• Journal of Microbiology and Biotechnology
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• 제19권2호
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• pp.121-127
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• 2009

Sequencing analysis of a 5-kb DNA fragment from Streptomyces venezuelae ATCC 15439 revealed the presence of one 3.1-kb open reading frame(ORF), designated as afsR-sv. The deduced product of afsR-sv(1,056 aa) was found to have high homology with the global regulatory protein AfsR. Homology-based analysis showed that aftR-sv represents a transcriptional activator belonging to the Streptomyces antibiotic regulatory protein(SARP) family that includes an N-terminal SARP domain containing a bacterial transcriptional activation domain(BTAD), an NB-ARC domain, and a C-terminal tetratricopeptide repeat domain. Gene expression analysis by reverse transcriptase PCR(RT-PCR) demonstrated the activation of transcription of genes belonging to pikromycin production, when aftR-sv was overexpressed in S. venezuelae. Heterologous expression of the aftR-sv in different Streptomyces strains resulted in increased production of the respective antibiotics, suggesting that afsR-sv is a positive regulator of antibiotics biosynthesis.

• Structural Engineering and Mechanics
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• 제74권2호
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• pp.283-296
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• 2020

The coupled hydro-mechanical loading conditions commonly occur in the geothermal and petroleum engineering projects, which is significantly important influence on the stability of rock masses. In this article, the influence of flaw inclination angle of fracture behaviors in rock-like materials subjected to both mechanical loads and internal hydraulic pressures is experimentally studied using the 3-D X-ray computed tomography combined with 3-D reconstruction techniques. Triaxial compression experiments under confining pressure of 8.0 MPa are first conducted for intact rock-like specimens using a rock mechanics testing system. Four pre-flawed rock-like specimens containing a single open flaw with different inclination angle under the coupled hydro-mechanical loading conditions are carried out. Then, the broken pre-flawed rock-like specimens are analyzed using a 3-D X-ray computed tomography (CT) scanning system. Subsequently, the internal damage behaviors of failed pre-flawed rock-like specimens are evaluated by the 3-D reconstruction techniques, according to the horizontal and vertical cross-sectional CT images. The present experimental does not only focus on the mechanical responses, but also pays attentions to the internal fracture characteristics of rock-like materials under the coupled hydro-mechanical loading conditions. The conclusion remarks are significant for predicting the rock instability in geothermal and unconventional petroleum engineering.

• Archives of Plastic Surgery
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• 제37권4호
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• pp.457-460
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• 2010

Purpose: The great toe presents a reconstructive challenge for plastic surgeons. The big toe has much importance not only for the gait and the stability, but also for appearance aspects. Few reports have documented the reconstruction of big toe defects and we report a unique case of free flap reconstruction technique. Methods: A 41-year-old man with right great toe open fracture with soft tissue necrosis was referred from the orthopedic surgery department. On physical examination, there was the skin necrosis circumferentially and the fratured bone was severely fragmented. The metatarsophalangeal (MTP) joint of the big toe was intact. After the wound debridement, we harvested the innervated anterolateral thigh flap and transposed to the defected area. After five months, we finally retouched the flap by the dorsal defatting and distal debulking. Results: He had an uneventful postoperative course without infection, dehiscence and flap necrosis. He has remained asymptomatic for eight months without any recurrence such as the osteomyelitis. Finally, he kept the normal gait and posture with weight bearing on the reconstructed great toe and foot. Conclusion: The anterolateral thigh flap is described for the reconstruction of the great toe. It involves two stage procedure with the minimal donor site morbidity and provides a good cosmetic result.

• 대한족부족관절학회지
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• 제25권1호
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• pp.17-24
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• 2021

Surgical treatments for chronic lateral ankle instability include anatomic repair, anatomic reconstruction using an auto or allograft, non-anatomic reconstruction, and arthroscopic repair. Open anatomic repair using the native ligament with or without reinforcement of the inferior extensor retinaculum is commonly performed in patients with sufficient ligament quality. Non-anatomical reconstruction using the adjacent peroneus brevis tendon is typically used only in patients with poor-quality ligament remnants or when previous repair failed. Anatomical reconstruction can be considered in patients in whom anatomical repair is expected to fail and when performed using auto or allografts can provide good to excellent short-term results, although the long-term outcomes of these methods remain unclear. Arthroscopic repair can provide good to excellent short-term clinical outcomes, but evidence supporting this technique is limited. The advantages and disadvantages of various surgical methods should be compared, and appropriate treatment should be implemented based on patient characteristics.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2009년도 학술대회
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• pp.436-442
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• 2009

