• Journal of Food Hygiene and Safety
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• v.2 no.2
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• pp.75-81
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• 1987

Bifunctional monoterpene 유도체의 향의 유무는 분자내에 존재하는 두 개의 관능기인, proton donor(AH)와 proton acceptor(B)가 olfaction과 구조활성 상호작용(SAR)과 밀접한 관계가 있다. 일반적으로 Ohloff가설에 의하면, p-menthane monoterpene 분자내의 AH와 B의 입체배위적 최소거리가 3${\AA}$ 이하인 경우 향을 갖고, 3${\AA}$ 이상인 경우는 향을 갖지 않는다. Bifunctional pinanone, thujane, carane, carvomenthone 및 기타 menthone 유도체 등을 이용하여 이 가설을 확대 연구하였다. Bifunctional monoterpene인 (원문이미지참조) 등은 분자내에 각각 AH (OH 혹은 COOH)와 B (C=O)의 입체배위적 최소 거리가 항상 3${\AA}$ 이하여서 향을 가지며, 이들은 olfactory three point attachment에 의한 구조활성 상관관계를 가지는 것으로 사료된다. 상기 화합물의 proton donor인 OH, 혹은 COOH가 각각 acetylation이나 methylation되는 경우에는 proton donor로서의 기능 상실로 향이 사라지게 되었다.

• KSBB Journal
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• v.13 no.6
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• pp.631-637
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• 1998

The theoretical research of olfaction began about a hundred years ago and the electrophysiological expermental techniques have been used for the olfaction research from 1950's. However, olfaction has not been studied so much as other senses. Recently interest in the offaction mereases for its industrial applications. We descenbe the companson of vertibrate and insect olfactory organs, smell perception mechanism, olfactory signaing transduction, and industnal applications f olfactory system, it is expected that the vanous ongeing researches on the olfactory system will contribute to sensor and scent industnes.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.5
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• pp.478-485
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• 2014

In order to the excellent differentiation of syndromes, we study on the individual characteristic factor by the inspection of face colour and tongue & the auscultation and olfaction. To the subject of diagnosis special books and diagnostics textbook of korean medicine, we arrange the individual characteristic factor by the inspection of face colour and tongue & the auscultation and olfaction. The inspection on the individual characteristic factor was analyzed the face colour, inspection of tongue. The auscultation and olfaction on the individual characteristic factor was analyzed the 25 types by the five-voice (五音) in Huang Di Nei Jing (黃帝內經). As the results, the individual characteristic factor is very important item of the four methods of diagnosis and the differentiation of syndromes. And Therefore the process on four methods of diagnosis and differentiation of syndromesis is necessary to divide the signs of individual characteristic factor and the signs of disease.

• Journal of Aquaculture
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• v.12 no.1
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• pp.63-69
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• 1999

A series of experiments were conducted to examine on what stimulus giant danio (Danio malabaricus) were mainly responsible for detecting alarm substance. When 0.15 ml alarm substance (10 ppm) was introduced into the tank, fish showed no notable change in swimming pattern. However, the introduction of 1.5 ml alarm substance (100 ppm) could induce fright reaction about in 6 minutes. Further, when 15 ml alarm substance (1,000 ppm) was introduced into the tank, fish showed the following fright reaction in a few seconds; suppressing to feed diet, no swimming, strong chasing, and visual alertness. In detecting alarm substance, fish were mainly depending on the chemical stimulus (nares) rather than the vision stimulus (eyes) because fish detected alarm substance by the chemical cue showed the significantly stronger fright reaction than by the visual cue. The time for fish to show the initial fright reaction after detecting alarm substance by the chemical cue was shorter than by the visual cue. Also after alarm substance was introduced into the tank, olfaction-deprived fish showed significantly weaker fright reaction and less frequency of chasing than the normal fish which detected alarm substance by both olfaction and gustation stimulus. These results indicated that chemical stimulus, especially olfaction might be the primary sensory modality used in the detection of the alarm substance for giant danio.

