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Correlation Between Nitrogen Dioxide as an Air Pollution Indicator and Breast Cancer: a Systematic Review and Meta-Analysis

  • Keramatinia, Aliasghar;Hassanipour, Soheil;Nazarzadeh, Milad;Wurtz, Morten;Monfared, Ayad Bahadori;Khayyamzadeh, Maryam;Bidel, Zeinab;Mhrvar, Narges;Mosavi-Jarrahi, Alireza
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.1
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    • pp.419-424
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    • 2016
  • Background: The aim of this systematic review was to study the relationship between exposure to nitrogen dioxide ($NO_2$) in the ambient air and breast cancer incidence. Materials and Methods: A systematic review was performed based on the MOOSE guideline for review of observational studies. We searched five online databases (PubMed, Science Direct, Google Scholar, EBSCO, and Scopus) from their conception to June 2014. A pooled estimate of the correlation between $NO_2$ exposure and breast cancer incidence was calculated using Pearson's correlation coefficient. Results: A total of 654 titles were retrieved in the initial search of the databases. Further refinement and screening of the retrieved studies produced a total of five studies from four countries. The studies included three ecological studies (aggregate level) and two individual based studies (one prospective cohort and the other one a case-control study). The ecological studies were pooled and the meta-analysis of correlation coefficient without z transformation showed a pooled estimate of r = 0.89 with 95% CI of 0.84 to 0.95. Using z transformation, the pooled r was 1.38 with 95%CI of 1.11 to 1.59. No significant heterogeneity between studies was observed. Following a sensitivity analysis and the removal of each study from pooled analysis we did not see any significant change in the pooled estimate. Conclusions: It was concluded that there is a tendency toward a weak association between exposure to $NO_2$ in ambient air and breast cancer at the individual level and a significant association at the aggregate level.

Risk of Breast Cancer and Total Malignancies in Rheumatoid Arthritis Patients Undergoing TNF-α Antagonist Therapy: a Meta-analysis of Randomized Control Trials

  • Liu, Yang;Fan, Wei;Chen, Hao;Yu, Ming-Xia
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.8
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    • pp.3403-3410
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    • 2014
  • Context: Interest exits in whether TNF-alpha antagonists increase the risk of breast cancer and total malignancies in patients with rheumatoid arthritis (RA). Objectives: To analyze the risk of malignancies, especially breast cancer, in patients with RA enrolled in randomized control trials (RCTs). Methods: A systematic literature search for RCTs from 1 January 1998 to 1 July 2013 from online databases, such as PubMed, WILEY, EMBASE, ISI web of knowledge and Cochrane Library was conducted. Studies included RCTs that compared the safety of at least one dose of the five TNF-${\alpha}$ antagonists with placebo or methotrexate (MTX) (or TNF-${\alpha}$ antagonists plus MTX vs placebo plus MTX) in RA patients for more than 24 weeks and imported all the references into document management software EndNote${\times}6$. Two independent reviewers selected studies and extracted the data about study design, patients' characteristics and the type, number of all malignancies. Results: 28 RCTs from 34 records with 11,741 patients were analyzed. Of the total, 97 developed at least one malignancy during the double-blind trials, and breast cancer was observed in 17 patients (17.5% of total malignancies). However, there was no statistically significant increased risk observed in either the per protocol (PP) model (OR 0.65, 95%CI [0.22, 1.93]) or the modified intention to treat (mITT) model (OR 0.75, 95%CI [0.25, 2.21]). There were also no significant trend for increased risk of total malignancies on anti-TNF-${\alpha}$ therapy administered at approved doses in either model (OR, 1.06, 95%CI [0.64, 1.75], and OR, 1.30, 95%CI [0.80, 2.14], respectively). As to the two models, modified intention to treat model analysis led to higher estimation than per protocol model analysis. Conclusions: This study did not find a significantly increased risk of breast cancer and total malignancies in adults RA patients treated with TNF-${\alpha}$ antagonists at approved doses. However, it cannot be ignored that more patients developed malignancies with TNF-${\alpha}$ antagonists therapy compared with patients with placebo or MTX, in spite of the lack of statistical significance, so that more strict clinical trials and long-term follow-up are needed, and both mITT and PP analyses should be used in such safety analyses.

