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Preparation of Nanoparticles in Drug Delivery System Using Guar Derivatives and Dialysis Method

  • Na, Kun;Kim, Yu-Eun;Lee, Ki-Young
    • Journal of Microbiology and Biotechnology
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    • v.9 no.1
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    • pp.50-55
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    • 1999
  • To develop a new form of controlled release dosage for administering for indomethacin (IND), two formulations of IND-loaded nanoparticles were designed based on polysaccharide (guar) derivatives. Nanoparticles prepared by the dialysis method were characterized with respect to morphology, size distribution, drug content, and in vitro drug release. Morphological studies by scanning electron microscopy (SEM) indicated that guar acetate (GA) nanoparticles were spherical in shape and had a smooth surface. The particle size distributions of formulation I (40mg of GA) and formulation II (80mg of GA) were shown to be $250.78\pm185.13nm$ and $718\pm145.90nm$ in distilled water ($20$^{\circ}C$), respectively. The drug loading efficiencies of nanoparticles were approximately 26% and 31% for formulations I and II, respectively. The differential scanning calorimetry (DSC) results indicated that the IND was perfectly distributed within GA nanoparticles. We also found, from the X-ray diffractometry analysis, that a decrease in the degree of crystallinity of the drug occurred in the nanoparticles. No changes between the original IND and the released IND from GA nanoparticles were detected by FT-IR. Using guar acetate, it is possible to design nanoparticles which allow the controlled release of IND over an extended period of time.

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Development of Polymeric Water Absorbent Film(PWAF) for the Collection of Size-classified Fog Droplets

  • Ma, Chang-Jin;Mikilo-kasahara;Park, Kum-Chan
    • Journal of Korean Society for Atmospheric Environment
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    • v.17 no.E1
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    • pp.17-24
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    • 2001
  • For the purpose of collecting fog droplets as a function of size a new sampling method was developed in this study. Formation of 100$\pm$10㎛ thickness of polymeric water absorbent film (PWAF) on a nuclepore filter could be successfully realized. Also applicability of particle induced X-ray emission (PIXE) method to the chemical analysis of size-segregated fog droplets collected on PWAF was examined experimentally with synthetic fog droplets generated from a nebulizer. Absorption capacity of S-PAAS polymeric water absorbent shows marked decreases in the range less than 1 wt% and slight decrease between 1 and 3.5 wt% of every salt concentration. Dependency of absorption capacity on pH shows the maximum at pH 7. No apparent peak which can influence the quantitative analysis of elements dissolved and suspended in fog droplets was found at PIXE spectrum of PWAF blank. PWAF kept the original shape without rupture under the PIXE analytical conditions of beam intensity for 10 to 60 nA and irradiation time of 4∼5 min. It should be said that the proposed new technique in the work is helpful to get more detailed information of fog droplets, to clarify the fog formation processes, and to develop a model of acid deposition process.

Co-simulation for Dynamic Characteristic Analaysis of Solenoid Valve for Vehicle (자동차용 솔레노이드 밸브의 동특성을 위한 연성해석)

  • Kim, Ki-Chan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.6
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    • pp.3821-3826
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    • 2014
  • This paper proposes a methodology for developing the performance of a solenoid valve for vehicles based on the dynamic analysis model by an electromagnetic field. The high performance solenoid model with a low current and high thrust was induced through the shape optimal design of the yoke and plunger. To perform the dynamic analysis of the solenoid valve, the input current profile was analyzed. The speed and thrust information was analyzed by FEM with this current profile. The co-simulation method of the circuit model of control logic and electromagnetic model of the solenoid valve was also proposed to analyze the performance with several current patterns. Finally, the performance of the original model and optimal one was compared.

