• 제목/요약/키워드: Oral Output

검색결과 63건 처리시간 0.028초

Sex determination from lateral cephalometric radiographs using an automated deep learning convolutional neural network

  • Khazaei, Maryam;Mollabashi, Vahid;Khotanlou, Hassan;Farhadian, Maryam
    • Imaging Science in Dentistry
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    • 제52권3호
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    • pp.239-244
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    • 2022
  • Purpose: Despite the proliferation of numerous morphometric and anthropometric methods for sex identification based on linear, angular, and regional measurements of various parts of the body, these methods are subject to error due to the observer's knowledge and expertise. This study aimed to explore the possibility of automated sex determination using convolutional neural networks(CNNs) based on lateral cephalometric radiographs. Materials and Methods: Lateral cephalometric radiographs of 1,476 Iranian subjects (794 women and 682 men) from 18 to 49 years of age were included. Lateral cephalometric radiographs were considered as a network input and output layer including 2 classes(male and female). Eighty percent of the data was used as a training set and the rest as a test set. Hyperparameter tuning of each network was done after preprocessing and data augmentation steps. The predictive performance of different architectures (DenseNet, ResNet, and VGG) was evaluated based on their accuracy in test sets. Results: The CNN based on the DenseNet121 architecture, with an overall accuracy of 90%, had the best predictive power in sex determination. The prediction accuracy of this model was almost equal for men and women. Furthermore, with all architectures, the use of transfer learning improved predictive performance. Conclusion: The results confirmed that a CNN could predict a person's sex with high accuracy. This prediction was independent of human bias because feature extraction was done automatically. However, for more accurate sex determination on a wider scale, further studies with larger sample sizes are desirable.

한방근무 간호사의 업무분석 (An Analysis on Nursing Activity in Oriental Hospital)

  • 강현숙;조결자;김광주;김귀분;조미영;서연옥;신혜숙;전은영;정숙자;이혜진
    • 대한간호
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    • 제33권5호
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    • pp.63-75
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    • 1995
  • The need of oriental nursing role is recently increasing. The implication of this trend is enormous not only for the need of independent of independent oriental nursing intervention. Hence, this study was designed to describe the characteristics of oriental nursing activity and identify the meaning of nursing activity in oriental hospital. A total of 24 nurses were selected by convenience sampling from eight units at one oriental hospital. A total of 168 data were collected using minute-by-minute recording during nurse s work shift. The data were analyzed using nova and scheffe method as post-hoc test The results of this study are as follows; 1. the category of nursing activity in oriental hospital 74.4% of nursing activity was the patient-oriented nursing care. The nursing activity included others (18.28%), the function-oriented nursing care (7.07%), and staff-oriented care (0.2%). 29.1 % of the patient-oriented nursing care was the direct care, and 24. 5 % of the patient-oriented nursing care was the indirect care. There was a lack of patient education and the communication patient. 2. Nursing activity in oriental hospital by characteristics 1) Nursing activity by unit For patient-oriented nursing care, there was a statistically significant difference among 8 units. In the critical care unit, the patient-oriented nursing care was mostly performed. For function-oriented nursing care, there was statistically significant difference among 8 units. In the physical therapy unit, the function-oriented nursing care was mostly performed. 2) Nursing activity in oriental hospital For all kinds of nursing activity, there was a statistically significant difference between shifts. In night shift patient-oriented nursing care, function-oriented nursing care, and other kinds of nursing care was mostly performed. Patient-oriented nursing care included indirect care, treatment set management, and the breaktime. In day shift, staff-oriented nursing care was performed. 3) Nursing activity in oriental hospital For all kinds of nursing activity, there was not a statistically significant difference by day. The day has not impact on nursing activity. 3. the meaning of activity in oriental hospital The results of this study show that the patient-oriented care was vital check, input! output check, medication, bedsore prevention, nasogastric feeding, oral care, catheterization care, perinatal care, nursing care associated with acupuncture and moxacautery, observation (fever, sweating), heat and cold application communication with patent and family, and patient room management In conclusion, two issues associated with the findings of the research appeated to be involved in the difficulty of nursing activity in hospital. The first issue was the nursing care in oriental hospital provided by nurses who have a limited understading of the principles of oriental medicine. The second issue was the deficiency of systematic guideling for oriental nursing activity. The findings suggest the need to develop the systematic guideline for oriental nursing activity. The need of continuing education for nurses who work in the oriental hospital, and the need of nursing education including oriental nursing are critical.

