• 대한의생명과학회지
• /
• 제10권3호
• /
• pp.245-251
• /
• 2004

Microbial infection provokes one of the most serious complications to the patients with indwelling catheters. Ciprofloxacin (CFX) was added into the catheter materials (polyurethane or silicone) during the manufacturing process to avoid the microbial infection. Efficacy of the catheters containing CFX was investigated by using the in vitro zone of growth inhibition test method. The catheters made of polyurethane or silicone exhibited a strong antimicrobial activity against the major catheter-related microorganisms (S. aureus, S. epidermidis, P. aeruginosa and E. coli), when CFX was incorporated into the catheters. Fetal bovine serum (FBS) did not affected antimicrobial activities of the polyurethane catheters with CFX loading of 0.5 and 1.0％ (W/W) against S. aureus and S. epidermidis. However, the polyurethane catheters with 1.0％ (W/W) of CFX loading showed a significantly (P<0.05) reduced antimicrobial activity against E. coli when the catheters were exposed to FBS. Silicone catheters with 1.0 and 1.5％ (W/W) of CFX loading demonstrated effective antimicrobial activity against S. epidermidis for at least 2 weeks. These results suggest that the use of catheters containing ciprofloxacin could be effective in preventing catheter-related infections.

• 한국항공운항학회지
• /
• 제23권2호
• /
• pp.7-14
• /
• 2015

This paper deals with an optimal determination process for the built-in location of localizer under restrictive siting area conditions of a domestic P-airport. Aerodynamic forces and moments acting on the localizer structure can be used a reference to find the safe distance from jet blast and the position at which the reasonable structural loading is applied. Wind tunnel experiment is conducted to measure aerodynamic loadings. The finite element analysis for structural deformation is employed to get the information of structural failure. A new localizer's position is determined by considering aerodynamic loading, structural strength and thermal loading due to jet blast. Deflector effect was also investigated in this study. In conclusion, the location of localizer can be placed at shorter than the current position and greatly decreased if the deflector is applied at the front of localizer.

• Archives of Pharmacal Research
• /
• 제28권8호
• /
• pp.988-994
• /
• 2005

The purpose of the present study was to prepare multivesicular liposomes with a high drug loading capacity and to investigate its potential applicability in the oral delivery of a peptide, human epidermal growth factor (rhEGF). The multivesicular liposomes containing rhEGF was prepared by a two-step water-in-oil-in-water double emulsification process. The loading efficiency was increased as rhEGF concentration increased from 1 to 5mg/mL, reaching approximately $60\%$ at 5 mg/mL. Approximately $47\%$ and $35\%$ of rhEGF was released from the multivesicular liposomes within 6 h in simulated intra-gastric fluid (pH 1.2) and intra-intestinal fluid (pH 7.4), respectively. rhEGF-loaded multivesicular liposomes markedly suppressed the enzymatic degradation of the peptide in an incubation with the Caco-2 cell homogenate. However, the transport of rhEGF from the multivesicular liposomes to the basolateral side of Caco­2 cells was two times lower than that of the rhEGF in aqueous solution. The gastric ulcer healing effect of rhEGF-loaded multivesicular liposomes was significantly enhanced compared with that of rhEGF in aqueous solution; the healing effect of the liposomes was comparable to that of the cimetidine in rats. Collectively, these results indicate that rhEGF-loaded multivesicular liposomes may be used as a new strategy for the development of an oral delivery system in the treatment of peptic ulcer diseases.