• Journal of the Korean Society of Clothing and Textiles
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• v.34 no.6
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• pp.1033-1041
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• 2010

This study investigates the combined effect of clothing interest and fashion innovativeness on dimensions of scent quality (pleasantness, intensity, familiarity, and congruency) to understand which dimensions of scent quality have significant positive effects on the appeal of scented apparel products. The survey data were statistically analyzed. A structural equation modeling using LISREL was conducted to test the model. Results indicate that clothing interest has a significant impact on scent quality attitude. Positive evaluations of the product were most strongly influenced by the pleasantness quality of the scent. Intensity and familiarity were factors that affected the approach of consumer responses toward scented products. Congruency was not a significant scent quality in generating positive responses for apparel products among consumers.

• Hanyang Medical Reviews
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• v.34 no.3
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• pp.130-136
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• 2014

Animals find nutritious foods to survive, while avoiding aversive and toxic chemicals through the chemosensory faculties of olfaction and taste. The olfaction is comparatively well characterized, but the studies of taste are only recently developing since after 2000. Genetic, immunohistochemistry, and electrophysiological studies with knock-out transgenic mice opened up the taste field in mammals. Taste in insects has been only recently been studied after mammalian taste receptors were identified. Flies also discriminate the differences of sweet, salty and sour food, while being able to detect and reject potential foods contaminated with toxins or detrimental chemicals. These discriminatory abilities indicate that flies house basic taste receptors in their taste organs like humans. For the last decade, the sweet and bitter gustatory receptors in Drosophila have been characterized. In this review, we compare the taste anatomy between humans and insects. We also introduce five canonical taste sensations in Drosophila. In addition, we introduce new taste repertoires, that fruit flies can sense water and fatty acids as well as the carbonation buffer in beverage. These studies on simple model organisms will open up a new potential for scientists to further investigate these characteristics in vertebrates.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1999.03a
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• pp.175-176
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• 1999

• Journal of Sensor Science and Technology
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• v.26 no.5
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• pp.297-300
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• 2017

Realistic media comprised of metadata of the five senses to provide enhanced experiences by stimulating our memory and sensations have had an increasingly pervading effect in our daily lives. Many researchers and companies are in the process of developing their own authoring systems running on different platforms to serve realistic media, resulting in compatibility issues among the systems. To tackle these issues, the International Organization for Standardization have standardized the interface, data format, protocol, API, etc. required to provide the realistic media. In particular, the ISO/IEC 23005 standard, which is called MPEG-V in SC29/WG 11, has defined XML schemas for olfaction interaction based on electronic nose (E-Nose), and scent display. In this paper, the MPEG-V standard for olfaction interaction is reviewed, and a data flow diagram that can be used for olfactory interaction based on the MPEG-V standard was designed. In addition, the necessary schemas related to the E-Nose sensor for olfactory interaction was provided.

• Journal of Rhinology
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• v.25 no.2
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• pp.63-68
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• 2018

Olfactory dysfunction is one of the most common complaints of patients with chronic rhinosinusitis. Patients who suffer from olfactory dysfunction report a negative effect on their overall quality of life. Chronic rhinosinusitis-related olfactory impairment is the most treatable form of olfactory disorder; however, outcomes after endoscopic sinus surgery (ESS) are challenging to predict. Previous studies have documented a wide range in overall improvement after ESS. The purpose of this study is to review the factors that predict changes in olfaction after ESS.

• BMB Reports
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• v.54 no.6
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• pp.295-304
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• 2021

Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory dysfunction is also associated with memory and cognitive dysfunction and is an incidental finding of AD dementia. Here we review neuropathological research on the olfactory system in AD, considering both structural and functional evidence. Experimental and clinical findings identify olfactory dysfunction as an early indicator of AD. In keeping with this, amyloid-β production and neuroinflammation are related to underlying causes of impaired olfaction. Notably, physiological features of the spatial map in the olfactory system suggest the evidence of ongoing neurodegeneration. Our aim in this review is to examine olfactory pathology findings essential to identifying mechanisms of olfactory dysfunction in the development of AD in hopes of supporting investigations leading towards revealing potential diagnostic methods and causes of early pathogenesis in the olfactory system.