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급성 파라콰드중독후 생존한 15예 환자의 임상적 고찰 (Clinical study of the 15patients survived after acute paraquat intoxication)

  • 김동웅
    • 대한예방한의학회지
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    • 제3권1호
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    • pp.36-36
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    • 1999
  • From January 1994 to April 1997, there was 15 survivals who was admitted to the department of internal medicine, Wonkwang Oriental Medicine' Hospital in Cheun-ju, after ingestion of paraquat, and treated with Oriental and western medicine therapy. For the patients, I investigated clinical symptoms, gastroduodenoscopy, intake by oral and parenteral route, and output by urine and stool, serum ALP, AST. ALT, Bilirubin, BUN, Creatinine level and urine analysis. On admission day, the LFT level was as follows. The serum mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin was 10.05${\pm}$2.75 KAU, 66.67${\pm}$9.88 IU/L, 43.80${\pm}$7.74 IU/L, 1.89${\pm}$1.22 ㎎/dl and 1.10${\pm}$1.14 ㎎/dl respectively. After that day, administered Gamdutang and checked the mean LFT level regullary. Until the 3rd day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was 11.0l${\pm}$3.16 KAU, 56.47${\pm}$7.19 IU/L, 59.00${\pm}$7.57 IU/L, 2.54${\pm}$1.78 ㎎/dl, 1.64${\pm}$1.59 ㎎/dl respectively. From 4th day to 7th day, the mean ALP; AST, ALT, Total Bilirubin and Direct Bilirubin level was 12.51${\pm}$3.49 KAU, 77.85${\pm}$7.17 IU/L, 58.00${\pm}$9.09 IU/L, 2.54${\pm}$1.97 ㎎/dl, and 1.80${\pm}$1.81 ㎎/dl respectively. From 8th day to 10th day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was 12.43${\pm}$3.14 KAU, 41.13${\pm}$6.49 IU/L, 50.40${\pm}$7.17 IU/L, 1.66${\pm}$1.90 ㎎/dl and 1.14${\pm}$1.50 ㎎/dl respectively. From 11th day to 14th day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was 12.30${\pm}$3.25 KAU, 31.07${\pm}$3.85 IU/L, 43.33${\pm}$5.49 IU/L, 1.62${\pm}$1.95 ㎎/dl, 1.17${\pm}$1.71 ㎎/dl respectvely. On admission day, the mean RFT level as follows. Serum BUN and Creatinine level was 28.73${\pm}$5.19 ㎎/dl and 1.82${\pm}$1.27 ㎎/dl respectively. After that day, administered Gamdutang and checked the mean RFT level regullary. Until the 3rd day, the mean BUN and Creatinine level was 32.12${\pm}$5.65 ㎎/dl and 2.31${\pm}$0.45 ㎎/dl respectively. From 4th day to 7th day, the mean BUN and Creatinine level was 31.07${\pm}$5.47 ㎎/dl and 1.92${\pm}$0.79 ㎎/dl respectively. From 7th day to 10th day, the mean BUN and Creatinine level was 17.47${\pm}$3.57 ㎎/dl and 1.33${\pm}$0.59 ㎎/dl respectively. From 11th day to 14th day, the mean BUN and Creatinine level was 11,93${\pm}$3.16 ㎎/dl, 1.27${\pm}$0.38 ㎎/dl respectively.

