• 대한한방소아과학회지
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• 제28권4호
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• pp.45-63
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• 2014

Objectives The purpose of this study is to investigate the clinical characteristics in children and adolescents with peripheral facial palsy that was treated with Korean medicine. Methods The study was conducted based on 284 cases that consisted of 261 children (less than 19 years old) who visited the hospital of Korean medicine from August 2010 to August 2014. Then, this study was analyzed by reviewing the patients' charts. Results The incidence of facial palsy in pediatric patients was more common in boys than in girls and the mean age was 11.2 years. The prevalence of facial palsy was more common in winter and most were diagnosed with Bell's palsy. Recurrence was identified in 12.6% of the patients. The average age of the first attack was 9.5 years. It took about 3.2 years for recurrence to occur from the first onset. It took about 5 days to visit the hospital of Korean medicine from the onset. 81% of the patients came within 1 week from the onset. 50.7% of the cases did not receive any treatment before and 49.3% were previously treated at other hospitals. More than half of the patients (65.1%) received Korean medicine first. 54.6% of the patients were hospitalized and 45.4% received outpatient treatments in the hospital of Korean medicine. Outpatient treatments were administered about 11.5 times while hospitalized patients were treated for an average of 16.6 days. In general, hospitalized patients were treated more often than the outpatient group. An overall average duration of treatment was 70.6 days from the onset of facial palsy until the last day of treatment, and 53.0 days from the first day of treatment until the last day of treatment. 41.5% of the cases were treated only with Korean medicine and 49.0% were treated with a combination of Korean and Western medicine. The types of Korean medicine treatment used for facial palsy in descending order of frequency were acupuncture, Infra red, herbal medicine, SSP therapy, electro-acupuncture, carbone, hot pack, cupping, and moxibustion. The treatments that were most frequently used from Western medicines were steroid as monotherapy (61.7%) and a combination of steroids and antiviral therapy (37.6%). Conclusions This result showed that the risk of facial palsy recurrence among children is relatively high and that facial palsy requires a long-term treatment. It's helpful to explain about prognosis, treatment duration, and recurrence potential in children. Facial palsy in children is treated in various ways but more studies about the therapeutic effects of Korean medicine, Western medicine, and combination of Korean-Western medicine in children are needed.

• 생명과학회지
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• 제22권5호
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• pp.650-656
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• 2012

느타리버섯의 생산단가를 절감할 목적으로 한의원 등에서 폐기처리 되고 있는 한방슬러지를 수거하여 느타리 버섯 배지의 개발을 행하였다. 한방재료의 일반성분을 검토한 결과 조회분 함량은 홍화대와 지리오갈피가 11.6%와 10.1%를 나타내어 대조구인 폐면의 9.6% 보다 높게 나타났다. 조지방 함량은 모든 시험구에서 대조구인 폐면보다 높게 나타났다. 조단백 함량은 폐면배지에서는 9.8%로 검출되었으나 야생 쑥, 지리오갈피, 한방슬러지 및 홍화대에서는 각각 14.9%, 13.9%, 13.4% 및 11.5%로 대조구보다 높게 나타났다. 한방슬러지, 야생쑥 및 지리오갈피의 pH는 5.27~5.72 범위로 폐면이 나타낸 pH 5.70과 거의 같은 수준이었다. 느타리버섯의 균사 성장에 미치는 각 한방재료의 첨가농도는 3% 및 6%의 첨가보다 9%의 첨가구에서 느타리버섯 균사의 성장이 양호하였다. 그러나 한방재료의 첨가는 $P.$ $tolaassi$의 생육 및 $Trichoderma$ $sp.$의 생육에는 크게 영향을 미치지 못하였다. 폐면배지에 9%의 한방슬러지를 첨가하여 실시한 현장 실험결과 버섯의 균사생장은 폐면배지에서 보다 약 2~3일 정도 빠르게 나타났고, 버섯의 수확량은 10~15% 정도 증수되었으며 또한 버섯의 대 및 갓 등이 균일하고 우수하였다.

• 대한의생명과학회지
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• 제13권3호
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• pp.161-168
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• 2007

