• Journal of Korean Society of Rural Planning
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• v.15 no.2
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• pp.9-17
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• 2009

The purpose of this study is to discuss issues on how locality can be revealed through landscape planning and design especially in the local environment. Over the past decade, there has been substantial increase in architects and landscape architects working internationally. There are many that believe this may lead to a unifying global brand of design that overlooks the identity and specificity of place. This lead us to think opportunities and challenges for designers working internationally to understand and create a unique sense of place. Relations between contemporary design trend and local identity will be studied through case studies. Design strategies and languages on revealing locality will be also discussed with the Suncheon Education Culture Center project.

• International Journal of Computer Science & Network Security
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• v.22 no.9
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• pp.358-368
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• 2022

Social media is a window for everyone, individuals, communities, and companies to spread ideas and promote trends and products. With these opportunities, challenges and problems related to security, privacy and rights arose. Also, the data accumulated from social media has become a fertile source for many analytics, inference, and experimentation with new technologies in the field of data science. In this chapter, emphasis will be given to methods of trend analysis, especially ensemble learning methods. Ensemble learning methods embrace the concept of cooperation between different learning methods rather than competition between them. Therefore, in this chapter, we will discuss the most important trends in ensemble learning and their applications in analysing social media data and anticipating the most important future trends.

• International Journal of High-Rise Buildings
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• v.12 no.2
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• pp.137-143
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• 2023

The use of Engineered Wood Systems (EWS), especially mass-timber, as a structural alternative or complement to steel and concrete is gaining interest and acceptance across different sectors of architecture, engineering, and construction, including in high-rise buildings. Focussing on the Australian context, this study examines the levels of adoption and barriers to using timber as a primary structural material in multi-storey buildings. Data collected from semi-structured interviews with stakeholders at the forefront of adoption in structural design, construction, and property development indicates that timber in multi-storey projects in Australia still faces industry-wide challenges. Designers' awareness and attitudes towards timber adoption are generally positive and suitable for flagship projects, including tall buildings, but for enduring and widespread impact, long-term investment in education within and outside the range of stakeholders already committed to promoting timber adoption is needed.

• Biomolecules & Therapeutics
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• v.32 no.1
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• pp.13-24
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• 2024

Cytokines influence the overall cancer immune cycle by triggering tumor antigen expression, antigen presenting, immune cell priming and activation, effector immune cell recruitment and infiltration to cancer, and cancer killing in the tumor microenvironment (TME). Therefore, cytokines have been considered potential anti-cancer immunotherapy, and cytokine-based anti-cancer therapies continue to be an active area of research and development in the field of cancer immunotherapy, with ongoing clinical trials exploring new strategies to improve efficacy and safety. In this review, we examine past and present clinical developments for major anticancer cytokines, including interleukins (IL-2, IL-15, IL-12, IL-21), interferons, TGF-beta, and GM-CSF. We identify the current status and changes in the technology platform being applied to cytokine-based immune anti-cancer therapeutics. Through this, we discuss the opportunities and challenges of cytokine-based immune anti-cancer treatments in the current immunotherapy market and suggest development directions to enhance the clinical use of cytokines as immuno-anticancer drugs in the future.

• 대한예방의학회:학술대회논문집
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• 2005.10a
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• pp.31-44
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• 2005

In summary, air pollution issues in the United States are addressed by a core group of regulations supplemented by active Interventions as needed by public health agencies. The strategies employed by public health officials must be flexible and innovative to address the needs of the citizens, As you can see from the examples cited above, the collaboration of public health agencies can be critical in protecting communities from adverse exposures. In the US state and local governments have the primary responsibility for health and safety issues, including those associated with air pollution. The federal agencies have responsibilities when activities between states are involved and or the issues are of national significance. Significant challenges and opportunities remain to identify the relationship to air pollution and other environmental factors and the incidence of disease, and hence develop and implement Intervention strategies.

• International Journal of High-Rise Buildings
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• v.1 no.1
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• pp.61-72
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• 2012

When Cole Porter wrote the song "Anything Goes" in 1934, he did not include skyscraper examples. The recently completed Chrysler and Empire State buildings followed decades of tall building development in a logical and predictable line. Today, dramatic improvements in materials and methods of analysis, design and fabrication have given architects and engineers freedom to imagine, and contractors to build, towers in configurations never seen before. If writing now, Porter would surely have mentioned such designs to demonstrate anything goes. Or does it? This article explores the possibilities and challenges of tall building structural design through current and proposed projects. Examples include engineering buildings with outward forms that appear structurally unfavorable and taking advantage of load reduction through shaping opportunities.

• Transactions on Electrical and Electronic Materials
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• v.11 no.3
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• pp.106-111
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• 2010

The convergence of significantly different and disparate technologies such as spintronics, carbon nano tube field effect transistors, photon and bio-responsive molecular switches, memristor and memristive systems and metamaterials, coupled with energy scavenging sources are gaining a renewed focus in the quest for new products. This paper will provide an insight into an anticipated technological revolution and will highlight a futuristic Roadmap to capture opportunities that are brought about as the results of formulation of new circuit components basically driven by emergence of nanoscale materials as part of System on System integration. Challenges as the result of new lumped components such as memristor, metamaterial-based lumped components and the like that will challenge the designers' comfort zone will also be discussed.

• BMB Reports
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• v.50 no.4
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• pp.164-174
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• 2017

Mitochondria are cytosolic organelles essential for generating energy and maintaining cell homeostasis. Despite their critical function, the handful of proteins expressed by the mitochondrial genome is insufficient to maintain mitochondrial structure or activity. Accordingly, mitochondrial metabolism is fully dependent on factors encoded by the nuclear DNA, including many proteins synthesized in the cytosol and imported into mitochondria via established mechanisms. However, there is growing evidence that mammalian mitochondria can also import cytosolic noncoding RNA via poorly understood processes. Here, we summarize our knowledge of mitochondrial RNA, discuss recent progress in understanding the molecular mechanisms and functional impact of RNA import into mitochondria, and identify rising challenges and opportunities in this rapidly evolving field.

• International Journal of High-Rise Buildings
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• v.6 no.4
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• pp.301-306
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• 2017

The design and construction of supertall buildings has grown dramatically in recent years. This area of practice has traditionally fallen within the purview of a very small group of architects and engineers, but this is rapidly changing, as unprecedented growth and densification has spread to markets not traditionally known for high rise construction. The design community has been increasingly committed to the adoption of green and sustainable design, and the integration of smarter, cleaner technologies across the building spectrum. This paper examines current supertall design trends, and suggests that recently completed and planned projects are trending towards more sustainable solutions, and that a unique set of best practices are emerging specific to Supertalls.

• Ceramist
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• v.22 no.2
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• pp.170-181
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• 2019

All-solid-state batteries have received increasing attention because of their high safety aspect and high energy and power densities. However, the inferior solid-solid interfaces between solid electrolyte and active materials in electrode, which cause high interfacial resistance, reduce ion and electron transfer rate and limit battery performance. Recently, spark plasma sintering is emerging as a promising technique for fabricating solid electrolytes and composite-electrodes. Herein, this paper focuses on the overview of spark plasma sintering to fabricate solid electrolytes and composite-electrodes for all-solid-state batteries. In the end, future opportunities and challenges associated with SPS technique for all-solid-state batteries are described.