광원의 종류에 따른 복합레진의 중합거동 및 중합률에 관한 연구 (THE POLYMERIZATION RATE AND THE DEGREE OF CONVERSION OF COMPOSITE RESINS BY DIFFERENT LIGHT SOURCES)

  • 류주희;이인복;유현미;김미자;석창인;권혁춘
    • Restorative Dentistry and Endodontics
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    • 제29권4호
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    • pp.386-398
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    • 2004
  • Objectives: The purpose of this study was to observe the reaction kinetics and the degree of polymerization of composite resins when cured by different light sources and to evaluate the effectiveness of the blue Light Emitting Diode Light Curing Units (LED LCUs) compared with conventional halogen LCUs. Materials and Methods: First, thermal analysis was performed by a differential scanning calorimeter (DSC). The LED LCU (Elipar Freelight, $320{\;}mW/\textrm{cm}^2$) and the conventional halogen LCU (XL3000, $400{\;}mV/\textrm{cm}^2$) were used in this study for curing three composite resins (SureFil, Z-250 and AEliteFLO). Second. the degree of conversion was obtained in the composite resins cured according to the above curing mode with a FTIR. Third, the measurements of depth of cure were carried out in accordance with ISO 4049 standards. Statistical analysis was performed by two-way ANOVA test at 95% levels of confidence and Duncan's procedure for multiple comparisons. Results: The heat of cure was not statistically different among the LCUs (p > 0.05). The composites cured by the LED (Exp) LCUs were statistically more slowly polymerized than by the halogen LCU and the LED (Std) LCU (p < 0.05). The composite resin groups cured by the LED (Exp) LCUs had significantly greater degree of conversion value than by the halogen LCU and the LED (Std) LCU (p =0.0002). The composite resin groups cured by the LED (Std) LCUs showed significantly greater depth of cure value than by the halogen LCU and the LED (Exp) LCU (p < 0.05).

치커리 화이바 발효물의 장 기능 및 변비개선 효과 (Effects of Fermented Chicory Fiber on the Improvement of Intestinal Function and Constipation)

  • 신선;박성선;이환명;허정무
    • 한국식품영양과학회지
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    • 제43권1호
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    • pp.55-59
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    • 2014
  • 치커리 화이바는 콜레스테롤 개선, 배변활동 원활, 식후혈당 상승억제의 기능성을 바탕으로 건강기능식품 기능성 원료로 사용되고 있다. 배변활동에 도움을 주는 치커리 화이바를 발효하여 변비개선 효능을 확인한 결과 실험기간 동안 식이 섭취량이 증가한 반면 체중이 유의적으로 감소하는 것으로 보아 비만예방에 효과가 있을 것으로 생각된다. 장 기능 개선효과를 확인하기 위해 소화관 이동률을 측정한 결과 대조군에 비해 양성 대조군 FWP(차전자피복합물), 실험군 CF(치커리 화이바), 실험군 FCF(치커리 화이바 발효물)에서 소화관 이동률이 증가하였고, 특히 실험군 FCF 1.62 mg/g (P<0.01)과 실험군 4.13 mg/g(P<0.05)의 경우 실험군 CF 동일 농도에 비해 소화관 이동률이 유의적으로 증가하였다. 또한 변비개선 효과를 확인하기 위해 대장 내 잔류하고 있는 변의 개수를 확인한 결과 변비를 유발시킨 loperamide 처리군은 대조군에 비해 대장 내에 변이 잔류하면서 배변활동이 제대로 이루어지지 않아 대장 내 변의 개수가 유의적으로 증가한 반면, 양성 대조군 FWP와 실험군 CF, 실험군 FCF에서 대장 내 변의 개수를 유의적으로 감소시켰고 특히 실험군 FCF 2.06 mg/g의 경우 실험군 CF 동일 농도에 비해 대장 내 변의 개수를 유의적으로 감소시켰다(P<0.01). 본 연구결과를 통해 치커리 화이바를 발효함으로써 배변활동 및 변비개선능이 비발효 치커리 화이바에 비하여 더욱 증진되는 것을 확인할 수 있었다. 따라서 발효된 치커리 화이바가 배변 및 변비 기능성을 증진시키는 소재로 활용될 수 있을 것으로 사료된다.

