• Toxicological Research
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• v.19 no.1
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• pp.67-72
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• 2003

Cholestatic liver injury results from the accumulation of toxic bile salts within the liver. The aim of the present study is to elucidate the changes in expression and cellular localization of apoptosis related proteins in the liver of bile duct-ligated (BDL) rat. Extrahepatic cholestasis was induced by double ligation of the common bile duct and cut between the ligatures. Animals were sacrificed at day 3 and at week 1, 2, 4, 6, and 8 after BDL. The number of TUNEL positive cells was increased significantly after 3 days of BDL, decreased over 2 weeks and remained constant thereafter. Fas expression was not changed and activation of caspase 8 did not occur. Fas immunoreactivity was exclusively observed in the cytoplasm of hepatocytes, indicating that Fas expressed in rat hepatocytes is a soluble form. Hepatocyte apoptosis was associated with Bax expression, which showed a peak at day 3 and decreased over time gradually. Immnunostaining of Bax was observed in hepatocytes and bile duct epithelial cells (BEC) of control and BDL rats. Bcl-2 was increased over time in BDL rats. These results suggest that apoptosis of hepatocytes in BDL rats is independent of Fas and controlled by Bax expression.

• Speech Sciences
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• v.13 no.3
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• pp.207-219
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• 2006

The present study was designed to investigate the comprehension of 'who' and 'what' questions in 2- to 3-year-old normal children. Sixty children were divided into 3 groups depending on their ages, i.e., age groups 2;6-2;11, 3;0-3:5, and 3;6-3;11. Three types of 'who' questions and 2 types of 'what' questions were generated depending on the attached case markers, i.e., who-nominative, who-accusative, who-dative, what-nominative, and what-accusative. The children watched 36 cuts of short video recordings. After watching each cut, they were asked to answer one of the 5 types of wh-questions. For the 'who-nominative' and 'what-accusative' questions, even the late 2-year-old children performed with over 70% of accuracy, and the late 3-year-old children performed with over 95% of accuracy. For the 'who-accusative' and 'who-dative' questions, the late 2-year olds exhibited difficulty in comprehension with performance accuracy of 41% and 33%, respectively. However, the late 3-year olds could comprehend those questions correctly with over 90% of accuracy. On the other hand, in answering 'what-nominative' questions, the children did not show rapid development across the age groups, as the mean performance accuracies of the 3 groups were 39%, 49%, and 59%, respectively. The results indicated that children's understanding of a wh- question is largely affected by the case of the interrogative.

• Composites Research
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• v.23 no.6
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• pp.7-13
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• 2010

Type3 cylinder is a composite pressure vessel fully over-wrapped with carbon/epoxy composite layers over an aluminum liner, which is the most ideal and safe high pressure gas container for CNG vehicles due to the lightweight and the leakage-before-burst characteristics. During service in CNG vehicle, if a fiber cut damage occurs in outer composite layers, it can degrade structural performance, reducing cycling life from the original design life. In this study, finite element modeling and analysis technique for the composite cylinder with fiber-cut crack damage is presented. Because FE analysis of type3 cylinder is path dependant due to plastic deformation of aluminum liner in autofrettage process, method to introduce a crack into FE model affect analysis result. A crack should be introduced after autofrettage in analysis step considering real circumstances where crack occurs during usage in service. For realistic simulation of this situation, FE modeling and analysis technique introducing a crack in the middle of analysis step is presented and the results are compared with usual FE analysis which has initial crack in the model from the beginning of analysis. Proposed analysis technique can be used effectively in the evaluation of influence of damage on composite layers of type3 cylinder and establish inspection criteria of composite cylinder in service.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.6 no.4
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• pp.296-301
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• 2005

This study was conducted to get the basic data on an effect of food waste compost for rock cut-slopese vegetation. Two foreign cool-season grasses and native plants were used for this experiment. Cool-season grasses were Festuca ruba and Lolium perene, Native plants were Amorpha fruticosa, and Indigofera pseudo-tinctoria. Amorpha fruticosa, Indigofera psendo-tinctoria, and Lolium perenne decreased in germination rate and plant height at NaCl concentrations of $0.4\%$ or over suddenly. Festuca rubra occurred to the sudden growth hindrance at NaCl concentrations of $0.2\%$ or over. Amorpha fruticosa and Indigofera pseudo-tinctoria appeared for germination of $45\%$ at all experiment plots. Lolium perenne increased in plant height as trial rate of food waste compost was abundant. Ground cover rate was the highest in Mixture III by $89.3\%$ and was fluctuated from $47.0\%$ after 30 days to $64.1\%$ after 45 days in Mixture 1. Descending order of ground cover rates in 4 treatments was Mixture III, Mixture IV, Mixture II, and Mixture I. As the growth

