• Analytical Science and Technology
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• v.24 no.2
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• pp.78-84
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• 2011

The fragmentation patterns of a serine protease inhibitor, camostat, and its degradation product, 4-(4-guanidinobenzoyloxy)phenylacetic acid (GBPA), were for the first time investigated by a triple quadrupole tandem mass spectrometry equipped with an electrospray source (ESI-MS/MS) in positive and/or negative ion mode under collision-induced dissociation (CID). The positive CID spectrum of camostat showed distinctly that the single bond (C-O) cleavage between carbonyl group and oxygen atom of the ester bonds of the compound favorably occurred and then the loss of N,N-dimethylcarbamoylmethyl group was more susceptible than that of guanidine moiety. In the positive ion CID spectrum of GBPA, the initial cleavage between the carbonyl group and oxygen atom of 4-guanidinobenzoyloxy group also occurred, yielding the most abundant fragment ion at m/z 145. On the other hand, the negative CID spectrum of GBPA characteristically showed the occurrence of the most abundant peak at m/z 226 resulting from the sequential neutral losses of $CO_2$ and HN=C=NH from the parent ion at m/z 312.

• Journal of the Korean Regional Science Association
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• v.34 no.3
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• pp.55-68
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• 2018

This paper aims to analyze the changes of the population distribution of metropolitan area by the development of the new town-type innovative city, focusing on the case of the Daegu Innovative City. Using dataset in the survey of population trend and the migration statistics microdata provided by the Statistics Korea, we decomposed population changes of Daegu and surrounding regions into natural increase and social increases(net migration). As a result of the analysis, Dong-gu, where the Daegu Innovation City is located, experienced population growth due to its increase of net migration, whereas the total population in Daegu been decreasing continuously between 2007 and 2016. In particular, the occurrence of high net migration to Dong-gu in 2014 showed a pattern consistent with the completion of the Daegu Innovative City development and the relocation of government institutions from the Seoul metro area. As a result of analyzing the migration to Dong-gu, the population moved from the Seoul metro area was 6.9% of the total, while the population moving from the other 7 gu-gun areas in Daegu (35.8%) and the surrounding regions (8.2%) were significantly high. In particular, the migration to Dong-gu were from neighboring areas, such as Suseong-gu, Buk-gu and Gyeongsan-si. Therefore, the development of the new town-type innovative city could accelerate toward sprawling urban structure.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.6
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• pp.678-686
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• 2019

In this study, marine heat waves on coastal waters of Republic of Korea were detected using satellite-based Sea Surface Temperature Anomaly (SSTA). The detected results were compared with the warm water issues reported by the National Institute of Fisheries Science (NIFS). Marine heat waves detection algorithm using SSTA based on a threshold has proposed. The threshold value was defined as 2℃ for caution and 3℃ for warning issues, respectively. Daily averaged SST data from July to September of 2017-2018 were used to generate SSTA. The satellite-based detection results were classified into nine areas according to the place names used in the NIFS warm water issues. In the comparison of frequency of marine heat waves occurrence to each area with the warm water issue, most areas in the southern coast showed a similar pattern, that is probably NIFS uses spatially well distributed buoys. On the other hand, other sea areas had about two times more satellite detection results. This result seems to be because NIFS only considers the water temperature data measured at limited points. The results of this study are expected to contribute to the development of a satellite-based warm/cold water monitoring system in coastal waters.

