• 대한간호학회지
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• 제37권3호
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• pp.353-364
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• 2007

Purpose: This study is aimed to analyze and clarify the ambiguous concept of insight. Method: This study used the process of Walker & Avant's concept analysis. Results: Insight can be defined in terms of its attributes as follows: Insight 1) comes as a release to the tension of inquiry, (2) is the outcome of the process to discover the overall structure of the problem situation and psychologically restructurize it, (3) comes suddenly and unexpectedly, (4) is to clearly perceive the solution of the abstract problem, and (5) promotes obtaining another new insight. The antecedents of insight include inquiry that can not be resolved easily and also a state where basic knowledge related to the inquiry can be utilized. The consequence of the insight is (1) a new judgement is made, (2) the problem is solved, (3) previous insight is retained and transferred, and it also facilitates the generation of fresh insight, and (4) it passes into the habitual texture of one's mind. Conclusion: Nurse educators need to facilitate nursing students and nurses to accumulate systematically, various information that can become the basis of insight and provide them with an opportunity to experience a variety of problems. In addition, it is important to provide questions to learners as an education strategy to allow them to gain insight into problem solving. From now on, insight needs to be studied in conjunction with critical thinking and questioning in order to enhance nurses' ability to resolve problems.

• 한국유체기계학회 논문집
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• 제15권6호
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• pp.39-45
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• 2012

This paper describes the outcome of the design of a 200 kW class micro gas turbine and the sensitivity of its performance (efficiency and power) to the variations in major design parameters. The reference design parameters were set up based on the best available component technologies. The resulting net electricity generation efficiency of the micro gas turbine package was found to be competitive to those of other systems in the market. The sensitivities of power and efficiency to the variations in compressor and turbine efficiencies, pressure ratio, turbine inlet temperature, recuperator effectiveness, secondary air ratio, pressure loss ratios of both the cold and hot sides of the recuperator were estimated. Based on the sensitivity data, a simplified method to predict the variation in system performance responding to the combinations of small changes in all design parameters were set up and validated.

• Annals of Clinical Neurophysiology
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• 제8권1호
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• pp.53-57
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• 2006

Background: Vstibular evoked myogenic potentials(VEMP) have been known to be useful documenting abnormality in patients with various vestibular disorders and brainstem lesions but the studies of VEMP in patients with hemispheric lesions are rare. Methods: We recorded VEMP in 21 consecutive patients with acute ischemic stroke in the supratentorial lesions without evidence of brainstem or vestibular end organ lesions. All patients underwent magnetic resonance imaging and the main outcome measures of VEMP were recorded in all subjects. We interpreted each parameters of VEMP using our normal laboratory data. Results: VEMP abnormalities(prolonged latency or asymmetry of amplitude) were found in 57%(12/21) of acute infarction patients with supratentorial lesions. Bilateral VEMP abnormalities were found in six patients and unilateral abnormalities were found in another six patients with ipsilateral abnormalities in the three and controlateral abnormalities in the three patients. Conclusions: VEMP abnormalities were found in supratentorial stroke patients in our studies and this findings suggest supranuclear control may affect the generation of VEMP potentials.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2002년도 춘계공동학술대회
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• pp.1079-1084
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• 2002

Systems engineering technology development program for Korea next-generation high-speed railway(KNHR) system in progress is a national large-scale system development program that is not only a large-size and complex but also multi-disciplinary in nature. Using the RDD-IOO, a systems engineering tool, the KNHR program can establish requirements traceability and development process management in the course of development. This paper presents the results from a computer-aided systems engineering application to KNHR system technology development project over the three years of activities. The traceability among the system design database in the vertical direction of SE process, as the results of the first year and the second year research was accomplished. The database in both the requirement management domain and the project management domain was developed and set up the traceability between them in the horizontal direction of the SE process in the V model as the results of the third year research. Therefore, KNHR design database was built to support the life-cycle management of the system as well as to reuse the knowledge in future programs. In the following development phase, this database will be utilized to accomplish the test and integration activities providing a baseline database. The outcome of the study contributes to the establishment of the model-based systems engineering approach as a best practice in the accumulation and advancement of systems engineering technology for railway system development.

• 한국정보시스템학회지:정보시스템연구
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• 제20권4호
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• pp.119-143
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• 2011

Recently, Information System (IS) development projects such as the next generation IS project of the financial business domain have shown tendency to become large and complex. Accordingly, a large number of enterprises have introduced a Project Management Office (PMO) to successfully manage multiple complex large-scaled projects. Many researches and empirical studies have proved the positive results of PMO-based projects. For example, most PMO-based projects have been accomplished successfully without exceeding the planned deadline and budget. However, even in the case of PMO-based projects, participants are still supported by legacy Project Management Systems (PMS) developed without considering the PMO. It implies that recent large projects are hardly performed efficiently because of the large gap between the legacy PMS tools developed only for single small projects and the real process of PMO-based project management. Therefore, we attempt to design and develop a PMO-based PMS in which the role and responsibility of PMO are completely implemented. To demonstrate our systems practicality, we applied the devised system to the real project management cases of "K" bank in The Republic of Korea. According to the results of case analysis, all of the four projects supported by our PMO-based PMS have been completed without exceeding planned deadline and budget, and the quality of their final outcome is appraised to be superior.