• Journal of The Korean Society of Clinical Toxicology
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• v.16 no.2
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• pp.68-74
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• 2018

Purpose: In 2012, a revised guideline for acute acetaminophen overdose was proposed in the UK, recommending that the treatment threshold should be lowered to 100 mcg/ml at 4 hours after ingestion without risk stratification of hepatotoxicity. However, the poison centers in some developing countries do not have laboratory resources to provide serum drug levels in time. The primary aim of the study is to evaluate the cut-off value of reported dose per kilogram to determine when N-acetylcysteine treatment is warranted under the revised guideline. Methods: Data were collected retrospectively from the toxicology registry of an urban emergency medical center between 1st January 2010 and 30th June 2017. Inclusion criteria were single acute overdose of more than 75 mg/kg in 15 hours from ingestion and over 14 years of age. Subgroups were created by 25 mg/kg increments of reported dose, then sensitivity, specificity, positive predictive value and negative predictive value were calculated for the cut-off values of 100 mg/kg, 125 mg/kg, 150 mg/kg and 175 mg/kg for toxic serum level over '100-treatment line'. Results: A total of 99 patients were enrolled in the study; 24 patients showed toxic serum levels (24.2%). Zero of 17 patients with an ingestion dose under 100 mg/kg showed toxic level (0%), and 0 of 15 under 125 mg/kg (0%), 2 of 14 under 150 mg/kg (14.3%), and 4 of 12 under 175 mg/kg (33.3%) had toxic levels. The higher the ingested dose per kilogram of weight, the higher the frequency of the toxic serum concentration on the first test (${\chi}^2$ test for trend, ${\chi}^2=22.66$, p-value<0.001) and the sensitivity of each value was 100%, 100%, 92% and 76%. Conclusion: In acute single acetaminophen intoxication, the ingestion dose of 100 mg/kg of weight will be useful in determining the need for the N-acetylcysteine antidote in the indigent laboratory environment.

• Journal of the Korean Vacuum Society
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• v.20 no.5
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• pp.361-366
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• 2011

An in-situ, real-time monitoring of GaN epilayers grown by low pressure metalorganic chemical vapor deposition system modified for spectral reflectance was performed. Reflectance spectrums from 190~861 nm were observed using p-polarized light with incident angle of $75^{\circ}$. All reflectance spectrums showed interference oscillation caused by multiple reflection within GaN epilayers, and the spectrum from GaN with low crystalline quality showed weak reflectance intensity and much low amplitude of the oscillation because many defects in GaN resulted in light scattering and absorption. Signal variation of reflected light which was selected around strong constructive wavelength range was also observed during $NH_3$ supplying and $NH_3$ cut-off. There was no significant change in signal intensity when $NH_3$ cut-off for 10 sec, but it showed higher intensity when $NH_3$ was cut off for over 30 sec and its intensity kept unchanged. This result indicates that GaN surface was N-terminated during $NH_3$ supplying but Ga-terminated during $NH_3$ cut-off because of high nitrogen equilibrium vapor pressure of GaN, and metallic Ga-terminated surface caused slightly higher reflectance intensity.

• Horticultural Science & Technology
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• v.31 no.2
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• pp.165-172
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• 2013

This study was conducted to investigate the effect of bulblet size on growth and bulb enlargement of Lilium Oriental hybrids, such as 'Sorbonne', 'Siberia', and 'Casa Blanca', grown in areas of high altitude (780 m), in 2009. The bulblets were oriented from tissue culture and planted to produce virus-free bulblets. All the three cultivars showed high vitality, with more than 93% producing shoots, even from small bulblets with a bulb circumference (BC) of less than 6 cm. Bulblets with BC 9-10 cm showed an increased height and number of leaves rapidly to induce the phase conversation from vegetative growth to reproductive growth. The bulblets of BC 9-10 cm in 'Sorbonne', 'Siberia', and 'Casa Blanca' had 2.0, 2.9, and 2.8 flower bud sets per plant, respectively. However, the flowers from those bulblets were not adequate as standard bulbs to produce cut-flowers for the domestic market. The larger bulblets showed more prosperous characteristics in growth and development of Lilium Oriental hybrids. Small bulblets had a high occurrence of viruses and leaf blight symptoms during cultivation, indicating the aggravated disease symptoms in the previously infected bulbs. 'Sorbonne' cultivars showed a high rate of enlargement of bulbs, and small bulblets under BC 6 cm produced more than 23% of the standard bulbs of BC 14-16 cm, which could produce cut-flowers for export. However, 'Casa Blanca' bulblets with BC 6-9 cm produced low bulbs of BC 14-16 cm at 21% level. 'Casa Blanca' cultivars had more bulb roots, longer root lengths, and higher weights than 'Sorbonne' and 'Siberia' cultivars. 'Casa Blanca' cultivars with BC over 9-10 cm grew rapidly and produced a high quantity of bulbs. In these results, 'Sorbonne' bulblets of BC 9-10, 'Siberia' bulblets of BC 10-12 cm, and 'Casa Blanca' bulblets of BC 10-12 cm produced 89%, 86%, and 93% of the standard bulbs of BC 14-16 cm, respectively. It is recommended that bulblets larger than the above sizes be used to produce cut-flowers for the export market. Experiment results suggest that production of bulbs larger than BC 18 cm requires bulblets that are larger than BC 12-14 cm of the three cultivars for the highest quality cut-flowers.

