• Journal of the Korean Institute of Traditional Landscape Architecture
• /
• v.34 no.4
• /
• pp.110-118
• /
• 2016

The United Nations Food and Agriculture Organization (FAO) has established the Globally Important Agriculture Heritage Site in 2002, designating the Agricultural Heritages with global value, and carries forward conservation and management. In Korea, the Agricultural Heritage system was adopted to conserve and manage the valuable resources of agricultural space in 2012. Although, the interest in the Agricultural Heritage has been developed, the valuation standards for unique value of the Korea Agricultural Heritage has not been yet established, so discovery and designation of the Agricultural Heritage are at a standstill. Meanwhile, a study from the conceptual viewpoint of the Agricultural Heritage, resources investigation for discovery of the Agricultural Heritage, index development, and a study for conservation and management methods through sightseeing are focused, and a study for the valuation standards about the Korea Agricultural Heritage are not focused. Therefore, the study has analyzed a value of the Korea Agricultural Heritage, and suggested the standards of evaluation a value of the Agricultural Heritage rightly. This study suggested the valuation standards of the Korea Agricultural Heritage used in discovery and designation of the Agricultural Heritage, so prepared a base to conduct the valuation considering the characteristics of the Agricultural Heritage. Such standards will contribute to conservation and management of the Agricultural Heritage in the future.

• Journal of agriculture & life science
• /
• v.46 no.1
• /
• pp.163-176
• /
• 2012

TTo increase productivity of a strong extracellular alkaline protease (BCAP), stable strains of Bacillus clausii I-52 carrying another copy of BCAP gene in the chromosome were developed. Integrative vector, pHPS9-fuBCAP carrying BCAP promoter, ribosome binding site, signal sequence and active protease gene was constructed and transferred into B. clausii I-52, and integration of the constructed plasmid into chromosome was identified by PCR. An investigation was carried out on BCAP production by B. clausii I-52 and transformant C5 showing the highest relative activity of alkaline protease using submerged fermentation. Maximum enzyme activity was produced when cells were grown under the submerged fermentation conditions at $37^{\circ}C$ for 48 h with an aeration rate of 1 vvm and agitation rate of 650 rpm in a optimized medium (soybean meal 2%, wheat flour 1%, sodium citrate 0.5%, $K_2HPO_4$ 0.4%, $Na_2HPO_4$ 0.1%, NaCl 0.4%, $MgSO_47H_2O$ 0.01%, $FeSO_47H_2O$ 0.05%, liquid maltose 2.5%, $Na_2CO_3$ 0.6%). A protease yield of approximately 134,670U/ml was achieved using an optimized media, which show an increase of approximately 1.6-fold compared to that of non-transformant (83,960 U/ml). When the stability of transformant C5 was examined, the integrated plasmid pHPS9-fuBCAP was detected in the transformant after cultivation for 8 days, suggesting that it maintained stably in the chromosomal DNA of transformant C5.

• Proceedings of the KOR-BRONCHOESO Conference
• /
• 1976.06a
• /
• pp.85.3-86
• /
• 1976

Sudden deafness requires immediate investigation and treat if there is to be any prospect of salvaging the hearing. It present an otological emergency and a diagnostic challenge. Sn Sudden sensorineural deafness can be caused by a wide variety of pathologies. A battery of tests and investigations must be performed forthwith if treatment is to be started without further delay. The concept that nothing can be done for the patient with sensori-neural deafness must be abandoned. Some pathologies causing sudden deafness are not amenable to therapy or can show only partial reversibility. But there are several causes, showing little or no spontaneous recovery, which do responed to appropriate treatment. It is important to identify them and concentrate on their management. The age and sex ratios and the unilaterral or bilateral nature of the lesion are related to the etiology and depend upon which type of case is included in the series. Though individually rare, collecting for about 2.5 per cent of new otoloical patients. Some 70 per cent of cases are unilateral. Viral, bacterial and treponemal infections accounted for about 30 per cent of the cases. Some 16 per cent were due to vascular lesions of the cochlea. In almost 22 per cent there was no obvious cause (idiopathic), they occurred in young adult and were either sensory or neural. About 12 per cent were traumatic and 9 per cent were ototoxic in origin. The remaining 11 per cent were due to a group of rarities. The two vital factors are the site of the lesion and the duration of the hearing loss. The earlier these are diagnosed and treated the better the response. The etiology, pathology and treatment are reviewed.

