• The Journal of Internal Korean Medicine
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• v.29 no.2
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• pp.529-534
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• 2008

Renal cell carcinoma(RCC) is one of the major malignant renal cell tumors. Although RCC can metastasize to almost every organ, the most common metastatic sites are the lung parenchyma, the bones, the liver, and the brain. Adrenal metastasis from RCC is extremely rare. Adrenal metastasis from RCC shows poor prognosis, with little benefit from chemotherapy, radiation therapy, hormone therapy or immunotherapy. In this report, we describe a case of an RCC patient who showed lung and adrenal metastasis. The patient underwent left nephrectomy and chemotherapy(sunitinib), which were not effective. He refused further conventional medical treatment, and instead started treatment with Traditional Korean Medicine using allergen-removed Rhus verniciflua Stokes. After about 3 months of this treatment, the size of the adrenal tumor had decreased significantly with good performance status. Further study will be needed to demonstrate the tumor regression effect of allergen-removed Rhus verniciflua Stokes on patients with metastatic renal cell carcinoma.

• The Journal of Korean Society for School & Community Health Education
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• v.8 no.1
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• pp.1-11
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• 2007

Objectives: School must provide the proper sex education to students, thereby, the students for have right standards of sexuality and preventing from sexual crimes. This study conducted to identify the effectiveness and students' satisfaction level on Sex education program for middle school students prepared by the Ministry of Education and Human Resources. Methods: The sample size of the study was 644 students(458 female students and 186 male students) in middle school. A self reporting type of questionnaire survey was conducted from May 2 through May 27, 2005. Collected data were processed using SPSSwin 12.0; The data were analysed through t-test, stepwise multiple regression analysis. Results: Lectures and audiovisual materials were mostly used for sex education for students. Many students were satisfied with the program of physical and sexual organ development, pregnancy, contraceptive methods and sexual abuse. Many students wanted to study more on courtship, love, and marriage. The programs which the students did not understand well were sexually transmitted diseases, pregnancy and mass media and sex. Forty six percentage of the students reported that they were satisfied with the education program. Thirty three percentage of the students said that they were not satisfied with the program. The students who had earlier menstruation experience and the students whose academic achievement were higher were more satisfied with sex education program (P<.05). The students who were satisfied with the sex education CD prepared by the ministry of education were more satisfied with sex education program. (P<.001). When the CDs were appropriately used, the students were more satisfied with the education program (P<.05). The sound and pictures in the CD did not much affect the students. Audiovisual programs were more effective than lectures.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.5
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• pp.668-676
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• 2001

Two growth performance experiments were undertaken in order to compare the nutritional benefit of micronized dehulled barley (MDB) with wheat and maize. In the first experiment, ninety-six 24 d old Cotswold pigs with an average body weight of 9.5 kg were randomly allotted into one of four dietary treatments. The wheat and MDB ratio in the four complex diets were 100% wheat, 75% wheat+25% MDB, 50% wheat+50% MDB and 100% MDB; cereal was about 47% of the whole diet and varied by using different ratios of wheat and MDB. Starter phase was started at a bodyweight 9.9 kg; grower phase continued at liveweight 37.1 kg and finished at 74.0 kg. The ADFI, ADG and feed efficiency (F/G) were not affected (p>0.05) by the level of MDB in the diet from 9.9 to 37.1 kg live weight. However, ADFI was (p<0.05) less (14%) for the pigs fed the 75 or 100% of MDB based diets without affecting F/G during the second phase (37.1 to 74.0 kg live weight). Pigs fed the MDB based diet had a lower (p<0.05) plasma urea nitrogen (PUN) concentration than the pigs fed the wheat-based diet. In the second experiment, the trial started at 9.9 kg body weight and ended at market weight (107.6 kg), with three different phases in the trial. One hundred and twenty Cotswold pigs were randomly assigned to one of three dietary treatments. The maize and MDB ratio in the three diets were 100% maize, 50% maize+50% MDB and 100% MDB. Diet treatments did not affect (p>0.05) growth performance, PUN level, carcass characteristics and organ size, except for an improvement (p<0.05) in ADG for the pigs in the starter phase fed 50% and 100% MDB based diets.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.38 no.2
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• pp.179-190
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• 2001

