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Improving Diagnostic Accuracy for Malignant Nodes and N Staging in Non-Small Cell Lung Cancer Using CT-Corrected FDG-PET (비소세포폐암에서 CT-보정 양전자단층촬영술을 이용한 악성 림프절 평가 및 N 병기 결정 성적 향상)

  • Lee, Eun-Jeong;Choi, Joon-Young;Lee, Kyung-Soo;Chung, Hyun-Woo;Lee, Su-Jin;Cho, Young-Seok;Choi, Yong;Choe, Yearn-Seong;Lee, Kyung-Han;Kwon, O-Jung;Shim, Young-Mog;Kim, Byung-Tae
    • The Korean Journal of Nuclear Medicine
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    • v.39 no.4
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    • pp.231-238
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    • 2005
  • Purpose: We investigated prospectively whether the interpretation considering the patterns of FDG uptake and the findings of unenhanced CT for attenuation correction can improve the diagnostic accuracy for assessing malignant lymph node (LN) and N stage in non-small cell lung cancor (NSCLC) using CT-corrected FDG-PET (PET/CT). Materials & Methods: Subjects were 91 NSCLC patients (M/F 62/29, age: $60{\pm}9$ yr) who underwent PET/CT before in dissection. We evaluated the maximum SUV (maxSUV), patterns of FDG uptake, short axis diameter, and calcification of LN showing abnormally increased FDG uptake. Then we investigated criteria improving the diagnostic accuracy and correlated results with postoperative pathology. In step 1, in was classified as benign or malignant based on maxSUV only. In step 2, LN was regarded as benign if it had lower maxSUV than the cut-off value of step 1 or it had calcification irrespective of its maxSUV. In step 3, LN regarded as malignant in step 2 was classified as benign if they had indiscrete margin of FDG uptake. Results: Among 432 LN groups surgically resected (28 malignant, 404 benign), 71 showed abnormally increased FDG uptake. We determined the cut-off as maxSUV=3.5 using ROC curve analysis. The sensitivity, specificity, and accuracy for assessing malignant LN were 64.3%, 86.9%, 85.4% in step 1, 64.3%, 95.0%, 93.1% in step 2, and 57.1%, 98.0%, 95.4% in step3, respectively. The accuracy for assessing N stage was 64.8% in step 1, 80.2% in step 2, and 85.7% in step 3. Conclusion: interpreting PET/CT, consideration of calcification and shape of the FDG uptake margin along with maxSUV can improve the diagnostic accuracy for assessing malignant involvement and N stage of hilar and mediastinal LNs in NSCLC.

Variation in Catch Size and Changes in Reproductive Biology of Common Octopus Octopus vulgaris in the Coastal Waters Off Gyeongnam, Korea (경남 지역에서 서식하는 참문어(Octopus vulgaris)의 자원 변동과 생식 생태의 변화)

  • Song, Se Hyun;Park, Jong Hyeok;Ji, Hwang-Sung;Choi, Jung Hwa;Kim, Hee Jun;Jeong, Jae Mook;Kim, Do Hoon
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.53 no.1
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    • pp.57-66
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    • 2020
  • The purpose of this study was to provide information about annual variations in catch size and changes in reproductive biology in the common octopus Octopus vulgaris, a commercially important species. Samples were collected from coastal waters off Gyeongnam, Korea, by coastal trap and coastal complex fishery from February to December 2018. Octopus vulgaris have been decreasing in this region since 2007 and catch prices have been increasing. The mantle length (ML) of O. vulgaris ranged from 1.2 to 21.2 cm and body weight ranged from 42.6 to 5,537 g. The sex ratio differed significantly from what was expected, at 0.45:0.55 (P<0.05). Mature females were found from February to December, except in October and November, and males occurred from February to December, except in October. The gonadosomatic index value was higher from May to September than in other months. The total number of eggs in fecund individuals ranged from 40,280 in 578.1 g of body weight to 138,994 in 1,666.5 g of body weight. The relationship between body weight and fecundity was F=76.486BW1.0087 (r2=0.7897). At 50% group maturity, average weight was estimated to be 636.35 g, while it was 969.30 g at 75% maturity and 1736.55 g at 97.5% maturity. This study highlights changes in catch size and reproductive biology between 2007 and 2018. These results provide basic evidence that may be used to establish regulatory policy for O. vulgaris fisheries.

Photo-Leakage Currents in Organic Thin-Film Transistor

  • Cho, Sang-Mi;Han, Seung-Hoon;Kim, Jun-Hee;Lee, Sun-Hee;Choo, Dong-June;Uchiike, H.;Oh, Myung-Hwan;Jang, Jin
    • 한국정보디스플레이학회:학술대회논문집
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    • 2005.07b
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    • pp.1386-1389
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    • 2005
  • We report the light illumination effect on the performance of pentacene organic thin-film transistor (OTFT). The TFT performance with and without illumination were measured at various temperatures. The off-state currents increase linearly with light intensity in the region of gate voltage where the holes are majority carriers in the TFT channel. The minimum photocurrents of OTFT increase with increasing light intensity.

