• 농약과학회지
• /
• 제8권1호
• /
• pp.1-7
• /
• 2004

화본과 제초제의 대표적인 화합물인 광학활성 fenoxaprop-p-ethyl[ethyl(R)-2-{4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy}propionate]을 4-(6-chloro-1,3-benzoxazol-2-yloxy)phenol과 ethyl (S)-O-(p-toluenesulfonyl)lactate의 치환반응(Walden Inversion)을 이용하여 90%의 수율(광학활성순도 : 99.9% 이상)로 얻었다. 4-(6-chloro-1,3-benzoxazol-2-yloxy)phenol은 기초적인 원료인 아미노페놀, 우레아, 클로린, 유황 등을 자일렌, 메탄올, 디클로로에탄 등의 용매를 사용하여 6단계의 반응을 거처 70% 의 수율로 합성하였다.

• 대한화학회지
• /
• 제25권6호
• /
• pp.376-382
• /
• 1981

페나실브로미드와 치환아닐린류와의 반응속도를 메탄올과 DMF중에서 전기전도도 법으로 측정한 결과 반응속도는 치환기의 전자를 주는 능력이 강할 수록 빨랐으며, 메탄올 속에서 보다 DMF 속에서 더 빨랐다. ${\delta}H^{\neq}$와 ${\delta}S^{\neq}$ 사이에서는 등속 관계가 성립하였으며, 이때 등속 온도는 메탄올에서는 $539^{\circ}K$, DMF에서는 $400^{\circ}K$ 였다. 그러나 p-니트로 아닐린은 용매효과 때문에 직선에서 벗어났다. $Br{\o}nsted$ plot의 경우 메탄올과 DMF에서 log k = 0.57p$K_a$-1.28 (r = 0.996) in MeOH at $45^{\circ}C$; log k = 0.65p$K_a$-0.88 (r = 0.970) in DMF at $45^{\circ}C$,로서 좋은 직선관계가 성립하였다. Hammett${\sigma}$ 도시 결과 이 반응은 아닐린의 친핵치환 반응이었으며, 다음의 식이 얻어졌다. log k/$k_0$ = -2.00${\sigma}$ + 0.06 (r = 0.985) in MeOH; log k/$k_0$ = -2.22${\sigma}$ + 0.08 (r = 0.995) in DMF. 그리고 DMF에서 $4-NO_2$기가 직선에서 벗어났다. 이는 치환기에 의한 용매효과에 기인하는 것이라고 생각된다. 이상의 결과로부터 본 반응의 치환기 효과는 전이상태에서 결합의 형성이 보다 우세한 $S_N2$ 메카니즘으로 진행되고 있으며, 결합의 형성은 DMF 용매에서 더욱 진행되고 있다.

• 대한수학회보
• /
• 제45권1호
• /
• pp.143-155
• /
• 2008

Let p be a prime number. It is known that the order o(r) of a root r of the irreducible polynomial $x^p-x-l$ over $\mathbb{F}_p$ divides $g(p)=\frac{p^p-1}{p-1}$. Samuel Wagstaff recently conjectured that o(r) = g(p) for any prime p. The main object of the paper is to give some subsets S of {1,...,g(p)} that do not contain o(r).

