• Journal of Life Science
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• v.33 no.9
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• pp.754-765
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• 2023

Exosomes are a type of extracellular vesicle containing proteins and messenger and microRNAs; they are secreted by all cell types. Once released, exosomes are selectively taken up by other cells adjacent or at a distance, releasing their contents and reprogramming the target cells. Since exosomes are natural vesicles produced by cells as small sizes, it is generally accepted that exosomes have a non-toxic nature and non-immunogenic behaviors. Recently, exosomes have elicited scientific attention as drug delivery vehicles to the central nervous system. The central nervous system has a blood-brain barrier that makes it difficult for drugs to penetrate. Thus, the blood-brain barrier has been a major obstacle to the development of drugs for treating neurodegenerative diseases. However, accumulating evidence suggests that exosomes can cross the blood-brain barrier primarily through transcytosis. Consequently, exosomes are expected to become a new delivery vehicle that can cross the blood-brain barrier and deliver drugs into the brain parenchyma. In addition, since different types of exosomes are secreted depending on the cell type and disease state, exosomes can also be utilized as biomarkers for the diagnosis of diseases in the central nervous system. In this review, we summarized recent research trends on exosomes, including clinical trials as biomarkers and treatment options for diseases in the central nervous system.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.1
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• pp.233-251
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• 2023

Metropolitan buses are managed as either a direct seat type or a metropolitan express type according to the 「Passenger Transport Service Act」. However, a management system that reflects the characteristics of metropolitan buses is not currently established. Therefore, in this study, the driving characteristics of metropolitan buses, dangerous driving behavior characteristics of metropolitan bus drivers, metropolitan bus accident characteristics, and the safety management system of domestic and foreign buses and other means were investigated. Through this, a plan for strengthening the safety management of metropolitan buses suitable for Korea was presented by dividing it into short-term and mid to long term. The short-term plan is a plan that can be carried out through consultation between metropolitan bus agencies and transportation companies, and the mid to long term plan is a plan that can be implemented only when related laws are revised. Through this study, it is expected to serve as an opportunity for in-depth discussions by the government, business operators, and related experts to strengthen the safety management of metropolitan buses.

• Journal of the Korean Geotechnical Society
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• v.23 no.6
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• pp.103-114
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• 2007

Sands distributed in Jeju island's coastal areas, Korea, can be classified as silicate sand derived from volcanic rock, carbonate sand derived from shells, and mixed sands containing both silicate and carbonate sands. These three types of sands typically exist in Jeju coastal areas. Samples of silicate, carbonate and mixed sands were obtained from Samyang beach, Gimnyeong beach, and Jeju harbor area, respectively. Compression tests were conducted to assess the compression characteristics of these sands. As a result of these tests, each sand showed different behaviors. For Samyang beach sand, it appeared that initial compression is a larger than the other two sands. For Cimnyeong and Jeju harbor sands, however, the additional compression occurred after initial compression. This could result from the crushing, shattering, and rearrangement of sand particles. In addition, settlement behavior of Jeju harbor ground according to the construction stages was analyzed using the measured data. It showed that in addition to the initial elastic compression, a considerable additional compression occurred with time. The settlements of Jeju harbor ground were predicted by using the elastic settlement calculation methods (empirical methods) and the compression test method. The empirical methods, which did not consider the crushing, shattering, and rearrangement of particles could show smaller result than that occurring actually.

• Journal of the Korean Geotechnical Society
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• v.24 no.7
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• pp.25-36
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• 2008

The plane strain test can reproduce the real field condition and failure behavior precisely over other laboratory shear tests. Accordingly, this test has been utilized to investigate the shearing behaviors associated with overall failure behavior and local deformation of soils. However, most plane strain tests have been carried out with restrained end plates due to difficulties in manufacturing the equipment and also performing it. This restraint induces different results with real field because of shear stress on end plates. In this study, plane strain tests with/without bottom plate restraint were performed on Jumunjin-sand. The measurement of overall and local deformation was accomplished by digital image correlation technique as well as external LVDT. By applying digital image correlation method using two consecutive images captured through the transparent wall, local deformation behavior of various parts inside the specimen was estimated. And the formation and development of shear band caused by the restrained effect of end plate and the deformation mechanism of sand under plane strain condition were examined.

