• Tuberculosis and Respiratory Diseases
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• 제75권5호
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• pp.188-198
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• 2013

Over the past decade, several kinase inhibitors have been approved based on their clinical benefit in cancer patients. Unfortunately, in many cases, patients develop resistance to these agents via secondary mutations and alternative mechanisms. To date, several major mechanisms of acquired resistance, such as secondary mutation of the epidermal growth factor receptor (EGFR) gene, amplification of the MET gene and overexpression of hepatocyte growth factor, have been reported. This review describes the recent findings on the mechanisms of primary and acquired resistance to EGFR tyrosine kinase inhibitors and acquired resistance to anaplastic lymphoma kinase inhibitors, primarily focusing on non-small cell lung carcinoma.

• Integrative Medicine Research
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• 제2권4호
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• pp.131-138
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• 2013

The skeletal muscle in our body is a major site for bioenergetics and metabolism during exercise. Carbohydrates and fats are the primary nutrients that provide the necessary energy required to maintain cellular activities during exercise. The metabolic responses to exercise in glucose and lipid regulation depend on the intensity and duration of exercise. Because of the increasing prevalence of obesity, recent studies have focused on the cellular and molecular mechanisms of obesity-induced insulin resistance in skeletal muscle. Accumulation of intramyocellular lipid may lead to insulin resistance in skeletal muscle. In addition, lipid intermediates (e.g., fatty acyl-coenzyme A, diacylglycerol, and ceramide) impair insulin signaling in skeletal muscle. Recently, emerging evidence linking obesity-induced insulin resistance to excessive lipid oxidation, mitochondrial overload, and mitochondrial oxidative stress have been provided with mitochondrial function. This review will provide a brief comprehensive summary on exercise and skeletal muscle metabolism, and discuss the potential mechanisms of obesity-induced insulin resistance in skeletal muscle.

• 한국응용곤충학회지
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• 제31권3호
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• pp.314-327
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• 1992

Insecticide resistance is a serious is a serious threat to IPM, resulting in various adverse effects not to mention the loss of yield in agriculture. One approach to counter the problem is the disruption of resistance mechanisms. This can be achieved by (1) compounds which show a negative correlation with resistance at the site of action, (2) specific metabolic inhibitors which serve as synergists, or (3) a certain combination of two insecticides producing a joint action. This approach, however, requires certain precautions for the side effects may cause an increase in toxicity to mammals. Owing to the recent advances in theoretical studies on resistance management employing computer simulation and mathematical models, a few principles to reduce the risk of development of resistance have been clarified. They are helpful in designing operational strategies with regard to, for instance, insecticide doses to be applied, mode of application, and choice and nature of the insecticide(s) to be used. For restoration of insecticide susceptibility of a resistant population, reintroduction of susceptible individuals to the resistant population is feasible when certain conditions are met. Natural enemies which developed resistance to insecticides can be an important component of IPM as has been shown in the pest management in apple orchards. After all, the implementation of a successful resistance management program depends upon cooperation between different sigments of the agricutural community. Although resistance is a preadaptive phenomenon, in some cases spontaneous loss of resistance does occur without contamination by susceptible individuals. The instability of resistance in these insects implies the possible existence of a switch machanism controlling the expression of resistance gene(s). Elucidation of such a mechanism may eventually provide us with a new technical approach with which we can combat the problem of insecticide resistance.

• 열처리공학회지
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• 제22권5호
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• pp.298-306
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• 2009

Gas nitriding and post oxidation were performed on stainless steels and SACM 645 steel. With increasing gas nitriding time, the increasing rate of nitrided layer was most rapid on SACM 645 steel and the nitriding depth of nitrided layer was most narrow on STS 304 steel among three steels. Corrosion resistance was increased with post oxidation on stainless steels and with increasing time the effect of corrosion resistance was decreased to compare with relatively short gas nitriding time. An improvement effect of corrosion resistance was consisted of predominantly on austenitic stainless steel by post oxidation after gas nitriding among three steels and it was relatively less influenced on martensitic stainless steel.

• Structural Engineering and Mechanics
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• 제36권1호
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• pp.19-36
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• 2010

The load and resistance factors are generally obtained using the First Order Reliability Method (FORM), in which the design point should be determined and derivative-based iterations have to be used. In this paper, a simple method for estimating the load and resistance factors using the first four moments of the basic random variables is proposed and a simple formula for the target mean resistance is also proposed to avoid iteration computation. Unlike the currently used method, the load and resistance factors can be determined using the proposed method even when the probability density functions (PDFs) of the basic random variables are not available. Moreover, the proposed method does not need either the iterative computation of derivatives or any design points. Thus, the present method provides a more convenient and effective way to estimate the load and resistance factors in practical engineering. Numerical examples are presented to demonstrate the advantages of the proposed fourth moment method for determining the load and resistance factors.