햅틱 피드백 장치를 이용한 치과 수술 시뮬레이션 (Dental Surgery Simulation Using Haptic Feedback Device)

  • 윤상연;성수경;신병석
    • 정보처리학회논문지:소프트웨어 및 데이터공학
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    • 제12권6호
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    • pp.275-284
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    • 2023
  • 가상 현실 시뮬레이션은 다양한 분야에서의 교육과 훈련에 활용이 되며, 특히 최근에는 의료 분야에서 많이 사용되고 있다. 교육/훈련용 시뮬레이터는 의사가 실제 수술 도구를 이용하여 실제 환자에 대해 처치를 하는 것과 같은 느낌이 나게 하는 촉감/역감 생성 및 영상/음향 출력 하드웨어와 여기에 실감 나는 영상과 촉감을 생성해주는 소프트웨어로 이루어진다. 기존의 시뮬레이터들은 수술 시에 사용되는 다양한 수술 도구들을 모사하기 위해 다양한 형태의 하드웨어들을 사용해야 하므로 복잡하고 비용이 많이 소요되는 문제가 있다. 이 논문에서는 포스 피드백 장치와 변형 가능한 햅틱 컨트롤러를 이용한 치과 수술 시뮬레이션 시스템을 제안한다. 햅틱 하드웨어들은 수술 도구와 수술 부위의 충돌 여부를 파악하고 그에 따른 저항감과 진동감을 제공한다. 특히 길이 변화, 굽힘과 같은 변형이 가능한 햅틱 컨트롤러는 여러 수술 도구들의 형태에 따라 느껴지는 다양한 감각을 표현할 수 있다. 사용자가 햅틱 피드백 장치를 조작하면 햅틱 피드백 장치의 움직임이나 버튼 클릭 등의 이벤트가 시뮬레이션 시스템에 전달되어 치과용 수술 도구와 구강 내부 모델들 사이의 상호작용이 발생하고 이에 따른 햅틱 피드백이 햅틱 피드백 장치로 전달된다. 이러한 기반 기술들을 활용하여 정교한 3차원 모델로 표현된 가상 환경에서 대표적인 치과 수술기법인 매복 사랑니 발치 수술의 현실적인 훈련 경험을 제공한다.

($CO_2$)레이저를 이용한 백서의 치은절제술시 출력에 따른 초기 치유과정의 비교 (A Comparative Study of Initial Healing Process in White Rats after Gingivectomy using $CO_2$ Laser of different watts)

  • 조규성;홍성재;최성호;채중규;김종관
    • Journal of Periodontal and Implant Science
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    • 제27권3호
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    • pp.603-619
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    • 1997
  • 레이저를 이용한 연조직 수술은 출혈이 없어 시야를 좋게 하고 시술시간이 단축되며, 술후 종창이 최소화 되고, 통증이 감소화 최소화된 반흔 형성, 그리고 레이저가 조사되는 일부 부위의 멸균효과등이 장점이 있어 최근에 의학분야 및 치의학분야에서 많이 사용되는 추세에 있다. 이에 본 연구에서는 $CO_2$레이저를 이용한 백서의 치은절제술시의 치유과정과 레이저 출력을 달리 하였을때의 치유과정을 관찰하기 위해, 백서의 상악전치의 치은조직에서 치은절제술 효과를 얻을 수 있는 최소 출력인 4watts를 이용한 부위를 대조군으로, 6watts를 이용한 부위를 실험군으로 하여, 술후 2일, 3일, 1주, 3주후에 각각 실험동물을 희생시켜 치유결과를 조직학적으로 비교 관찰하여 다음과 같은 결과를 얻었다. 대조군과 실험군 모두에서 2일째에서만 작은 크기의 혈병이 관찰되었고, 그 이후에서는 관찰되지 않았다. 2. 염증세포 침윤지역 크기는 대조군과 실험군 모두에게 2일째 가장 컸으며, 그 크기는 시간이 경과될수록 줄어들어 2주째는 거의 소실되었으며, 실험군의 경우 대조군에 비해 2,3째까지 크기가 더 컸으나, 1주째부터는 크기의 차이가 관찰되지 않았다. 3. 육아조직은 대조군, 실험군 모두 시간의 경과에 따라 점점 성숙되어, 2주째부터는 거의 정상 치은 결합조직으로 대체되는 소견을 보였고, 3주째에서는 완전한 치유양상을 보였다. 실험군의 경우 대조군보다 3일째까지는 그 크기가 더 컸으나 1주째부터는 크기의 차이가 없다. 4. 대조군과 실험군 모두에게 치은의 상피화하는 2일째에서 시작되는 소견을 보였고, 1주부터 상피돌기와 부분적인 접합상피의 재생이 관찰되었으며, 2주째부터는 구강열구상피의 각화가 시작되어 3주째에는 각화의 완성이 관찰되었다.

