• 생물정신의학
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• 제26권2호
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• pp.79-87
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• 2019

Objectives The aim of this study was to investigate the impact of clinical and psychological factors on the quality of life of children and adolescents with epilepsy and their families. Methods Children and adolescents with epilepsy and their families (n = 63, age range = 6-17 years) completed questionnaires on epilepsy-related variables, quality of life, children's depressive symptoms, children's anxiety, children's behavioral problems, children's attention problems, parental stress, and parental anxiety. Stepwise regression analysis was performed to determine the significant predictive variables that affect quality of life. Results In the correlational analysis, children's attention problems (r = 0.363, p = 0.004), parental anxiety (r = 0.377, p = 0.003), parental stress (r = 0.564, p < 0.001), and children's behavioral problems (r = 0.503, p < 0.001) showed a significant correlation with quality of life. Parental stress (β = 0.415, p = 0.001, adjusted R² = 0.345) and children's behavioral problems (β = 0.285, p = 0.02, adjusted R² = 0.345) were significantly related to the quality of life. Conclusions Clinicians should pay attention to parental stress and children's behavioral problems, which affect quality of life in families with pediatric epilepsy.

• Journal of Microbiology and Biotechnology
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• 제33권3호
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• pp.398-409
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• 2023

LncRNAs play crucial roles in the progression of colon adenocarcinoma (COAD), but the role of LINC01232 in COAD has not received much attention. The present study was designed to explore the related mechanisms of LINC01232 in the progression of COAD. LINC01232, miR-181a-5p, p53, c-myc, Bcl-2, cyclin D1, p16, Bax, VEGF, E-cadherin, vimentin, N-cadherin and SDAD1 expressions were determined by western blot and qRT-PCR. CCK-8, tubule formation, and Transwell assays were employed to detect proliferation, angiogenesis, and migration/invasion of COAD cells, respectively. The relationship between LINC01232 and miR-181a-5p was predicted by LncBase Predicted v.2, and then verified through dual luciferase reporter gene assay. According to the results, LINC01232 was highly expressed in COAD cells and enhanced proliferation, angiogenesis, migration, and invasion of COAD cells. Downregulated LINC01232 promoted expression of p53 and p16, and inhibited c-myc, Bcl-2 and cyclin D1 expressions in COAD cells, while upregulation of LINC01232 generated the opposite effects. LINC01232 was negatively correlated with miR-181a-5p while downregulated miR181a-5p could reverse the effects of siLINC01232 on cell proliferation, angiogenesis, migration, and invasion. Similarly, miR-181a-5p mimic could also offset the effect of LINC01232 overexpression. SiLINC01232 increased the expressions of Bax and E-cadherin, and decreased the expressions of VEGF, vimentin, N-cadherin and SDAD1, which were partially attenuated by miR-181a-5p inhibitor. Collectively, LINC01232 enhances the proliferation, migration, invasion, and angiogenesis of COAD cells by decreasing miR-181a-5p expression.

• 대한수학회보
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• 제34권2호
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• pp.317-334
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• 1997

The existence of an operator-valued function space integral as an operator on $L_p(R) (1 \leq p \leq 2)$ was established for certain functionals which involved the Labesgue measure [1,2,6,7]. Johnson and Lapidus showed the existence of the integral as an operator on $L_2(R)$ for certain functionals which involved any Borel measures [5]. J. S. Chang and Johnson proved the existence of the integral as an operator from L_1(R)$ to $C_0(R)$ for certain functionals involving some Borel measures [3]. K. S. Chang and K. S. Ryu showed the existence of the integral as an operator from $L_p(R) to L_p'(R)$ for certain functionals involving some Borel measures [4].