In this proposed study, observing and analyzing contrast enhanced abdominal CT images, we segmented the liver automatically. We computed the ratio of each gray value from the estimated gray value range. With the average value of mesh image, we distinguished the liver from the noise parts. We divided the region based on immersion simulation. The threshold value is determined from the mesh image which is generated from each gray value portion of the liver and is used in dividing the liver to the noise region. To get the outline of the liver, we generated template image which represents the lump of the liver, and subtracted it from the binary image. With the results we use the proposed algorithm using 8-connectivity instead of the present opening algorithm, to reduce the processing time. We computed the volume from the segmented organ size and presented a clinical demonstration with the animal experiment

• Korean Journal of Medicinal Crop Science
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• v.4 no.3
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• pp.199-204
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• 1996

We investigated the structures of floral organs and the developmental process of each floral organs in Bupleurum falcatum. The overall size of a floral was about 2mm. The lengths of ray, pedicel, pistil and stamen were 22.5mm, 3.6mm, 1.0mm and 1.3mm respectively. The ovary surface was 0.9mm in length and 1.4mm in width. And the developmental periods of each floral organs were as follows; 1 through 6 days in stamen emergence, 6 through 9 days in petal detachment and pistil emergence, 9 through 16 days in pistil ma­turation, and above 16 days in pistil degeneration after onset of flowering. This plant was admitted to be a allogamous plant, especially with the protandry form of dichogamy.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.18 no.3
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• pp.515-527
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• 1996

The most serious problem resulting from estrogen deficiency induce osteo porosis. Recently, they make efforts to inquire a relation between hematopoietic organ and bone loss due to estrogen deficiency. Estrogen have an effect on growth and formation of skeletal system, and inhibit bone resorption under the influence of osteoblast and osteoclast, and basically inhibit the increase of hematopoietic progenitor and immune factor connected with bone resorption and prevent the osteoid formation. The purpose of this article was to observe the change of spleen and effect on hematopoietic function following estrogen administration. In this study, female rats of 150g weight was ovariectomized, after 70 days, experimental group was injected estrogen at interval of a week and sacrificed on 1, 2, 3, 4, 6 weeks. Control group was sacrificed after ovariectomy on 11, 12, 13, 14, 16 weeks without estrogen injection, and normal rats were sacrificed for harvest of spleen and femur. Paraffin sections and H&E stain was performed, and observed under light microscope. The obtained results were as follows. 1. From 11 to 12 weeks at bone marrow of control group, hematopoietic cells were decreased in comparison with normal group, and lipid infiltration was seen, and irregular bone remodelling was seen after 13 weeks. From 14 to 16 weeks, there were more decreased hematopoietic cells and lipid degeneration, and lipid degeneration of hematopoietic cells appeared. 2. All the bone marrow of experimental group, the structure of hematopoietic cells with decreased lipid infiltration was recovered from 2 weeks of estrogen adminstration and maintained to 6 weeks. 3. At spleen of control group, borders of white and red pulp was not well demarcated, and size of white pulp was decreased. 4. At spleen of experimental group, borders between white and red pulp have been well demarcated from 3 weeks of estrogen adminstration relatively, and white pulp was increased with distinct border. From above findings, we could regarded that estrogen deficiency due to ovariectomy influenced on hematopoietic cells of bone marrow and spleen, and histologic recovery of hematopoietic cells were observed after 3 weeks of estrogen adminstration even if it was not reach to normal group.

• Childhood Kidney Diseases
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• v.19 no.2
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• pp.131-135
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• 2015

Purpose: The aim of this study was to establish a simple formula to predict renal length in children using a Technesium-99m dimercaptosuccinic acid (DMSA) scan data, and to compare it with the formula derived from ultrasonography, which is widely accepted. Methods: Children who underwent a DMSA scan and ultrasonography were reviewed retrospectively, and those who had anatomical urinary tract abnormalities or urinary tract infections were excluded. Results: A total of 230 children (84 males and 146 females; age, 1 month to 16 years; mean age, $16.8{\pm}27.4$ months). Mean renal length measured by DMSA scan was longer than that by ultrasonography ($6.38{\pm}1.16$ vs. $6.02{\pm}1.14cm$; P < 0.001). Renal length was correlated with age, weight, height, and body surface area on the DMSA scan and ultrasonography, and showed the strongest positive correlation with height. The following formulae were established to predict renal length: mean renal length (cm) = 5.433 ${\times}$ height (m) + 2.330 (R2, 0.833) using the DMSA scan data, and mean renal length (cm) = 5.367 ${\times}$ height (m) + 2.027 (R2, 0.853) using ultrasonography data. Conclusion: We propose a simple height-based formula to predict renal length in children using a DMSA scan data, and validate it by comparing with ultrasonography formula.

