• Asian Oncology Nursing
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• v.7 no.1
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• pp.68-78
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• 2007

Purpose: The purpose of this study was to examine the effects of cold oral gargling on oral discomfort among Non-Hodgkin's lymphoma patient undergoing chemotherapy. Method: An quasi-experimental, nonequivalent control group design was used. Thirty two patients receiving chemotherapy at G hospital in P city were recruited from August 1, 2002 to October 20, 2002. Sixteen were conveniently allocated into the experimental group and 16 into the control group. Participants in the experimental group used cold oral gargling while their counterparts used room temperature oral gargling. Subjective and objective oral discomforts were measured by the instruments developed by Beck. The SPSS WIN 10.0 program was used to analyze the data with t-test, ${\chi}^2$ -test, and repeated measures ANOVA. Findings: The participants in the experimental group reported less oral discomfort and showed better oral conditions than those in the control group at the post 7th, 14th, and 21st days. Participants in the experimental group reported better oral conditions in taste, tongue, eating, and saliva than those in the control group. Conclusion: The cold oral gargling seemed to be more beneficial than room-temperature oral gargling in reducing oral discomfort for the Non-Hodgkin's lymphoma patients undergoing chemotherapy.

• Journal of Korean society of Dental Hygiene
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• v.15 no.2
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• pp.217-223
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• 2015

Objectives: The purpose of this study is to investigate cognitive function, performance of activities of daily living, and recognition on oral health with the cognitive function testto dementia or dementia-suspected patients in the outpatients. Methods: The subjects were 94 dementia or dementia-suspected patients visiting C University hospital for the dementia test. Study instruments included Korea Mini-Mental State Examination KMMS, The Bayer-Activities of Daily Living Scale; B-ADL, Seoul-Instrumental Activities of Daily Living; S-IADL, Global Deterioration Scale; GDS, Korean Dementia Screening Questionnaire; KDSQ, and underlying diseases. Results: Dementia or dementia-suspected patients were 42 by KMMSE test, 25 patients had impaired functioning of daily living by B-ADL test, 27 patients showed the presence of depression by GDS test, and 45 patients showed impaired functioning of daily living. There was a statistically significant difference in the subjective recognition on oral health conditions. There was a statistically significant difference in the subjective recognition on oral health conditions by ADL. There was a positive correlation between the cognitive function and ADL performance. Higher cognitive function is proportional to ADL performance. Conclusions: The cognitive function was closely associated with ADL and subjective oral health conditions.

• Journal of Korean society of Dental Hygiene
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• v.19 no.6
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• pp.931-939
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• 2019

Objectives: The purpose of this study was to determine the importance of brushing before sleeping by comparing the use of oral care products, frequency of dental clinic visits, and oral conditions between individuals who brush and do not brush their teeth before sleeping using data from the 5th and 6th Korean National Health and Nutrition Survey (KNHANES). Methods: Statistical analysis was performed using SPSS 21.0 on data files obtained according to a complex sampling design, and a significance level of <0.05 was set. General characteristics of the participants and year were analyzed using chi-square analysis. Data on the oral conditions, use of oral care products, and frequency of dental clinic visits were analyzed using logistic regression and linear regression. Results: Individuals who brushed their teeth before sleeping showed greater use of oral care products and more frequent dental clinic visits, oral examinations, preventive treatment, and treatment for simple caries (p<0.05) than individuals who did not. Individuals who did not brush their teeth before sleeping showed higher prevalence of permanent teeth caries and periodontal disease, as well as chewing and speaking problems (p<0.05), than those who bushed before sleeping. Conclusions: Individuals who do not brush before sleeping exhibit poorer oral health and lower use of oral care products and frequency of recent dental treatment than those who brush before sleeping. Therefore, it is necessary to alter the government's active policy and improve education about the importance of brushing before sleeping to improve oral health.

• Journal of Korean society of Dental Hygiene
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• v.21 no.6
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• pp.741-750
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• 2021

Objectives: To provide basic data for oral health policy by identifying the differences in oral health behaviors and conditions among middle-aged people in their 40s and 50s and relating these to their health-related quality of life, and to identify factors affecting health-related quality of life. Methods: In this study, secondary data from the National Health and Nutrition Examination Survey were used. Data were gathered from 8,127 participants, of which 2,353 were middle-aged (40-59 years old). Covariance analysis was performed using a complex sample general linear model to investigate the changes in the subjects' health-related quality of life (EQ-5D) according to their general characteristics, oral health behaviors, and oral health status. Results: Oral health behavior was not significantly related to health-related quality of life. In contrast, a higher oral health status (chewing function) was associated with better health-related quality of life. Conclusions: In conclusion, this study suggested a close relationship between oral health status (chewing function) and health-related quality of life. Therefore, it is necessary to recognize the importance of oral health in improving the health-related quality of life of middle-aged people in their 40s and 50s, as well as in informing oral health policies and preventive measures for individuals and communities.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.39 no.5
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• pp.246-250
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• 2013

Rhinocerebral mucormycosis (RCM) is an opportunistic, potentially life-threatening fungal disease. This infective disease invades not only the facial sinuses, but also the maxilla, zygoma, and rhino-cerebral structures with a massive destruction of the facial skeletons and soft tissue. This disease progresses within various underlying diseases, such as diabetes mellitus, hematologic malignancy, renal failure, and systemic immunodepression. The relationship between mucormycosis and these underlying conditions have been discussed extensively in the literature. The authors studied 6 cases of RCM diagnosed by a tissue biopsy and treated at the department of oral and maxillofacial surgery, from 1997 to 2012. Patients were treated with several kinds of surgical interventions and antifungal agents, and their clinical & radiological signs, underlying conditions, surgical methods, and outcomes were analyzed.

