• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.27 no.9
• /
• pp.865-871
• /
• 2016

This work presents a radar signal interferer to be used for evaluating the mutual interference among automotive radars. The developed interfering signal generator is composed of a reference signal generator and a 77 GHz transmitter. Reference signal generator is made up of commercial chips and board, it can generate various modulated signal such as triangular wave, sawtooth wave and random frequency hopping. The transmitter generates 77 GHz band signal by multiplying modulated reference signal frequency 28 times. Transmitter was fabricated using 65 nm CMOS process, it can operate horn antenna by built in on-chip waveguide feeder. The transmitter exhibited 7.31~8.06 dBm output power over a frequency lock range of 75.6~77 GHz.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.10
• /
• pp.4169-4172
• /
• 2015

Background: Oral carcinoma (OC) remains as one of the most difficult malignancies to cure. Hesa-A is an Iranian herbal-marine compound that has shown promising anti-tumor properties on various human cancer cells, although the mechanisms of action remain to be addressed. This study was conducted to evaluate the effect of two doses of Hesa-A on mRNA expression of p53 as a main prognosticator of OC. Materials and Methods: 60 rats were randomly divided into 5 groups of 12 animals each. Rats in carcinoma groups received 0, 250 and 500 mg/kg body weight of Hesa-A three times a day. The two other groups considered as treated and untreated healthy groups. At the end of experiment, animals were sacrificed and tongue tissues subjected to H and E staining and real time PCR. Results: Our results indicated that compared to healthy group, p53 over expressed ~ 40% in untreated carcinoma group. After treatment with 250mg/kg and 500mg/kg body weights of Hesa-A, p53 level dropped by 53.4% and 13.6 %, respectively, compared to untreated carcinoma group (p<0.05, p<0.0001). Moreover, there was a significant relation between p53 mRNA content and observed pathological changes in studied groups (p<0.05). Conclusions: These data provide insights into the mechanism(s) by which Hesa-A improves clinical outcome of oral carcinoma by modulation of p53 expression.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2007.10a
• /
• pp.113-116
• /
• 2007

T-DMB (Terrestrial-DMB) service is now available in the metropolitan area, but due to the bandwidth limitation, it is allowed to provide up to CIF resolution. As users' requests for high-quality mobile multimedia services are rapidly increasing and additional bandwidth can be provided by adopting the hierarchical modulation transmission technology, the research on the Advanced Terrestrial-DMB(AT-DMB) service using the SVC(Scalable Video Coding) scheme is being actively studied. In this paper, through computer simulations, first, while keeping the current T-DMB service unchanged, the visual qualities of AT-DMB services are investigated by varying the additional bandwidth. Then, by considering the cases that the overall bandwidth can be allowed to dynamically allocate to the T-DMB/AT-DMB video services, the performance characteristics between two layers are compared over the different kinds of video sequences.

• Korean Journal of Acupuncture
• /
• v.33 no.4
• /
• pp.204-212
• /
• 2016

Objectives : The aim of the study is to investigate the effects of moxibustion on the pain behavior and expression of TRPM8 in the dorsal root ganglion(DRG) in the rat model of ambient cold(AC) exposed osteoarthritis(OA). Methods : OA was induced by the injection of $50{\mu}l$ of 2% monosodium iodoacetate(MIA) into the knee joint cavity. To examine the level of pain, weight bearing forces(WBFs) of affected limb was measured. For the AC exposure, the animals were housed in 6 h/day at $4^{\circ}C$ for 14 days after MIA injection. Moxibustion treatment was performed at EX-LE4 and EX-LE5 with 5 cons(1, 7 or 10 mg) per day for 13 days from 5 days after MIA injection. The expressions of TRPM8 in DRG were measured by western blotting analysis. Results : The WBFs of MIA-AC group were decreased significantly compared to MIA group at 2, 3, 6, 7, 8 and 9 days after arthritis induction. After the first 6 h-AC exposure, expressions of TRPM8 in MIA-AC group were increased significantly compared to those of naive group. After moxibustion treatment, only the WBFs of 7 mg treated group were restored significantly. Moreover, the over-expressions of TRPM8 were attenuated by the moxibustion treatment in AC exposed rats. Conclusions : The data suggest that AC can increase arthritic knee pain via up-regulated TRPM8 and moxibustion treatment improve the arthritic pain via modulation of TRPM8 expression in DRG in the rat model of AC exposed MIA induced arthritis.