삼차원 재구성 기법은 대상을 파괴하지 않고도 그 내부 구조의 공간적 해석을 가능하게 해주는 단층 영상을 생성해주기 때문에, 산업, 의료분야에서 널리 사용되고 있다. 최근 영상 장비의 성능 향상으로 고해상도의 CT 영상을 얻을 수 있게 되었으나, 대용량 데이터를 재구성하기 위해 많은 시간이 소요된다. 본 논문에서는 재구성에서 가장 많은 시간이 소요되는 여과와 역투사 과정을 범용 그래픽스 하드웨어를 사용하여 최적화하는 방법을 제안한다. 여과에서는 네 장의 영상을 압축하여 동시에 처리하는 기법을 적용하고, 역투사 과정에서는 깊이 테스트를 이용하여 계산량을 줄이는 방법을 사용한다. 제안된 방법으로 구현된 GPU 기반 프로그램은 OpenMP 를 사용하여 최적화 된 CPU 기반 프로그램에 비해 약 50 배 이상 속도가 향상되었다.

• KIEAE Journal
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• 제3권3호
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• pp.59-66
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• 2003

From an sustainable perspective, one unique characteristic of Open Housing is its ability to individualize variable elements (infill) from the permanent elements (support) in accordance with the residents' needs. Such environment-friendly elements of Open Housing can contribute to increasing the life span of the building, reducing the scope of reconstruction, and minimizing the amount of disposed building materials during demolition. The purpose of this research is to analyze the flexibility concept from a typological perspective, so that the concept of open housing can be better understood and its development can be promoted. The main method of this study was content analysis. Based on literature review of flexibility concept in a typological approach, a primary categories were established to describe the flexibility concept such as time for flexibility, scope, and the degree of openness. Subsequently each criterion was elaborated as follows: planning, supply, and utility in the time stage; internal and external flexibility in its scope; and fixed, semi-free, and free flexibility in its openness degree. This research exposes the lack of comprehensive knowledge of Open Housing caused by rather uniform features of previous studies. This research establishes and promotes a systematic approach for a more holistic meaning of Open Housing. This approach should contribute to the proper utilization and further development of sustainable housing.

• Hip & pelvis
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• 제30권4호
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• pp.260-268
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• 2018

Purpose: This study was performed to assess the clinical and radiological outcomes following one-stage hip reconstruction, consisting of open reduction femoral shortening and pelvic osteotomy, for neglected developmental dislocation of the hip (DDH). Materials and Methods: This is a retrospective analysis of 77 hips in 65 patients (46 females and 19 males; 12 had bilateral dislocations), operated at a Ghurki Trust Teaching Hospital in Pakistan between 2013 and 2015. The average age at surgery was $11.02{\pm}3.43$ years. According to the Tonnis classification, there were 10, 14, 22, and 31 patients in grades 1, 2, 3, and 4, respectively. The pelvic procedure utilized in this study was triple osteotomy (47 hips) followed by double and Salter osteotomy (18 and 12 hips, respectively). Postoperative evaluations were conducted using the modified MacKay's scoring system (functional outcomes) and Severin's scoring method (radiological assessment). Results: Postoperatively, there were 38 (49.4%), 19 (24.7%), 14 (18.2%), and 6 (7.8%) hips in Severin grade I, II, III and IV, respectively. According to the modified McKay criteria, there were 22 hips (28.6%) in excellent condition, 44 (57.1%) in good condition, 9 (11.7%) in fair condition and 2 (2.6%) in poor condition. Both patients with poor outcomes had an unstable, painful hip with evidence of avascular necrosis of the femoral head. Conclusion: Based on the results presented here, we recommend the single stage procedure of open reduction, femoral shortening and pelvic osteotomy for treatment of DDH in older children with good to excellent functional and radiological outcomes.

• 구강회복응용과학지
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• 제16권2호
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• pp.133-147
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• 2000