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Nanoparticle Cleaning of AMLCD Backplane

  • Oh, J.H.;Kang, D.H.;Choi, M.H.;Kim, S.H.;Choo, B.K.;Hur, J.H.;Jang, J.;Kim, I.H.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2006.08a
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    • pp.1425-1428
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    • 2006
  • We have proposed a novel cleaning technology with organic nanoparticles for high-performance TFT array. The surface of the TFT layer becomes more hydrophilic after cleaning by the nanoparticles. This is concluded from the comparison of contact angles for the samples cleaned by various methods. It is found that the drain currents in the subthreshold and off-state regions are less than those for the TFTs cleaned with conventional method.

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New S-PVA Technology for Advanced LCD Performance

  • Um, Yoon-Sung;Park, Seung-Beom;Kim, Hoon;You, Hye-Ran;Lyu, Jae-Jin;Kim, Kyeong-Hyeon;Kim, Sang-Soo
    • 한국정보디스플레이학회:학술대회논문집
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    • 2007.08a
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    • pp.403-406
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    • 2007
  • A New S-PVA which is named as charge-shared super PVA (CS S-PVA) LCD mode is proposed. CS SPVA controls the voltage ratio of low pixel by sharing system between low pixel and control cap, resulting in improved off-axis image quality and transmittance increase without any side effects. Moreover, the new S-PVA LCD mode is free of image-sticking. Operating schemes and display performance of CS S-PVA are presented.

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Predictive Values of Magnetic Resonance Imaging Features for Tracheostomy in Traumatic Cervical Spinal Cord Injury

  • Jeong, Tae Seok;Lee, Sang Gu;Kim, Woo Kyung;Ahn, Yong;Son, Seong
    • Journal of Korean Neurosurgical Society
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    • v.61 no.5
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    • pp.582-591
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    • 2018
  • Objective : To evaluate the magnetic resonance (MR) imaging features that have a statistically significant association with the need for a tracheostomy in patients with cervical spinal cord injury (SCI) during the acute stage of injury. Methods : This study retrospectively reviewed the clinical data of 130 patients with cervical SCI. We analyzed the factors believed to increase the risk of requiring a tracheostomy, including the severity of SCI, the level of injury as determined by radiological assessment, three quantitative MR imaging parameters, and eleven qualitative MR imaging parameters. Results : Significant differences between the non-tracheostomy and tracheostomy groups were determined by the following five factors on multivariate analysis : complete SCI (p=0.007), the radiological level of C5 and above (p=0.038), maximum canal compromise (MCC) (p=0.010), lesion length (p=0.022), and osteophyte formation (p=0.015). For the MCC, the cut-off value was 46%, and the risk of requiring a tracheostomy was three times higher at an interval between 50-60% and ten times higher between 60-70%. For lesion length, the cut-off value was 20 mm, and the risk of requiring a tracheostomy was two times higher at an interval between 20-30 mm and fourteen times higher between 40-50 mm. Conclusion : The American Spinal Injury Association grade A, a radiological injury level of C5 and above, an MCC ${\geq}50%$, a lesion length ${\geq}20mm$, and osteophyte formation at the level of injury were considered to be predictive values for requiring tracheostomy intervention in patients with cervical SCI.

Chemotherapy for Malignant Gliomas Based on Histoculture Drug Response Assay : A Pilot Study

  • Gwak, Ho-Shin;Park, Hyeon-Jin;Yoo, Heon;Youn, Sang-Min;Rhee, Chang-Hun;Lee, Seung-Hoon
    • Journal of Korean Neurosurgical Society
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    • v.50 no.5
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    • pp.426-433
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    • 2011
  • Objective : The Histoculture Drug Response Assay (HDRA), which measures chemosensitivity using minced tumor tissue on drug-soaked gelfoam, has been expected to overcome the limitations of in vitro chemosensitivity test in part. We analyzed interim results of HDRA in malignant gliomas to see if the test can deserve further clinical trials. Methods : Thirty-three patients with malignant gliomas were operated and their tumor samples were examined for the chemosensitivity to 10 chosen drugs by HDRA. The most sensitive chemotherapy regimen among those pre-established was chosen based on the number of sensitive drugs or total inhibition rate (IR) of the regimen. The response was evaluated by 3 month magnetic resonance image. Results : Among 13 patients who underwent total resection of the tumor, 12 showed no evidence of disease and one patient revealed progression. The response rate in 20 patients with residual tumors was 55% (3 complete and 8 partial responses). HDRA sensitivity at the cut-off value of more than one sensitive drug in the applied regimen showed a sensitivity of 100%, specificity of 60% and predictability of 70%. Another cut-off value of >80% of total IR revealed a sensitivity of 100%, specificity of 69%, and predictability of 80%. For 12 newly diagnosed glioblastoma patients, median progression-free survival of the HDRA sensitive group was 21 months, while that of the non-sensitive group was 6 months ($p$=0.07). Conclusion : HDRA for malignant glioma was inferred as a feasible method to predict the chemotherapy response. We are encouraged to launch phase 2 clinical trial with chemosensitivity on HDRA.