Salicornia herbacea L. (Chenopodiaceae: S. herbacea) is a salt marsh plant, which has long been prescribed in traditional medicines for the treatment of intestinal ailments, nephropathy, and hepatitis in Oriental countries. In order to elucidate the mechanisms of this herb, we conducted an anti-oxidative activity, the inhibition of nitric oxide (NO) production, and the suppression of the pro-inflammatory cytokine genes, with the solvent-extracts of S. herbacea. We found that both ethyl acetate and n-butanol tractions showed potent anti-oxidative effects in comparison to other fractions using xanthine oxidase assay with $IC_{50}$ values of $66.0{\pm}0.5\;{\mu}g/ml$ and $82.5{\pm}3.8\;{\mu}g/ml$, respectively. In addition, both ethyl acetate and n-butanol fractions showed more electron donating activity (EDA) than other tractions, according to DPPH (2, 2-Diphenyl-lpicrylhydrazyl radical) assay. The EDA of ethyl acetate fraction ($IC_{50}$ values of $117.5{\pm}3.8\;{\mu}g/ml$) is more significant than that of n-butanol fraction ($IC_{50}$ values of $375.0{\pm}12.5\;{\mu}g/ml$). Among potential anti-oxidative tractions, ethyl acetate traction dose-dependently suppressed lipopolysaccharide (LPS, $0.1\;{\mu}g/ml$)-induced nitric oxide (NO) production in RAW264.7 cell, while n-butanol did not. As expected, ethyl acetate fraction suppressed the expression of inducible NO synthase (iNOS) in RAW264.7 cell stimulated by $0.1\;{\mu}g/ml$ of LPS. Moreover, the ethyl acetate traction suppressed the expression of interleukin-1 $(IL)-1{\beta}$ and granulocyte/macrophage colony-stimulating factor (GM-CSF) mRNA in LPS-stimulated RAW264.7 cells. Therefore, these results suggest that S. herbacea may have anti-oxidative and anti-inflammatory activities by modulating radical-induced toxicity and various pro-inflammatory responses.

• 대한한의학방제학회지
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• 제28권3호
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• pp.289-300
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• 2020

Objectives : In this paper, We pointed out medico-historical meaning of Hyang'yak Kugŭppang (鄕藥救急方, Medical Recipes of Local Botanicals for Emergency Use), a medical book of Koryŏ Dynasty, breaking from the existing analysis view based on Hyang'yak (鄕藥), local herbs produced in Korean Peninsula. Methods : For that purpose, we analyzed the clinical characteristics of the diseases and symptoms, strategies of treatment, therapeutic tools, drug formulations, composition of herbal formulas in Hyang'yak Kugŭppang. Results : The following characteristics were confirmed in Hyang'yak Kugŭppang. First, it contained a way to cope with the diseases and symptoms that do not have to check the exterior, interior, cold, and heat. Also, it introduced basic strategies such as reducing, facilitating flow, draining downward, warming, or tonifying, etc. It mainly included herbal medicine as the therapeutic tools, and introduced formulas composed by single herb than complex recipes. It suggested external applications more than internal use, and proposed formulations in the form of decoctions or powders, etc. The herbs of formulas were used by experience without explanations of nature & taste, efficacy of each herbs. Conclusions : Hyang'yak Kugŭppang is a book of medical recipes for emergency use that has been distributed to help gentries, even if they do not have professional medical knowledge, to instantly cope with diseases and symptoms with medicines that are easy to obtain. Previous researches has analyzed the value of Hyang'yak Kugŭppang as a collection of information of hyang'yak, and used it as a historical basis of the uniqueness of Korean medicine. Since Hyang'yak Kugŭppang is not a book specialized for herbs, but rather a clinical medical book that introduces recipes for specific symptoms of diseases, if we pay attention to the clinical characteristics of Hyang'yak Kugŭppang, it will provide an opportunity to describe Koryŏ or Korean medicine in a new way.

• 대한예방한의학회지
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• 제22권2호
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• pp.65-75
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• 2018

Objectives : This study aimed to investigate the satisfaction of Korean medicine doctors (KMD) who conducted Korean medicine school doctor program (KMSD). We are going to use study as a foundation for activation KMSD program. Methods : Seoul Korean medicine association and Seoul metropolitan office of education conducted KMSD program for 22 schools in 2017. The program included health lessons, health counseling, and health care programs. After program finished, we carried out self-administered questionnaire survey to KMD who participated in KMSD program and we analysed it. Results : A total of 45 people answered the questionnaire, and 56% of respondents answered as 'Good progress' and 44% answered as 'Bad progress'. The reason for good progress was 'Good cooperation of School' (47.4%). 'Personalized program for participant' (23.68%), 'Support of Seoul Korean Medicine Association' (21.1%). The reason for 'Bad progress' was 'Bad cooperation of School' (37.8%), 'Lack of personal circumstances' (32.4%), 'Lack of motivation' (16.2%). The advantage of KMSD program included 'It is helpful for positive perception of the Korean medicine' and 'Korean medicine can contribute to improving public health, which is the health of schools' was 25%, 'It is helpful in expanding the services of Korean medicines to children and adolescents' was 17.6%, 'Highly satisfaction in participations' was 15.7%. The question of prerequisites for activation KMSD Program included 'Active cooperation of school' was 35.05%, 'Expand teaching materials and programs' was 20.62%, 'Support of Seoul Korean Medicine Association' was 15.46%. Conclusions : We will organize and activate programs of KMSD program and conduct program based on harmony of local community and school support, research of school health program. The program will contribute to improve student health and develop Korean health support program.