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급성 파라콰드중독후 생존한 15예환자의 임상적 고찰 (Clinical study of the 15 patients survived after acute paraquat intoxication)

  • 김동웅
    • 대한예방한의학회지
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    • 제3권1호
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    • pp.55-65
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    • 1999
  • From January 1994 to April 1997, there was 15 survivals who was admitted to the department of internal medicine, Wonkwang Oriental Medicine Hospital in Cheun-ju, after ingestion of paraquat, and treated with Oriental and western medicine therapy. For the patients, I investigated clinical symptoms, gastroduodenoscopy, intake by oral and parenteral route, and output by urine and stool, serum ALP, AST. ALT, Bilirubin, BUN, Creatinine level and urine analysis. On admission day, the LFT level was as follows. The serum mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin was $10.05{\pm}2.75\;KAU$, $66.67{\pm}9.88\;IU/L$, $43.80{\pm}7.74\;IU/L$, $1.89{\pm}1.22\;mg/dl$ and $1.10{\pm}1.14\;mg/dl$ respectively. After that day, administered Gamdutang and checked the mean LFT level regullary. Until the 3rd day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was $11.01{\pm}3.16\;KAU$, $56.47{\pm}7.19\;IU/L$, $59.00{\pm}7.57\;IU/L$, $2.54{\pm}1.78\;mg/dl$, $1.64{\pm}1.59\;mg/dl$ respectively. From 4th day to 7th day, the mean ALP; AST, ALT, Total Bilirubin and Direct Bilirubin level was $12.51{\pm}3.49\;KAU$, $77.85{\pm}7.17\;IU/L$, $58.00{\pm}9.09\;IU/L$, $2.54{\pm}1.97\;mg/dl$, and $1.80{\pm}1.81\;mg/dl$ respectively. From 8th day to 10th day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was $12.43{\pm}3.14\;KAU$, $41.13{\pm}6.49\;IU/L$, $50.40{\pm}7.17\;IU/L$, $1.66{\pm}1.90\;mg/dl$ and $1.14{\pm}1.50\;mg/dl$ respectively. From 11th day to 14th day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was $12.30{\pm}3.25\;KAU$, $31.07{\pm}3.85\;IU/L$, $43.33{\pm}5.49\;IU/L$, $1.62{\pm}1.95\;mg/dl$, $1.17{\pm}1.71\;mg/dl$ respectvely. On admission day, the mean RFT level as follows. Serum BUN and Creatinine level was $28.73{\pm}5.19\;mg/dl$ and $1.82{\pm}1.27\;mg/dl$ respectively. After that day, administered Gamdutang and checked the mean RFT level regullary. Until the 3rd day, the mean BUN and Creatinine level was $32.12{\pm}5.65\;mg/dl$ and $2.31{\pm}0.45\;mg/dl$ respectively. From 4th day to 7th day, the mean BUN and Creatinine level was $31.07{\pm}5.47\;mg/dl$ and $1.92{\pm}0.79\;mg/dl$ respectively. From 7th day to 10th day, the mean BUN and Creatinine level was $17.47{\pm}3.57\;mg/dl$ and $1.33{\pm}0.59\;mg/dl$ respectively. From 11th day to 14th day, the mean BUN and Creatinine level was $11.93{\pm}3.16\;mg/dl$, $1.27{\pm}0.38\;mg/dl$ respectively.

