• 제목/요약/키워드: Organic synthesis

검색결과 1,222건 처리시간 0.027초

팔라듐 촉매를 이용한 퀴놀론핵과 Heteroaryl Stannes의 결합 - C-7 heteroaryl 쿼놀론 유도체의 합성 - (Palladium-Catalyzed Coupling between Quinolone Moieties and Heteroaryl Stannes - Synthesis of C-7 heteroaryl Quinolone Derivatives -)

  • 남상훈;함원훈;김기수;임태균;양재권
    • 약학회지
    • /
    • 제37권6호
    • /
    • pp.615-620
    • /
    • 1993
  • The cross-coupling reaction of organo tin reagents with a variety of organic halides, catalyzed by palladium, provides a novel method for generating a carbon-carbon bond. We used this method for the antibacterial agents, and synthesis of new quinolone derivatives which have carbon-carbon bond at C-7 position of general quinolone moieties. Aryl tin, quinolone moieties, and palladium catalyst were refluxed in DMF to afford new quinolone derivatives. This palladium catalyzed coupling reactions have capacity for further synthetic elaboration.

  • PDF

Synthesis and Antibacterial Activities of Triphenyltin Cephalosporins

  • Park, Sang-Woo;Kim, You-Seung;Chung, Young-Keun
    • Archives of Pharmacal Research
    • /
    • 제12권3호
    • /
    • pp.231-232
    • /
    • 1989
  • Although it has been known that organometallic $\beta$-lactam compounds improve the resistance to $\beta$-lactamases as well as their pharmacological activities, only a few results on organometallic $\beta$-lactam antibiotics were reported. In the course of our extensive study on the development of new cephalosporins, we were interested in organotin compounds since they show some biological activities.

  • PDF

One-pot Synthesis of Cinnamylamines with Various Protecting Groups from Cinnamyl Ethers

  • Jung, Young-Hoon;Kim, Ji-Duck
    • Archives of Pharmacal Research
    • /
    • 제24권5호
    • /
    • pp.371-376
    • /
    • 2001
  • The reaction of various alkyl cinnamyl ethers with CSI afforded the corresponding cinnamylamines with various protecting groups, such as -NHMoc, -NHiPoc, -NHCbz, -NHPnz, -NHTroc and -NHAloc. In the case of cinnamyl t-butyl ether and cinnamyl p-methoxybenzyl ether, the corresponding cinnamyl carbamates were formed via a different reaction pathway from the above.

  • PDF

Asymmetric Synthesis in Pharmaceutical Manufacturing Chemistry

  • Jew, Sang-Sup
    • 대한약학회:학술대회논문집
    • /
    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
    • /
    • pp.59-61
    • /
    • 2003
  • Organic compounds play an important role in the area of pharmaceutical, agrochemical, and other materials, which possess useful biological activities. Generally, such biological activities are come from the interaction of the organic compounds with the receptors in biological system, such as enzymes. Such receptors are composed of the chiral building blocks such as amino acid or carbohydrate, which means the biological active sites of receptors are chiral. (omiited)

  • PDF

Synthesis and Characterization of New Push-Pull Chromophores Containing BF2-Azopyrrole Derivatives

  • Ko, HayeMin
    • 대한화학회지
    • /
    • 제60권1호
    • /
    • pp.21-27
    • /
    • 2016
  • Novel push-pull chromophores containing 5’-(4-(bis(9,9-dimethyl-9H-fluoren-2-yl)aniline (bisDMFA) as a donor and phenylazo-methylpyrrolyl-boron difluoride (PhAPy-BF2) as an acceptor were designed and synthesized by the Knoevenagel condensation reaction for organic solar cells. Various electron withdrawing moieties were effectively introduced using 2,4-dimethyl-1H-pyrrole to afford new asymmetric BF2-azopyrrole molecules that were characterized by UV-vis spectroscopy and cyclic voltammetry measurements.