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Genomic and Proteomic Databases: Foundations, Current Status and Future Applications

  • Navathe, Shamkant B.;Patil, Upen;Guan, Wei
    • Journal of Computing Science and Engineering
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    • v.1 no.1
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    • pp.1-30
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    • 2007
  • In this paper we have provided an extensive survey of the databases and other resources related to the current research in bioinformatics and the issues that confront the database researcher in helping the biologists. Initially we give an overview of the concepts and principles that are fundamental in understanding the basis of the data that has been captured in these databases. We briefly trace the evolution of biological advances and point out the importance of capturing data about genes, the fundamental building blocks that encode the characteristics of life and proteins that are the essential ingredients for sustaining life. The study of genes and proteins is becoming extremely important and is being known as genomics and proteomics, respectively. Whereas there are numerous databases related to various subfields of biology, we have maintained a focus on genomic and proteomic databases which are the crucial stepping stones for other fields and are expected to play an important role in the future applications of biology and medicine. A detailed listing of these databases with information about their sizes, formats and current status is presented. Related databases like molecular pathways and interconnection network databases are mentioned, but their full coverage would be beyond the scope of a single paper. We comment on the peculiar nature of the data in biology that presents special problems in organizing and accessing these databases. We also discuss the capabilities needed for database development and information management in the bioinformatics arena with particular attention to ontology development. Two research case studies based on our own research are summarized dealing with the development of a new genome database called Mitomap and the creation of a framework for discovery of relationships among genes from the biomedical literature. The paper concludes with an overview of the applications that will be driven from these databases in medicine and healthcare. A glossary of important terms is provided at the end of the paper.

Study on features that pregnant women find important and desirable when choosing maternity wear - Focused on British pregnant women in London -

  • Park, Hye-Sook;Lee, Jae-Jung
    • Archives of design research
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    • v.20 no.2 s.70
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    • pp.41-52
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    • 2007
  • Today, many pregnant women also advance up the business ladder and remain very active. They are consequently increasingly aware of the clothes they can wear. Despite these social changes, maternity wear has not been specially designed to satisfy the consumer's demands. From this, the purposes of this study are to investigate the current status of maternity wear and the apparent buying trends of pregnant women through a customers' opinion survey and interviews for the future maternity markets. In summary, the survey and interviews illustrate some important points which are that: Firstly, not all pregnant women buy maternity wear. Some pregnant women said they couldn't find enough difference in maternity wear prices even though they would like to buy some, commenting that maternity clothes were too expensive for such a short period of time. Also some already had maternity wear from a previous pregnancy, or had been passed on from friends and family. Secondly, on the other hand, many respondents were strongly concerned with style and quality rather than price because they agreed that there were not enough suitable maternity clothes for work and special occasions. Therefore some respondents would buy a maternity outfit for a special occasion. It also indicates that for a particular time, place or occasion like a party, wedding or other celebration, some respondents would buy a special outfit to make themselves feel good. Finally, according to the survey, the most important design concept is for wearable designs which change with the body during pregnancy; followed closely by designs which are able to be re-used when the pregnancy has finished. Nowadays, as recycling and saving resources are the biggest issues, if maternity manufacturers are encouraged to develop new products incorporating these new design concepts, more maternity markets will be developed to buy maternity wear.

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The Health Belief Model - Is it relevant to Korea?

  • Lee, Mi-Kyung;Colin William Binns;Kim, Kong-Hyun
    • Korean Journal of Health Education and Promotion
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    • v.2 no.1
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    • pp.1-19
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    • 2000
  • With rapid economic development, the emphasis of the public health movement in Korea has shifted towards addressing the burden of chronic disease. With this shift in direction comes a greater focus on health behaviour and the need for planning models to assist in lifestyle modification programs. The Health Belief Model (HBM), which originated in the US, has generated more research than any other theoretical approach to describe and predict the health behaviour of individuals. In recent years it has been applied in many different cultures and modifications have been suggested to accommodate different cultures. Given the centrality of language and culture, any attempts to use models of health behaviour developed in a different culture, must be studied and tested for local applicability. The paper reviews the applicability and suitability of the HBM in Korea, in the context of the Korean language and culture. The HBM has been used in Korea for almost three decades. The predictability of the HBM has varied in Korean studies as in other cultures. Overall, this literature review indicates that the HBM has been found applicable in predicting health and illness behaviours by Korean people. However if the HBM is used in a Korean context, the acquisition of health knowledge is an important consideration. Most new knowledge in the health sciences is originally published in English and less frequently in another foreign language. Most health knowledge in Korea is acquired through the media or from health professionals and its acquisition often involves translation from the original. The selection of articles for translation and the accuracy of translation into language acceptable in the Korean culture become important determinants of health knowledge. As such translation becomes an important part of the context of the HBM. In this paper modifications to the HBM are suggested to accommodate the issues of language and knowledge in Korea.