• 생약학회지
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• 제36권2호통권141호
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• pp.102-108
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• 2005

We have studied the physico-chemical change and pharmacological transformation of traditional herbal medicines with processing. Evodia fruit (EF) has processed for the purpose of detoxification and reduction of its bitter taste. There are various methods of processing EF in Oriental medicinal reference. Among them, we processed EF according to the method of Sang-han theory, the most famous medicinal reference. We processed EF with washing in hot water, and then dried. Processed EFs(PEFs) were prepared according to the above procedure through repetition of 1,3,5 and 7 times respectively. The contents of weight loss, water extract, diluted ethanol extract, ether extract, total ash, acid insoluble ash, alkaloids and limonin in non-processed EF (NPEF) and PEFs were examined. The weight loss, and contents of water extract and dilute ethanol extract in PEF showed decrease in proportion to increase of washing time, while the contents of ether extract, total ash and acid insoluble ash showed little change as compared with those of NPEF. And the content of evodiamine and rutaecarpine was not changed distinctly. However, the content of limonin decreased in the final processed material in proportion to increase of washing times with hot water. And the intense of bitter taste in PEF was also reduced. These results were ascribed to the flowing-out of the water-soluble portion. The biological activities of NPEF and PEF were also investigated. In the test of DPPH scavenging effect, xanthine oxidase inhibition effect and TBA-Rs effect, PEF was more effective than NPEF in vitro. Also, both NPEF and PEF showed potent analgesic and anti-inflammatory effects against in mice. Especially, PEF by 3 times washing with hot water was more effective than other PEFs. From these results, it is considered that PEF should be prepared by 3 times washing with hot water.

• 한국식품영양학회지
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• 제27권3호
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• pp.532-537
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• 2014

황백(Cortex Phellodendri: CP)은 황벽나무(Phellodendron amurense)의 건조된 수피로부터 얻어진다. 이 수피는 한국의 전통 한약제로서 설사, 황달, 무릎과 발의 통증, 요도관 및 피부 감염증에 폭넓게 사용되어 왔다. 이들 기능성 성분의 분리 및 정제는 박층 크로마토크래피, 컬럼 액체 크로마토크래피 및 HPLC와 같은 여러 분석법들이 동양의 약초연구에 이용되어 왔다. 본 연구는 CP로부터 berberine을 분리하기 위해 향류분배 크로마토크래피법(CPC)으로 효과적으로 수행하였다. 두 용매의 CPC 최적조성은 n-butanol: acetic acid: water(4:1:5 v/v/v)이었다. 이동상의 유속은 1,000 rpm 회전력에서 상승법으로 분당 3 mL 속도로 전개시켰다. CPC에서 분리된 분획분은 prep-HPLC로 정제하였다. $^1H$-NMR 스펙트럼은 4.10과 4.20 ppm에서 $3H(-OCH_3)$, 6.10 ppm에서 2H의 ($-OCH_2O-$) proton signal의 공명이 관찰되었다. 2개의 방향족 proton은 이중결합 패턴을 보였다. H-11과 H-12 doublet은 각각 7.98과 8.11에서 나타났다. $^{13}C$-NMR 스펙트럼에서는 C2와 C3의 methylenedioxy group($-OCH_2O-$), C9과 C10에 methoxy group($-OCH_3$)이 4개의 치환된 형태로 보였다. 분리 정제된 berberine의 화학구조는 $^1H$, $^{13}C$-NMR, ESI-MS 데이터 분석으로 확인하였다.

• 한국미생물·생명공학회지
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• 제38권1호
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• pp.105-111
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• 2010

소목은 전통적으로 타박상, 염증 등의 질병치료를 위해 민간의학에서 오래 동안 사용되어 온 한약재야다. 소목의 섬재로부터 항균효과를 조사하기 위하여 MeOH 추출에 의한 hexane, $CHCl_3$, EtOAc, n-BuOH, MeOH 및 $H_2O$ 분획을 얻었다. 분획 시료 중 3.94%의 가장 높은 수율의 EtOAc 분획이 조사된 인채 병원성 세균에 대해 가장 강한 항균활성 나타냈다. 또한 EtOAc 분획의 항균활성은 Gram (-) 균주 보다 Gram (+) 균주에 더 효과적이며, Gram (-) 균주에 대해서는 세균에 따른 항균활성의 차이를 보였다. EtOAc 분획은 silica gel adsorption column chromatography 및 Sephadex LH-20을 이용하여 분리하였으며 수득한 주요 성분은 채결정을 통하여 얻어진 단일물질을 HPLC를 이용하여 순도를 측정하였다. 300g의 C. sappan으로부터 3.94%의 EtOAc 분획을 얻었으며 EtOAc분획물은 분석한 결과 10 mg에는 1.67 mg의 brazilin을 포함하였다. 분리된 활성울질은 짧은 황색 결정의 단일 화합물로 MS에 의해 분자량이 285로 나타났으며, $^1H$-NMR, $^{13}C$-NMR에 의한 구조분석으로 brazilin($C_{16}H_{14}O_5$을 동정하였다. 이 같은 결과는 소목의 MeOH 추출에 의한 EtOAc 분획에 존재하는 brazilin이 S. aureus와 같은 인체 병원성 Gram (+) 균주에 대한 생약치료제로 활용이 가능할 것을 시사한다.