• Korean Journal of Clinical Laboratory Science
• /
• v.51 no.1
• /
• pp.26-33
• /
• 2019

Recently, the rapid growth of the companion animal market has led to the development of animal disease diagnosis kits. Therefore, the utility of the introduction of biomarkers for the development of animal molecular diagnostics is being reevaluated. A good biomarker should be precise and reliable, distinguish between normal and diseased states, and differentiate between different diseases. Recently reported genetic markers, tumor markers (cell free DNA, circulating tumor cells, granzyme, and skin tumors), and others (brucellosis, programmed death recovery-1, symmetric dimethylarginine, periostin, and cysteinyl leukotrien) have been developed. The biomarkers are used for risk prediction or for the screening, diagnosis, and monitoring of disease progression. The most important criteria for related biomarkers are disease specificity. Many potential biomarkers have emerged from laboratory and test studies, but they have not been validated in independent or large-scale clinical studies. Candidate biomarkers evaluate disease associations, verify the effectiveness of biomarkers for early detection and disease progression, and incorporate them into humans and animals. In the future, it will be necessary to reevaluate the utility of well-structured biomarker-based research and study the development of kits that can be used in on-site tests in accordance with the trends introduced in the diagnosis of animal diseases.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.22 no.5
• /
• pp.502-508
• /
• 2021

Predicting the settlement of soft ground is an important aspect of soft ground design. In this study, a method is proposed that increases the reliability of settlement predictions based on-site investigation data, including piezocone penetration test results, at the Gimhae-Jinyoung district, adjacent area to the Nakdong River. Soils in the area waweres classified using the Robertson Chart (1986, 1990), and theoretical settlement was calculated using the equations proposed by Terzaghi (1925) and Sanglerat (1972). SPSS was used to obtain the correlation between theoretical and measured settlements. Results produced settlement prediction errors for the Terzaghi and Sanglerat methods of 17.28% and 26.96%, respectively. A correction factor calculated by SPSS correlation analysis for the relation between and theoretical and measured settlements is proposed that improves the reliability of settlement prediction in soils of the classification examined.

• Journal of the Korean GEO-environmental Society
• /
• v.23 no.3
• /
• pp.15-22
• /
• 2022

This study aims to observe the swelling representative rocks in Korea and to suggest improvements in the use of test methods and prior analysis in relation to the weathering of rocks. The swelling test and analysis were performed on the drilling cores obtained for the ground investigation at the domestic highway construction site. For the method of determining the absorption expansion index of rocks, the method proposed in "Standard Methods for Sample Collection and Specimen Preparation" of ISRM and Korean Rock Engineers Standard Rock Test Method was used. The specimen for the measurement of the expansion displacement was cylindrical with a height of 10 cm and a diameter of 5 cm. The existing swelling analysis method evaluates the sensitivity to weathering by using the maximum expansion displacement, but since the classification by bedrock grade is unclear, it is reasonable to use the rate of change of the expansion displacement according to the immersion time. It is necessary to conduct an experiment to distinguish between weathering and fault deterioration. In addition, long-term weathering prediction technology for each cancer type is needed through the expansion displacement analysis of the chemical weathering stage.

• Journal of the Korea Institute of Building Construction
• /
• v.23 no.4
• /
• pp.417-428
• /
• 2023

The demolition of domestic infrastructures mirrors other significant construction initiatives in presenting a markedly high accident rate. A comprehensive investigation into the origins of such accidents is crucial for the prevention of future incidents. Upon detailed inspection, the causes of demolition construction accidents are multifarious, encompassing unsafe worker behavior, hazardous conditions, psychological and physical states, and site management deficiencies. While statistics relating to demolition construction accidents are consistently collated and reported, there exists an exigent need for a more foundational cause categorization system based on accident type. Drawing from Heinrich's Domino Theory, this study classifies the origins of accidents(unsafe behavior, unsafe conditions) and human errors(human factors) as per the type of accidents experienced during demolition construction. In this study, a three-step model of QFD-FMEA(Quality Function Deployment - Failure Mode Effect Analysis) is employed to systematically categorize accident causes according to the types of accidents that occur during demolition construction. The QFD-FMEA method offers a technique for cause classification at each stage of the demolition process, including direct causes(unsafe behavior, unsafe environment), and human errors(human factors) through a tri-stage process. The results of this accident cause classification can serve as safety knowledge and reference checklists for accident prevention efforts.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.28 no.4C
• /
• pp.205-212
• /
• 2008