• Wind and Structures
• /
• 제1권4호
• /
• pp.303-315
• /
• 1998

Full-scale measurements have been made to determine the increase in wind speed over two exposed embankments, one of $23^{\circ}$ slope and 4.7 m in height, the other of $24^{\circ}$ slope and 7.3 m in height. Measurements were made at heights of 5, 10 and 15 m above the upper edge of each embankment and at the same heights approximately 100 m upwind in the lower-level approach fetch. Despite the modest sizes of the embankments, the maximum recorded increase in mean wind speed was 28% and the minimum was 13%; these increase relate to increases in wind loads on structures erected at the top of the embankments of 64% and 28% respectively. The associated increases in gust speeds are estimated at 33% and 18%, which imply increases in gust loading of 77% and 39% respectively. These experimental results are compared with predictions obtained from a computational fluid dynamics (CFD) analysis, using three high Reynolds number eddy-viscosity models and estimates from the UK wind loading code, BS 6399: Part 2. The CFD results are generally in agreement with the experimental data, although near-ground effects on the embankment crest are poorly reproduced.

• 한국균학회지
• /
• 제23권4호통권75호
• /
• pp.354-358
• /
• 1995

용존 유기물의 농도를 BOD로 신속히 측정하여 폐수처리 공정에 feed back할 수 있는 Yeast BOD sensor 를 제작하여 BOD 측정의 거동을 조사하였다. BOD sensor의 감응도는 yeast의 활성이 가장 높은 pH 7.0 및 온도 $30^{\circ}C$에서 가장 높게 나타났다. Sensor에 충전되는 효모의 양도 감응도에 영향을 미치며 투석막 단위면적당 $ 0.14\;mg/cm^2$가 최적의 균체량이었다. 오염물질의 종류에 따라 BOD sensor의 출력 신호가 다르게 나타났으며 각각의 오염물질 속에 효모균를 전처리 시킨 후 sensor에 충전할 경우 sensor 의 감응도가 크게 증가하였다.

• 대한화학회지
• /
• 제63권4호
• /
• pp.260-265
• /
• 2019

Alcohol dehydrogenase (ADH) (EC 1.1.1.1) was selected as the enzyme which will be immobilized on ultrafiltration membrane by fouling with different transmembrane pressure of 1, 2 and 3 bars. ADH will catalyze formaldehyde (CHOH) to methanol ($CH_3OH$) and simultaneously oxidized nicotinamide adenine dinucleotide (NADH) to $NAD^+$. The concentration of enzyme and pH are fixed at 0.1 mg/ml and pH 7.0 respectively. The objective of the study focuses on the effect of different transmembrane pressure (TMP) on enzyme immobilization in term of permeate flux, observed rejection, enzyme loading and fouling mechanism. The results showed that at 1 bar holds the lowest enzyme loading which is 1.085 mg while 2 bar holds the highest enzyme loading which is 1.357 mg out of 3.0 mg as the initial enzyme feed. The permeate flux for each TMP decreased with increasing cumulative permeate volume. The observed rejection is linearly correlated with the TMP where increase in TMP will cause a higher observed rejection. Hermia model predicted that at irreversible fouling with standard blocking dominates at TMP of 3 bar, while cake layer and intermediate blocking dominates at 1 and 2 bar respectively.

• 한국안전학회지
• /
• 제37권5호
• /
• pp.1-6
• /
• 2022

In this study, to confirm the effects of the mixed load of normal and shear forces acting on a fixing bolt, fatigue design criteria were developed by varying the loading angle and conducting tensile and fatigue tests. After evaluating and comparing the test results under different loading angles, the evaluation criteria were selected. These evaluation criteria were then applied to develop the design criteria. An Arcan fixture was designed and manufactured to simultaneously apply a mixed load of normal and shear forces to the fixing bolt of a turntable, and a fatigue test was conducted. S-N diagrams for various loading angles were obtained, and a 1% P-S-N diagram of failure probability was determined using statistical processing techniques. Our results show that failures of the fixing bolt can be prevented using these diagrams as a basis for developing fatigue design criteria.

