• Korean Journal of Acupuncture
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• v.26 no.2
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• pp.15-25
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• 2009

Objective: This paper aimed to understand influences on EEG conducting acupuncture stimulation, by comparing the changes in the acupoints on the body before and after normal people are treated with acupuncture at PC9 and TE3, which are referred to as Wood points(木穴), and PC5 and TE1, which are referred to as the Metal points(金穴) among the five shu points of Yin pericardium Meridian and Yang Triple Energizer Meridian. Methods: The study was performed on 30 healthy female volunteers in their 20's. EEG was measured for 5 minutes before acupuncture stimulation was conducted on PC9, TE3, PC5 and TE1. During 20 minutes of acupuncture treatment, the same items were continuously measured to find out whether there were any changes in them, and they were measured for 5 minutes after removing the acupuncture needles in order to implement a comparative analysis. Results: Comparision of EEG data before and after the treatment at PC9 shows no significant differences in all wave. Compared with the pre-acupuncture period at TE3, $\delta-\theta$ wave decreased significantly (P<0.05) during the acupuncture stimulation periods. Compared with the pre-acupuncture period at PC5, $\delta-\theta$ wave and high $\alpha$ wave increased significantly (P<0.05) during the acupuncture stimulation periods. And Mid $\beta$ wave and high $\beta$ wave decreased significantly (P<0.05) during the acupuncture periods and the post acupuncture periods. Compared with the Pre-acupuncture period at TE1, $\delta-\theta$ wave, $\theta$ wave and high $\alpha$ wave increased significantly (P<0.05) during the acupuncture stimulation periods. And Low $\beta$ wave decreased significantly (P<0.05) during the acupuncture periods. Conclusion: When acupuncture stimulation was performed on PC9 and TE3, referred to as the "Wood points", brain waves were stabled, while when acupuncture was performed on PC5 and TE1, called the "Metal points", a brain was waked. From the findings of this study, we hypothesize that the wood properties, from which growing starts in all things, are related with fast waves of EEG, and the metal properties, which stabilize and converge in all things, are related with slow waves of EEG.

• Journal of Bio-Environment Control
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• v.32 no.3
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• pp.242-248
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• 2023

This study was conducted to evaluate the effects of trinexapac-ethyl (TE) and prohexadione-calcium (PC) on the growth and turf quality of perennial ryegrass (Lolium perenne L.). Treatments were designed as follows; control (non-treatment), TE (TE 0.01 a.i. g·m^-2·100mL^-1), and PC (PC 0.01 a.i. g·m^-2·100mL^-1). Compared with control, turf color index and chlorophyll content of TE and PC treatments were not significantly different. As applied plant growth regulators (PGRs), shoot length in the TE and PC was decreased by 8.9-12.4% and 6.7-13.6%, respectively, and clipping yield by 44.4-45.8% and 40.6-40.9%. When evaluated with the growth of shoot length after applying PGRs, residual days of TE and PC were 43.6 and 37.9 days after treatment of PGRs (DAT) in the 1st experiment (July 29-August 26), respectively, and 38.3 and 39.5 DATs in the 2nd experiment (September 30-October 28). These results indicated that an application of TE or PC decreased shoot length and clipping yield in the perennial ryegrass, and their residual time was about 40±3 DATs. Perennial ryegrass applied with PGRs like TE and PC was not significant seasonal difference, and might be not phytotoxic.

• Journal of Pharmacopuncture
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• v.6 no.3
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• pp.91-106
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• 2003

Objectives : The aim of this study was to examine the effects of electroacupuncture(EA) at the PC6(Naegwan) and the TE5 (Oegwan) on nounal humans using power spectral analysis. Methods : EEG power spectrum exhibit site-specific and state-related differences in specific frequency bands. In this study, power spectrum was used as a measure of complexity. 30 channel EEG study was carried out in 30 subjects(30 males ; age=23.7 years). Results : In ${\alpha}$(alpha) band, the power values at F7 channels(p<0.05) during the PC6-acupoint treatment were significantly were decreased. In ${\beta}$(beta) band, the power values at Fp1, Fz, TT1, T5, P3, P4, Po1, P02, O1, Oz, O2 channels(p<0.05) during the non-acupoint treatment and at Fp1, F4, F8 channels(p<0.05) during the TE5-acupoint treatment significantly were increased. In ${\theta}$(theta) band, the power values at Fp1 channels(p<0.05) during the non-acupoint treatment and at Oz channels(p<0.05) the TE5-acupoint treatment significantly were increased. but, the power values at F7 channels(p<0.05) during the non-acupoint treatment were significantly were decreased. In ${\delta}$(delta) band, the power values at TCP1, TCP2, CP1, T5 channels(p<0.05) during PC6-acupoint treatment were increased and the power values at F7, TT2 channels(p<0.05) during non-acupoint treatment were increased. but, the power values at the TE5-acupoint treatment significantly was decreased than the before-acupuncture treatment.