A well-planned, precise occlusal adjustment of natural teeth has some distinct advantages over other forms of occlusal therapy. It should be emphasized, however, that an occlusal adjustment is an irreversible procedure and has definite contraindications in some mouths. Generally, the treatment methods for the patients that has open-bite will be following as below. : (1) Use of removable orthopedic repositioning appliance, (2) Orthodontics, (3) Full or partial reconstruction of the dentition, (4) Orthognathic surgical procedure, (5) Occlusal adjustment of the existing natural teeth, (6) Any combination of the above. Above all, the advantages of occlusal adjustment of natural teeth are : (1) the patient is more able to adapt to the changes in jaw position and posture; (2) the phonetic or speaking ability of the patient is not significantly changed and usually is improved; (3) the esthetics of the natural teeth is not altered and often is better; (4) the hygiene of the individual teeth is easily maintained; and (5) the functional usage of the teeth as cutting and chewing devices is markedly improved. The objective of an occlusal adjustment, as with any form of occlusal therapy, is to correct or remove the occlusal interferences, or premature contacts, on the occluding parts of the teeth which prevent a centric relation closure of the mandible. A systematic, disciplined approach can be followed in treatment, the objectives should be listed. They are : (1) Centric relation occlusion of the posterior teeth. (2) Proper "coupling" of the anterior teeth. (3) An acceptable disclusive angle of the anterior teeth in harmony with the condylar movement patterns. (4) Stability of the corrected occlusion. (5) Resolution of the related symptoms. For the patient with open-bite on anterior and posterior teeth, this case report shows the treatment methods in combination the fixed prosthesis with the selective cutting of the natural teeth. Occlusal adjustment is no longer an elective procedure but a mandatory one for patients requiring restorations and those in treatment for TMD dysfunctions or those whose dentitions show signs of occlusal trauma. Occlusal adjustment is essential for all who do not display the above lists.

• 대한관절경학회지
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• 제16권1호
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• pp.1-8
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• 2012

목적: 새로운 수술 적응증으로 선별한 성장판이 열려있는 전방십자인대 손상 환자에서 성장판을 통과하는 전방십자인대 재건술 후 임상적 및 방사선적 결과를 분석하고자 하였다. 대상 및 방법: 2005년 1월부터 2007년 1월까지 성장판이 열린 환자에서 성장판을 통과하는 십자인대 재건술을 시행한 환자 15명을 대상으로 평균 4.3년(4-6) 추시하였다. 수술 적응증은 역연령이 남자는 16세, 여자는 14세 이상이고, 성장판이 2 mm 이하로 열려있는 경우와 Risser sign과 성 성숙도(Tanner stage) 3 이상으로 설정하였다. 사용된 이식건은 모두 동종 전경골건를 사용하였으며, 대퇴골과 경골 부위 고정은 각각 endobutton과 bioscrew로 시행하였다. 기능적 평가는 Lysholm knee score scale과 Tegner activity level scale, International Knee Documentation Committee (IKDC) 2000 subjective score를 조사하였다. 이학적 검사상 안정성은 Lachman과 pivot shift 검사로 평가하였다. 방사선적 평가는 stress 영상에서 건측과의 전방 전위의 차이와, 최종 추시 시 scannogram상 양측간 하지부동정도, 대퇴경골각, 해부학적 및 역학적 외측 원위 대퇴각, 역학적 내측 근위 경골각의 차이로 하였다. 결과: Lysholm knee score scale은 술 전 평균 51점에서 술 후 최종 추시 상 97점으로, Tegner activity level scale은 술 전 평균 2.6점에서 술 후 7.1점으로, IKDC score는 술 전 평균 32.6점에서 술 후 88.3점으로 호전되었다. 건측과의 전방 전위의 차이는 술 전 평균 6.7(${\pm}1.0$) mm에서 술 후 평균 1.9(${\pm}0.9$) mm로 호전되었다. 골 변형을 평가하기 위한 모든 영상 지표들은 건측과 통계적으로 유의한 차이를 보이지 않았으며, Scannogram 상 하지부동은 평균 1.5 mm로 5 mm를 초과하는 하지부동은 관찰되지 않았다. 결론: 저자들의 새로운 수술 적응증으로 선별할 경우, 성장판이 열려있는 환자에서도 성장판을 통과하는 전방십자인대 재건술로 유의한 성장장애 없이 좋은 임상적 결과를 얻을 수 있을 것으로 사료된다.

• Journal of Yeungnam Medical Science
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• 제20권1호
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• pp.13-27
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• 2003

In the past, the report of shoulder instability undergoing open shoulder stabilization had satisfactory outcomes of greater than 90%. However, the functional loss of open procedure is severe in abduction and external rotation especially. Current arthroscopic techniques for shoulder instability result in success rate equal to open surgical procedure when the labrum is properly fixed to the glenoid rim using suture anchors, the capsule is tightened, and associated bony and soft tissue pathology is addressed. The arthroscopic surgery facilitates the view within shoulder joint for more accurate diagnosis, reduces operating time, minimises postoperative pain, reduces operative morbidity, improves shoulder function, and provides the possibility to perform other procedure simultaneously. However, to accomplish a successful arthroscopic stabilization procedure and to prevent complications, numerous advanced arthroscopic skill must be mastered. Although the arthroscope provides means to visualize new lesions, the pathomechanism and biomechanical explanation is not clear yet. Further studies are necessary to develop for shoulder reconstruction.