• Journal of Korean society of Dental Hygiene
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• v.21 no.1
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• pp.27-40
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• 2021

Objectives: This study investigated the working conditions of dental hygienists and their challenges in providing oral care to older adults with dementia using focus group interviews. Methods: We collected data for approximately a month beginning from August 2020 and divided the study subjects into two groups: the health dental hygienist and the clinical dental hygienist groups. A total of 11 subjects participated in this study. Results: The oral health management of older adult patients with dementia has not been efficiently carried out in local communities or dental medical institutions. In addition, dental hygienists encounter difficulties in managing the oral health of these patients and hope to actively learn more about their special cases. Conclusions: Based on the results of this study, it is necessary to develop a manual or program for the professional implementation of oral health interventions for older adults with dementia.

• Journal of dental hygiene science
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• v.17 no.5
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• pp.423-432
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• 2017

This study aimed to investigate the effect of repeated oral health education on the oral health of preschool children. This study classified the control group of children of 5~6 years of age where the oral health education was conducted one time, and the experiment group where the oral health education was conducted 4 times. The oral health conditions of each group and their risk of developing dental caries were also assessed. No significant difference was observed in the participants in terms of general characteristics, oral health conditions, risk of developing dental caries, and oral health behavior after oral health education. The two groups did not show a significant difference (p<0.001) in dental plaque index before and after oral health education, and showed a significant difference (p<0.001) according to the number of education sessions. Before oral health education, the participants in both groups were brushing their teeth incorrectly. However, after the third session, 56.7% of the participants in the experimental group and 9.4% in the control group used the correct method of tooth brushing. A significant difference was observed between the two groups (p<0.05). In addition, when the tooth-brushing time was compared, the two groups showed a significant difference (p<0.001), and a significant difference was observed in terms of the number of education sessions (p<0.05). In summary, repeated oral health education had significant influences on the dental plaque index, tooth-brushing method, brushing occlusal surfaces, and tooth-brushing time. Therefore, when oral health education is carried out, repeated oral health education in children is more effective than one-time oral health education as reflected in the changes in dental plaque index and oral health behavior. Moreover, oral health education is considered effective in changing the oral health behavior of children when conducted at least 3 times.

• Biomolecules & Therapeutics
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• v.26 no.1
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• pp.29-38
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• 2018

During cancer progression, cancer cells are repeatedly exposed to metabolic stress conditions in a resource-limited environment which they must escape. Increasing evidence indicates the importance of nicotinamide adenine dinucleotide phosphate (NADPH) homeostasis in the survival of cancer cells under metabolic stress conditions, such as metabolic resource limitation and therapeutic intervention. NADPH is essential for scavenging of reactive oxygen species (ROS) mainly derived from oxidative phosphorylation required for ATP generation. Thus, metabolic reprogramming of NADPH homeostasis is an important step in cancer progression as well as in combinational therapeutic approaches. In mammalian, the pentose phosphate pathway (PPP) and one-carbon metabolism are major sources of NADPH production. In this review, we focus on the importance of glucose flux control towards PPP regulated by oncogenic pathways and the potential therein for metabolic targeting as a cancer therapy. We also summarize the role of Snail (Snai1), an important regulator of the epithelial mesenchymal transition (EMT), in controlling glucose flux towards PPP and thus potentiating cancer cell survival under oxidative and metabolic stress.

• Journal of Oral Medicine and Pain
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• v.46 no.1
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• pp.14-19
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• 2021

Various conditions such as pain or effusion of temporomandibular joint, degenerative condylar resorption, and articular disc displacement can be a cause of malocclusion. However, the reasons of occlusal changes are ambiguous in some patients. Unexpected occlusal change in patients with or without temporomandibular disorder (TMD) symptom was mostly caused by masticatory muscular disorders. This article reports two cases of recovery of occlusal relationship in TMDs patients after stabilization splint therapy. Stabilization splint therapy could be useful in certain conditions of occlusal changes in TMD.

• Journal of Microbiology and Biotechnology
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• v.32 no.10
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• pp.1234-1244
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• 2022

Oral streptococci are considered as an opportunistic pathogen associated with initiation and progression of various oral diseases. However, since the currently-available treatments often accompany adverse effects, alternative strategy is demanded to control streptococci. In the current study, we investigated whether short-chain fatty acids (SCFAs), including sodium acetate (NaA), sodium propionate (NaP), and sodium butyrate (NaB), can inhibit the growth of oral streptococci. Among the tested SCFAs, NaP most potently inhibited the growth of laboratory and clinically isolated strains of Streptococcus gordonii under anaerobic culture conditions. However, the growth inhibitory effect of NaP on six different species of other oral streptococci was different depending on their culture conditions. Metabolic changes such as alteration of methionine biosynthesis can affect bacterial growth. Indeed, NaP enhanced intracellular methionine levels of oral streptococci as well as the mRNA expression level of methionine biosynthesis-related genes. Collectively, these results suggest that NaP has an inhibitory effect on the growth of oral streptococci, which might be due to alteration of methionine biosynthesis. Thus, NaP can be used an effective bacteriostatic agent for the prevention of oral infectious diseases caused by oral streptococci.