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A Study on Production of Low Storage Capacity of Character Animation for 3D Mobile Games (3D 모바일 게임용 저용량 3D캐릭터 애니메이션 제작에 관한 연구)

  • Lee Ji-Won;Kim Tae-Yul;Kyung Byung-Pyo
    • The Journal of the Korea Contents Association
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    • v.5 no.5
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    • pp.107-114
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    • 2005
  • The next generation of 3D mobile games market is becoming increasingly active, more as a result of improvement in the CPU speed of hardware phone, embarkation of 3D engines and high memory capacity, In response to this trend, popular 3D games of PS2 (PlayStation2) and popular online games are being launched as mobile games. However, mobile units have different hardware characteristics compared to those of other platforms such as the PC or the game console. Therefore, mobile game versions of the popular PC games face many limitations in many aspects such as in battery capacity, size of display, capacity of the game, and other user interface issues. Among these many limitations, study for allowing low capacity storage of the game is becoming important. In addition, realistic animation of the 3D character on the small screen of the mobile unit is more important than any other matter. The purpose of this study is to find a solution to providing realistic 3D character animation, and for decreasing the storage capacity of character animation for application in 3D mobile games.

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A Meta Analysis of Using Structural Equation Model on the Korean MIS Research (국내 MIS 연구에서 구조방정식모형 활용에 관한 메타분석)

  • Kim, Jong-Ki;Jeon, Jin-Hwan
    • Asia pacific journal of information systems
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    • v.19 no.4
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    • pp.47-75
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    • 2009
  • Recently, researches on Management Information Systems (MIS) have laid out theoretical foundation and academic paradigms by introducing diverse theories, themes, and methodologies. Especially, academic paradigms of MIS encourage a user-friendly approach by developing the technologies from the users' perspectives, which reflects the existence of strong causal relationships between information systems and user's behavior. As in other areas in social science the use of structural equation modeling (SEM) has rapidly increased in recent years especially in the MIS area. The SEM technique is important because it provides powerful ways to address key IS research problems. It also has a unique ability to simultaneously examine a series of casual relationships while analyzing multiple independent and dependent variables all at the same time. In spite of providing many benefits to the MIS researchers, there are some potential pitfalls with the analytical technique. The research objective of this study is to provide some guidelines for an appropriate use of SEM based on the assessment of current practice of using SEM in the MIS research. This study focuses on several statistical issues related to the use of SEM in the MIS research. Selected articles are assessed in three parts through the meta analysis. The first part is related to the initial specification of theoretical model of interest. The second is about data screening prior to model estimation and testing. And the last part concerns estimation and testing of theoretical models based on empirical data. This study reviewed the use of SEM in 164 empirical research articles published in four major MIS journals in Korea (APJIS, ISR, JIS and JITAM) from 1991 to 2007. APJIS, ISR, JIS and JITAM accounted for 73, 17, 58, and 16 of the total number of applications, respectively. The number of published applications has been increased over time. LISREL was the most frequently used SEM software among MIS researchers (97 studies (59.15%)), followed by AMOS (45 studies (27.44%)). In the first part, regarding issues related to the initial specification of theoretical model of interest, all of the studies have used cross-sectional data. The studies that use cross-sectional data may be able to better explain their structural model as a set of relationships. Most of SEM studies, meanwhile, have employed. confirmatory-type analysis (146 articles (89%)). For the model specification issue about model formulation, 159 (96.9%) of the studies were the full structural equation model. For only 5 researches, SEM was used for the measurement model with a set of observed variables. The average sample size for all models was 365.41, with some models retaining a sample as small as 50 and as large as 500. The second part of the issue is related to data screening prior to model estimation and testing. Data screening is important for researchers particularly in defining how they deal with missing values. Overall, discussion of data screening was reported in 118 (71.95%) of the studies while there was no study discussing evidence of multivariate normality for the models. On the third part, issues related to the estimation and testing of theoretical models on empirical data, assessing model fit is one of most important issues because it provides adequate statistical power for research models. There were multiple fit indices used in the SEM applications. The test was reported in the most of studies (146 (89%)), whereas normed-test was reported less frequently (65 studies (39.64%)). It is important that normed- of 3 or lower is required for adequate model fit. The most popular model fit indices were GFI (109 (66.46%)), AGFI (84 (51.22%)), NFI (44 (47.56%)), RMR (42 (25.61%)), CFI (59 (35.98%)), RMSEA (62 (37.80)), and NNFI (48 (29.27%)). Regarding the test of construct validity, convergent validity has been examined in 109 studies (66.46%) and discriminant validity in 98 (59.76%). 81 studies (49.39%) have reported the average variance extracted (AVE). However, there was little discussion of direct (47 (28.66%)), indirect, and total effect in the SEM models. Based on these findings, we suggest general guidelines for the use of SEM and propose some recommendations on concerning issues of latent variables models, raw data, sample size, data screening, reporting parameter estimated, model fit statistics, multivariate normality, confirmatory factor analysis, reliabilities and the decomposition of effects.