In this research, the effect of rock mass weathering on the side shear resistance of drilled shaft socketed into igneous-metamorphic rock was investigated. For that, 23 cast-in-place concrete piles with diameters varying from 400mm to 1,500mm were constructed at four different sites, and the static axial load tests were performed to examine the resistant behavior of the piles. A comprehensive field/laboratory testing program at the field test site was also performed to describe the in situ rock mass conditions quantitatively. The side shear resistance of rock socketed piles was found to have no intimate correlation with the compressive strength of the intact rock. However, the global rock mass strength, which was calculated by the Hoek and Brown criteria, was found to closely correlate to the side shear resistance. The ground investigation data regarding the rock mass conditions (e.g. $E_m$, $E_{ur}$, $p_{lm}$, RMR, RQD, j) were also found to be highly correlated with the side shear resistance, showing the coefficients of correlation greater than 0.75 in most cases. Additionally, the applicability of existing methods for the side shear resistance of weathered granite-gneiss was verified by comparison with the field test data. The existing methods which consider the effect of rock mass condition were modified and/or extended for weathered rock mass where mass factor j is lower than 0.15, and RQD is below 50%.

• Mass Spectrometry Letters
• /
• v.14 no.4
• /
• pp.153-159
• /
• 2023

The copper ion, Cu(II), binding sites for amyloid fragment Aβ1-16 (=Aβ16 ) were investigated to explain the biological activity difference in the Aβ16 aggregation process. The [M+Cu+(z-2)H]^z+ (z = 2, 3 and 4, M = Aβ16 monomer) and [D+Cu+(z-2)H]^z+ (z = 3 and 5, D = Aβ16 dimer) structures were investigated using electrospray ionization (ESI) mass spectrometry (MS) and tandem mass spectrometry (MS/MS). Fragment ions of the [M+Cu+(z-2)H]^z+ and [D+Cu+(z-2)H]^z+ complexes were observed using collision-induced dissociation MS/MS. Three different fragmentation patterns (fragment "a", "b", and "y" ion series) were observed in the MS/MS spectrum of the (Aβ16 monomer or dimer-Cu) complex, with the "b" and "y" ion series regularly observed. The "a" ion series was not observed in the MS/MS spectrum of the [M+Cu+2H]⁴⁺ complex. In the non-covalent bond dissociation process, the [D+Cu+3H]⁵⁺ complex separated into three components ([M+Cu+H]³⁺, M³⁺, and M²⁺), and the [M+Cu]²⁺ subunit was not observed. The {M + fragment ion of [M+Cu+H]³⁺} fragmentation pattern was observed during the covalent bond dissociation of the [D+Cu +3H]⁵⁺ complex. The {M + [M+Cu+H]³⁺} complex geometry was assumed to be stable in the [D+Cu+3H]⁵⁺ complex. The {M + fragment ion of [M+Cu]²⁺} fragmentation pattern was also observed in the MS/MS spectrum of the [D+Cu+H]³⁺ complex. The {M + [y₉+Cu]¹⁺} fragment ion was the characteristic fragment ion. The [D+Cu+H]³⁺ and [D+Cu+3H]⁵⁺ complexes were likely to form a monomer-monomer-Cu (M-M-Cu) structure instead of a monomer-Cu-monomer (M-Cu-M) structure.

• Journal of the Korean GEO-environmental Society
• /
• v.24 no.12
• /
• pp.5-11
• /
• 2023

Economic damage is occurring due to landslides and debris flows that occur when the ground artificially created for roads or photovoltaic power generation facilities is weakened by rainfall such as torrential rain. In order to understand the stability of the artificially created ground, it is very important to check the ground information such as the compositional state and mechanical characteristics of the stratum. However, since most of the investigation sites are steep slopes or there are no access roads, it is not easy to enter the drilling equipment commonly used to check ground information and perform standard penetration tests. In this study, a dynamic cone penetration test (DCP) device using a miniaturized auger drilling equipment and an automatic drop device was developed to check the cone resistance value and the dynamic cone penetration test value and analyze the correlation with the standard penetration test value to confirm its applicability at the mountain solar power generation site. As a result, the cone resistance value is q_d = 0.46 N and the dynamic cone penetration test value is N_d = 1.58 N, confirming a value similar to the results of existing researchers to secure its reliability.