• Investigative Magnetic Resonance Imaging
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• v.8 no.1
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• pp.32-41
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• 2004

Purpose : To measure the NMR relaxation properties of MnPC, to observe the characteristics of liver enhancement patterns on MR images in experimentally implanted rabbit VX2 tumor model, and to estimate the possibility of tissue specific contrast agent for MnPC in comparison with the hepatobiliary agent. Materials and Methods : Phthalocyanine (PC) was chelated with paramagnetic ions, manganese (Mn). 2.01 g (5.2 mmol) of phthalocyanine was mixed with 0.37 g (1.4 nlmol) of Mn chloride at $310^{\circ}C$ for 36 hours and then purified by chromatography ($CHCl_3:\;CH_3OH=98:2$, volume ratio) to obtain 1.04 g $(46\%)$ of MnPC (molecular weight = 2000 daltons). The T1/T2 relaxivity (R1/R2) for MnPC were determined at a 1.5 T (64 MHz) MR spectrometer. VX2 tumor model was experimentally implanted in the liver parenchyma of rabbits. All MR studies were performed on 1.5 T. The human extremity radio frequency coil of a bird cage type was employed. MR images were acquired at 17 to 24 days after VX2 carcinoma implantation.4 mmol/kg MnPC and 0.01 mmol/kg Mn-DPDP were injected via the ear vein of rabbits. T1-weighted images were obtained with spin-echo (TR/TE=516/14 msec) and fast multiplanar spoiled gradient recalled (TR/TE : 80/4 msec, $60^{\circ}$ flip angle) pulse sequence. Fast spin-echo (TR/TE=1200/85 msec) was used to obtain the T2-weighted images. Results : The value of T1/T2 relaxivity (R1/R2) of MnPC was $7.28\;mM^{-1}S^{-1}$ and $55.56\;mM^{-1}S^{-1}$ respectively at 1.5 T (64 MHz). Because the T2 relaxivity of MnPC that bonded strongly, covalently manganese with phthalocyanine was very high, the signal intensity of liver parenchyma was decreased on postcontrast T2-weighted images and we could easily distinguish the VX2 carcinoma within the liver parenchyma. When MnPC was administrated intravenously, the tumor margin delineation was more remarkable than Mn-DPDP-enhanced images. The enhancement of liver parenchyma with MnPC persisted at relatively high levels over at least one hour after injection of the contrast agents. Conclusion : The hepatic uptake and biliary excretion of MnPC, which are similar to Mn-DPDP, suggest that this agent is a new liver-specific agent. Also, MnPC seems to be used as a dual contrast agent (T1 and T2) with high T2 relaxivity. However, it is warranted that MnPC needs further investigation as a potential contrast agent for MR imaging of the liver. That is, further characterizations of MnPC are needed in vivo and in vitro before clinical trials. The diagnostic potential of MnPC will also have to be examined more in the animal models of additional types.

• Investigative Magnetic Resonance Imaging
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• v.6 no.1
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• pp.35-40
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• 2002