• 디지털융복합연구
• /
• 제14권8호
• /
• pp.343-353
• /
• 2016

본 연구는 임상간호사의 기본심리욕구, 셀프리더십, 직무스트레스가 간호업무성과에 미치는 영향을 알아보기 위한 서술적 조사연구다. 연구대상자는 2016년 2월부터 2016년 3월까지 P시와 D도에 소재한 3차 의료기관에 근무하는 간호사 160명을 할당표집 하였으며, 자료수집은 자가보고 설문지법을 사용하였다. 자료 분석은 SPSS/WIN 18.0프로그램으로 t-test와 분산분석, 상관분석, 다중회귀분석의 방법을 이용하였다. 연구결과 간호업무성과는 일반적 특성 중 연령, 결혼여부, 임상경력, 직위, 근무형태에 따라, 셀프리더십은 연령, 결혼여부, 종교, 임상경력, 직위와 근무위형에 따라, 직무스트레스는 직위에 따라 유의미한 차이를 보였다. 간호업무성과는 기본심리욕구(r=.59, p<.001), 자율성(r=.31, p<.001), 유능감(r=.68, p<.001), 관계성(r=.48, p<.001, 셀프리더십(r=.58, p<.001) 및 직무스트레스(r=.19, p<.05)와 정적상관 관계가 있었다. 간호업무성과에 대하여 기본심리욕구(${\beta}$=.43), 셀프리더십(${\beta}$=.33), 직무스트레스(${\beta}$=.21)은 47.3%의 설명력을 보였다. 본 연구결과 기본심리욕구, 셀프리더십, 직무스트레스는 간호업무성과를 향상시키는 것으로 확인되었다. 그러므로 임상간호사의 간호업무 향상을 위한 간호사의 기본심리욕구와 셀프리더십을 증가시키기 위한 프로그램 개발이 요구된다.

• Molecules and Cells
• /
• 제39권7호
• /
• pp.543-549
• /
• 2016

MicroRNAs (miRNAs) have been reported to be involved in many neurodegenerative diseases. The present study focused on the role of hsa-miR-144-3p in one of the neuro-degenerative diseases, Parkinson's disease (PD). Our study showed a remarkable down-regulation of miR-144-3p expression in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-treated SH-SY5Y cells. MiR-144-3p was then overexpressed and silenced in human SH-SY5Y cells by miRNA-mimics and miRNA-inhibitor transfections, respectively. Furthermore, ${\beta}$-amyloid precursor protein (APP) was identified as a target gene of miR-144-3p via a luciferase reporter assay. We found that miR-144-3p overexpression significantly inhibited the protein expression of APP. Since mitochondrial dysfunction has been shown to be one of the major pathological events in PD, we also focused on the role of miR-144-3p and APP in regulating mitochondrial functions. Our study demonstrated that up-regulation of miR-144-3p increased expression of the key genes involved in maintaining mitochondrial function, including peroxisome proliferator-activated receptor ${\gamma}$ coactivator-$1{\alpha}$(PGC-$1{\alpha}$), nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM). Moreover, there was also a significant increase in cellular ATP, cell viability and the relative copy number of mtDNA in the presence of miR-144-3p overexpression. In contrast, miR-144-3p silencing showed opposite effects. We also found that APP overexpression significantly decreased ATP level, cell viability, the relative copy number of mtDNA and the expression of these three genes, which reversed the effects of miR-144-3p overexpression. Taken together, these results show that miR-144-3p plays an important role in maintaining mitochondrial function, and its target gene APP is also involved in this process.

• 한국전문물리치료학회지
• /
• 제22권4호
• /
• pp.27-33
• /
• 2015

The purpose of this study was to find which spatiotemporal gait parameters gained from stroke patients could be predictive factors for the gait part of Tinetti Performance-Oriented Mobility Assessment (POMA-G). Two hundred forty-six stroke patients were recruited for this study. They participated in two assessments, the POMA-G and computerized spatiotemporal gait analysis. To analyze the relationship between the POMA-G and spatiotemporal parameters, we used Pearson's correlation coefficients. In addition, multiple linear regression analyses (stepwise method) were used to predict the spatiotemporal gait parameters that correlated most with the POMA-G. The results show that the gait velocity (r=.67, p<.01), cadence (r=.66, p<.01), step length of the affected side (r=.49, p<.01), step length of the non-affected side (r=.53, p<.01), swing percentage of the non-affected side (r=.47, p<.01), and single support percentage of the affected side (r=.53, p<.01) as well as the double support percentage of the non-affected side (r=-.42, p<.01) and the step-length asymmetry (r=-.64, p<.01) correlated with POMA-G. The gait velocity, step-length asymmetry, cadence, and single support percentage of the affected side explained 67%, 2%, 2%, and 1% of the variance in the POMA-G, respectively. In conclusion, gait velocity would be the most predictive factor for the POMA-G.

