• Biomolecules & Therapeutics
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• v.29 no.2
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• pp.227-233
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• 2021

Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon and ubiquitous environmental toxin with known harmful effects to human health. Abnormal phenotypes of keratinocytes are closely associated with their exposure to B[a]P. Resorcinol is a component of argan oil with reported anticancer activities, but its mechanism of action and potential effect on B[a]P damage to the skin is unknown. In this study, we investigated the effects of resorcinol on B[a]P-induced abnormal keratinocyte biology and its mechanisms of action in human epidermal keratinocyte cell line HaCaT. Resorcinol suppressed aryl hydrocarbon receptor (AhR) activity as evidenced by the inhibition of B[a]P-induced xenobiotic response element (XRE)-reporter activation and cytochrome P450 1A1 (CYP1A1) expression. In addition, resorcinol attenuated B[a]P-induced nuclear translocation of AhR, and production of ROS and pro-inflammatory cytokines. We also found that resorcinol increased nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activity. Antioxidant response element (ARE)-reporter activity and expression of ARE-dependent genes NAD(P)H dehydrogenase [quinone] 1 (NQO1), heme oxygenase-1 (HO-1) were increased by resorcinol. Consistently, resorcinol treatment induced nuclear localization of Nrf2 as seen by Western analysis. Knockdown of Nrf2 attenuated the resorcinol effects on ARE signaling, but knockdown of AhR did not affect resorcinol activation of Nrf2. This suggests that activation of antioxidant activity by resorcinol is not mediated by AhR. These results indicate that resorcinol is protective against effects of B[a]P exposure. The mechanism of action of resorcinol is inhibition of AhR and activation of Nrf2-mediated antioxidant signaling. Our findings suggest that resorcinol may have potential as a protective agent against B[a]P-containing pollutants.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.10C
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• pp.929-934
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• 2007

In this paper, we enumerate the number of distinct autocorrelation distributions that M-ary Sidel'nikov sequences can have, while we change the primitive element for generating the sequence. Let p be a prime and $M|p^n-1$. For M=2, there is a unique autocorrelation disuibution. If M>2 and $M|p^k+1$ for some k, $1{\leq}k, then the autocorrelatin distribution of M-ary Sidel'nikov sequences is unique. If M>2 and $M{\nmid}p^k+1$ for any k, $1{\leq}k, then the autocorrelation distribution of M-ary Sidel'nikov sequences is less than or equal to ${\phi}(M)/k'(or\;{\phi}(M)/2k')$, where k' is the smallest integer satisfying $M|p^{k'}-1$.

• The Korean Journal of Zoology
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• v.39 no.2
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• pp.164-172
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• 1996

KP elements derived from Korean populations (Seoul, Cheonan and Taegu) of Drosophila melunoguster were examined for their molecular structure. The entire 1.15 kb sequence of the three KP elements KC-137 (Cheonan), KS-95 (Seoul) and KT-99 (Taegu) have been obtained by PCR amplification using inverted repeat primers and DNA sequencing. The 1.15 kb fragments of KP elements were cloned into pCRmll vector plasmids, and subsequently sequenced. The sequence of the three KP elements in these populations suggested that there might have been derived from the complete P element by a 1753 bp internal deletion between positions 808 and 2560. Therefore these KP elements were confirmed to be identical to that isolated from M'10 strains widely distributed in most Eurasian populations of D. melanoguster. Sequence comparison with the 2.9 kb complete P element in pn25.1 revealed that KC-137 has only shown to be two base substitutions of A to G and G to A at positions 62 and 242, respectively. The retained sequence of the two KP elements KS-95 and KT-99 shows complete homology to the P factor in pn25.1. Based on this result, the two base substitutions in KC-137 might be due to Taq DNA pollunerase errors. Finally, it is suggested that the high copy numbers of KP elements provieds an explanation for the suppression of P-mediated hybrid dvssenesis in Korean population of D. melunogoster.

• Korean Journal of Mathematics
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• v.28 no.3
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• pp.587-601
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• 2020

In this paper we propose a way of enhancing eigenvalue approximations with the Bank-Weiser error estimators for the P1 and P2 conforming finite element methods of the Laplace eigenvalue problem. It is shown that we can achieve two extra orders of convergence than those of the original eigenvalue approximations when the corresponding eigenfunctions are smooth and the underlying triangulations are strongly regular. Some numerical results are presented to demonstrate the accuracy of the enhanced eigenvalue approximations.