Morphological multivariate analyses of Isodon excisus complex (Lamiaceae) in Korea

  • Kim, Sang-Tae;Ma, Youn-Ju
    • Korean Journal of Plant Taxonomy
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    • v.41 no.3
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    • pp.223-229
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    • 2011
  • The taxonomy of the Isodon excisus complex has been ambiguous and problematic because the morphological characters, especially characters related to the leaf distinguishing subgroups of the complex in the original descriptions, are variable. To elucidate the taxonomic structure of the I. excisus complex in Korea, 34 characters were measured from 70 OTUs representing different locations and analyzed by principal component analysis (PCA). The analysis showed that principle component axis 1, 2, 3 (PC1, PC2, PC3) represents 52.0% of the total variance and characters showing high loading values for PC1 were leaf shape, density of non-glandular hairs on the lower surface of the leaf, and characters related to the teeth of the leaf. The length of apical tooth and the angle between two widest points of the leaf were highly correlated to PC2 and PC3, respectively. Three-dimensional scatter plotting of OTUs for PC1, PC2, and PC3 axis showed that the areas of previously recognized three subgroups of I. excisus completely overlapped. Our result supported that just one taxon, I. excisus var. excisus, should be recognized in the complex at the variety level.

Conservation Laboratory of Keimyung University Museum (계명대학교 박물관 보존과학실 소개)

  • Kim, Byeong-Ju
    • 보존과학연구
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    • s.6
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    • pp.247-258
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    • 1985
  • Conservation laboratory was attached to Keimyung University Museum inMarch 1980 and ever since it has been devoted mainly to the processing andconservation of metal objects. A number of objects have been processed inthis laboratory during the period, including those already in the collection ofthe Museum, those which were discovered during the three major excavationsof Kaya tombs conducted by the Museum, and those processed on commissionfrom other museums in the country,The activities of this laboratory include: (1) conserving the objects againstfurther erosion; (2) raising the archaeological value of the objects by revealingthe structure of such parts of the objects as concealed under rust; and (3)recovering the original shape of damaged objects.The methods adopted by the laboratory include: (1) removing from theobjects the ionized chlorine which usually are the major cause of erosion; (2)strengthening the objects by soaking them in acrylic resins; and (3) applyingresins to the surface of the objects to protect them from further erosion.Chemicals much employed by the laboratory includes the acrylic resin(Ruschot; developed jointly by the Cultural Property Research Institute ofKorea and Samwha Paint Company), the sodium sesquicarbonate, the sodiumhydroxide, the lithium hydroxide, and the benzotriazole.Major apparatus in the laboratory includes the vacuum immersion tank, theairbrasive, the ultrasonic cleaner, the pH-ion meter, the water bath, the zoomstereo microscope, the drying oven, and the drill.

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Investigation of Mechanical Property of Polypropylene and CF/PP Composites with Number of Recycle (재활용 횟수에 따른 폴리프로필렌 및 탄소섬유 강화 PP 복합재료의 물성 변화 관찰)

  • Kwon, Dong-Jun;Wang, Zuo-Jia;Lea, Tea-Ung;Park, Joung-Man
    • Composites Research
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    • v.26 no.5
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    • pp.303-308
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    • 2013
  • Carbon fiber (CF) reinforced polypropylene (PP) compositeis was increased to amount consumed. In this study, recycle of composites by recycle times. CF was containing 20%. Mechanical and interfacial propertis of CF/PP was evaluation for number of recycle time. Mechanical assessment of CF/PP was tension, bending, fatigue tension test and izod test method. Interfacial assessment of CF/PP was wettability test and FE-SEM of fracture surface method. Fiber and matrix was changed to recycle time. The more recycle of CF/PP, the more interfacial bonding was decreased. Because fiber and matrix was damaged to thermal damage. And then reinforced CF was shorter than original shape.

