PDC) law based on this observer. By applying Lyapunov-Krasovskii theorem to the closed-loop system, the sufficient condition for the asymptotic stability of the equilibrium Point is derived and converted into the linear matrix inequality (LMI) Problem.

• 한국염색가공학회지
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• 제14권3호
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• pp.53-58
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• 2002

Cotton fabric was treated with TiO$_2$-PEG600 mixed solution by pad-dry-cure and wet-fixation process to improve the performance properties as well as antibiosis effect and its laundering durability. In this paper, the effects of concentration of $TiO_2/PEG$ and fixation process were investigated on laundering durability and properties of cotton fabric treated with glyoxal. As the concentration of $TiO_2/PEG$ increased fixation, W.I., K/S of treated cotton fabric increased. Application of wet-fixation method provided a further improvement in fixation, laundering durability of treated cotton fabric.