• Journal of Environmental Health Sciences
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• v.33 no.5
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• pp.408-421
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• 2007

The concentration characteristics of atmospheric particle matters (PM) including $PM_{2.5},\;PM_{10}$, and TSP were evaluated through the measurement data of PM_{2.5}$ (fine particulate), PM_{10-2.5}$ (coarse particulate), and PM_{over-10}$ collected using a MCI (multi-nozzle cascade impactor) sampler of a three-stage filter pack in spring of 2006 in Iksan area. During the sampling period of 10-15 March and 24 days from 8 April to 2 May, 32 samples for PM of each size fractions were collected, and then measured for PM mass concentrations and water-soluble inorganic ion species. Average concentrations of $PM_{2.5},\;PM_{10}$, TSP were $57.9{\pm}44.1mg/m^3$, $96.6{\pm}89.1mg/m^3$, and $114.8{\pm}99.7mg/m^3$, respectively. Water-soluble inorganic ion fractions to PM mass were found to be 36.5%, 18.0%, and 11.1% for $PM_{2.5}$, $PM_{10-2.5}$ and $PM_{over-10}$, respectively. By showing the high concentrations of PM samples during Asian dust events, those three fractions of PM were distinguished between the samples of Asian dust event and the samples of no event. However, the increase of PM concentrations observed during Asian dust events showed a different pattern for some Asian dust events. The differences of those three fractions in the size distribution may depend on differences on place of occurrence of Asian dust storm and course of transport from China continent to Iksan area in Korea. However, the extent of PM mass contribution during Asian dust events was generally dominated by the coarse particles rather than the fine fraction of PM. The variations of water-soluble inorganic ion species concentration in those three PM fractions between the samples of Asian dust event and the samples of no event were also discussed in this study.

• Journal of the Korean earth science society
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• v.41 no.5
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• pp.447-458
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• 2020

This study presents the K-means clustering analysis-based classification of the meteorological patterns affecting the occurrence of high PM₁₀ concentration in the southeastern region of the Korean peninsula for the last five years (2014-2018). Regional differences in Busan, Ulsan, and Gyeongnam related to high PM₁₀ episodes, were clarified through the statistical comparison study using synoptic scale meteorological elements using NCEP (National Centers for Environmental Prediction/FNL (Final Operational Global Analysis) re-analysis meteorological data. Meteorological patterns were classified into a total of five categories (C1-C5). The incidence of each cluster was 24.8% (C1), 21.3% (C2), 20.4% (C3), 17.3% (C4), and 16.2% (C5), respectively. The high PM₁₀ concentration in the southeastern region resulted from long and short range transports (C1, C3, C5) from outside of the region, and the emissions (C2, C4) inside the region. In the high PM₁₀ episodes in Busan, Ulsan, and Gyeongnam regions, meteorological characteristics such as different geopotential height and wind speed at 500 hPa in each cluster and the change in the location of high pressure over Korean Peninsula is strongly associated with the dispersion of PM₁₀ around inventories in the region and the tendency of long-range transportation of PM₁₀ emitted from outside of region.

• Korean journal of applied entomology
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• v.31 no.3
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• pp.205-240
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• 1992

In reality, it is a green revolution of the entire agricultural matrix in Korea that integrated pest control plays an important role in the possible breakthrough in rice self-sufficiency. In paddy agroecosystem as man-modified environment, rice is newly established every year by transplantation under diverse water regimes which affect a microclimate. Standing water benefits rice by regulating the microclimate, but it favors the multiplication of certain pets through the amelioration of the microclimate. Further, the introduction of high yielding varieties with the changing of cultural practices results in changing occurrence pattern of certain pests. In general, japonica type varieties lack genes resistant to most of the important pests and insect-borne virus diseases, whereas indica type possesses more genes conferring varietal resistance. Thus, this differences among indica type, form the background of different approaches to pest management. The changes in rice cultivation such as double cropping, growing high-yielding varieties requiring heavy fertilization, earlier transplanting, intensvie-spacing transplanting, and intensive pesticide use as a consequence of the adoption of improves rice production technology, have intensified the pest problems rather than reduced them. The cultivation of resistant varieties are highly effective to the pest, their long term stability is threathened because of the development of new biotypes which can detroy these varieties. So far, three biotypes of N. lugens are reported in Korea. Since each resistant variety is expected to maintain several years the sequential release of another new variety with a different gene at intervals is practised as a gene rotation program. Another approach, breeding multilines that have more than two genes for resistance in a variety are successfully demonstrated. The average annual rice losses during the last 15 years of 1977-’91 are 9.3% due to insect pests without chemical control undertaken, wehreas there is a average 2.4% despite farmers’insecticide application at the same period. In other words, the average annual losses are prvented by 6.9% when chemical control is properly employed. However, the continuous use of a same group of insecticides is followed by the development of pest resistance. Resistant development of C. suppressalis, L. striatellus and N. cincticeps is observed to organophosphorous insecticides by the mid-1960s, and to carbamates by the early 1970s in various parts of the country. Thus, it is apparent that a scheduled chemical control for rice production systems becomes uneconomical and that a reduction in energy input without impairing the rice yield, is necessarily improved through the implementation of integrated pest management systems. Nationwide pest forecasting system conducted by the government organization is a unique network of investigation for purpose of making pest control timely in terms of economic thresholds. A wise plant protection is expected to establish pest management systems in appropriate integration of resistant varieties, biological agents, cultural practices and other measures in harmony with minimizing use of chemical applications as a last weapon relying on economic thresholds.

