• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.323-333
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• 2016

Background: Ovarian cancer remains a major worldwide health care issue due to the lack of satisfactory diagnostic methods for early detection of the disease. Prior studies on the role of serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in detecting ovarian cancer presented conflicting results. New tools to improve the accuracy of identifying malignancy are urgently needed. We here aimed to evaluate the diagnostic utility of tissue CA125 and HE4 gene expression in comparison to serum CA125 and HE4 in discriminating benign from malignant pelvic masses. Materials and Methods: One-hundred Egyptian women were enrolled in this study, including 60 epithelial ovarian cancer (EOC) patients and 20 benign ovarian tumor patients, as well as 20 apparently healthy women. Preoperative serum levels of CA125 and HE4 were measured by immunoassays. Tissue expression levels of genes encoding CA125 and HE4 were determined by quantitative real time polymerase chain reaction (qRT-PCR). The diagnostic performance of CA125 and HE4, measured either as mRNA or protein levels, was evaluated by receiver operating characteristic (ROC) curves. Results: The serum CA125+HE4 combination and serum HE4, with area under the curve (AUC) values of 0.935 and 0.932, respectively, performed significantly better than serum CA125 (AUC=0.592; P<0.001). Tissue CA125 and HE4 (AUC=1) performed significantly better than serum CA125 (P<0.001), serum HE4 (P=0.016) and the serum CA125+HE4 combination (P=0.018). Conclusions: Measurement of tissue CA125 and HE4 gene expression not only improves discriminatory performance, but also broadens the range of differential diagnostic possibilities in distinguishing EOC from benign ovarian tumors.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5081-5084
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• 2015

Background: Breast cancer is a malignant tumor that starts from cells of the breast and is seen mainly in women. It's the most common cancer in women worldwide and is a major threat to health. The purpose of this study was to fit a Cox proportional hazards model for prediction and determination of years of survival in Iranian patients. Materials and Methods: A total of 366 patients with breast cancer in the Cancer Research Center were included in the study. A Cox proportional hazard model was used with variables such as tumor grade, number of removed positive lymph nodes, human epidermal growth factor receptor 2 (HER2) expression and several other variables. Kaplan-Meier curves were plotted and multi-years of survival were evaluated. Results: The mean age of patients was 48.1 years. Consumption of fatty foods (p=0.033), recurrence (p<0.001), tumor grade (p=0.046) and age (p=0.017) were significant variables. The overall 1- year, 3-year and 5-year survival rates were found to be 93%, 75% and 52%. Conclusions: Use of covariates and the Cox proportional hazard model are effective in predicting the survival of individuals and this model distinguished 4 effective factors in the survival of patients.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6339-6342
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• 2014

Background: The incidence of rectal cancer is increasing in younger age groups. Limited data is available regarding survival outcome in younger patients with conflicting results from western world. The goal of this study was to determine survival in patients with rectal cancer <30 years of age and compare it with their older counterparts in the Pakistani population. Materials and Methods: A retrospective chart review of patients operated for rectal adenocarcinoma between January 2005 and December 2010 was performed. Patients were divided into two groups, Group 1 aged ${\leq}30years$ and Group 2 aged >30years. Patient characteristics, surgical procedure, histopathological details and number of loco-regional and distant failures were compared. Expected 5 year survival was calculated using Kaplan Meier curves and significance was determined using the Log rank test. Results: There were 38 patients in group 1 and 144 in group 2. A significantly high number of younger patients presented with poorly differentiated histology (44.7% vs 9.7%) (p=0.0001) and advanced pathological stage (63.1% vs 38.1%) (p=0.04). Predicted overall 5 year survival was 38% versus 57% in groups I and II, respectively (p=0.05). Disease free survival was 37% versus 52% and was significantly different (p=0.007). Conclusions: Early onset rectal cancer is associated with poor pathological features and a worse outcome in Pakistani population.

• Transactions of the Korean Society of Automotive Engineers
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• v.8 no.3
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• pp.110-118
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• 2000

For reasonable fatigue design and estimation of fatigue durability considered fatigue strength and stiffness of the automotive body structure, many fatigue data must be insured according to the shapes, materials, and welding conditions of the spot welded lap joints. However, because it is actually difficult problem, there is need to establish a new method to be able to predict its fatigue life without any additional fatigue tests. Therefore, In order to improve such problems, in this study, the maximum stress function presenting the $\delta\sigma_{1max}―\delta P$ relation was defined form the relation between $\delta\sigma_{1max}-N_f$ and ${\delta}P-N_f$. By using the fatigue data on the IB type spot-welded lap joints previously obtained from the fatigue test results, fatigue life of the spot-welded lap joint previously obtained from the fatigue test results, fatigue life of the spot-welded lap joint having a certain dimension was tried to predict without any additional fatigue tests. And, its result was verified by ${\delta}P-$N_f$ curves. Obtained conclusion are as follows, 1) a maximum stress function considered the relation of the maximum principal stress, fatigue load, and the effects of geometrical factors of the IB type spot-welded lap joint was suggested. 2) the fatigue life predicted by the maximum principal stress function and the relation of $\delta\sigma_{1max}-N_f$ was well agreed with the fatigue life obtained through the actual fatigue test result. 3) the fatigue life of the IB type spot-welded lap joint having a certain dimension is able to be predicted without any additional fatigue tests from the fatigue life prediction method by the maximum principal stress function.