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Alloxan 투여 가토(家兎)에 대한 골절치유 실험 (Studies on the Fracture Healing in the Alloxan treated Rabbits)

  • 김성준
    • 대한약리학회지
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    • 제7권1호
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    • pp.53-65
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    • 1971
  • It is well known that diabetes mellitus is associated with metabolic derangements, such as hyper-glycemia, ketosis, glycosuria, and also widespread alterations in the blood vessels, kidneys, eyes, peripheral nerves and heart. It is also recognized that healing of skin wound is delayed in diabetics. In bone, according to Aegerter, osteopenia develops in diabetes mellitus and it is chiefly ascribed to overutilization of protein. Shim claims that total blood flow to the entire skeletal system is approximately 4 to 8 percent of resting cardiac output and blood supply to the skeletal system would be decreased on account of secondary arteriosclerotic changes in the diabetics. An adequate blood supply is an essential factor in the healing process of fracture, and disturbed blood flow, either local or systemic, will invariably delay union of the fragments or the fragments from being fused. As the author has encountered several cases of diabetics in whom healing of fracture was delayed or incomplete, this experimental study was undertaken to elucidate the effects of hyperglycemia and diabetes mellitus on the healing process of fracture. In this experiment adult albino rabbits, weighing about 2 kg. were used and divided into 6 groups. The femur of each animal was fractured surgically, and then the healing process of fracture was periodically checked by radiography at an interval of one week for a period of 6 weeks. Thereafter, all the rabbits were killed to obtain tissue preparation of the femur. The experimental groups were as follows; 1) Control group: Six rabbits sustained a surgical fracture to the femur, without being given any other treatment or drug. 2) Alloxan-treated group: For inducing diabetes, alloxan was given intravenously to 17 rabbits in various dose as follows; to 7 of them 40 mg/kg, to 6 rabbits 80 mg/kg and to 4 rabbits 120 mg/kg of body weight, respectively. 3) Insulin-treated group: Protamine-zinc insulin was injected subcutaneously to each of 6 rabbits in a daily dose of 1 unit per kilogram of body weight. 4) Group treated with insulin after alloxan: Four rabbits were given 80 mg of alloxan once and than 1 unit of insulin per kilogram of body weight daily. Another 5 rabbits were injected 1 unit of insulin per kg of body weight daily following administration of alloxan in a dose of 120 mg/kg. 5) Homotransplantation group: Following intravenous injection of alloxan in a dose of 120 mg/kg, 10 rabbits underwent homotransplantation of a short bone segment to the femur. Five of them were subsequently given 1 unit/kg of insulin daily. 6) Sugar-treated group: six rabbits were fed $15{\sim}20$ gm of sugar daily throughout the period of experiment. The results obtained are summarized as follows; 1. Blood sugar level and damage to the pancreatic islet increased proportionately when alloxan was given to the rabbits in various doses. No appreciable change could be observed in the islets when the blood sugar level was altered by either oral administration of sugar or subcutaneous injection of insulin. 2. Comparing with the control group, healing of fracture was delayed in the alloxan-treated group, while callus formation and periosteal reaction were shown to be more prominent in this group and subsequently, the ultimate osseous tissue formed at the fracture site was significantly smaller in amount and less compact. These findings were more marked as the amount of alloxan increased. 3. Administration of insulin prevented the delay in healing process of fracture in the rabbits with alloxan-induced hyperglycemia. In this case, the course and progression of fracture healing were almost similar to those of control group. 4. Union between the host bone and the fragment transplanted from other rabbit of the same species was more delayed in the group treated with alloxan alone than in the group to which insulin was administered after development of alloxan-induced diabetes. In both groups periosteal new bone developed from the ends of the host bone, above and below the transplanted fragment, and directly fused with failure of periosteal callus to bridge the adjacent ends of the host bone and the transplanted fragment. 5. The healing process of fracture was not inhibited by alteration in blood sugar level when the blood sugar was abnormally increased by excessive sugar intake or lowered by administration of insulin alone. The healing of fracture in these groups progressed similarly as in the control group. In brief summary, it appears that the healing process of fracture would be definitely disturbed in diabetic state brought about by damage to the pancreatic islet. As such an inhibition could be overcome with insulin, it seems that insulin plays an important role in healing of fracture, but alteration in blood sugar level alone does not modify healing process of fracture to significant degree.

