• Natural Product Sciences
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• v.6 no.1
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• pp.25-30
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• 2000

To analyse scientifically the fundamental formulation theory and drug interaction of Chungpegagan-tang, the extraction level of puerarin and daidzin, the transforming activity of puerarin and daidzin to daidzein by human intestinal bacteria and in vitro cytotoxicity against tumor cell lines of Chungpesagan-tang were investigated. When Puerariae Radix was extracted with Chungpesagan-tang composing herbal medicines, the puerarin extraction level from these polyprescriptions was decreased by the extraction with Raphani Semen or Cimicifugae Rhizoma, but the other herbal medicines increased it. The activity transforming puerarin and daidzin to daidzein by human intestinal bacteria was increased by Raphani Semen, Cimicifugae Rhizoma and Angelicae Tenuissimae Radix, but decreased by Scutellariae Radix and Rhei Rhizoma. Puerariae Radix did not showed in vitro cytotoxicity against tumor cell lines. However, by its anaerobic incubation with human intestinal bacteria, it showed a potent cytotoxicity. When the main components, puerarin and daidzin, of Puerariae Radix were incubated with human intestinal bacteria, the main metabolites were daidzein and calycosin. These metabolites had the most potent cytotoxicity, compared to those of puerarin and daidzin. Raphani Semen, Rhei Rhizoma and Chungpesagan-tang had also the potent cytotoxicity against tumor cell lines by the anaerobic incubation with human intestinal bacteria.

• Korean Journal of Acupuncture
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• v.28 no.1
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• pp.125-137
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• 2011

Objectives : The Primo system is a hypothesis on the new circulation system. It orginates from Bonghan theory. Bonghan theory is about the anatomical substance of acupuncture point and meridian system. It has been regarded as a misunderstanding of the lymphatic system or as a made-up story for the past 40 years. Since 2002, many studies have been published either to support the theory or to refute the old viewpoint. But there are still difficulties about the proper sampling. The purpose of this study is to find out the discriminative criteria of Organ Surface Primo sytem by reviewing the Kim Bonghan's publications. Methods : Abstract of description about the Organ Surface Primo system in 5 publications of Kim Bonghan are weighted by the reverse order of publication. Results and Conclusions : 6 characters of anatomical structure and 11 characters of histological structure are founded as repeated descriptions. We hope that this summarized characteristics would be a good guide to Primo system experiments.

• The Korea Journal of Herbology
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• v.28 no.5
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• pp.53-60
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• 2013

Objectives : To prove the channel-tropism theory in herbology, we investigated the anti-diabetic effect of six herbal plants used for lower wasting-thirst in streptozotocin-induced diabetic rats. Methods : Diabetes was induced in male Sprague-Dawley rats by consecutive injection of streptozotocin (30 mg/kg i.p.) for 5 days. The rats were divided into normal control, diabetic control, and diabetic treatment with Lycii Radicis Cortex (LRC, 300 mg/kg); Corni Fructus (CF, 300 mg/kg); Bombyx Batryticatus (BB, 50 mg/kg); Lycii Fructus (LF, 300 mg/kg); Phellodendri Cortex (PC, 300 mg/kg); Epimedii Herba (EH, 300 mg/kg); and glibenclimide (10 mg/kg) as a reference drug. Herbal extracts or reference drug were administered orally for 28 days. The changes of body weight, food intake and water intake, and serological markers such as blood glucose, serum total cholesterol, triglyceride (TG), blood urea nitrogen (BUN), and creatinine (Cr) were measured. Results : The decrease of body weight and the increase of food and water intake in STZ-induced diabetic rats was improved by the administration of CF and LF. Also, the enhancement of blood glucose and serum total cholesterol, TG, BUN and Cr in STZ-induced diabetic rats was significantly inhibited by the administration of CF, BB, LF and glibenclimide. On the other hand, EH strongly inhibited the increase of BUN and Cr in the sera of STZ-induced diabetic rats. Conclusions : These results suggest that among six herbal medicines used lower emaciation of emaciation-thirst disease, CF, BB, LF and EH show a characteristics including the channel-tropism theory.

• Journal of Korean Medical classics
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• v.20 no.3
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• pp.1-8
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• 2007

In "Hwangjenaegyeong", pathogenesis is explained based on theory of Yin and Yang. According to the theory, all environments surrounding us, physical and emotional both, are related to outbreak of diseases. This also reflects one of the major theories in oriental medicine, in which a human body is perceived as a correspondence to natural environment. In this theory, the main idea is to understand changes in the universe based on mutual correlations from within. This kind of perspective is easily criticized from scientific point of view. Whereas modern science pursue analytic thinking and objective information, the theories above seem rather vague. However, from a different angle, through a characteristic perspective of oriental medicine, actual significance can be found in the theory. Many diseases result from one's intemperate living habits. Therefore, much prevention can be made by self-control. Also, once disease occurs, the essential step to treatment is to find cause in the living environment and regain balance. Natural cure will take its' course when living habits recover moderate pace and are back in harmony with the environment.

• Korean Journal of Acupuncture
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• v.27 no.4
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• pp.25-34
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• 2010

Objective : This paper introduces a unique meridian theory developed by Japanese philosopher Yuasa Yasuo. Method : His meridian theory is well organized in his philosophy, so we systematically review his major works and philosophy from which we systematize his meridian theory. And we critically examine it with current studies. Results and Conclusions : He tried to overcome Cartesian mind-body dualism by Eastern thought and newly developing neurophysiology. He articulated "body scheme" from human information systems, primarily nervous system and meridian system, which regulate physiological functions. It consists of 1st external sensory motor circuit, 2nd circuit of coenesthesis, 3rd emotion-instinct circuit and 4th circuit of unconscious quasi-body. Meridian system is the 4th circuit, through which he thought various affect(emotion) flows. Based on the relationship of emotion-autonomic nervous system- meridian-skin, he tried to confirm the existence of meridian system. His theory illuminates mind-body problem and emotion-meridian relationship in traditional East Asian medicine.