• Child Health Nursing Research
• /
• 제8권1호
• /
• pp.32-43
• /
• 2002

The purpose of this study was to provide basic data on elementary school children's lifestyle and to contribute to developing on the health education program in elementary schools. The subjects were 1,412 children in 4 elementary schools in Gangwon-Do and Chonrabuk-Do area. Data collection was done from September to November 2001 by questionnaire and school health documents. The questionnaire corrected for the purpose of this study which had been developed by Bronson School of Nursing(1991), 'Lifestyle Questionnaire for School-age Children'. The questionnaire consists of 3 categories; 'Activities that promote health', 'Injury prevention', 'Feeling'. Cronbach coefficient alpha for the 29 items was .68. The data analyzed to obtain frequency, mean, percentage, t-test, ANOVA and Pearson correlation coefficient by SPSS Win program. The results of this study were as follows. 1. Females(50.2%) of gender, 6th grade(24.2%) of grade, nuclear family(82.0%) of family type, beyond college graduate(54.5%) of father's school career, under high school graduate(58.1%) of mother's school career, first of birth order(47.1%) were majority. Mean of father's age was 41.2 and mother's age was 38.1. 2. The mean of lifestyle was 66.4, feeling was 73.3, activities that promote health was 60.3 and injury prevention was 64.0. The highest degree of activities that promote health was 「I eat fruits」and injury prevention was 「I look both ways when crossing streets」and feeling was 「I enjoy my family」. The lowest degree of activities that promote health was 「I visit the dentist every tear」 and injury prevention was 「I wear a helmet when I go on bike trips」 and feeling was 「I think it is okay to cry」. 3. There were significant differences in lifestyle of gender(t=4.309, p=.000), grade(F=6.299, p=.000), father's age(t=2.534, p=.011), father's education(t=-4.933, p=.000), mother's education(t=-3.360, p=.001), birth order (t=5.363, p=.000). There were significant differences in activities that promote health of gender(t=-2.462, P=.014), grade(F=4.893, p=.000), father's education(t=-4.480, p=.000), birth order(t=4.343, p=.000), in injury prevention of gender(t=-4.452, p=.000), grade(F=8.636, p=.000), father's age(t=3.386, p=.001), mother's age(t=2.059, p=.040), father's education(t=-6.051, p=.000), mother's education(t=-5.173, p=.000), birth order(t=4.417, p=.000) and in feeling of gender (t=-3.285, p=.001), grade(F=7.526, p=.000), mother's age(t=-3.268, p=.001). 4. Activities that promote health was positively correlated with injury prevention(r=.432, p=.000), feeling(r=.210, p=.000), lifestyle (r=.785, p=.000). Injury prevention was positively correlated with feeling(r=.256, p=.000), lifestyle(r=.854, p=.000) also feeling was positively correlated with lifestyle(r=.504, p=.000). These findings suggest the need to develop nursing strategy to promote elementary school children's health. Because helmet use score in injury prevention marked the lowest score, it is necessary to encourage helmet use when planning injury prevention and health promotion.

• 환경생물
• /
• 제17권4호
• /
• pp.513-519
• /
• 1999

광양만 해수를 대상으로 총 17개의 조사정점을 선정, 1996년 7월부터 1997년 4월까지 계절별로 19종류의 VOCs를 분석.조사하였다. 조사대상 VOCs 중 methylene chloride, tetrachloromethane, 1, 1, 1-trichloroethane, trichloroethane, 1, 1, 1, 2-tetrachloroethane, trichloroethylene, bromoethane, dibromoethane, bromobenzene, 1-ethyl-3-methylbenzene등 총 10개 항목은 전체 조사지점 및 조사 시기 동안에 검출되지 않았으며, chloroform, 1, 2-dichloroethane, ethylbenzene, benzene, toluene, m, p-xylene, methylethylketone, styrene, hexane 등의 조사항목은 소량의 범위에서 조사시기와 정점을 달리하여 검출되었다. 특히 chloroform과 toluene은 0.6~49.9$\mu$g/1, 0.42~48.3$\mu$g/1로서 높은 농도의 범위를 나타내었으며, 검출빈도도 다른 조사 대상 VOCs에 비해 높은 것으로 조사되었다. 이화학적 환경요인과 VOCs와의 상관관계에서 toluene만이 수온(r=-0.524), pH(r=0.319)가 비교적 높은 상관성을 보였으며 나머지 항목은 매우 낮은 상관성을 보였다. VOCs 상호간의 상관성에서 benzene의 경우 toluene, m, p-xylene, ethylbenzene과 높은 상관계수(r=0.549~0.662)를 보였다. 이러한 결과는 광양만에서 VOCs의 배출이 같은 시기에 이루어지고 있음을 시사하는 것으로 추측된다.