A Uer Evaluation Study of Library Computer Systems by Specific Student User Groups In Selected Academic Libraries both in the Republic of Korea and in the States (국내외 대학도서관에서 사용되는 도서관전산화시스템의 이용자 평가연구 - 학생이용자 집단을 중심으로 -)

  • 박일종
    • Journal of Korean Library and Information Science Society
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    • v.34 no.1
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    • pp.423-446
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    • 2003
  • Library and information science professionals have to grasp user's needs and make the best decisions when designing, acquiring, and managing library information systems. However, it is not easy for them to make the decision owing to the lack of an understanding of the characteristics of a specific user group in computer-based information systems in libraries. The aim of this study was to provide information on the characteristics and abilities of specific user groups such as male & female student groups, undergraduate & graduate ones, Sciences and Humanities majored ones etc. The actual OPAC systems were searched by specific student user groups in selected academic libraries in both Republic of Korea and the States for the purpose(Author, Title, and Subject search). Ouestionnaire was prepared and administered to Korean college students in the city of Taegu, Korea and adjacent area. Two hundred and seven usable questionnaires were obtained and analyzed. These were analyzed using descriptive, inferential statistics, and SPSS software. The major findings by data analysis of this study were described in chapters 4 and 5 of this paper in detail. Also, conclusions were drawn from the findings in this paper, and recommendations were proposed when designing, adopting, or managing a new system.

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A Study on Automatic Classification of Newspaper Articles Based on Unsupervised Learning by Departments (비지도학습 기반의 행정부서별 신문기사 자동분류 연구)

  • Kim, Hyun-Jong;Ryu, Seung-Eui;Lee, Chul-Ho;Nam, Kwang Woo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.9
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    • pp.345-351
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    • 2020
  • Administrative agencies today are paying keen attention to big data analysis to improve their policy responsiveness. Of all the big data, news articles can be used to understand public opinion regarding policy and policy issues. The amount of news output has increased rapidly because of the emergence of new online media outlets, which calls for the use of automated bots or automatic document classification tools. There are, however, limits to the automatic collection of news articles related to specific agencies or departments based on the existing news article categories and keyword search queries. Thus, this paper proposes a method to process articles using classification glossaries that take into account each agency's different work features. To this end, classification glossaries were developed by extracting the work features of different departments using Word2Vec and topic modeling techniques from news articles related to different agencies. As a result, the automatic classification of newspaper articles for each department yielded approximately 71% accuracy. This study is meaningful in making academic and practical contributions because it presents a method of extracting the work features for each department, and it is an unsupervised learning-based automatic classification method for automatically classifying news articles relevant to each agency.

User Satisfaction of Mobile Convergence Device: The Expectation and Disconfirmation Approach (모바일 복합 단말기 사용자 만족: 기대-불일치 접근)

  • Lee, Seung-Chang;Suh, Eung-Kyo
    • Journal of Distribution Science
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    • v.10 no.11
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    • pp.89-99
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    • 2012
  • Purpose - Mobile devices, especially mobile terminals capable of telecommunication and wireless connectivity, are leading the advancements in consumer electronics. Digital convergence drives the functions of various devices, such as cellular phones, MP3 players, personal digital assistants, and gaming, into a single device. This trend would continue and applications such as digital audio and video streaming (including personalized content delivery mechanisms) would soon be on a handheld device. As customers want mobile convergence devices, manufacturers are driving new initiatives in the emerging mobile device market. Given the roles played by device design and service content in user satisfaction of a mobile convergence device, this study focuses on identifying and measuring the constructs for the process by which user satisfaction is achieved. This study synthesizes the expectation-disconfirmation paradigm with empirical theories in user satisfaction. Device and service levels are separated, and nine key constructs for user satisfaction of mobile convergence devices are proposed. Insight into this process could help web-based businesses to improve user satisfaction, thus enhancing the effectiveness of e-commerce for sellers and buyers. Research design, data, methodology - This study draws on three users of mobile convergence devices as examples. To test there search model and hypotheses, survey questionnaires were sent to 607 mobile device users. Mobile device users were initially identified from several members, and subjects were randomly drawn. Data from 577 survey responses were finally analyzed. The unit of measurement and analysis in this research study is at a personal level. Results - The measurements for the constructs were developed and tested in a two-phase study. In the first phase, the device and service dimensions were identified, and instruments for measuring them were developed and tested. In the second phase, using the salient dimensions of the device and service as the formulating first-order factors, instruments were developed and empirically tested to measure satisfaction of the device and service. In measuring satisfaction of mobile convergence devices, the critical tasks are to identify the key constructs of such user satisfaction and to develop validated instruments to measure them. Hence, the results of this study have immediate implications for businesses and for research in user satisfaction of mobile convergence devices. Conclusions - This study provides reliable instruments for operationalizing key constructs in the analysis of user satisfaction of mobile convergence devices within the expectation-disconfirmation paradigm. Hence, convergence device makers will be able to examine whether their websites meet their customers' expectations by examining the device aspect of the mobile convergence device customers, and the service aspect expectations and disconfirmation. Moreover, the introduction of expectation and disconfirmation constructs brings the marketing aspect of convergence devices into focus for such retailers, an aspect crucial to the effective design of websites for online businesses. In addition,this study provides the metrics required to initiate future studies on user satisfaction of mobile convergence devices.