• Molecules and Cells
• /
• v.28 no.4
• /
• pp.375-382
• /
• 2009

The 26S proteasome is a 2-MDa complex with a central role in protein turn over. The 26S proteasome is comprised of one 20S core particle and two 19S regulatory particles (RPs). The RPN12a protein, a non-ATPase subunit of the 19S RP, was previously shown to be involved in cytokinin signaling in Arabidopsis. To further investigate cellular roles of RPN12a, RNAi transgenic plants of RPN12a were constructed. As expected, the 35S:RNAi-RPN12a plants showed cytokinin signaling defective phenotypes, including abnormal formation of leaves and inflorescences. Furthermore, RNAi knock-down transgenic plants exhibited additional unique phenotypes, including concave and heart-shape cotyledons, triple cotyledons, irregular and clustered guard cells, and defects in phyllotaxy, all of which are typical for defective cytokinin signaling. We next examined the mRNA level of cytokinin signaling components, including type-A ARRs, type-B ARRs, and CRFs. The expression of type-A ARRs, encoding negative regulators of cytokinin signaling, was markedly reduced in 35S:RNAi-RPN12a transgenic plants relative to that in wild type plants, while type-B ARRs and CRFs were unaffected. Our results also indicate that in vivo stability of the ARR5 protein, a negative regulator of cytokinin signaling, is mediated by the 26S proteasome complex. These results suggest that RPN12a participates in feedback inhibitory mechanism of cytokinin signaling through modulation of the abundance of ARR5 protein in Arabidopsis.

• The Plant Pathology Journal
• /
• v.32 no.6
• /
• pp.552-562
• /
• 2016

Pathogenesis-related proteins play multiple roles in plant development and biotic and abiotic stress tolerance. Here, we characterize a rice defense related gene named "jasmonic acid inducible pathogenesis-related class 10" (JIOsPR10) to gain an insight into its functional properties. Semi-quantitative RT-PCR analysis showed up-regulation of JIOsPR10 under salt and drought stress conditions. Constitutive over-expression JIOsPR10 in rice promoted shoot and root development in transgenic plants, however, their productivity was unaltered. Further experiments exhibited that the transgenic plants showed reduced susceptibility to rice blast fungus, and enhanced salt and drought stress tolerance as compared to the wild type. A comparative proteomic profiling of wild type and transgenic plants showed that overexpression of JIOsPR10 led to the differential modulation of several proteins mainly related with oxidative stresses, carbohydrate metabolism, and plant defense. Taken together, our findings suggest that JIOsPR10 plays important roles in biotic and abiotic stresses tolerance probably by activation of stress related proteins.

• Molecular & Cellular Toxicology
• /
• v.3 no.2
• /
• pp.137-144
• /
• 2007

The mechanism of cytotoxicity of doxifluridine, a prodrug fluorouracil (5-FU), has been ascribed to the misincorporation of fluoropyrimidine into RNA and DNA and to the inhibition of the nucleotide synthetic enzyme thymidylate synthase. Increased understanding of the mechanism of 5-FU has led to the development of strategies that increases its anticancer activity or predicts its sensitivity to patients. Using GeneChip?? Rhesus Macaque Genome arrays, we analyzed gene expression profiles of doxifluridine after two weeks repeated administration in cynomolgus monkey. Kegg pathway analysis suggested that cytoskeletal rearrangement and cell adhesion remodeling were commonly occurred in colon, jejunum, and liver. However, expression of genes encoding extracellular matrix was distinguished colon from others. In colon, COL6A2, COL18A1, ELN, and LAMA5 were over-expressed. In contrast, genes included in same category were down-regulated in jejunum and liver. Interestingly, MMP7 and TIMP1, the key enzymes responsible for ECM regulation, were overexpressed in colon. Several studies were reported that both gene reduced cell sensitivity to chemotherapy-induced apoptosis. Therefore, we suggest they have potential as target for modulation of 5-FU action. In addition, the expression of genes which have been previously known to involve in 5-FU pathway, were examined in three organs. Particularly, there were more remarkable changes in colon than in others. In colon, ECGF1, DYPD, TYMS, DHFR, FPGS, DUT, BCL2, BAX, and BAK1 except CAD were expressed in the direction that was good response to doxifluridine. These results may provide that colon is a prominent target of doxifluridine and transcriptional profiling is useful to find new targets affecting the response to the drug.

