• 농업과학연구
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• 제44권2호
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• pp.188-195
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• 2017

Biotech crops can only be commercialized after they receive safety approvals, which require thorough risk assessments of their release to the environment. Environmental release experiments are indispensable for environmental risk assessments, and each country has been preparing its own regulations for the safety management of experiments on the environmental release of biotech crops in confined fields. In this study, we compared and analyzed the safety management regulations of the environmental release of biotech crops in Korea, USA, Japan, European Union, and China. Each country had safety management regulations for the environmental release of biotech crops, and these regulations were generally not much different from the Korean regulations. However, there was a difference amongst the USA, Japan, and China in regulations for isolation distances to prevent gene diffusion through pollen-flow during environmental release experiments of biotech crops. In order to establish the isolation distance regulation suitable for the Korean environment, relevant data were collected and presented. For setting the isolation distance for environment release of biotech crops, it is suggested to refer to the isolation distance information provided in the Guidance of Seed Management in Korea. The results of this study are expected to help establish the safety management of biotech crops in Korea.

• Journal of Pharmaceutical Investigation
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• 제31권1호
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• pp.19-25
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• 2001

The purpose of this study was to use a ternary polymeric matrix system for high drug loading of a highly soluble drug for controlled release delivery. The controlled drug delivery of diltiazem HCl (solubility > 50% in water at $25^{\circ}C$) with high loading dose (the final loading dose of drug was 34%) from a ternary polymeric matrix (gelatin, pectin, HPMC) was successfully accomplished. This simple monolithic system with 240 mg drug loading provided near zero-order release over a 24 hour-period by which time the system was completely dissolved. The release kinetics of diltiazem HCl tablet with high loading dose from the designed ternary polymeric system was dependent on the ratios of HPMC : pectin binary mixture. The release rate increased as pectin : HPMC ratio were increased. Swelling behavior of the ternary system and the ionic interaction of formulation components with cationic diltiazem molecule appear to control drug diffusion and the release kinetics. Comparable release profiles between commercial product and the designed system were obtained. The binding study between gelatin with diltiazem HCl showed the presence of two binding sites for drug interaction with subsequent controlled diffusion upon swelling. This designed delivery system is easy to manufacture and drug release behavior is highly reproducible and offers advantages over the existing commercial product.

• Nuclear Engineering and Technology
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• 제56권8호
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• pp.3097-3111
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• 2024

Since the level 2 PSA of OPR-1000 was the requirement for regulatory purposes, Cs-137 release estimation was contained as the Nuclear Safety Act of ROK in which the Cs-137 release frequency exceeding 100 TBq was determined to happen less than 1.0E-6 per year after the Fukushima Daiichi Accident. However, Cs-137 release estimation from the conventional level 2 PSA of OPR-1000 provided uncertainty due to dominant accident sequence consideration. Thus, this study aimed to develop systematic methods through the overall framework to quantify realistic uncertainty concerns of radioactive material release using sensitivity and uncertainty analysis methods and apply them to OPR-1000. This framework helped to quantify confidential value for the Cs-137 release under the BEPU approach using both parametric and non-parametric methods to cover both realistic and conservative points. Uncertainty propagation analysis showed the unexpected uncertainty increase of Cs-137 release exceeding 100 TBq. The non-parametric uncertainty analysis provided higher conservative concerns for safety than the realistic concerns in terms of economics when compared with the parametric uncertainty analysis. Wilks' uncertainty analysis showed the importance to consider conservative Cs-137 release in order to reach the higher safety need. Sensitivity analysis showed reasonable relationships between engineering safety parameters with the Cs-137 release.

• 한국농공학회논문집
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• 제56권3호
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• pp.11-17
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• 2014

We investigated the applicability of steel slag as a capping material in order to minimize phosphorus(P) release into seawater. Steel slag is a byproduct from the iron and steel industries and the use of steel slag has some advantages in respect of both cost and environmental concern. P removal by steel slag were studied in a batch system with respect to changes in contact time and initial concentration. Kinetic adsorption data were described well by pseudo 2nd order model, indicating rate limiting step for P adsorption to steel slag is chemical sorption. Equilibrium adsorption data fitted well to Langmuir isotherm model which describes for single layer adsorption. The maximum P adsorption capacity of steel slag was 7.134 mg-P/L. Increasing the depth of steel slag produced a positive effect on interruption of P release. More than 3 cm of steel slag was effective for blocking P release and 5 cm of steel slag was recommended as the depth for capping of P contaminated marine sediments. Increasing P concentration and flow rate had a negative effect on P removal ratio. It was concluded that the steel slag has a potential capping material for blocking P release from marine sediments.