• Economic and Environmental Geology
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• v.29 no.5
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• pp.545-559
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• 1996

Rare metal (Nb-Zr-REE) ore deposits are located in the Chungju area. Geotectonically, the rare metal ore deposits are situated in the transitional zone between Kyeonggi massif and Okcheon belt. The rare metal deposits are distributed in Kyemyeongsan Formation which consist of schist and alkaline igneous rocks. Alkali granite has suffered extensive post-magmatic metasomatism and hydrothermal processes. The ore contains mainly Ce-La, Ta-Nb, Y, Y-Nd, Nd-Th group minerals. More than 15 RE and REE minerals are found in the ore deposits. Allanite, one of the Ce-La rich REE minerals belonging to the epidote group, is the most common mineral in the studied area. The allanite- bearing rocks may be devided into seven types by features of occurrence and mineral associations; zircon type (ZT), allanite-vein type (AT), feldspar type (KT), fluorite type (FT), quartz-mica type (QT), iron-oxide type (MT), and amphibole type (HT). The allanite veins (AT) and zircon rich rocks (ZT) contain the highest total REE contents. Differences in REE abundance can be interpreted in terms of varying portions of magmatic hydrothermal fluid. Petrographical and chemical data are presented for allanites which were collected from different types. The allanites show wide variations in optical properties, due in part to differences in their chemical composition (depending on the types) and to the degree of crystallinity of the individual specimens. Allanite metamicts in biotite are generally surrounded by well developed pleochroic haloes. Usually, allanite is accompanied by zircon and other REE-bearing minerals. CaO and total REE contents $({\sum}RE_2O_3)$ range from 9.29 to 18.79% and 11.66 to 26.31%, respectively. Also, SiO, (28.87~32.61%), $Al_2O_3$ (8.30~16.88%), and $Fc_2O_3$ (16.74~24.38%) contents show varying contents from type to type. The ${\sum}RE_2O_3$ of allanite has positive relationships with $Fe_2O_3$ and negative relaton with CaO, $SiO_2$, and $Al_2O_3$ Backscattered electron microscope images (BEl) of allanite shows that the its mineral composition and texture is very complex. The allanite-bearing hosts show distinct light REE enrichment with strong negative Eu anomaly except for HI. The HT has an almost flat REE distribution pattern with a small negative Eu anomaly. The chemical variation of the allanites with occurrences and mineral association can be related to condition of temperature and oxidation states in precipitation environment.