Purpose : To evaluate the NMR relaxation properties and imaging characteristics of tissue-specificity for a newly developed macromolecular MR agent. Materials and methods : Phthalocyanine (PC) was chelated with paramagnetic ion, Mn.2.01g (5.2 mmol) of Phthalocyanine was mixed with 0.37g (1.4 mmol) of Mn chloride at $310^{\circ}C$ for 36 hours and then purified by chromatography (CHC13/CH3OH 98/2 v/v, Rf, 0.76) to obtain 1.04g (46%) of MnPC (molecular weight= 2000d). The $T1}T2$ relaxivity of MnPC was measured in 1.5T(64 MHz) MR using 0.1 mM MnPC. The MR image characteristics of MnPC was evaluated using spin-echo (TR/TE=500/14 msec) and gradient-echo (FLASH) (TR/TE=80/4 msec, flip angle=60) techniques in 1.57 MR scanner. The images of rabbit liver were obtained every 10 minutes up to 4 hours. To study the effect of concentration on image, 20 mM, 50 mM, 100 mM of MnPC were tested. Results : The relaxivities of MnPC at 1.5T(64MHz) were Rl=7.28 $mM^{-1}S^{-1},{\;}R2=55.56mM^{-1}S^{-1}$. Compared to the values of Gd-DTPA (Rl[=4.8 $mM^{-1}S^{-1})$], R2[=5.2 $mM^{-1}S^{-1}])$]), both T1/T2 relaxivities of MnPC were higher than those of Gd-DTPA. For both of SE and FLASH techniques, the contrast enhancement reached maximum at 10 minutes after bolus injection and the enhancement continued for more than 2 hours. When compared with small molecular weight liver agents such as Gd-EOB-DTPA, Gd-BOPTA and MnDPDP, MnPC was characterized by more prolonged enhancement time. The time course of MR images also revealed biliary excretion of MnPC. Conclusion : We developed a new macromolecular MR agent, MnPC. The relaxivities of MnPC were higher than those of small molecular weight Gd-chelate. Hepatic uptake and biliary excretion of MnPC suggests that this agent is a new liver-specific MR agent.

• Investigative Magnetic Resonance Imaging
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• v.3 no.2
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• pp.154-158
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• 1999

Purpose : The purpose of this study was to find the optimum TE value for enhancing $T_2^{*}$ weighting effect and minimizing the SNR degradation and to compare the BOLD effects according to the changes of TE in 1.5T and 3.0T MRI systems. Materials and Methods : Healthy normal volunteers (eight males and two females with 24-38 years old) participated in this study. Each volunteer was asked to perform a simple finger-tapping task (sequential opposition of thumb to each of the other four fingers) with right hand with a mean frequency of about 2Hz. The stimulus was initially off for 3 images and was then alternatively switched on and off for 2 cycles of 6 images. Images were acquired on the 1.5T and 3.0T MRI with the FLASH (fast low angle shot) pulse sequence (TR : 100ms, FA : $20^{\circ}$, FOV : 230mm) that was used with 26, 36, 46, 56, 66, 76ms of TE times in 1.5T and 16, 26, 36, 46, 56, 66ms of TE in 3.0T MRI system. After the completion of scan, MR images were transferred into a PC and processed with a home-made analysis program based on the correlation coefficient method with the threshold value of 0.45. To search for the optimum TE value in fMRI, the difference between the activation and the rest by the susceptibility change for each TE was used in 1.5T and 3.0T respectively. In addition, the functional $T_2^{*}$ map was calculated to quantify susceptibility change. Results : The calculated optimum TE for fMRI was $61.89{\pm}2.68$ at 1.5T and $47.64{\pm}13.34$ at 3.0T. The maximum percentage of signal intensity change due to the susceptibility effect inactivation region was 3.36% at TE 66ms in 1.5T 10.05% at TE 46ms in 3.0T, respectively. The signal intensity change of 3.0T was about 3 times bigger than of 1.5T. The calculated optimum TE value was consistent with TE values which were obtained from the maximum signal change for each TE. Conclusion : In this study, the 3.0T MRI was clearly more sensitive, about three times bigger than the 1.5T in detecting the susceptibility due to the deoxyhemoglobin level change in the functional MR imaging. So the 3.0T fMRI I ore useful than 1.5T.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.4
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• pp.337-346
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• 2015

Sprain is the injury of meridian-muscle, and is caused by qi and blood obstruction or regional stagnation of qi and blood. So we take the channel points where pain flows. If we take the locations that feel pain, those locations are treatments points and ashi points. So we searched over the ashi points appearing on the patients with wrist sprain. Ashi points appeared on LI5, TE4, SI5 around wrist joints, LI10, LI11, LU6 around elbow joints, LI14, LU3, LU4, PC2 around upper arm. Also, ashi points appeared much on ST17, KI23, PC1, SP18, ST18 around thoracic region, and, on BL15, BL44, BL13 around anterior and thoracodorsal region, in order stated. Ashi points of the highest frequency appeared on LI14 around upper arm, and on LI5, TE4 around wrist joint, and SI5, ST17, KI12, PC1, SP18 appeared with second highest frequency. And ashi points on elbow points and thoracodorsal region appeared with the same frequency. Therefore, it is possible for us to know that the pain location appears in order of upper arm, anterior thoracic region, elbow joint region, and, thoracodorsal region, in treating wrist joints. There was a tendency that pain and movement disturbance recovered more quickly, depending on the pain reduction, as we found out the ashi points closely from stagnated qi and blood caused by wrist arthritis, and relaxed the stiff location. Rubbing treatments in treating pain ashi points is considered to play an important role to reduce pain effectively, so it is necessary to make a further study.