• Journal of Korean Society of Forest Science
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• v.72 no.1
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• pp.37-44
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• 1986

Seasonal changes of water relations parameters were obtained from p-v curves in leaves of Quercus grosseserrata and Quercus acutissima. The osmotic pressure at full hydration, ${\pi}_o$, and osmotic pressure at incipient plasmolysis, ${\pi}_p$, were high in newly emerged leaves but decreased with leaf development in each of the species. Water deficit at turgor loss was 10 to 20% in each of the species during the growing season. Maximum bulk elastic modulus in cell walls at full turgor, Emax, rises rapidly with leaf development before senescence in each of the species. Seasonal change of number of osmoles solute in symplasm per dry weight, Ns/DW, was higher in Quercus grosseserrata leaves than Quercus acutissima leaves, while relative water content (Vp/Vo, $RWC^*$, Vo/Vt) was relatively constant in each of the species.

• Journal of the Microelectronics and Packaging Society
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• v.12 no.2 s.35
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• pp.129-134
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• 2005

Electroplating copper is the important role in formation of 3D stacking interconnection in SiP (System in Package). The I-V characteristics curves are investigated at different electrolyte conditions. Inhibitor and accelerator are used simultaneously to investigate the effects of additives. Three different sizes of via are tested. All via were prepared with RIE (reactive ion etching) method. Via's diameter are 50, 75, $100{\mu}m$ and the height is $100{\mu}m$. Inside via, Ta was deposited for diffusion barrier and Cu was deposited fer seed layer using magnetron sputtering method. DC, pulse and pulse revere current are used in this study. With DC, via cannot be filled without defects. Pulse plating can improve the filling patterns however it cannot completely filled copper without defects. Via was filled completely without defects using pulse-reverse electroplating method.

• Journal of the Korean Chemical Society
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• v.39 no.12
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• pp.910-917
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• 1995

Analytical conditions for single column ion chromatographic determination of five anions such as F-, Cl-, NO2-, NO3-, and SO42- were optimized with respect to analysis time and separation efficiency. At the optimum condition of 2.0 mM phthalic acid at pH 4.5, five anions were effectively separated in 10 minutes so that analysis time could be reduced by 40% compared to other recommended conditions. Under this condition all the calibration curves of five anions were linear with a correlation coefficient > 0.999. Analytical results for nine commercial bottled waters were presented.

• Journal of Environmental Health Sciences
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• v.31 no.4 s.85
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• pp.340-348
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• 2005

Laboratory scale experiments were conducted to compare the performance of two types of sequencing batch reactor(SBR) systems, anoxic-oxic-anoxic-oxic $((AO)_2)$ SBR and anoxic-oxic-anoxic $(A_2O)$ SBR on the biological nitrogen and phosphorus removal. Also, the profiles of DO and pH in reactors were used to monitor the biological nutrient removal in two SBRs. The break point in the pH and DO curves at the oxic period coincided with the end of nitrifying activity at about 1 h 30 min in oxic phase, and the change in pH appears to be related to nitrate concentration. The TOC removal efficiency in $A_2O$ SBR was higher than that in $(AO)_2$ SBR. The denitrification was completed at the influent period. The 2nd non-aeration and aeration periods were not necessary for the nitrogen and phosphorus removal because of the low influent TOC concentration in this study. The release and uptake of phosphorus in $AO_2$ SBR was much higher than that in $(AO)_2SBR.$ In order to uptake more phosphorus, the 1st aeration period in $A_2O$ SBR should be prolonged.

• Radiation Oncology Journal
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• v.4 no.2
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• pp.165-172
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• 1986

In electron therapy, lead cutout or low-melting alloy block is used for shaping the field. Material for shaping electron field affects the output factor as wet 1 as the collimation system. The authors measured the output factors of electron beams for shaped fields from Clinac-18 using ionization chamber of Farmer type in polystyrene phantom. They analyzed the parameters that affect the output factors. The output factors of electron beams depend on the incident energy, collimation system and size of shaped field. For shaped field the variation of output factor for the field size (A/P) has appearence of a smooth curve for all energy and all applicator collimator combination. The output factors for open field deviate from the curves for shaped fields. An output factor for a given field can be calculated by equivalent field method such as A/P method, if a combination of applicator and collimator is fixed.

• Korean Journal of Microbiology
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• v.25 no.4
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• pp.346-352
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• 1987

One hundred and seventeen colonies were screened for the detection of the production of exodextranase on the dextran-mineral salts medium. Ten colonies out of them produced the dextranase. Flavobacterium multivorum greatly producing the enzyme was isolated from soil, identified and then studied for various biochemical characteristics. The activity of the dextranase in the cultured medium was high between pH8 and 9 at $35^{\circ}C$, and between $45^{\circ}C$ and $55^{\circ}C$ at pH8. By the growth curves the generation times of the bacterium were approximately 52 minutes in the LB broth, 38 minutes in the LB plus 1% dextran and 660 minutes in the dextran-salts. The strain did not have ant plasmid, and was susceptible to genramicin, cotrimoxazole and cefoperazone, and moderately susceptible to chloramphenicol, cefamandole and cefotaxime, but resistant to ampicillin, cephalothin, tetracycline, amikacin and tobramycin.