• 재활간호학회지
• /
• 제13권2호
• /
• pp.140-150
• /
• 2010

Purpose: This study aims to find the factors that affect the degree of self-care performance in Parkinson's disease (PD) patients. Method: This study used a descriptive correlational design. The data were collected using a sample of 80 PD patients, from the university affiliated Parkinson Center in Busan. Pearson's correlations and multiple regression analyses were conducted using the SPSS 18.0. Results: The mean score of the self-care performance was 3.61 (${\pm}0.40$). The highest score observed of self-care performance subscale was medication subscale ($4.55{\pm}0.50$) and the lowest score was observed in the exercise subscale ($3.03{\pm}0.64$). The self-care performance had significant correlations with depression (r=-.32, p<.01), self-care knowledge (r=.28, p<.05), function of motion (r=.25, p<.05), ability of daily activity (r=.22, p<.05), self-efficacy (r=.24, p<.05), and support from medical staff (r=.24, p<.05). The significant predictors of self-care performance included depression (${\beta}=-.28$), status of employment (${\beta}=-.27$), self-care knowledge (${\beta}=-.21$), support from medical staff (${\beta}=-.28$), and educational level (${\beta}=-.28$), accounting for 34% of the variance in the self-care performance. Conclusion: Depression, self-care knowledge, medical support are significant predictors which affect the self-care performance with PD patients.

• 한국학교보건학회지
• /
• 제12권2호
• /
• pp.231-242
• /
• 1999

This study was designed to identify the relation between health beliefs and compliance with weight control behavior in obese high school students living in Chonnam province. The data were collected from May 24 to 29, 1999. The instruments used in this study were modified by the authors on the basis of the results of the study's related references. The data were analyzed by descriptive statistics, t-test, ANOVA, Pearson's Correlation using the SAS PC+ program. The results were as follows : 1. The correlation between health concern and compliance with weight control behavior was revealed as statistically significant (r= .34, p= .005). From the correlation of variables, it is concluded that there were statistically significant relations between health concern and benefit (r= .25, p= .043), between health concern and barrier (r= .33, p= .008), between susceptibility and severity (r= .64, p= .000), between susceptibility and benefit (r= .42, p= .000), between susceptibility and barrier (r= .44, p= .003), between severity and benefit (r= .37, p= .002), between severity and barrier (r= .56, p= .000), and between benefit and barrier (r= .38, p= .002). Thus, perceived susceptibility, perceived severity, perceived benefit, and perceived barrier had an indirect influence on compliance with weight control behavior. 2. In the analysis of the relationship between general characteristics and compliance with weight control behavior and health belief variables: Sex (t=2.56, p= .010) was revealed as the influencing variable of health concern. The number of those subjects living together (F=2.88, p= .044) was revealed as the influencing variable of susceptibility. Sex (t=3.47, p= .047), income (F=1.67, p= .051) was revealed as the influencing variable of barrier. 3. In the analysis of the relationship between obese characteristics and compliance with weight control behavior and health belief variables: Perception of weight (F=9.21, p= .000), family history of obesity (t=4.89, p= 030), environment of obesity (t=14.30, p= .000) were revealed as the influencing variables of susceptibility. Perception of weight (F=4.86, p= .001), symptoms of obesity (t=4.46, p= .006), family history of obesity (t=6.59, p= .012), environment of obesity (11.30, p= .001), and reasons of weight control (F=3.07, p= .010) were revealed as the influencing variables of severity. Symptoms of obesity (F=4.15, p= .009), reasons of weight control (F=2.41, p= .046) were revealed as the influencing variables of benefit. Environments of obesity (t=4.23, p= .044) were revealed as influencing variables of barrier. These results suggest that for improvement in compliance with weight control behavior, school nurses should stimulate the students' concerns about health.