• Korean Journal of Poultry Science
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• v.27 no.1
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• pp.63-71
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• 2000

The testis is an extremely heterogeneous organ, containing numerous compartments types. Morphometric studies were performed of 3 avian species (pigeon, pheasant and chicken) to determine volume density absolute volume, numerical density, total number of serminiferous tubule components, and sperm production, especially those related to the Sertoli cell, and to make comparisons among the species. Volume density of seminiferous tubule components per testis was determined by point counting method. Testis volume and sperm production were measured by routine techniques. Numerical density (the number of cells per unit volume of testis) of seminiferous tubule components per testis was determined by morphometry (Floderus method). The volume density of seminiferous tubules per testis was 91.58, 92.18 and 94.21% in pigeon, pheasant, and chicken, respectively. The volume density of spermatogonium, spermatocyte, spermatid, spermatozoon, and Sertoli cell did not produce significant changes in the three species. The absolute volume of spermatogonium, spermatocyte, spermatid, and Sertoli cell showed significant changes in the three species (p<0.05). The average volume of Sertoli cell ranged from 758.34(pheasant) to 1,212.9 ㎛$^3$(chicken) and was not significantoy different in the three species(p>0.05). The number of Sertoli cells per testis showed significant differences in the three species : 34.52 $\times$10(sup)6, 186.82$\times$10(sup)6, 810.62$\times$10(sup)6 in pigeon, pheasant, and chicken, respectively(p<0.05). The sperm production was significantly different in the three species : 3,018$\times$10(sup)6, 993.9$\times$10(sup)6, and 8.9$\times$10(sup)6 in chicken, pheasant, and pigeon, respectively(p<0.05). These results suggest that number of Sertoli cells may be more important than Sertoli cell size in explaining the difference in sperm production among the three species.

• Clinical and Experimental Pediatrics
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• v.63 no.7
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• pp.239-250
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• 2020

The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and other infectious diseases. The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ cells are unknown. It has been suggested that in viral pneumonia, virus itself is not a direct cause of acute lung injury; rather, aberrant immune reactions of the host to the insults from viral infection are responsible. According to its epidemiological and clinical characteristics, SARS-CoV-2 may be a virus with low virulence in nature that has adapted to the human species. Current immunological concepts have limited ability to explain such unsolved issues, and a presumed immunopathogenesis of COVID-19 is presented under the protein-homeostasis-system hypothesis. Every disease, including COVID-19, has etiological substances controlled by the host immune system according to size and biochemical properties. Patients with severe pneumonia caused by SARS-CoV-2 show more severe hypercytokinemia with corresponding lymphocytopenia than patients with mild pneumonia; thus, early immunomodulator treatment, including corticosteroids, has been considered. However, current guidelines recommend their use only for patients with advanced pneumonia or acute respiratory distress syndrome. Since the immunopathogenesis of pneumonia may be the same for all patients regardless of age or severity and the critical immune-mediated lung injury may begin in the early stage of the disease, early immunomodulator treatment, including corticosteroids and intravenous immunoglobulin, can help reduce morbidity and possibly mortality rates of older patients with underlying conditions.

• Radiation Oncology Journal
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• v.12 no.3
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• pp.295-300
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• 1994

It was the purpose of present study to develop a new thermoseed for heating deep-seated tumors and assessment of the effect of magnetic control on thermoseeds. Aqueous suspension of iron micro spheres (Ferropolysaccharide) was injected directly into the VX-2 hepatoma and heated with 1.2 MHz inductive radiofrequency unit. Aqueous thermoseed suspension was delivered to the tumor by simple percutaneous injection. The limitation of the thermoseed heating method is the positional change of thermoseed particles in the tumor after implantation. The thermoseed particles could enter the systemic blood circulation and cause a severe embolization of a critical organ. To minimize this limitation, we have used the magnetic control after loading the thermoseed in the tumor, W hen ferropolysaccharides were exposed to a strong magnetic field, they magnetized and subsequently exerted a magnetic force on each other, forming larger aggregates of particles. The size of aggregated Particles were too big to enter the systemic blood circulation. Thus, unlike other thermoseed method, we hold the thermoseed particles stationary in the tumor. The temperature of the injected site and immediate vicinity elevated by $4-5^{\circ}C$. The temperature of the surrounding normal hepatic tissue elevated by $1-2^{circ}C$ only. The heating effect within the tumor was variable depending on the density of ferromagnetic aqueous suspension. Our results suggest that inductive heating of tumor injected with ferropolysaccharide solution offers the possibility of effective heat delivery to the defined tumor volume, which is difficult to heat with other heating devices.