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A Study on the Influence of Factors That Makes Web Sites Credible (웹사이트의 신뢰성 평가에 영향을 미치는 요인과 각 요인의 중요도에 관한 연구)

  • Kim, Young-Ki
    • Journal of the Korean Society for Library and Information Science
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    • v.41 no.4
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    • pp.93-111
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    • 2007
  • The Internet is now an integral part of the everyday lives of a majority of people. Web users are becoming increasingly skeptical of the information and services offered online. They are demanding web sites that offer credible information. This study focused on what features of web sites affect the perception of web credibility. For this purpose, I took the responses from 648 people and extracted 49 factors that affect web credibility. I placed the individual factors - the specific questions asked in the survey - into one of four categories expertise. trustworthiness, ads and other and calculated the means for each of the 49 factors. As a result, 29 out of 49 factors increase the Perceptions of credibility and 20 factors decrease the web credibility. Sites with frequently update. the credentials of authors, strict content guides, search capabilities, clear connections to the real world fared good in credibility. Technical problems such as broken links, site sown, or typographical errors were rated the most negative on this scale On the other end of the scale, a domain name that ends in' .org' or' .or.kr' caused little change in perception of credibility.

Analysis of Questions and Answers Posted on the Internet Blogs about Prenatal Genetic Diagnosis and Screening (블로그를 통해 본 산전 기형아 검사와 양수검사에 대한 질문과 댓글 분석)

  • Jun, Myunghee;Shin, Gyeyoung;Choi, Kyung Sook
    • The Journal of the Korea Contents Association
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    • v.15 no.3
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    • pp.252-264
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    • 2015
  • The purpose of this study was to identify pregnant women's needs for information on prenatal genetic diagnosis and screening. This study is consisted of two phases. In the first phase in December 2011, six blogs featuring questions and answers on prenatal genetic diagnosis and screening were selected from four major search engines in Korea by using the keywords "prenatal genetic diagnosis," "prenatal genetic screening", and "amniocentesis." An analyzing framework was constructed on the basis of 389 posts on six blogs between November 2006 and October 2011. In the second phase, the contents of the "MomsHolicbaby" blog posted from November 2010 to October 2011 were reviewed. Then, pregnant women's questions on prenatal genetic diagnosis and screening (100 questions) and amniocentesis (200 questions with 1,665 answers) were analyzed using descriptive statistics. Among posters who had ever been recommended to undergo amniocentesis, 56.5% described feelings of anxiety, 25.5% did not know the purpose of the test, and 33.9% refused to undergo the test. Among 295 posters answering questions about amniocentesis, 61.4% disagreed with undergoing the test. The results show that there is a need for healthcare professionals to provide more educational and emotional support to pregnant women considering prenatal genetic diagnosis and screening. Providing online health information can be integrated into prenatal genetic education for pregnant women as well as nurses. In addition, prenatal women's preferences about undergoing amniocentesis should be reflected in the current legal discussion on criteria for termination of pregnancy.