• Journal of the Korean Geotechnical Society
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• v.23 no.12
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• pp.83-94
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• 2007

Piled raft foundations have been highlighted as an economical design concept of pile foundations in recent years. However, piled raft foundations have not been widely used in Korea due to the difficulty in estimating the complex interaction effects among rafts, piles and soils. The authors developed an effective numerical program to analyze the behavior of piled raft foundations for practical design purposes and presented it briefly in this paper. The developed numerical program simulates the raft as a flexible plate consisting of finite elements with eight nodes and the raft is supported by a series of elastic springs representing subsoils and piles. This study imported another model to simulate pile groups considering non-linear behavior and interaction effects. The apparent stiffnesses of the soils and piles were estimated by iterative calculations to satisfy the compatibility between those two components and the behavior of piled raft foundations can be predicted using these stiffnesses. For the verification of the program, the analysis results about some example problems were compared with those of rigorous three dimensional finite element analysis and other approximate analysis methods. It was found that the program can analyze non-linear behaviors and interaction effects efficiently in multi-layered soils and has sufficient capabilities for application to practical analysis and design of piled raft foundations.

• Journal of Popular Narrative
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• v.25 no.1
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• pp.193-215
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• 2019

According to ethical literary criticism, every type of literature has its text. The original definition of oral literature refers to the literature disseminated orally. Before the dissemination, the text of oral literature is stored in the human brain, which is termed as "brain text". Brain text is the textual form used before the formation of writing symbols and its application to a recording of information, and it still exists after the creation of writing symbols. Other types of texts are written text and electronic text. Brain text consists of brain concepts, which, according to different sources, can be divided into objective concepts and abstractive concepts. Brain concepts are tools for thinking while thought comes from thinking with understanding and an application of brain concepts. Brain text is the carrier of thought. The termination of the synthesis of brain concepts signifies the completion of thinking, which produces thoughts to form brain text. Brain text determines thinking and behavioral patterns that not only communicate and spread information, but also decide our ideas, thoughts, judgments, choices, actions and emotions. Brain text is also a deciding factor for our lifestyle and moral behaviors. The nature of a person's brain text determines his thoughts and actions, and most importantly determines who he is.

• Tunnel and Underground Space
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• v.33 no.3
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• pp.189-207
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• 2023

In the present study, the thermoshearing experiment on a rough rock fracture were modeled using a three-dimensional grain-based distinct element model (GBDEM). The experiment was conducted by the Korea Institute of Construction Technology to investigate the progressive shear failure of fracture under the influence of thermal stress in a critical stress state. The numerical model employs an assembly of multiple polyhedral grains and their interfaces to represent the rock sample, and calculates the coupled thermo-mechanical behavior of the grains (blocks) and the interfaces (contacts) using 3DEC, a DEM code. The primary focus was on simulating the temperature evolution, generation of thermal stress, and shear and normal displacements of the fracture. Two fracture models, namely the mated fracture model and the unmated fracture model, were constructed based on the degree of surface matedness, and their respective behaviors were compared and analyzed. By leveraging the advantage of the DEM, the contact area between the fracture surfaces was continuously monitored during the simulation, enabling an examination of its influence on shear behavior. The numerical results demonstrated distinct differences depending on the degree of the surface matedness at the initial stage. In the mated fracture model, where the surfaces were in almost full contact, the characteristic stages of peak stress and residual stress commonly observed in shear behavior of natural rock joints were reasonably replicated, despite exhibiting discrepancies with the experimental results. The analysis of contact area variation over time confirmed that our numerical model effectively simulated the abrupt normal dilation and shear slip, stress softening phenomenon, and transition to the residual state that occur during the peak stress stage. The unmated fracture model, which closely resembled the experimental specimen, showed qualitative agreement with the experimental observations, including heat transfer characteristics, the progressive shear failure process induced by heating, and the increase in thermal stress. However, there were some mismatches between the numerical and experimental results regarding the onset of fracture slip and the magnitudes of fracture stress and displacement. This research was conducted as part of DECOVALEX-2023 Task G, and we expect the numerical model to be enhanced through continued collaboration with other research teams and validated in further studies.