• 센서학회지
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• 제13권1호
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• pp.47-55
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• 2004

This paper presents drug release properties of active drug delivery system (DDS) using volume change of polypyrrole (PPy). The incorporation of various chemical substances into the PPy and controlling its release with the externally applied voltage to the PPy are possible. In order to confirm possibility for drug delivery system qualitatively, indicator(phenol red) was examined as a dopant of PPy. The applied voltage to the PPy electrode was set to -2 V and this negative voltage makes the anionic indicator released in saline solution. After qualitative analysis, in order to confirm quantitative drug release characteristic of PPy, salicylate which is one of the aspirin substance was used as a dopant of PPy. As a result, the salicylate release characteristics with time was thoroughly investigated while varying the electrode area, polymerization time, the applied voltage for drug release. Based on these quantitative results, a preliminary experiment was carried out to check the feasibility of the PPy applicable to the neuronal system.

• Nuclear Engineering and Technology
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• 제53권3호
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• pp.812-824
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• 2021

In order to reduce risks from the Steam Generator Tube Rupture (SGTR) accident and to meet safety targets, various measures have been analyzed to minimize the amount of fission product (FP) release. In this paper, we propose an introduction of a Containment Filtered Venting System (CFVS) connected to the steam generator secondary side, which can reduce the amount of FP release while minimizing adverse effects identified in the previous studies. In order to compare the effect of new equipment with the existing strategy, accident simulations using MELCOR were performed. As a result of simulations, it is confirmed that CFVS operation lowers FP release into the environment, and the release fractions are lower (minimum 0.6% of the initial inventory for Cs) than that of the strategy which intends to depressurize the primary system directly (minimum 15.2% for Cs). The sensitivity analyses identify that refill of the CFVS vessel is a dominant contributor reducing the amount of FP released. As the new strategy has the possibility of hydrogen combustion and detonation in CFVS, the installation of an igniter inside the CFVS vessel may be considered in reducing such hydrogen risk.

• 한국자동차공학회논문집
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• 제3권1호
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• pp.129-135
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• 1995

This study aims to compare the heat release calculated using the ensemble average of pressure data with the heat release calculated using the least squares method for pressure data. This paper propose a heat release computation method that can analyze the most correct, straight and simple method to analyse combustion phenomenon. In conclusion, we found that the least squares method of third-order was the best computational method for heat release calculation.

• 한국경영과학회지
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• 제28권1호
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• pp.1-10
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• 2003

A recent trend In flexible manufacturing systems (FMS) Is to utilize the Identical versatile machines with fast tool delivery devices. Unlike a conventional FMS where parts are fed to the machines with the required tools, tools are acquired from other machines using a tool delivery system and parts can be finished on the same machine In these FMS. Therefore it Is more important problem 4o plan tool flow using tool delivery system In these FMS rather than part flow In conventional FMS. According to the existing study, In FMS 20∼30 percent of the total management cost Is the cost related with tools and It Is possible to reduce the tool Inventory by 40 percent using efficient tool allocation. In this study, In FMS under dynamic tool allocation strategy, a new method of part release considering tool flow at the stage of part release Is proposed. In order to prove the efficiency of the proposed part release It is compared with other part release through simulation experiments. Performance measures in these experiments are the throughput and the number of tardy parts.

• Journal of Pharmaceutical Investigation
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• 제24권3호spc1호
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• pp.33-39
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• 1994

We have studied the effect of loading amount and particle size on the rate of release of 5-fluorouracil (5-FU) from ethylene-vinyl acetate (EVA) matrix. Release rate increased as the loading amount and particle size increase. We also studied the effect of additives (lactose and algin) on the rate of release of 5-FU. Both algin and lactose promoted the rate of release. The ability to increase the rate is in the order of algin>lactose>5-FU. Scanning electron microscope study clearly shows that large cavities and cracks are created. The results imply that, by the proper combinations of the amount of the additive, $EVA_c$ and drug, the rate of drug release can be modulated over a wide range of values.

• KSBB Journal
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• 제18권2호
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• pp.107-110
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• 2003

스텐트 재질인 stainless steel 표면에 모델 약물인 rose bengal을 포함한 생분해성 고분자 PLGA, PHB, MCL-PHA를 코팅하여 약물방출 특성을 조사하였다. PLGA의 농도가 낮을수록, rose bengal의 농도가 높을수록, dip-coating 시간이 길수록 약물방출이 증가하였으며, PHB > PLGA > MCL-PHA의 순서로 약물이 빨리 방출되었다. 이는 생분해성 고분자의 농도 및 종류, 약물의 농도, dip-coating 시간 등을 변화시켜 약물방출을 조절할 수 있음을 나타낸다.