• 폴리머
• /
• 제29권6호
• /
• pp.593-598
• /
• 2005

Layer-by-layer(LbL) 자기 조립법에 의한 poly(ethylene-alt-maleic anhydride)(PEMAh)/poly(4-vinyl pyridine)(P4VP) 다층막의 염료 흡착 거동 및 pH 변화에 의한 염료 방출 거동을 Rodamine 6G(R6G)를 지시제로 사용하여 조사하였다. UV-vis 분광 분석을 이용하여 (PEMAh/P4VP)n 다층막의 두께 및 R6G의 흡착 및 방출 거동을 조사하였다. 다층막에 흡착되는 R6G의 흡착량은 필름의 두께 증가에 따라 선형적으로 증가하였다. (PEMAhAh/P4VP)n 다층막의 투과성은 pH 조건에 민감한 거동을 보였으며, 방출액의 pH가 감소할수록 R6G 방출 속도와 방출량은 증가하였다. PEMAh/poly(ethyleneimine)(PEI) capping layer를 (PEMAh/P4VP)n 다층막에 추가로 적층함으로써 흡착된 R6G의 방출 속도를 조절할 수 있었다.

• 한국운동역학회지
• /
• 제16권3호
• /
• pp.9-18
• /
• 2006

These studies show that I applied to functional insole (a specific S company) for minimizing shocks and sprain people's ankle arising from running. How to an effect on human body which studied a kinematics and kinetics from 10 college students during experiments. This study imposes several conditions by barefoot, normal running shoes and put functional insole shoes ran under average $2.0{\pm}0.24$ meter per second by motion analysis, ground reaction force and electromyography that used to specific A company. First of all, Motion analysis was caused by Achilles tendon angle, Angle of the lower leg, Angle of the knee, Initial sole angle and Barefoot angle. Second, Contact time, Vertical impact force peak timing, Vertical active force and Active force timing, and Maximum loading rate under impulse of first 20 percent and Value of total impulse caused Ground reaction force. Third. The tendon fo Quadriceps femoris, Biceps femoris, Tibialis anterior and gastronemius medials caused. electromyography. 1. Ground reaction force also showed that statically approximates other results from impact peak timing (p.001), Maximum loading rate(p<.001), Maximum loading rate timing (p<.001) and impulse of first 20 percent (p<.001). 2 Electromyography showed that averagely was distinguished from other factors, and did not show about that. Above experiment values known that there was statically difference between Motion analysis and Ground reaction force under absorbing of the functional insole shoes which was not have an effect on our body for kinetics and kinematics.

• Asian-Australasian Journal of Animal Sciences
• /
• 제13권7호
• /
• pp.1010-1016
• /
• 2000

Effect on the bio-mass and nutrient yield of Lemna perpusilla Torry was studied at two nutrient loading frequencies. Six polythene sinks ($6{\times}2{\times}0.5m^{3}$ area) randomly allocated to two treatments having three sinks in each treatment. Each sink containing $6{\times}2{\times}0.35m^{3}$ water body, was changed either daily with 12.6 kg anaerobically fermented cattle manure (effluent) or with 76 kg efluent at six-day interval. Media Kjeldhal-N (40 vs. 36 mg/L; p>0.05) and $NH_3$-N (9 vs 7 mg/L; p<0.05) concentration were higher in daily charged sinks than those charged at six-day interval. However, temperature ($28.48{^{\circ}C}\;vs.\;28.60{^{\circ}C}$) and pH (6.82 vs. 6.84) were sinilar in both groups of sinks. Biomass (93 vs. $80g/m^{2}/d$) and crude protein (1.24 vs. $1.11g/m^{2}/d$) yield were non-significantly (p>0.05) higher in the daily charged than 6-d interval charged ponds. However, dry matter (4.52 vs. 4.15%), organic matter (83 vs. 84%), crude protein (31.4 va. 29.6%) and organic carbon (47 vs. 47%) content were similar in both daily and 6-d interval charged ponds. There were no apparent relationships between the crude protein content of Lemna and the media Kjeldhal-N or $NH_3$-N concentration apparently due to saturated level of nutrient (N in particular). It was concluded that with the level of effluent used for two treatments, nutrient-loading frequency had no significant effect on the biomass and protein yield of Lemna. Technique described here can be used for year-round duckweed production from fermented cattle manure for feeding poultry/fish in smallholder production system.