• 한국표면공학회지
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• 제30권1호
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• pp.33-43
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• 1997

The effects of process parameters substrate such as substrate current and substrate temperature on the corrosion resistance of ion plated TiN film were investigated. TiN fims were deposited on speed steel on which Ti or Ni hed been previously evaporated. Dense TiN films could be obtained under higher substrate current(1A) and substrate temperature($500^{\circ}C$), whereas TiN films deposited with lower substances current(0.5A) and substrate temperature($300^{\circ}C$) showed porous structure. The corrosion resistances of high speed steel was considerably increased when dense TiN films had been formed on it. The effect of Ti and Ni interlayer on the increase of the corrosion resistance was also significant with dense TiN films, while there was little effect of interlayer on the corrosion resistance when TiN films were porous. the effect of interlayer on the corrosion resistance was more outstanding with Ti then with Ni, because Ti reacts more easily with oxygen to form an oxide layer, and it also shows higher resistance against chlorine containing corrosion media.

• 국제물리치료학회지
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• 제4권2호
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• pp.611-617
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• 2013

The purpose of this study is to identify the effective lumbar area exercise program to prevent falls of the elderly by dividing 14 female elders over 65 living in Daegu into two groups such as resistance exercise group and resistance & stabilization exercise group, and applying a 60 minute exercise program three times a week for 12 weeks. The followings are the results. First, both of resistance exercise and resistance & stabilization exercise brought improvement of lumbar strength and there was no significant difference between two groups. Second, there was no significant difference in lower limb strength in resistance exercise group but resistance & stabilization exercise group showed significant increase in lower limb flexor strength. To make a summary of the above results, it can be said that 12 weeks' resistance & stabilization exercise is effective to the lumbar strength and lower limb strength of the elderly. Accordingly, if combining resistance exercise and stabilization exercise appropriately, we can build a successful preventive program which even the elderly who cannot perform resistance exercise easily can follow.

• 한국콘텐츠학회논문지
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• 제13권6호
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• pp.158-166
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• 2013

본 연구는 사람들이 소셜미디어 수용을 왜 거부하는지를 혁신저항모델과 지각된 위험이론을 적용하여 탐색하였다. 모든 새로운 기술이나 혁신은 수용과정에서 채택 또는 저항이라는 과정을 거친다. 그러므로 저항이라는 것도 수용을 위한 하나의 과정으로 볼 수 있다. 이에 따라 본 연구는 소셜미디어를 적용하여 수용자들이 왜 혁신을 거부 또는 저항하는지를 탐색하였다. 이를 위해 소셜미디어(트위터) 비이용자인 대학생 268명의 자료를 분석에 활용하였다. 주요결과로는 다음과 같다. 첫째, 소셜미디어에 대한 상대적 이점은 혁신저항에 통계적으로 유의미한 부적 영향을 미치는 것으로 나타났다. 둘째, 소셜미디어에 대한 인지적 복잡성은 혁신저항에 통계적으로 유의미한 영향을 미치지 못한 것으로 나타났다. 셋째, 소셜미디어에 대한 지각된 위험은 혁신저항에 통계적으로 유의한 정적 영향을 미치는 것으로 나타났다. 결론적으로 소셜미디어가 사회적 대인관계 매체로서 보다 강화되기 위해서는 상대적 이점을 높이고, 명예훼손이나 인식공격과 같은 위험요소를 줄일 수 있도록 해야 할 것이다.

• KSTLE International Journal
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• 제4권2호
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• pp.47-51
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• 2003

Sliding wear tests have been carried out in room temperature air and water in order to compare the wear resistance of Zr-xNb-xSn alloys of various alloying elements (Nb and Sn). The main focus was to quantitatively compare the wear properties of the recently developed Zr-xNb-xSn alloys with the commercial ones using the evaluation parameters of the wear resistance with the consideration of the worn area. As a result, the recently developed alloys had a similar wear resistance compared with the commercial ones. The dominant factor governing the wear resistance was the protruded volume of the wear debris that was formed on the worn area in the air condition, but the accommodation of the plastic deformation on the contact area in water. In addition, the worn area size appeared to be very different depending on the tested alloys. To evaluate the wear resistance of each test specimen, the ratio of the wear volume or the protruded volume to the worn area ($D_e$ or $D_p$) is investigated and proposed as the evaluation parameters of the wear resistance.

• Corrosion Science and Technology
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• 제11권4호
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• pp.135-140
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• 2012

The linear polarization resistance method is one of the widely used techniques for the corrosion rate monitoring in the water circulating systems of plants. The measurement is simple and rapid, so that a continuous on-line monitoring is possible without any shutdown of plants. A 2-electrode polarization corrosion rate measurement system was installed in a laboratory using a data acquisition board and PC. The signal processing parameters were optimized for the accurate corrosion rate measurement, and the polarization resistance was compensated with the solution resistance measured by the high frequency sine wave signal of an output channel. The precision of corrosion rate data was greatly improved by removing the initial noise signals on measuring the polarization resistance.