• 제목/요약/키워드: Organic chemistry

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Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton

  • Tanjung, Mulyadi;Tjahjandarie, Tjitjik Srie;Mardhiyyah, Shola;Rahman, Ghinsha Zakatina;Aldin, Muhammad Fajar;Saputri, Ratih Dewi;Ahmat, Norizan
    • Natural Product Sciences
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    • 제28권2호
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    • pp.58-61
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    • 2022
  • Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1 - 3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC50 value of 11.2 μM.

Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton

  • Tanjung, Mulyadi;Tjahjandarie, Tjitjik Srie;Mardhiyyah, Shola;Rahman, Ghinsha Zakatina;Aldin, Muhammad Fajar;Saputri, Ratih Dewi;Ahmat, Norizan
    • Natural Product Sciences
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    • 제28권1호
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    • pp.40-43
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    • 2022
  • Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1-3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC50 value of 11.2 μM.

A Simple, Efficient, Catalyst-Free and Solvent-Less Microwave-Assisted Process for N-Cbz Protection of Several Amines

  • Aouf, Zineb;Mansouri, Rachida;Lakrout, Salah;Berredjem, Malika;Aouf, Nour-Eddine
    • 대한화학회지
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    • 제61권4호
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    • pp.151-156
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    • 2017
  • A simple, green and chemo-selective method for the N-benzyloxycarbonylation of amines, ${\beta}$-amino alcohols, ${\alpha}$-amino esters and sulfonamides has been developed under microwave irradiation. Good to excellent yields of the N-benzyloxycarbamates compounds were obtained in short times without any side products.

Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata

  • Tanjung, Mulyadi;Nurmalasari, Intan;Wilujeng, Aisyah Kanti;Saputri, Ratih Dewi;Rachmadiarti, Fida;Tjahjandarie, Tjitjik Srie
    • Natural Product Sciences
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    • 제24권4호
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    • pp.284-287
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    • 2018
  • A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3',5'-diisoprenyl-2',4'-dihydroxy-6'-methoxyphenylethanone (2) and 3'-isoprenyl-2',4',6'-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedunculata (L.) Miq. The structures were determined by HRESIMS, 1D and 2D NMR. The inhibitory activity of the isoprenylated acetophenone derivatives against murine leukemia P-388 cells showed compound 1 moderate activity with $IC_{50}$ $15.42{\mu}M$.

Biosurface Organic Chemistry: Interfacial Chemical Reactions for Applications to Nanobiotechnology and Biomedical Sciences

  • Chi, Young-Shik;Lee, Jung-Kyu K.;Lee, Kyung-Bok;Kim, Dong-Jin;Choi, In-Sung S.
    • Bulletin of the Korean Chemical Society
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    • 제26권3호
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    • pp.361-370
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    • 2005
  • In this review, the field of biosurface organic chemistry is defined and some examples are presented. The aim of biosurface organic chemistry, composed of surface organic chemistry, bioconjugation, and micro- and nanofabrication, is to control the interfaces between biological and non-biological systems at the molecular level. Biosurface organic chemistry has evolved into the stage, where the lateral and vertical control of chemical compositions is achievable with recent developments of nanoscience and nanotechnology. Some new findings in the field are discussed in consideration of their applicability to nanobiotechnology and biomedical sciences.