• Journal of Oriental Neuropsychiatry
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• v.24 no.spc1
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• pp.3-14
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• 2013

Objectives : Hwabyung Research Center of The Korean Society Of Oriental Neuropsychiatry has attempted to develop 'Clinical Guidelines for the Treatment of Hwabyung' based on the clinical study on the theory of oriental medicine and phenomenological approach. The purpose of this guideline is to establish the basic clinical principles and improve the clinical convenience. Methods : Hwabyung Research Center constructed a committee of experts and advisory group. We extracted the core questions, collected the existing data and evaluated them. Simultaneously, we conducted studies on the major topics. Results : We selected and made suitable tools for the assessment and evaluation. We discovered evidences from clinical studies and developed the standard clinical principles. Conclusions : 'Clinical Guidelines for the Treatment of Hwabyung' is expected to be useful at the primary medical clinics of oriental medicine.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.596-599
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• 2005

Human health is affected by not only physical conditions but also mental and social well-being. Changes of human emotions show up as gestures, facial expressions and sweating. Human emotions are affected by such automatic nerve system functions as blood pressure, blood circulation speed, heart beats, pupillary reflex, fluid transfusion, muscular contraction and digestive organs, all of which influence the holistic diseases. The Oriental Medicine sees from a perspective of unity of divinity and men that human life activities are united in terms of their physical and mental functions. From such a perspective, human Five Organs are linked with Five Mental(五神) and Seven Emotions(七情), while they are affected by each other, influencing the life activities both directly and indirectly. Based on Confucianism, Sa-Sang Theory argues that human emotions can be categorized into four energy states and therefore, that human diseases and physiological conditions there of may be determined differently depending on the Four Energies(四氣). There seems to be some common points between Sa-Sang Theory and the conventional Oriental Medicine in that human emotions affect individuals' health conditions, so there seems to be much room for mutual complementation.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.3
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• pp.353-360
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• 2010

Huang di's Four Classics introduces the first full-scale Yin-Yang theory. The ancient idea of Yin-Yang could be classified systematically throughout Huang di's Four Classics and make itself the cause of creation, movement, and variation. The Tao of essence and Reason-Law(理法) is a single 'One'(一) and completes the reality of Tao adopting Yin-Yang as an elementary. The elementary of Yin-Yang has rules and laws and then the Tao manifest itself through Yin-Yang. The features of Yin-Yang theory in Huang di's Four Classics are placed on the explanation of the structure of the universe embodied as class and system. The class and system are the structured worlds in the space based on the upper and lower sides Yin-Yang idea(上下陰陽觀). It means the system by Yin-Yang theory, corresponding to the flat structure of the Sky and the Earth mentioned in Gaitian theory, one of the ancient theory of the universe structure. By adopting Huang di's Four Classics' Tian-zhi Yin-Yang theory(天地陰陽論) and developing the class system in human bodies, The Hwangjenegyeng appreciates human bodies as a whole. In addition, by applying Four seasons Yin-Yang theory not only to human bodies but also to the space of Liu-he(六合) and the time of Four Seasons(四時), it developed Yin-Yang theory of Huang di's Four Classics more abundantly and embodied Yin-Yang theory in many fields including physiology, pathology, diagnostics, and prescriptions.

• Journal of Haehwa Medicine
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• v.23 no.2
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• pp.1-4
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• 2015

Learning can be defined as its objects, main question for the objects, and its unique way to organize all the knowledge acquired as the results of the question. From the point of view like this, Traditional Korean Medicine(TKM) can be defined as learning for human body and its functions, health and diseases based on the theory of the Yin and Yang and of the five elements. Nowaday Many papers based on laboratory work publish for the name of scientization of TKM, but from the viewpoint of definition of learning, they have a problem that there is no basic theory. If TKM could be communicated with western natural science, it has to be solved. And oriental physiology has a same object and same questions with western physiology, so oriental physiology can be useful to make a bridge between TKM and western natural science.

• The Journal of Korean Medicine
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• v.26 no.2 s.62
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• pp.1-12
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• 2005

Objectives: Malignant gliomas are often treated with cisplatin (cis-diamminedichloroplatinum(II), CDDP) and radiation but results remain unsatisfactory. Since malignant glioma displays moderate resistance to conventional therapy, a new treatment modality is needed to improve the outcome of patients with these tumors. The aim of this study was to investigate the effects of the combined use of Jongjihwan(JJH) and cisplatin(CDDP) on cultured malignant glioma cells, A172. Methodss & Results: The combined use of cisplatin and Jeongjihwan had synergistic effects on Al72 cells during 24 hr-incubation, This treatment resulted in a decrease of cell viability, Which was revealed as apoptosis Characterized by activation of caspase-3 protease as well as cleavage of poly ADP-ribose polymerase (PARP) with change of mitochondria membrane potential transition. The expression of members of the Bcl-2 protein family was modulated during co-treatment with Jeongjihwan and cisplatin. Activation of caspase-3 and mitochondrial alterations were central to co-treatment with Jeongjihwan and cisplatin-induced apoptosis. Conclusions: We conclude that co-treatment with Jeongjihwan and cisplatin-induced activation of the mitochondrial pathway enables cell death. Also, we suggest the combined theory of JJH and cisplatin could be a useful method for glioblastoma.