• Transactions on Electrical and Electronic Materials
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• v.3 no.2
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• pp.28-31
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• 2002

The Cdl-xZnxTe film was fabricated by thermal evaporation for the flat-panel X-ray detector. The stoichimetric ratio and the crystal structure of a polycrystalline Cd$_{1-x}$ Zn$_{x}$Te were investigated by EPMA and XRD, respectively. The leakage current and X-ray sensitivity of the fabricated films were measured to analyze the X-ray response characteristic of Zn in the polycrystalline CdZnTe thin film. The leakage current and the output charge density of Cd$_{0.7}$Zn$_{0.3}$Te thin film were measured to 0.37 nA/cm$^2$ and 260 pc/cm$^2$ at an applied voltage of 2.5 V/${\mu}{\textrm}{m}$, respectively. Experimental results showed that the increase of Zn doping rates in Cd$_{1-x}$ Zn$_{x}$Te detectors reduced the leakage current and improved the signal to noise ratio significantly.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.330.1-330.1
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• 2014

개인용 노트북, 태블릿 PC, 핸드폰 기술 발전에 의해 언제 어디서나 데이터를 작성하고 기록하는 일들이 가능해졌다. 특히 cloud 시스템을 이용하여 데이터를 휴대기기에 직접 저장하지 않고 server에 기록하는 일들이 가능해짐에 따라 server 기기의 성능, server-room power 및 space 에 대한 관심이 증가하였다. Storage class memory (SCM) 이란 memory device와 storage device의 장점을 결합한 memory를 일컫는 기술로 현재 소형 디바이스 부분부터 점차 그 영역을 넓히고 있다. 그중 phase change material을 이용한 phase change memory (PCM) 기술이 가장 각광받고 있다. PCM의 경우 scaling됨에 의해 cell간의 열 간섭으로 인한 data 손실의 우려가 있어 cell의 면적을 최소화 하여 소자를 제작하여야 한다. 기존의 sputtering등의 PVD 방법으로는 한계가 있어 ALD 공정을 이용한 PCM에 대한 연구가 활발히 진행중이다. 특히 tellurium 원료기체로 silyl 화합물 [1]을 사용하여 주로 $Ge_2Sb_2Te_5$의 조성에 초점을 맞춰 진행되고 있으나, 세부 공정에 대한 기본적인 연구는 미비하다. 본 연구에서는 Ge-Sb-Te 3원계 박막을 형성하기 위한 Sb-Te 화합물의 증착 공정에 대한 연구를 수행하였다. 특히 원료기체로 Si이 없는 새로운 Te 원료기체를 이용하여 조성 조절을 하였고, 박막의 물성을 분석하였다. 또한 공정온도에 따른 박막의 물성 변화를 분석하였다.

• JSTS:Journal of Semiconductor Technology and Science
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• v.11 no.3
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• pp.146-152
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• 2011

Thermal stability of $Ge_2Sb_2Te_5$ (GST) and $SiO_2$ doped GST (SGST) films for phase change random access memory applications was investigated by observing the change of surface roughness, layer density and composition of both films after isothermal annealing. After both GST and SGST films were annealed at $325^{\circ}C$ for 20 min, root mean square (RMS) surface roughness of GST was increased from 1.9 to 35.9 nm but that of SGST was almost unchanged. Layer density of GST also steeply decreased from 72.48 to 68.98 $g/cm^2$ and composition was largely varied from Ge : Sb : Te = 22.3 : 22.1 : 55.6 to 24.2 : 22.7 : 53.1, while those of SGST were almost unchanged. It was confirmed that the addition of a small amount of $SiO_2$ into GST film restricted the deterioration of physical and chemical properties of GST film, resulting in the better thermal stability after isothermal annealing.