• Journal of Intelligence and Information Systems
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• v.29 no.2
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• pp.285-301
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• 2023

Due to the increasing demand and importance of non-face-to-face education, open online learning platforms are getting interests both domestically and internationally. These platforms exhibit different characteristics from online courses by universities and other educational institutions. In particular, students engaged in these platforms can receive more learner autonomy, and the development of tools to assist learning is required. From the past, researchers have attempted to utilize process mining to understand realistic study behaviors and derive learning patterns. However, it has a deficiency to employ it to the open online learning platforms. Moreover, existing research has primarily focused on the process model perspective, including process model discovery, but lacks a method for the process pattern and instance perspectives. In this study, we propose a method to identify learning patterns within an open online learning platform using process mining techniques. To achieve this, we suggest three different viewpoints, e.g., model-level, variant-level, and instance-level, to comprehend the learning patterns, and various techniques are employed, such as process discovery, conformance checking, autoencoder-based clustering, and predictive approaches. To validate this method, we collected a learning log of machine learning-related courses on a domestic open education platform. The results unveiled a spaghetti-like process model that can be differentiated into a standard learning pattern and three abnormal patterns. Furthermore, as a result of deriving a pattern classification model, our model achieved a high accuracy of 0.86 when predicting the pattern of instances based on the initial 30% of the entire flow. This study contributes to systematically analyze learners' patterns using process mining.

• Journal of Animal Science and Technology
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• v.65 no.3
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• pp.535-549
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• 2023

This study was to investigate the effects of different phytogenic feed additives (PFA) dosage levels in growing- finishing pigs stressed by high stocking density. A total of 72 mix sexed 12 weeks growing pigs ([Landrace × Yorkshire] × Duroc) with initial body weight (BW) of 49.28 ± 4.58 kg were used for 8 weeks. There were 3 replicate pens in each treatment group, with 3 pigs per pen. The dietary treatment groups consisted of basal diets in animal welfare density (negative control [NC]), basal diet in high stocking density (positive control [PC]), PC + 0.04% essential oil (ES1), PC + 0.08% essential oil (ES2), PC + 0.10% bitter citrus extract & essential oil (CES1), PC + 0.20% bitter citrus extract & essential oil (CES2), PC + 0.05% grape pomace extract (GP1), PC + 0.10% grape pomace extract (GP2). The reduction of space allowance decreased (p < 0.05) average daily gain, feed efficiency, and digestibility of dry matter, crude protein, and gross energy. Also, the fecal score of PC groups increased (p < 0.05) compared with other groups. Basic behaviors (feed intake, standing, lying) were inactive (p < 0.05) and singularity behavior (biting) was increased (p < 0.10) under high stocking density. There was no difference in blood profile. However, the supplementation of PFA alleviated the negative effects such as reduced growth performance, nutrient digestibility, and some increasing stress indicators in th blood (cortisol) and animal behavior (biting). In conclusion, the negative effect of high stocking density was most effectively mitigated by the normal dosage of the mixture of bitter citrus extract and essential oil additive (CES1).

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.5B
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• pp.429-439
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• 2009

When Catastrophic extreme flood occurs due to dam break, the response time for flood warning is much shorter than for natural floods. Numerical models can be powerful tools to predict behaviors in flood wave propagation and to provide the information about the flooded area, wave front arrival time and water depth and so on. But flood wave propagation due to dam break can be a process of difficult mathematical characterization since the flood wave includes discontinuous flow and dry bed propagation. Nevertheless, a lot of numerical models using finite volume method have been recently developed to simulate flood inundation due to dam break. As Finite volume methods are based on the integral form of the conservation equations, finite volume model can easily capture discontinuous flows and shock wave. In this study the numerical model using Riemann approximate solvers and finite volume method applied to the conservative form for two-dimensional shallow water equation was developed. The MUSCL scheme with surface gradient method for reconstruction of conservation variables in continuity and momentum equations is used in the predictor-corrector procedure and the scheme is second order accurate both in space and time. The developed finite volume model is applied to 2D partial dam break flows and dam break flows with triangular bump and validated by comparing numerical solution with laboratory measurements data and other researcher's data.