• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.208-216
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• 2003

ISO 14649 (data model for STEP-NC) is a new interface scheme or language for CAD-CAM-CNC chain under established by ISO TC184 SCI. Up to this point, the new language is mainly made for milling and turning, and other processes such as EDM will be completed in the future. Upon completion, it will be used as the international standard language for e-manufacturing paradigm by replacing the old machine-level language, so called M&G code used since 1950's. With the rich information contents included in the new language, various intelligent functions can be made by the CNC as the CNC knows what-to-make and how-to-make. In particular, On-Machine Inspection required for quality assurance in the machine level, can be done based on the information of feature­based tolerance graph. Previously, On-Machine inspection has been investigated mainly for milling operation, and only a few researches were made for turning operation without addressing the data model. In this thesis, we present a feature-based on-machine inspection process by the 4 Tasks: 1) proposing a new schema for STEP-NC data model, 2) converting the conventional tolerance scheme into that of STEP-NC, 3) modifying the tolerance graph such that the tolerance can be effectively measured by the touch probe on the machine, and 4) generating collision-free tool path for actual measurement. Task 1 is required for the incorporation of the presented method in the ISO 14649, whose current version does not much include the detailed schema for tolerance. Based on the presented schema, the tolerance represented in the conventional drafting can be changed to that of STEP-NC (Task 2). A special emphasis was given to Task 3 to make the represented tolerance accurately measurable by the touch probe on the machine even if the part setup is changed. Finally, Task 4 is converting the result of Task into the motion of touch probe. The developed schema and algorithms were illustrated by several examples including that of ISO 14649 Part 12.

• The Korean Journal of Pain
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• v.37 no.3
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• pp.211-217
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• 2024

Background: Tolerance to the analgesic effects of opioids and non-steroidal anti-inflammatory drugs (NSAIDs) is a major concern for relieving pain. Thus, it is highly valuable to find new pharmacological strategies for prolonged therapeutic procedures. Biguanide-type drugs such as metformin (MET) are effective for neuroprotection and can be beneficial for addressing opioid tolerance in the treatment of chronic pain. It has been proposed that analgesic tolerance to NSAIDs is mediated by the endogenous opioid system. According to the cross-tolerance between NSAIDs, especially sodium salicylate (SS), and opiates, especially morphine, the objective of this study was to investigate whether MET administration can reduce tolerance to the anti-nociceptive effects of SS. Methods: Fifty-six male Wistar rats were used in this research (weight 200-250 g). For induction of tolerance, SS (300 mg/kg) was injected intraperitoneally for 7 days. During the examination period, animals received MET at doses of 50, 75, or 100 mg/kg for 7 days to evaluate the development of tolerance to the analgesic effect of SS. The hot plate test was used to evaluate the drugs' anti-nociceptive properties. Results: Salicylate injection significantly increased hot plate latency as compared to the control group, but the total analgesic effect of co-treatment with SS + Met50 was stronger than the SS group. Furthermore, the effect of this combination undergoes less analgesic tolerance over time. Conclusions: It can be concluded that MET can reduce the analgesic tolerance that is induced by repeated intraperitoneal injections of SS in Wister rats.

• Journal of Ecology and Environment
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• v.38 no.2
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• pp.195-211
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• 2015

The objectives of this research were to determine mean and maximum tolerance ranges of Carassius auratus ($C_a$) and Cyprinus carpio ($C_c$) populations on various physico-chemical parameters and ecological indicator metrics. Little is known about chemical tolerance ranges of the two species, even though these species are widely distributed species in aquatic ecosystems. Maximum tolerance ranges of $C_a$-population to total nitrogen (TN) and total phosphorus (TP) were $20.3mgL^{-1}$ and $2.0mgL^{-1}$, respectively. Optimal ranges of TN and TP in the $C_a$-population were $1.7-5.0mgL^{-1}$ and $0.06-0.30mgL^{-1}$, respectively. Such nutrient regimes of the $C_a$-population were evaluated as hypereutrophy, indicating high tolerance limits. The $C_c$-population had similar ecological characteristics to $C_a$-population, but the mean tolerance ranges of TN, TP, BOD, and COD were significantly (p < 0.05) greater than the $C_a$-population. Ecological patterns of trophic composition and tolerance guilds in the $C_a$-population were similar to those of the $C_c$-population. The model value of Index of Biological Integrity (IBI) of the habitat where C. auratus and C. carpio co-occurred averaged $15.0{\pm}4.3$ and $12.9{\pm}3.6$, respectively. Based on the modified criteria of the United States Environmental Protection Agency (Klemm et al. 1993), it indicated poor ecological health of both species. These results suggest that both species are highly tolerant to chemical and physical habitat conditions of waterbodies, and that the chemical tolerance range of $C_c$-population was higher than $C_a$-population.