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로타바이러스 감염성 설사에 대한 항-로타바이러스 난황항체의 치료 효과 (Therapeutic Effect of Anti-Rotavirus Chicken Egg Yolk Immunoglobulin(IgY) on Diarrhea by Infection of Rotavirus)

  • 임인석;이호석;김원용;최응상;정동혁;정후길;윤승섭;전호남
    • Clinical and Experimental Pediatrics
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    • 제48권12호
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    • pp.1354-1361
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    • 2005
  • 목 적 : 로타바이러스는 세계적으로 5세 이하 영유아 설사증의 1/3 이상을 차지하는 주요 원인체이다. 이 로타바이러스에 의한 급성위장관염의 치료는 탈수교정을 위한 경구 및 비경구 수액요법 외엔 특이한 치료법이 없는 상태로서 로타바이러스 감염에 대한 새로운 치료법이 필요한 상태이다. 이에 본 연구에서는 로타바이러스에 대한 난황 항체를 투여하여 환아에서의 로타바이러스 억제 효과 및 임상증상의 치료효과를 조사하였다. 방 법 : 본 연구는 두 부분으로 나누어 첫째 로타바이러스 위장관염 환아의 분변에서 바이러스 입자 감소 정도를 보았으며 둘째 환아에게 난황황체를 환아에게 직접 투여하여 임상증상이 개선되는 지를 보았다. 첫째로, 2001년 12월부터 2002년 9월까지 중앙대학교 용산병원 소아과에 급성 장관염을 주요 증상으로 내원한 환아의 분변을 대상으로 역수동 적혈구 응집반응으로 로타바이러스 항원의 존재 유무를 조사하였고 이중 양성인 13명의 환아의 3일간에 각각 걸친 분변시료를 재료로 정량 PCR을 시행하여 바이러스 양의 감소를 측정하였다. 13명 중 7명에게는 난황항체가 투여되었고 6명에게는 위약이 투여되었다. 둘째로는 같은 기간 로타바이러스 감염으로 진단된 36명을 대상으로 하여 18명에는 항-로타바이러스 난황항체가 함유된 난황 2.5 g을 5 mL의 물에 부유하여 하루 2회(아침, 저녁) 3일 동안 투여하였고 위약군 18명에게는 난황항체가 함유되지 않은 난황을 같은 기간 동안 같은 양을 투여한 이후 양군에서 치료 전후의 발열기간, 설사 횟수, 구토 횟수, 전해질 및 혈청 생화학치, 입원기간, 경구 섭취량, 소변 횟수를 비교 관찰하였다. 결 과 : 첫 번째 실험에서, 정량 PCR을 이용하여 환아 분변에서 바이러스 입자의 감소를 측정한 결과 위약군에서는 지속적으로 증가를 보였으나 투여군에서는 지속적인 바이러스 입자의 감소를 보였다. 두 번째 실험에서는 환아의 임상증상 치료효과 면에서 투여군에서 위약군에 비해 3일째에 설사 증상의 개선을 보였다. 결 론 : 항로타바이러스 난황항체의 로타바이러스 감염에 대한 치료효과를 본 결과 환아의 분변에서 바이러스 입자량의 감소와 함께 설사 증상의 개선의 치료 효과를 보이기 때문에 항로타바이러스 난황항체는 로타바이러스 감염증의 치료제가 될 수 있을 것으로 생각된다.