• 공학논문집
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• 제7권1호
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• pp.53-60
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• 2005

Community Wireless Networks define the next generation wireless services. Multimedia usages for financial services over community Wireless LAN (WLAN) based mesh networks require link stability. Several new services are being proposed for multimedia over WLANs. Portable Internet Services are implemented by several wireless carriers to proliferate their customer base. However, these services are still expensive and require a central telecom/wireless carrier whose monopoly and preference defines the availability of new services. Our research project identifies the usage of these critical services in public places over the financial services backbone architecture to provide efficient easy-to-use and economical services to their customers and merchants without being dependent on the central wireless carrier. The user connects to the network using his regular WLAN NIC using the Mesh Router/Bridge interconnectivity and obtains the needed multimedia and financial services from the ATM-AP Gateway, In our proposed scenario, the ATN AP-MR use AODV protocol and MR-MC is based on 802.11g/a/b IEEE standard. We use multi path routing protocols for reducing the congestion over a particular route. We demonstrate the results of our simulations and test-bed outcome to evaluate link failure rate and oversubscription factors to eliminate network congestion and non-availability of the critical financial services.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제20권4호
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• pp.259-262
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• 2017

Mitochondria play essential role in eukaryotic cells including in the oxidative phosphorylation and generation of adenosine triphosphate via the electron-transport chain. Therefore, defects in mitochondrial DNA (mtDNA) can result in mitochondrial dysfunction which leads to various mitochondrial disorders that may present with various neurologic and non-neurologic manifestations. Mutations in the nuclear gene polymerase gamma (POLG) are associated with mtDNA depletions, and Alpers-Huttenlocher syndrome is one of the most severe manifestations of POLG mutation characterized by the clinical triad of intractable seizures, psychomotor regression, and liver failure. The hepatic manifestation usually occurs late in the disease's course, but in some references, hepatitis was reportedly the first manifestation. Liver transplantation was considered contraindicated in Alpers-Huttenlocher syndrome due to its poor prognosis. We acknowledged a patient with the first manifestation of the disease being hepatic failure who eventually underwent liver transplantation, and whose neurological outcome improved after cocktail therapy.

• Molecules and Cells
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• 제26권4호
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• pp.329-337
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• 2008

Src-family kinases are critically involved in the control of cytoskeleton organization and in the generation of integrin-dependent signaling responses, inducing tyrosine phosphorylation of many signaling and cytoskeletal proteins. Activity of the Src family of tyrosine kinases is tightly controlled by inhibitory phosphorylation of a carboxy-terminal tyrosine residue, inducing an inactive conformation through binding with its SH2 domain. Dephosphorylation of C-ter tyrosine, as well as its deletion of substitution with phenylalanine in oncogenic Src kinases, leads to autophosphorylation at a tyrosine in the activation loop, thereby leading to enhanced Src activity. Beside this phophorylation/dephosphorylation circuitry, cysteine oxidation has been recently reported as a further mechanism of enzyme activation. Mounting evidence describes Src activation via its redox regulation as a key outcome in several circumstances, including growth factor and cytokines signaling, integrin-mediated cell adhesion and motility, membrane receptor cross-talk as well in cell transformation and tumor progression. Among the plethora of data involving Src kinase in physiological and pathophysiological processes, this review will give emphasis to the redox component of the regulation of this master kinase.

• The Korean Journal of Physiology and Pharmacology
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• 제25권5호
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• pp.489-494
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• 2021

Oxaliplatin, a third-generation platinum derivative, is the mainstay of current antineoplastic medications for advanced colorectal cancer therapy. However, peripheral neuropathic complications, especially cold allodynia, undermine the life-prolonging outcome of this anti-cancer agent. Rosavin, a phenylpropanoid derived originally from Rhodiola rosea, exhibits a wide range of therapeutic properties. The present study explored whether and how rosavin alleviates oxaliplatin-induced cold hypersensitivity in mice. In the acetone drop test, cold allodynia behavior was observed from days 3 to 5 after a single injection of oxaliplatin (6 mg/kg, i.p.). Cold allodynia was significantly attenuated following rosavin treatment (10 mg/kg, i.p.). Specific endogenous 5-HT depletion by three consecutive pretreatments with parachlorophenylalanine (150 mg/kg/day, i.p.) abolished the analgesic action of rosavin; this effect was not observed following pretreatment with naloxone (opioid receptor antagonist, 10 mg/kg, i.p.). Furthermore, 5-HT_1A receptor antagonist WAY-100635 (0.16 mg/kg, i.p.), but not 5-HT₃ receptor antagonist MDL-72222 (1 mg/kg, i.p.), blocked rosavin-induced analgesia. These results suggest that rosavin may provide a novel approach to alleviate oxaliplatin-induced cold allodynia by recruiting the activity of 5-HT_1A receptors.

• 한국지진공학회논문집
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• 제25권6호
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• pp.283-292
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• 2021

In this study, a structural health monitoring system for cable-stayed bridges is developed. In the system, condition assessment of the structure is performed based on measured records from seismic accelerometers. Response indices are defined to monitor structural safety and serviceability and derived from the measured acceleration data. The derivation process of the indices is structured to follow the transformation from the raw data to the outcome. The process includes noise filtering, baseline correction, numerical integration, and calculation of relative differences. The system is packed as a condition assessment program, which consists of four major processes of the structural health evaluation: (i) format conversion of the raw data, (ii) noise filtering, (iii) generation of response indices, and (iv) condition evaluation. An example set of limit states is presented to evaluate the structural condition of the test-bed and cable-stayed bridge.