• Archives of Reconstructive Microsurgery
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• v.20 no.1
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• pp.32-37
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• 2011

Purpose: Canalicular laceration is relatively common due to its exposed, vulnerable location in case of facial trauma. Conjunctivodacryocystorhinostomy has been the standard treatment for canalicular obstruction secondary to unrepaired canalicular laceration. In spite of a high rate of relieving tear-duct obstruction, this method is noted to be associated with low rate of patient satisfaction and a number of complications. The goal of this study is to report the good results of delayed lacrimal stent implantation with Mini Monoka$^{(R)}$ for patients whose canaliculi were not repaired by initial surgery. Methods: From May of 2005 to February of 2007, four patients who underwent delayed lacrimal stent implantation using Mini Monoka$^{(R)}$ in canalicular laceration were retrospectively reviewed. First, the previous scar incision was made over the lower lid and we identified the cut end of proximal lacerated canaliculus. The Mini Monoka$^{(R)}$ was passed through the punctum to the cut end of the proximal lacerated canaliculus. We identified the cut end of the distal lacerated canaliculus, whose cut end has rolled white edges after careful excision of the scarred lid tissue. We then passed Mini Monoka$^{(R)}$ through the lacerated inferior canaliculus. Using an operating microscope, we placed three interrupted sutures of 8-0 Ethilon to join the canalicular ends. Silicone stent was left in place for 6 months. The mean age of the patients was 48.5 years (range, 35 to 59 years). The time interval from initial trauma to delayed lacrimal stent implantation was between 3 and 31 days. Follow-up periods ranged from 12 and 20 months. Results: The results of reconstruction were classified into normal, fair and poor. Patent lacrimal drainage systems were achieved in three of the four cases. In one case, epiphora was encountered. No cases of stent displacement, conjunctivitis or granuloma formation were encountered. Conclusion: Even though canalicular reconstruction was delayed for a long time, attempting canalicular reconstruction would be acceptable before considering secondary operations like dacryocystorhinostomy and conjunctivodacryocystorhinostomy.

• Journal of the Korean Geotechnical Society
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• v.21 no.6
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• pp.137-146
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• 2005

299 railroad slopes were investigated and the failure characteristics and reinforcement patterns were analyzed. Stability analyses on the 14 cut-off soil slopes were carried out. Surficial failures were predicted by infinite slope analyses assuming the temporarily perched ground water table at soil surface during rainfall period. Limit equilibrium analyses were also carried out and the influences of rainfall infiltration on the slope stabilities were taken Into account by seepage analyses using finite element method and by assuming ground water tables to be located adjacent to soil surface. The adequacy of those analyses was evaluated by comparing the slope failure characteristics between analysis results and the past failure records. From the comparison results, it was deduced that the limit equilibrium analyses were not appropriate to estimate the shallow failure that occurred at most of the railroad cut-off soil slopes. For the better estimation of the surficial failure, not only the increase of pore-water pressure (reduction of matric suction), but also the influence of water flows over slope surface which erode soil mass, should be evaluated and considered.

• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.5
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• pp.82-90
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• 2018

The nuclear structures are composed of large diameter bars over No.36. If the hooked bars are used for anchorage of large diameter bars, too long length of the tail extension of the hook plus bend create congestion and make an element difficult to construct. To address those problems, headed bars were developed. Provisions of ACI 318-08 specify the development length of headed bars and ignore the effect of transverse reinforcement based on the background researches. However, if headed bars are used at the cut-off or lap splice, longitudinal reinforcements, which are deformed in flexural members, induce tensile stress in cover concrete and increase the tensile force in the transverse reinforcement. The object of this research is to evaluate the effects of transverse reinforcement on the anchorage capacity of headed bar so anchorage test with variable of transverse rebar spacing was conducted. Specimens, which can consider the behavior at the cut-off, were tested. Test results show that failure of specimen without transverse reinforcement was sudden and brittle with concrete cover lifted and developed stress of headed bars was less than half of yield strength of headed bars. On the other hand, in the specimen with transverse reinforcement, transverse rebar directly resist the load of free-end so capacity of specimens highly increased.