• 대한한방부인과학회지
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• 제31권3호
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• pp.97-108
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• 2018

Objectives: This survey was conducted to investigate the satisfaction level of the project of providing free herbal medicines to mothers living in Suncheon who gave birth to more than three. Methods: Using the online survey tool Survey Monkey, the mother was sent a questionnaire in a cell phone text to answer the questions on their cell phones. The mothers' contact information was based on the application form for a woman with three or more children, and a total of 27 people were surveyed and 20 responded. Results: The lowest level of satisfaction was 51 percent, the highest level of satisfaction was 100 percent, and the average was 86 percent. Conclusions: As the satisfaction level of the free herbal medicine support program is generally high, it is necessary to maintain the business continuously. And if other oriental medicine treatment is applied, more positive effect can be expected.

• 사상체질의학회지
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• 제20권2호
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• pp.30-42
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• 2008

1. Objectives This paper was tried to find out the clinical use of Gwanjung-tang by comparing patients' chief complain and natural symptom. 2. Methods The study was researched as clinically with medical records of 88 patients who visited a certain oriental medicine clinic which is in Seoul during January, 2000 and June, 2006. 3. Results 1) The male patient who was treated with Gwanjung-tang(寬中湯) is rare. The rate of patients who visited clinic in her forties is 27.3%, in fifties is 18.2%, in thirties is 15.9%, in sixties is 12.5%, in twenties is 10.3%. 2) Chief complain which made patients to visit clinic is a chest pain(19.3%), back pain and shoulder pain (15.9%), edema (12.5%), headache (9.1%), irregular menstruation (8.0%), dyspepsia (8.0%), fatigue (8.0%), insomnia (5.6%), menopausal disorder (4.5%), lumbago (4.5%), abnormal condition of stools (2.3%), and abnormal condition of urine (2.3%). 3) Natural symptom is classified into appetite, digestion, stools, urine, sweat, and sleep. The rate of patients who complained abnormal condition of digestion is 71.6%, of sleep is 59%, of stools is 52.3%, of urine is 47.7%, if sweat is 34.1%, and of appetite is 30.7%. 4) The rate of patients who is treated with Gwanjung-tang between thirty and forty packs is 43.2%, twenty packs is 39.7%, between fifty and sixty packs is 5.7%, between seventy and eighty packs is 2.3%, and between ninety and hundred packs is 3.4%. 5) The rate of patients who is treated with Gwanjung-tang during 15 days is 45.5%, between 16 and 30 days is 26.2%, between 31 and 60 days 7.9%, between 61 and 90 days 3.4%, between 91 and 120 days is 4.5%, and more than 120 days is 12.5%. 6) There are not many cases that chief complain was abnormal condition of digestion (8.0%), sleep (5.6%) stools (2.3%), and urine (2.3%). But the rate of patients who complained discomfort of digestion(71.6%), sleep(59%) stools (52.3%), and urine (47.7%) is significantly high. 7) According to "Sasang Sin Pyeon", Gwanjung-tang was used in To-sa-gwak-ran (吐瀉藿亂), Hae-su (咳嗽), Jeok-chui (積聚), Pyo-han -bu-jong (表寒浮腫), Chang-man (脹滿), Chil-gi (七氣), Dam-um (痰飮), Dam-goe (痰塊), Seom-jwa-yo-tong (閃挫腰痛), Bi-tong (臂痛) of Soeumin, and it is corresponds with clinical cases for various components. 4. Conclusions Gwanjung-tang is a medicine of reconciliation, and it makes Stomach to be warm and take down Yin Qi. The most important effect of Gwanjung-tang is Sun-qi(順氣). So it is considerable that Gyejibanhasenggang-tang (少陰人 桂枝半夏生薑湯), Hyangsayangwi-tang (少陰人 香砂養胃湯), and Gwakhyangjunggi-san (少陰人 藿香正氣散) is also effective to symptoms above, because these are medicines of reconciliatio.