• Journal of the Korean institute of surface engineering
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• v.36 no.6
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• pp.461-465
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• 2003

The microstructures and magnetic properties of electrodeposited Fe-45 wt%Ni-P alloys have been investigated. The structures of electrodeposited Fe-45 wt%Ni alloy was FCC i.e. ${\gamma}$ phase and the size of crystallite was 10 nm. The structure of electrodeposited Fe-45 wt%Ni-1 wt%P alloy showed ${\gamma}$ phase and 7 nm sized nanocrystalline. The electrodeposited Fe-45 wt%Ni-P alloys containing 2∼3 wt% of P exhibited ${\gamma}$ ＋ $\alpha$ dual phases. The electrodeposited Fe-45 wt%Ni-P alloys above 3.5 wt% showed an amorphous structure. P in the alloys acted grain refining and phase changing element. The resistivity of the electrodeposited alloys increased with P contents. Effective permeability at high frequency (above 1 MHz) increased with P contents up to 2 wt% and this was ascribed to the easier magnetization rotation owing to the reduction of eddy current. Effective permeability decreased with P contents above 3 wt% and this was ascribed to the transformation of the ferromagnetism of Fe-45 wt%Ni alloy gradually into paramagnetism with the introduction of P into the electrodeposited alloy matrix.

• Journal of the Korean Institute of Intelligent Systems
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• v.15 no.1
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• pp.104-109
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• 2005

Context-awareness is an important element that can provide service of good quality according to users' surrounding environment and status in ubiquitous computing environment. Information gathering tools for context-awareness use small size mobile devices which have easy movement and a mobile agent in mobile device. Now, Mobile agents are consuming much times and expense to collect and recognize each users' context information. Therefore, needs research about structure for users' context information awareness in early time to reduce mobile agent's load. This paper proposes a P2P mobile agent structure that mikes filtering techniques and a P2P agent in mobile agent. The proposed structure analyzes each user's context information in same area, and groups users who have similar preference degree. Grouped users share information using a P2P mobile agent. Also this structure observes and learns to continue on users' action and service, and measures new interrelation.

• Journal of the Korean Institute of Rural Architecture
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• v.16 no.4
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• pp.59-66
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• 2014

This paper deals with vibration of plates with concentrated mass on elastic foundation. The object of investigating natural frequencies of tapered thick plate on pasternak foundation by means of finite element method and providing kinetic design data for mat of building structures. Free vibration analysis that tapered thick plate in this paper. Finite element analysis of rectangular plate is done by use of rectangular finite element with 8-nodes. In order to analysis plate which is supported on pasternak foundation. The Winkler parameter is varied with 10, $10^2$, $10^3$ and the shear foundation parameter is 5, 10. This paper is analyzed varying thickness by taper ratio. The taper ratio is applied as 0.0, 0.25, 0.5, 0.75, 1.0. And the Concentrated Mass is applied as P1, Pc, P2 respectively.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.5
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• pp.471-482
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• 2016

In this study, we focused on a speed-up of KIESSI-3D program, which is based on FE-IE techniques, by introducing a p-version dynamic infinite element method. In order to evaluate performance of the KIESSI-3D, numerical analyses for eight real-scale SSI problems are carried out. We considered three types of KIESSI-3D numerical models whose radii of near-field soil region($r_0$)are 1.2, 1.5, and 3.0 times of basemat radius of structure(R). In addition, SSI analyses using the SASSI2010 program are carried out used for comparison of accuracy and runtime against those of the KIESSI-3D. Numerical results show that the KIESSI-3D model of $r_0=1.2R$ is enough to give accurate solution. In view of the computing speed, the new KIESSI-3D was up to 25 times faster than the old KIESSI-3D.

• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.4 s.44
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• pp.67-74
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• 2005

This paper presents a new infinite element for modeling far-field region in dynamic analysis of a fluid-saturated two-phase medium. The infinite element method combined to the infinite element method has been effectively applied to several engineering problems where the full space or half-space medium should be modeled. However, the currently available infinite element for dynamic analysis of two-phase porous medium has a limitation that Pl and P2 waves can only be Included in shape function expressing behavior ol the body. In this paper, the infinite element method is extended to simulate arbitrary number of multi-component waves. For this purpose, the far-field of the porous medium is assumed to be a layered half-space, while the near-field Includes structures as well as irregular soil medium. The accuracy and effectiveness of the proposed element have demonstrated using 1-D and 2-D wave propagation problems.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.28A no.5
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• pp.370-374
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• 1991

A high performance fully ion-implanted InP JFET was characterized for high speed switching elements. The switch has an insertion loss of 5.5dB with 31.6dB isolation at 1GHz. This device can effectively swithc a byte-multiplexed 2Gb/s signal and an eye-diagram taken at 2Gb/s shows an error-free eye pattern. Therefore, this device can be used as a switching element for high transmission data rate for monolithic integration of optoelectronic circuit in the long-wavelength region.