• Geomechanics and Engineering
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• 제17권4호
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• pp.343-354
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• 2019

The present study demonstrates the application of seismic petrophysics and amplitude versus angle (AVA) forward modeling to identify the reservoir fluids, discriminate their saturation levels and natural gas composition. Two case studies of the Lumshiwal Formation (mainly sandstone) of the Lower Cretaceous age have been studied from the Kohat Sub-basin and the Middle Indus Basin of Pakistan. The conventional angle-dependent reflection amplitudes such as P converted P ($R_{PP}$) and S ($R_{PS}$), S converted S ($R_{SS}$) and P ($R_{SP}$) and newly developed AVA attributes (${\Delta}R_{PP}$, ${\Delta}R_{PS}$, ${\Delta}R_{SS}$ and ${\Delta}R_{SP}$) are analyzed at different gas saturation levels in the reservoir rock. These attributes are generated by taking the differences between the water wet reflection coefficient and the reflection coefficient at unknown gas saturation. Intercept (A) and gradient (B) attributes are also computed and cross-plotted at different gas compositions and gas/water scenarios to define the AVO class of reservoir sands. The numerical simulation reveals that ${\Delta}R_{PP}$, ${\Delta}R_{PS}$, ${\Delta}R_{SS}$ and ${\Delta}R_{SP}$ are good indicators and able to distinguish low and high gas saturation with a high level of confidence as compared to conventional reflection amplitudes such as P-P, P-S, S-S and S-P. In A-B cross-plots, the gas lines move towards the fluid (wet) lines as the proportion of heavier gases increase in the Lumshiwal Sands. Because of the upper contacts with different sedimentary rocks (Shale/Limestone) in both wells, the same reservoir sand exhibits different response similar to AVO classes like class I and class IV. This study will help to analyze gas sands by using amplitude based attributes as direct gas indicators in further gas drilling wells in clastic successions.

• 충청수학회지
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• 제28권3호
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• pp.473-482
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• 2015

Let Qf be the maximal derivative of f with respect to the Bergman metric $b_B$. In this paper, we will find conditions such that $(1-{\parallel}z{\parallel})^s(Qf)^p(z)$ is bounded on B. We will also find conditions such that Bergman projection type operator $P_r$ is bounded operator from $L^p(B,d{\mu}_r)$ to the holomorphic Besov p-space Bs $B^s_p(B)$ with weight s.

• 한국산학기술학회논문지
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• 제21권10호
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• pp.166-173
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• 2020

이 연구의 목적은 인지적 종결 욕구를 측정하는 단축형 종결 욕구 척도(NFCS-SF: Need for Closure Scale-Short Form)를 타당화하기 위함이었다. 참가자들은 인지적 종결 욕구, 불확실성에 대한 인내력 부족, 우울과 불안 설문지를 작성하였다. 2017년 5월~7월 동안 수집된 536개의 자료 중, 총 495명의 참가자의 자료를 SPSS 20.0과 M-Plus로 분석하였다. 연구결과는 다음과 같다. 첫째, 탐색적 요인분석 결과를 토대로 각 하위 영역에서 3문항을 선정하여 15문항의 NFCS-SF를 구성하였다. 둘째, NFCS-SF의 내적 일치도가 양호했다(연구 1, Cronbach's α=.85; 연구 2, Cronbach's α=.84). 셋째, 확인적 요인분석 결과 5요인 구조가 지지되었다(χ²(80)=178.34, p<.001, CFI=.87, TLI=.83, RMSEA=.07, SRMR=.08). 넷째, NFCS-SF는 NFCS(r=.86, p<.01) 뿐 아니라 불확실성에 대한 인내력 부족(r=.58, p<.01), 우울(r=.16, p<.05)과 불안(상태 불안, r=.31, p<.01; 특성 불안, r=.29, p<.01) 척도와의 상관이 유의하였다. 이러한 연구결과를 토대로, 연구의 의의 및 한계와 후속 연구를 위한 제안을 토의하였다.