• Journal of Pharmacopuncture
• /
• v.20 no.3
• /
• pp.158-172
• /
• 2017

Nigella sativa (N. sativa, family Ranunculaceae) is a medicinal plant that has been widely used for centuries throughout the world as a natural remedy. A wide range of chemical compounds found in N. sativa expresses its vast therapeutic effects. Thymoquinone (TQ) is the main component (up to 50%) in the essential oil of N. sativa. Also, pinene (up to 15%), p-cymene (40%), thymohydroquinone (THQ), thymol (THY), and dithymoquinone (DTQ) are other pharmacologically active compounds of its oil. Other terpenoid compounds, such as carvacrol, carvone, 4-terpineol, limonenes, and citronellol, are also found in small quantities in its oil. The main pharmacological characteristics of this plant are immune system stimulatory, anti-inflammatory, hypotensive, hepatoprotective, antioxidant, anti-cancer, hypoglycemic, anti-tussive, milk production, uricosuric, choleretic, anti-fertility, and spasmolytic properties. In this regard, we have searched the scientific databases PubMed, Web of Science, and Google Scholar with keywords of N. sativa, anti-cancer, apoptotic effect, antitumor, antioxidant, and malignancy over the period from 2000 to 2017. The effectiveness of N. sativa against cancer in the blood system, kidneys, lungs, prostate, liver, and breast and on many malignant cell lines has been shown in many studies, but the molecular mechanisms behind that anti-cancer role are still not clearly understood. From among the many effects of N. sativa, including its anti-proliferative effect, cell cycle arrest, apoptosis induction, ROS generation, anti-metastasis/anti-angiogenesis effects, Akt pathway control, modulation of multiple molecular targets, including p53, p73, STAT-3, PTEN, and $PPAR-{\gamma}$, and activation of caspases, the main suggestive anti-cancer mechanisms of N. sativa are its free radical scavenger activity and the preservation of various anti-oxidant enzyme activities, such as glutathione peroxidase, catalase, and glutathione-S-transferase. In this review, we highlight the molecular mechanisms of apoptosis and the anti-cancer effects of N. sativa, with a focus on its molecular targets in apoptosis pathways.

• Journal of Astronomy and Space Sciences
• /
• v.34 no.4
• /
• pp.257-270
• /
• 2017

Solar activity is known to be linked to changes in the Earth's weather and climate. Nonetheless, for other types of extreme weather, such as tropical cyclones (TCs), the available evidence is less conclusive. In this study the modulation of TC genesis over the western North Pacific by the solar activity is investigated, in comparison with a large-scale environmental parameter, i.e., El-$Ni{\tilde{n}}o$-Southern Oscillation (ENSO). For this purpose, we have obtained the best track data for TCs in the western North Pacific from 1977 to 2016, spanning from the solar cycle 21 to the solar cycle 24. We have confirmed that in the El-$Ni{\tilde{n}}o$ periods TCs tend to form in the southeast, reach its maximum strength in the southeast, and end its life as TSs in the northeast, compared with the La-$Ni{\tilde{n}}o$ periods. TCs occurring in the El-$Ni{\tilde{n}}o$ periods are found to last longer compared with the La-$Ni{\tilde{n}}o$ periods. Furthermore, TCs occurring in the El-$Ni{\tilde{n}}o$ periods have a lower central pressure at their maximum strength than those occurring in the La-$Ni{\tilde{n}}o$ periods. We have found that TCs occurring in the solar maximum periods resemble those in the El-$Ni{\tilde{n}}o$ periods in their properties. We have also found that TCs occurring in the solar descending periods somehow resemble those in the El-$Ni{\tilde{n}}o$ periods in their properties. To make sure that it is not due to the ENSO effect, we have excluded TCs both in the El-$Ni{\tilde{n}}o$ periods and in the La-$Ni{\tilde{n}}o$ periods from the data set and repeated the analysis. In addition to this test, we have also reiterated our analysis twice with TCs whose maximum sustained winds speed exceeds 17 m/s, instead of 33 m/s, as well as TCs designated as a typhoon, which ends up with the same conclusions.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.47 no.10
• /
• pp.8-16
• /
• 2010

An orthogonal frequency division multiplexing (OFDM) system is a special case of multicarrier transmission, where a single data stream is transmitted over a number of lower-rate subcarriers. One of the main reasons to use OFDM is to increase robustness against frequency-selective fading or narrowband interference. However, in the radio systems the distortion introduced by high power amplifiers (HPA's) such as traveling wave tube amplifier (TWTA) considered in this paper, is also critical. Since the signal amplitude of the OFDM system is Rayleigh-distributed, the performance of the OFDM system is significantly degraded by the nonlinearity of the HPA in the OFDM transmitter. In this paper, we propose a simplicial canonical piecewise-linear (SCPWL) model based digital predistorter to compensate for nonlinear distortion introduced by an HPA in an OFDM system. Computer simulation is carried on an OFDM system under additive white Gaussian noise (AWGN) channels with 16-QAM and 64-QAM modulation schemes and modulator/demodulator implemented with 1024-point FFT/IFFT. The simulation results demonstrate that the proposed predistorter achieves significant performance improvement by effectively compensating for the nonlinearity introduced by the HPA.