• Korean Journal of Ecology and Environment
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• v.43 no.4
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• pp.459-470
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• 2010

In this study, we analyzed fish tolerance guilds in mainstems and tributaries of 65 streams and rivers arid their relations to water quality using dataset sampled from April to November, 2009. For the study, water quality parameters including biochemical oxygen demand (BOD), electric conductivity (EC), total nitrogen (TN), total phosphorus (TP), ammonia nitrogen ($NH_3$-N), nitrate nitrogen ($NO_3$-N) and phosphate phosphorus ($PO_4$-P) were analyzed in the laboratory and also tolerance ranges in 3 category fishes of sensitive, intermediate, and tolerant species with high abundance were analyzed. According to fish guild analysis, tolerant species was 58% of the total community and the proportion of omnivore species was 63% of the total, indicating a degradation of habitats and water quality. Water quality was shown typical longitudinal gradients from the headwater to the down-river; TN and TP increased toward the down-rivers except for the big point-source area and ionic contents, based on, electric conductivity showed same pattern. Tolerance guild analysis of 9 major species with high abundance indicated that sensitive groups had narrower tolerance range in the water quality than the groups of intermediate and tolerant species. In contrast, tolerant groups including Zacco platypus, Carassius auratus, and Opsarichthys uncirostris amurensis had wider tolerance ranges than the groups of sensitive and intermediate species. Thus, each group was evidently segregated from the tolerance levels. Principal Component Analysis (PCA) employed for the relations of water quality to fish species in each groups suggests that water quality had highest eigenvalues with fish species in the 1st axis of the PCA and nitrogen (TN, $NH_3$-N, $NO_3$-N) and phosphorus (TP) were key components differentiating three groups of sensitive, intermediate and tolerance guilds.

• IMMUNE NETWORK
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• v.3 no.3
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• pp.169-175
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• 2003

The intestinal immune system can discriminate between harmful and unharmful antigens and do not provoke productive immunity to unharmful antigen. Thus oral administration of antigen is one of classical methods for inducing antigen-specific immune tolerance in the periphery. Furthermore, oral tolerance has been investigated for the treatment of autoimmune disorders in human clinical trials. However, the detail mechanism of oral tolerance and contributing factors are not defined clearly at this time. Recent studies demonstrate unique types of immune cell that suppressing immune response, such as regulatory T cell and tolerogenic dendritic cell. This article reviews the factors involved in oral tolerance and discusses our current understanding base on the recent literatures and our works.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1996.04a
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• pp.813-818
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• 1996

This paper presents a method for tolerance design using the Taguchi Method(TM) and general purpose mechanism analysis program. Also the tolerance design method is with respect to performance improvement of a mechanism. To use the orthogonal array, mathematical model of a mechanism is established and experiments are carried out by the general purpose mechanism analysis program. The contact model is used to consider a clearance effect. This method is applied to the tolerance design of the VTR Deck mechanism. This method can be used in tolerance design of general mechanisms.

• Korean Journal of Pharmacognosy
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• v.17 no.2
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• pp.139-147
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• 1986

Ginseng saponins(GS), protopanaxadiol saponins(PD) and protopanaxatriol saponins (PT) were tested for the inhibition of the development of morphine tolerance and dependence antagonism of morphine analgesia and the loss of morphine tolerance and dependence in mice The results were as follows: 1. Inhibition of the development of morphine tolerance and dependence. 2. Antagonism of morphine analgesia. 3. Increase in the loss of morphine tolerance and dependence. Antagonism of morphine by ginseng saponins and its reversal by L-DOPA and 5-HTP suggest some possibility that catecholamines and serotonin levels might be associated with the results.

• International Journal of Human Ecology
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• v.17 no.1
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• pp.1-14
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• 2016

This paper presents a series of path models that were developed to test whether financial risk tolerance mediates the association between the following four variables and investing behavior: (a) male and married, (b) female and married, (c) male and single, or (d) female and single. Data for this study were obtained from a proprietary consumer survey of risk-tolerance attitudes. Four path models were developed to test relationships among the variables in 2008, 2009, 2010, and 2011. These years were chosen to represent the depth and recovery periods in the Great Recession. The total number of respondents was 29,641. Findings showed that financial risk tolerance was positively associated with risky investing behavior (i.e., equity ownership) in each of the four periods. The associations among the gender-marital status variables and investing behavior were mixed; however, findings did indicate that risk tolerance mediates these relationships by sometimes amplifying and occasionally attenuating risky behavior. Based on the findings, implications and limitation are presented.

• Journal of the Korea Society for Simulation
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• v.13 no.1
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• pp.51-63
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• 2004

Current distributed systems are attacked from the outside as well as in which new intrusions are occurred. In particular there is a growing but largely unnoticed intrusion threat due to the emerging middleware technologies such as CORBA, WAP, XML support, and enterprise application integrators. In order to cope with these attacks, intrusion tolerance technology is introduced. Intrusion tolerance technology means that it can provide services normally although attacks are occurred into system. There are intrusion tolerance architectures such as ITUA, HACQIT, SITAR, and so on as a part of DARPA project. In this paper, we analyze and discuss existing intrusion tolerance architectures with respect to intrusion tolerance technology. Also, we extract intrusion tolerant requirements, which are required to develop ,intrusion tolerant system. We propose UML-IT(Intrusion Tolerance) profiles and specify intrusion tolerant software by applying UML-IT profiles.

• Proceedings of the KIEE Conference
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• 2003.07b
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• pp.750-752
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• 2003

This paper presents a method of tolerance analysis for a electric machine. Tolerance analysis technique is required to find the tolerance band of design variables and estimate the characteristic distribution of the electric machine, because that manufacturing tolerances as well as measuring errors have a great influence on the electric machine. Therefore, this paper introduces Stochastic Response Surface Methodology to achieve the tolerance analysis. As an example, the tolerance analysis is applied to the analysis of torque characteristics for a BLDC motor from the electric point of view.