• 유통과학연구
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• 제12권8호
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• pp.43-54
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• 2014

Purpose - This study was based on a theoretical consideration of the structural relationship between the support and control of the franchisor and the satisfaction and strategic response (voice, loyalty, exit, neglect) of the franchisee. First, based on the preceding research, this study systematically organized the type of support and control of the franchisor. Second, the study examined the effects of a franchisor's support and control on the expectancy disconfirmation between affiliated franchisees' expectations before a franchise agreement and performance after operating an affiliated store. Third, the study looked into the effects of expectancy disconfirmation relating to a franchisor's support and control on an affiliated franchisees' general satisfaction. Fourth, this study examined the influence of the general satisfaction of a franchisee on affiliated franchisees' response strategies. Research design, data, and methodology - In this study, the population comprised the nation's franchisors, and the sample comprised franchisees conducting business in Seoul and Gyeonggi-do. A self-administered questionnaire was used; the author and examiner explained the study's parameters to the interviewees in advance, to lessen the rate of rejection of the answers and to maintain reliability. The author distributed 350 copies of the questionnaire and collected 327 copies (93.4%). The author removed 54 copies of the sample, as these copies belonged to franchisees that were not registered by the Fair Trade Commission and/or were thought to have either defects or inadequate answers. The author selected an effective sample of 273 copies to enter data and to do the statistical analysis. Results - Both a reliability analysis and a confirmatory factor analysis were performed to measure reliability and validity, and a structural equation model was used to conduct the hypothesis test and investigate the models. The hypothesis was tested (Table 5). The models had a suitable fit, for instance, χ² = 447.663(df = 212, p = .000), χ²/df = 2.112, GFI = .881, AGFI = .858, RMR = .083, RMSEA = .067, NFI = .932, and CFI = .961. The hypothesis test results were as follows. Hypothesis 1 was accepted (C.R. = -2.339, p = .019). Hypothesis 2 was accepted (C.R. = 15.213, p = .000). Hypothesis 3 was accepted (C.R. = -2.631, p = .006). Hypothesis 4 was accepted (C.R. = 16.271, p = .000). Hypothesis 5 was accepted (C.R. = 2.391, p = .017). Hypothesis 6 was accepted (C.R. = 5.777, p = .000). Hypothesis 7 was accepted (C.R. = 17.153, p = .000). Hypothesis 8 was accepted (C.R. = 24.746, p = .000). Hypothesis 9 was accepted (C.R. = -10.150, p = .000). Hypothesis 10 was accepted (C.R. = -12.124, p = .000). Conclusions - The research results showed that expectations for a franchisor's support and control had a significant influence on expectation disconfirmation in a negative way, whereas the performance of support and control were found to have a significant influence on expectation disconfirmation in a positive way. In addition, the expectation disconfirmation of support and control was found to have a significant influence on satisfaction of franchisees in a positive way. Generally, regarding the research on control, control is found to have a negative influence on the satisfaction of franchisees, but this study proves that control is found to affect it in a positive way through conformity.

• 대한통합의학회지
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• 제11권1호
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• pp.167-175
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• 2023

Purpose : The purpose of this study was to identify the degree of occupational therapist's sleep quality and examine the correlation between sleep quality and job stress. We also investigated the effects of the occupational therapist's sleep quality on job stress. Therefore, we aimed to investigate the importance of sleep quality and find a way to reduce job stress in occupational therapists. Methods : We conducted a study from November 7 to from December 23, 2022. To assess sleep quality and job stress, sleep quality of scale and Korean occupational stress scale-SF (KOSS-SF) were used. The general characteristics, sleep quality, job stress were examined using a frequency analysis and presented with descriptive statistics. The pearson correlation coefficient was used to determine, whether there was a correlation between sleep quality and job stress. To find what factors have and effect on job stress, we conducted a multiple regression analysis. A significance level of α=.05 was used to verify statistical significance. Results : First, average sleep quality score was 2.10±.19. Second, a significant correlation was found between sleep quality and job stress (p<.01). And As a result of the relationship between sleep quality sub-factors and job stress, day time dysfunction (r=.23, p<.01), restoration (r=.18, p<.05), difficulty of falling asleep (r=.38, p<.01). difficulty of awakening (r=.36, p<.01), satisfaction (r=.33, p<.01) and difficulty of maintaining sleep (r=.24, p<.05) showed a statistically significant relationship with job stress. Third, the sub-factors of sleep quality influencing job stress were difficulty of falling asleep (β =.26, p<.01), difficulty of awakening (β=.23, p<.01) and satisfaction (β=.21, p<.01). Conclusion : The results of this study, demonstrated the importance of sleep quality in affecting job stress. Therefore, follow-up studies are, necessary to develop interventions to improve, occupational therapist's sleep quality in the future.