Sentiment Analysis of movie review for predicting movie rating (영화리뷰 감성 분석을 통한 평점 예측 연구)

  • Jo, Jung-Tae;Choi, Sang-Hyun
    • Management & Information Systems Review
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    • v.34 no.3
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    • pp.161-177
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    • 2015
  • Currently, the influence of the Internet portal sites that can make it quick and easy to contact the vast amount of information is increasing. Users can connect the Internet through a portal to obtain information, such as communication between Internet users, which can be used to meet a variety of purposes. People are exposed to a variety of information from other users in the search for a movie and get information. The impact on the reviews and ratings with the limited number of characters of the film allows users to form a relationship to the movie, decide whether you want to see the movie or find another movie. but, the user can not read the whole movie review. When user see the overall evaluation, the user can receive the correct information. This research conducted a study on the prediction of the rating by the use of review data. Information of reviews, is divided into two main areas: the"fact" and "opinion". "Fact" is to convey the dispassionate information and "Opinion" is, to represent the user's feelings. In this study, we built sentiment dictionary based on the assessment and evaluation of the online review and applied to evaluate other movies. In the comparative study with a simple emotion evaluation technique, we found the suggested algorithm got the more accurate results.

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Metadata Design and Machine Learning-Based Automatic Indexing for Efficient Data Management of Image Archives of Local Governments in South Korea (국내 지자체 사진 기록물의 효율적 관리를 위한 메타데이터 설계 및 기계학습 기반 자동 인덱싱 방법 연구)

  • Kim, InA;Kang, Young-Sun;Lee, Kyu-Chul
    • Journal of Korean Society of Archives and Records Management
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    • v.20 no.2
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    • pp.67-83
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    • 2020
  • Many local governments in Korea provide online services for people to easily access the audio-visual archives of events occurring in the area. However, the current method of managing these archives of the local governments has several problems in terms of compatibility with other organizations and convenience for searching of the archives because of the lack of standard metadata and the low utilization of image information. To solve these problems, we propose the metadata design and machine learning-based automatic indexing technology for the efficient management of the image archives of local governments in Korea. Moreover, we design metadata items specialized for the image archives of local governments to improve the compatibility and include the elements that can represent the basic information and characteristics of images into the metadata items, enabling efficient management. In addition, the text and objects in images, which include pieces of information that reflect events and categories, are automatically indexed based on the machine learning technology, enhancing users' search convenience. Lastly, we developed the program that automatically extracts text and objects from image archives using the proposed method, and stores the extracted contents and basic information in the metadata items we designed.

A Study on the Validity of Refuting Literature about the Bonghan theory (봉한학설에 대한 반박문헌의 타당성에 관한 고찰)

  • Lee, Sang-Hun;Zhang, Wenji;Soh, Kwang-Sup;Lee, Byung-Chun;Sung, Baek-Kyung;Ryu, Yeon-Hee
    • Korean Journal of Acupuncture
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    • v.27 no.3
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    • pp.129-142
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    • 2010
  • Background : The Bonghan theory is a hypothesis on the anatomical structure of the acupuncture point and meridian system. It has been regarded as a misunderstanding of the lymphatic system, or as a made-up story, for the past 40 years. Since 2002, Many studies have been published either to support the theory or to refute the old viewpoint. Objective : The purpose of this study was to find out the validity of the refutation by reviewing the publications. Methods : Searches were made from online databases (Riss4u.net, Google.com, Sciencedirect.com, Pubmed.com, baidu.com, and ci.nii.ac.jp) from 1960 to 2009. The search terms that were used were "Bonghan," "Bong han," "봉한," "thread-like structure," "KИM БOH XaHOM", "CИCTEMA KEHPAK," "鳳漢," "鳳漢管," and "鳳漢学說." References from the searched publications were also used. Results : Since the 1960s, 107 publications were identified as related works, but only 11 publications sought to refute the Bonghan theory. Two publications were researches, and nine were reviews. In the analysis of the correlation of the arguments with the publication contents, it was found that the research of G. Kellner reviewed the Bonghan system properly but that V. V. Kosmatov did not classify the ear-reflex zone as a traditional acupuncture point. For the review publications, only two reviews contained proper arguments, but seven publications were identified as broad interpretations, wrong translations, etc. Moreover, the two proper reviews were grounded on the research of G. Kellner. Conclusions : We found that the scientific origin of the refutation of the Bonghan theory is only one research by G. Kellner. This result suggest that Bonghan theory was not discussed enough to determine the invention.