• 한국해양학회지
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• v.30 no.5
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• pp.442-457
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• 1995

The relationships of environmental factors to the distribution patterns of the three species of ophiuroids, Ophiura kinbergi, O. sarsi and ). sarsi vadicola from Yellow Sea southeast seas and East Sea of Korea were studied to characterize their habitual niches. These three species chosen for study illustrated distinct niche and patterns according to their various preferences mainly for bottom water temperature, bottom water salinity and depth from seven environmental variables which were depth, bottom water temperature and salinity, density, bottom water oxygen content, grain size of the surface sediment, and sediment sorting coefficient. The results of habitat niche study mainly dealing with O. sarsi vadicola suggested that the optimum habitat rages were approximately 6$^{\circ}C$∼10$^{\circ}C$ in bottom temperature and 31%∼33.5% in bottom water salinity which also corresponded with the characteristic ranges of Yellow Sea Bottom Cold Water and higher probabilities of occurrence (more than 70%) were found in depth ranging from 100 to 200 m. In addition, the habitats of O. kinbergi and O. sarsi were compared with that of O. sarsi vadicola. Their ranges of habitat niches were found to have different niches in physical space of bottom water temperature, bottom water salinity and depth. Based on the distribution pattern of O. sarsi vadicola in the Yellow Sea, the ecological barrier which confined the distribution of benthic macro-invertebrates in southern Yellow Sea was determined to be the Yellow Sea Warm Current (approximately 34% < and 18$^{\circ}C$ in December) which occurs between 33$^{\circ}$ and 34$^{\circ}$N of southern Yellow Sea in winter time.

• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.4
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• pp.550-555
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• 2009

Distribution of orthodontic patients in pediatric dental clinics has increased recently. So it is worth to study about the present status of orthodontic patients in pediatric dental clinics. The purpose of this study was to recognize the characteristics and orthodontic patterns of orthodontic patients in pediatric dental clinics. The material consisted of distribution and orthodontic analysis records of 792 new patients in the department of pediatric dentistry, Seoul National University Dental Hospital, from 2006 to 2008. Results were as follows 1. In age distribution, 8-year-olds group comprised 22%, 7-year-olds 19%, 9-year-olds 16%, 10-year olds 15%, 11-year-olds 11%, and other age groups comprised 18%. 2. In skeletal patterns, skeletal class I patients comprised 52%, class II 29%, and class III 19%. 3. In vertical facial types mesofacial comprised 41%, brachyfacial 35%, and dolichofacial 24%. 4. Out of 792 patients 218 patients(28%) showed anterior cross-bite, and the occurrence ratio of anterior cross-bite increased as the age decreased.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.9 no.1
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• pp.75-87
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• 2003

Recently, the occurrence and death rates of cancer have increased rapidly. Metastasis and recurrence is the most important factor of death from cancer. So inhibition of recurrence and metastasis can increase the cure rate of cancer disease. At the basic chinese traditional medicine(TCM), there are a lot of theory related to neoplasm treatment. The metastasis and recurrence of neoplasm was the basis of yudu(餘毒) on remained neoplasm cell and stagnation of blood, thermotoxo, phlegm, asthenia of healthy enerngy and stagnation of vital energy. The principles therapy of neoplasm on metastasis and recurrence was based on knowledge of the method of support the healthy energy and strengthen the body resistance, promote blood circulation to remove blood stasis, clear away heat and toxic materials, dissipate phlegm and disperse the accumulation of evils. But the major clinical features of neoplasm was to be considered in developing a treatment plan include (1) distinguish between clinical and pathologic staging - acute and chronic, (2) classification of pathologic pattern, and (3) distingction of body situation : for examples asthenia - sthenia etc. It was most important to distinguish between supporting the healthy and eliminating the evil factors and to treat differently at the root and the branch cause of a neoplasm. This paper's results indicate that identification and effective use of THM can inhibite netastasis and recurrence and then it will help increasing survival rate. Also as BioTechnology(BT) has developed rapidly nowadays, as genes related to cancer have revealed. So it will give rise to the development of searching the mechanism of herb medicines which have inhibition effects of metastasis and recurrence.