Dealing with Unruly Behavior on Board Aircraft: A Chinese Perspective

  • Qin, Huaping
    • The Korean Journal of Air & Space Law and Policy
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    • v.27 no.2
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    • pp.193-209
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    • 2012
  • China's airline industry is experiencing a booming development as one hand, on the other hand the incidents involving unruly behaviour on board aircraft also becomes a growing concern for the whole industry. The thesis examines the basic issues concerning the unruly behaviour, such as definition of unruly behaviour, the impact and root causes of unruly behaviour. Then it focuses on the China's legal sources governing the problem of unruly behaviour. Generally speaking, China's legislation with this respect is systematic and self-contained, except some minor shortcomings which need to be revised. Finally the thesis holds the view that the preventative measures jointly contributed by all the parties concerned are something more important than the legislation itself.

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Power Management for Mobile Terminal (모바일 단말에서의 전원관리 기술)

  • Lee, Junghee;Park, Hojun;Kim, Jaemyoung
    • IEMEK Journal of Embedded Systems and Applications
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    • v.2 no.3
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    • pp.194-201
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    • 2007
  • As the performance of the mobile terminal becomes higher, the power consumption gradually increases. As a result, power management is one of the most important issues in mobile system with battery. In this paper, we describe an DPM(Dynamic Power Management) using DVS(Dynamic Power Management) as a power management mechanism in Qplus operating system. DVS generally considers a specific device such as CPU, whereas we consider the relations with other hardware components as well as each component. We specially focus on the relation between CPU, memory and LCD devices. We also designs a kernel monitor to collect information to decide the policy for power management. According to the experimental results, the proposed method enables to save much power.

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ITU Plenipotentiary Conference (ITU 전권위원회 분담금 활용 정책동향 (ITU-PP))

  • Lee, Dong-Chul;Cho, Se-Hyun
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2012.05a
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    • pp.741-742
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    • 2012
  • 국제기구 중에서 가장 회원수가 많은 ITU(국제정보통신연합)의 분담금 수주에 대한 정책적인 분석을 통하여 아국의 분담금 납부 내역에 대한 분석을 통해 어느정도 이익이 되며, 분담금 납부에 대한 장단점 등을 분석을 통하여 국내 산업체 등이 향후 분담금을 지속적으로 납부하여야 하는지에 대해서도 검토의 필요성이 대두되고 있는 실정이다. 이는 우리나라가 1989년 ITU 이사국이 되면서 부터 정통부를 중심으로 국제기구에 분담금을 납부하기 시작하였으며, 현재 삼성전자, SKT, LGU, ETRI, KT 등 국내통신사업자가 주도 되어 납부하여 그 액수만 수억원에 이르고 있다. 가입이후 산업체 들이 좋은 성과를 내어 수출 등에 많은 기여는 하였지만 이는 분담금과는 무관한 듯하다. 우리나라가 가입하기 시작한 시점은 1993년 이후였으며, 이는 ETRI 재직중에 정부의 주도하에 산업체 가입을 종용하여 가입하기 시작한 것이다. 2014년 우리나라에서 전권위원회가 개최되는데, 이때를 계기로 사전에 검토하여 분담금을 조정할 필요성이 있다고 사료된다.

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A Study for Curriculum Development for Advanced Nurse Practitioner Program (전문간호사 양성을 위한 간호대학원 교과과정 및 운영방안 개발)

  • 조원정;이태화;김소야자;장순복;이원희;김광숙
    • Journal of Korean Academy of Nursing
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    • v.32 no.6
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    • pp.917-928
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    • 2002
  • The traditional nursing roles have become increasingly blurred. Nurses are now working in different ways and at higher levels of practice that enable nurses to adapt their roles and take on new responsibilities. The advanced role of nurses requires a different kind of master-level prepared education. Method & Result: This article describes an curriculum development process in preparing registered nurses for their advanced nurese' roles in the area of acute adult health nursing, geriatric nursing, pediatric nursing, neonatal intensive care nursing and oncology nursing. Several important issues to be solved regarding introduction of APN were also discussed. Conclusion: The curriculum that was proposed in the study will equip nurses to meet the challenges of future healthcare provision and will be a model to other areas of nursing practice and curriculum development.

Mesoporous Thin Films with Accessible Pores from Surfaces

  • Lee, U-Hwang;Kim, Min-Hye;Kwon, Young-Uk
    • Bulletin of the Korean Chemical Society
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    • v.27 no.6
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    • pp.808-816
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    • 2006
  • Among the many forms of mesoporous materials, thin films are important for the potential applications of this class of materials. Compared with the powder forms, however, there has been relatively little work done on thin films probably because of the lack of suitable and generalized synthetic mechanisms established. In this account, we will review the issues on mesoporous thin films with emphasis on the necessity of forming films with accessible pores from the film surfaces and on mesoporous thin films with metal oxides other than silica. Various methods that have been tried to utilize mesoporous thin films with accessible pores as templates for the synthesis of nanostructured materials are reviewed with the emphasis on the advantages of the electrochemical deposition technique.