• 한국산학기술학회논문지
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• 제17권8호
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• pp.164-171
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• 2016

본 연구의 목적은 아버지-아동 애착 수준을 확인하고, 결혼만족도, 부부갈등, 양육스트레스, 양육태도가 아버지-아동의 애착에 미치는 영향을 파악하는 것이다. 연구대상은 B시에 소재한 어린이집과 유치원에 다니는 아동의 아버지 131명이다. 자료는 구조적 설문지를 이용하여 2014년 2월16일부터 8월16일까지 수집하였다. 수집된 자료는 SPSS 21.0 통계 프로그램을 사용하여 기술통계, t-test, ANOVA, Pearson correlation 상관분석, 다중회귀분석을 이용하여 분석하였다. 아버지-아동 애착의 평균은 $3.79{\pm}0.47$이었으며, 일반적 특성 중 아버지의 월수입에 따라 아버지-아동 애착 점수가 차이(f=5.25, p<.010)를 보였다. 아버지-아동의 애착과 결혼만족도는 정적 상관이었다(r=.28, p=.001). 아버지-아동의 애착은 부부갈등(r=-.23, p=.010), 양육스트레스(r=-.44, p<.001), 양육태도 중 수용-거부적 태도(r=-.64, p<.001) 및 통제(r=-.30, p<.001)와는 부적 상관이었다. 아버지-아동 애착을 예측하는 모형은 통계적으로 유의하였고(F=89.29, p<.001), 모형의 설명력은 40%이었다. 아버지-아동 간 애착의 가장 큰 영향요인은 아버지의 수용-거부적인 양육태도로 나타났다(${\beta}=-0.64$, p<.001). 본 연구결과 아버지-아동의 애착은 중간보다 약간 높은 수준으로 향상시킬 필요가 있다, 아버지-아동의 애착증진을 위해 아버지의 수용-거부적 양육태도를 애정적 양육태도로 변화시킬 수 있는 전략 개발을 제언한다.

• 한국균학회지
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• 제26권4호통권87호
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• pp.551-561
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• 1998

S.B, P.S, C.P를 각각 처리한 배지에 배양된 진균류(Aspergillus phoenicis, Rhizopus acidus, Candida albicans)에서 원형질막을 분리하였다. 원형질막 단백질의 함량과 특성을 대조구와 비교하였다. A. phoenicis의 생장은 S.B 처리구에서 평균 64.0%가 감소하였다. R. acidus의 생장은 P.S 처리구에서 평균 69.0%가 감소하였다. 또한 C. albicans의 생장도 S.B 처리구에서 평균 59.5%의 감소를 나타내었다. 여러 진균세포 원형질막에 함유된 단백질의 함량은 S.B 처리구에서 평균 41.0%, 41.7%, 59.5%가 각각 억제되었다. A. phoenicis의 원형질막 단백질의 변화 양상은 처리구에서는 배양 1일째, 2일째는 대조구와 비슷한 경향을 나타내었다. 그러나 배양 1일째 $116\;KD{\sim}97\;KD$ 밴드는 거의 사라졌고 $45\;KD{\sim}29\;KD$ 밴드는 희미하게 관찰되었다. R. acidus는 S.B 처리구에서 배양 중간기부터 $116\;KD{\sim}97\;KD$ 밴드가 소실되었으며, P.S 처리구와 C.P 처리구는 배양초에 소실되기 시작하여 배양 36시간에는 완전히 소실되었다. C. albicans에서는 $116\;KD{\sim}97\;KD$ 밴드가 대조구와 비교하여 배양초에 소실되기 시작하였고 $66\;KD{\sim}45\;KD$밴드는 배양 96시간에 희미하게 나타났다. 특히 C.P 처리구에서는 배양 96시간에 완전히 소실되었다.