Segmentation of Measured Point Data for Reverse Engineering (역공학을 위한 측정점의 영역화)

  • 양민양;이응기
    • Korean Journal of Computational Design and Engineering
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    • v.4 no.3
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    • pp.173-179
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    • 1999
  • In reverse engineering, when a shape containing multi-patched surfaces is digitized, the boundaries of these surfaces should be detected. The objective of this paper is to introduce a computationally efficient segmentation technique for extracting edges, ad partitioning the 3D measuring point data based on the location of the boundaries. The procedure begins with the identification of the edge points. An automatic edge-based approach is developed on the basis of local geometry. A parametric quadric surface approximation method is used to estimate the local surface curvature properties. the least-square approximation scheme minimizes the sum of the squares of the actual euclidean distance between the neighborhood data points and the parametric quadric surface. The surface curvatures and the principal directions are computed from the locally approximated surfaces. Edge points are identified as the curvature extremes, and zero-crossing, which are found from the estimated surface curvatures. After edge points are identified, edge-neighborhood chain-coding algorithm is used for forming boundary curves. The original point set is then broke down into subsets, which meet along the boundaries, by scan line algorithm. All point data are applied to each boundary loops to partition the points to different regions. Experimental results are presented to verify the developed method.

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A Study on the Pattern Development of Knitwear According to Yarn Property - Focused on Shift One-Piece Dress - (니트웨어 소재 특성에 다른 패턴 개발 연구 - 쉬프트 원피스 드레스를 중심으로 -)

  • Yoon Hye-Jun;Song Mi-Ryong
    • The Research Journal of the Costume Culture
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    • v.13 no.6 s.59
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    • pp.896-909
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    • 2005
  • In need of studies on the kinds and structure of thread, the biggest variable factor in knitwear patterns, this study attempts: to examine the physical properties by thread type to basically establish systematic data in order to utilize various mixture and structure of yarn and to contribute to the development of optical patterns by building a systemic and scientific methods to produce knit wear patterns though a statistical analysis of the relation between the variations and physical properties. The results is as follows: with time, a feature of knit, which causes instability making it difficult to maintain the original shape, related to material properties, the weight and expansibility recovery rate have the greatest influence on the variation of wale lengths, though the amount varies by material. The variation of course contraction is closely related to density, the dense fabrics showing the highest values, due to the bust of the human body, the wale length variation of the front is greater than that of the back, by a regression analysis of material properties and the variations is obtained showing the weight, density and expansibility recovery rate have the greatest influence on the wale extension and course contraction of knit.

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Contour and Feature Parameter Extraction for Moving Object Tracking in Traffic Scenes (도로영상에서 움직이는 물체 추적을 위한 윤곽선 및 특징 파라미터 추출)

  • Lee, Chul-Hun;Seol Sung-Wook;Joo Jae-Heum;Nam Ki-Gon
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.37 no.1
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    • pp.11-20
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    • 2000
  • This paper presents the method of extracting the contour and shape parameters for moving object tracking in traffic scenes. The contour is extracted by applying difference image method in reduction image and the features are extracted from original image to grow the accuracy of tracking. We used features such as circle distribution, center moment, and maximum and minimum ratio. Data association problem is solved by these features. Kalman filters are used for moving object tracking on real time. The simulation results indicate that the proposed algorithm appears to generate feature vectors good enough for multiple vehicle tracking.

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Performance and Internal Flow Characteristics of an Axial Flow Pump for a Floating Type Water Treatment System (부유식 수처리시스템용 축류펌프의 성능 및 내부유동)

  • Singh, Patrick Mark;Choi, Young-Do
    • The KSFM Journal of Fluid Machinery
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    • v.17 no.3
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    • pp.52-58
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    • 2014
  • The development of efficient systems for water quality improvement for water sources such as lakes, dams and reservoirs has become a necessity to provide not only a cleaner and safer water to the urban society, but also to provide a cleaner and safer environment for the aquatic organisms living in lakes, dams and reservoirs. This study concentrates on the outlet design and internal flow analysis of an axial flow pump used in a floating type water treatment system completely powered by renewable energy source. The treatment system is designed to raise water from depths of about 3~5m up to the water surface where it is naturally mixed with air as it is released back to the reservoir. The outlet of a typical axial flow pump is modified to suit the floating type water mixer. The performance of the axial flow pump is studied by investigating the internal flow of the system. Results show that the change in outlet shape does not alter the performance of the original pump at the maximum efficiency point as long as the cross sectional area of inlet is the same as the outlet. The axial pump for floating type water treatment system has good cavitation performance in the whole flow passage.