The Effects of Water Addition on the Color and Crystalline Phase of Y2O3 Coatings Fabricated by Plasma Suspension Spray

  • Park, Sang-Jun;Lee, Jung-Ki;Oh, Yoon-Suk;Kim, Seongwon;Kim, Hyungsun;Lee, Sung-Min
    • Journal of the Korean Ceramic Society
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    • v.53 no.6
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    • pp.641-646
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    • 2016
  • The effects of water addition on $Y_2O_3$ coatings or thick films prepared by plasma suspension spray (SPS) have been investigated. Water addition in suspension media was found to be effective to control the color of a $Y_2O_3$ coating prepared by SPS. The color changed with water addition at the shortest stand-off distance of 50 mm even if samples had the same crystalline phase. Change was not correlated with fragmentation behavior of liquid suspension inside the plasma jet. Water content over 50 vol% was found to produce unmelted particles, indicating that water suppressed heat transfer to the particles. However, plasma jet temperature was not affected. Instead, the coating fabricated with water addition has higher oxygen and lower carbon content compared to these characteristics of the coating without water addition. This was attributed to the retarded complete evaporation of liquid media from the suspension droplet, resulting in inhibition of excessive heating and evaporation of the molten $Y_2O_3$ droplet. In this regard, crystalline phase development with respect to stand-off distance and water addition was discussed.

Manufacture and Characteristics of Peel-off Pack for Natural Cosmetics Using Pullulan and Polysaccharides (Pullulan과 Polysaccharides를 이용한 천연화장품용 필 오프 팩의 제조 및 특성)

  • Jun Soo Kwak;So Young Jung;So Min Lee;Seok-Ju Lee;Sofia Brito;Byungsun Cha;Hyojin Heo;Lei Lei;Sang Hun Lee;Ha-Hyeon Jo;You-Yeon Chun;Ye Ji Kim;Hyung Mook Kim;Mi-Gi Lee;Byeong-Mun Kwak;Bum-Ho Bin
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.49 no.1
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    • pp.67-74
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    • 2023
  • In this study, for a natural cosmetics market, we sought to explore alternatives that can replace polyvinyl alcohol (PVA) of peel-off packs. A peel-off type pack was prepared by combining pullulan, a water-soluble polysaccharide, and other polysaccharides (sodium hyaluronate, cellulose gum, hydroxyethyl cellulose, sodium alginate, corn starch), and the pH, viscosity, and stability against temperature of each peel-off type pack were confirmed. The thickness and tensile strength of the manufactured film were measured for comparison with the PVA peel-off type pack, and applicability, drying speed, and removal degree were measured. Among them, the pullulan-sodium hyaluronate peel-off type pack showed excellent film formation ability to replace the peel-off type pack containing PVA with 5.12% thin film thickness and 4.23% high film tensile strength. When applied to actual skin, the degree of spread of the pack, the usability that can be uniformly applied, and the formation and removal strength of the film when removed after drying were also similar to the peel-off type pack containing PVA. Therefore, it was confirmed that the film formed of pullulan-sodium hyaluronate showed enough physical properties to replace the PVA of the peel-off type pack as a natural peel-off type pack.

Studies on the Pull-up MEMS Switch for the Lower Actuation Voltage and High Speed using Double Electrode

  • Lee, Seong-Dae;Jun, Byoung-Chol;Baek, Tae-Jong;Kim, Soom-Koo;Kim, Sam-Dong;Rhee, Jin-Koo
    • Proceedings of the IEEK Conference
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    • 2005.11a
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    • pp.929-932
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    • 2005
  • We report a pull-up type RF MEMS switch using double electrode without elastic deformation of the cantilever involved in the actuation. At a voltage of 4.5 V, reliable actuations are achieved such that the movable lower contact pad is pulled up by the electrostatic force to make contact with the upper pad. At a frequency of 50 GHz, an insertion loss of 0.7 dB and an isolation of 50.7 dB are obtained from the switch. The measured transient times for switch-on and switch-off are 120 and 80 us, respectively.

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