• 제목/요약/키워드: Occupational cancer

검색결과 332건 처리시간 0.029초

Treatment of Vemurafenib-Resistant SKMEL-28 Melanoma Cells with Paclitaxel

  • Nguyen, Dinh Thang;Phan, Tuan Nghia;Kumasaka, Mayuko Y.;Yajima, Ichiro;Kato, Masashi
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권2호
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    • pp.699-705
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    • 2015
  • Vemurafenib has recently been used as drug for treatment of melanomas with $BRAF^{V600E}$ mutation. Unfortunately, treatment with only vemurafenib has not been sufficiently effective, with recurrence after a short period. In this study, three vemurafenib-resistant $BRAF^{V600E}$ melanoma cell lines, $A375P^R$, $A375M^R$ and SKMEL-$28^R$, were established from the original A375P, A375M and SKMEL-28 cell lines. Examination of the molecular mechanisms showed that the phosphorylation levels of MEK and ERK, which play key roles in the RAS/RAF/MEK/ERK signaling pathway, were reduced in these three cell lines, with increased phosphorylation levels of pAKTs limited to SKMEL-$28^R$ cells. Treatment of SKMEL-$28^R$ cells with 100 nM paclitaxel resulted in increased apoptosis and decreased cellular proliferation, invasion and colony formation via reduction of expression levels of EGFR and pAKTs. Moreover, vemurafenib-induced pAKTs in SKMEL-$28^R$ were decreased by treatment with an AKT inhibitor, MK-2206. Taken together, our results revealed that resistance mechanisms of $BRAF^{V600E}$-mutation melanoma cells to vemurafenib depended on the cell type. Our results suggested that paclitaxel should be considered as a drug in combination with vemurafenib to treat melanoma cells.

Organ dose reconstruction for the radiation epidemiological study of Korean radiation workers: The first dose evaluation for the Korean Radiation Worker Study (KRWS)

  • Tae-Eun Kwon;Areum Jeong;Wi-Ho Ha;Dalnim Lee;Songwon Seo;Junik Cho;Euidam Kim;Yoonsun Chung;Sunhoo Park
    • Nuclear Engineering and Technology
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    • 제55권2호
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    • pp.725-733
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    • 2023
  • The Korea Institute of Radiological and Medical Sciences has started a radiation epidemiological study, titled "Korean Radiation Worker Study," to evaluate the health effects of occupational exposure to radiation. As a part of this study, we investigated the methodologies and results of reconstructing organ-specific absorbed doses based on personal dose equivalent, Hp(10), reported from 1984 to 2019 for 20,605 Korean radiation workers. For the organ dose reconstruction, representative exposure scenarios (i.e., radiation energy and exposure geometry) were first determined according to occupational groups, and dose coefficients for converting Hp(10) to organ absorbed doses were then appropriately taken based on the exposure scenarios. Individual annual doses and individual cumulative doses were reconstructed for 27 organs, and the highest values were observed in the thyroid doses (on average 0.77 mGy/y and 10.47 mGy, respectively). Mean values of individual cumulative absorbed doses for the red bone marrow, colon, and lungs were 7.83, 8.78, and 8.43 mSv, respectively. Most of the organ doses were maximum for industrial radiographers, followed by nuclear power plant workers, medical workers, and other facility workers. The organ dose database established in this study will be utilized for organ-specific risk estimation in the Korean Radiation Worker Study.

직업성 피부질환에 대한 현황 파악 및 관리 대책 수립을 위한 연구 (A Study on the Establishment of Management Methods about Occupational Dermatoses)

  • 임현술;정해관;최병순;김지용;성열오;김양호
    • Journal of Preventive Medicine and Public Health
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    • 제29권3호
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    • pp.617-637
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    • 1996
  • Occupational dermatosis is one of the most prevalent occupational disorders. However, the extent of the occupational dermatoses including incidences and prevalencies of each disease entity, and etiologic materials are not yet welt stated in Korea. Authors reviewed the literatures on the statistic data and reports on the occupational dermatoses, and surveyed on the occupational dermatoses in two factories, and surveyed the physicians responsible to the occupational dermatoses with formed questionnaire. The results are as follows; 1. Among medical journals published since 1964, there were 31 articles on the occupational dermatoses. Of 31 articles, 18 were case reports and all others were review articles. Of 18 case reports, 9 were epidemiologic survey. The Workers' Periodic Health Examinations revealed that prevalence of the occupational dermatoses was highest(4.36 per 10,000 workers) in 1974, but number of the cases reported were decreased sharply since 1978 with some tendency to increase since 1981. There were 2,240 reported cases of occupational dermatoses between 1966 and 1992, which is 1.90% of all the reported occupational diseases. Skin infection and injuries due to chemicals were most frequent and there were 6 cases of skin cancer. 2. In an epidemiological survey on the dermatoses among 995 workers in a metal product manufacturing factory and 225 workers in a coal chemical factory, there were 794 with dermatomycosis, 296 workers with acne, 130 workers with scar, 123 workers with deformity of toe nails. Scars, photosensitivity dermatitis, deformity of finger and toe nails, and acne were more prevalent in the metal product manufacturing factory(p<0.05). In the metal prouct manufacturing factory, workers treating organic solvents and oils had more dermatoses than those without treating the materials(p<0.05). On the skin patch performed on 16 workers in the metal product manufacturing factory, there were 8 cases of irritation dermatitis and 5 cases of contact dermatitis. Prevalence of contact dermatitis in the metal product manufacturing factory was 1.3%. 3. On the questionnaire survey, 34 dermatologists, 29 doctors of preventive medicine, and 22 family physician replied. The proportion of occupational etiology among all dermatoses assumed by the physicians were below 9%, and the most important occupational dermatosis in Korea was contact dermatitis. Main etiologic materials related to the occupational dermatosis were organic solvent, acid and alkali, and metals. The reason for the scarcity of report of occupational dermatoses were difficulty in diagnosis and physician's ignorance of the occupational etiology. They replied that to prevent the occupational dermatoses in the workplace, the use of protective devices was most important, and development of diagnostic criteria on the occupational dermatoses is urgent. Above results shows us that there is many workers with occupational dermatoses, but they are mostly unreported. Measures to prevent and manage the occupational dermatoses are not satisfactory at present. Hence, authors suggest measures for the precise diagnosis, report and prevention of the occupational dermatoses. a. Dermatologist, preventive physician, and industrial hygienist should work as a team to examine the high risk group and establish the preventive measures. b. Disease entities, diagnostic criteria of occupational dermatoses should be listed, criteria for the compensation and job fitting at recruitment should be established, and manual for the proper treatment and effective prevention of each occupational dermatosis should be developed. c. Patch test antigens against each occupational category should be developed and it should be available to any physicians responsible. d. To facilitate the diagnosis of occupational dermatoses by the doctors responsible for the Workersr Periodic Health Examination, development of standardized questionnaire, education on the techniques of the patch test, and cooperation with the dermatologist in diagnosis of occupational dermatoses is essential.

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대학병원 내 외래간호사의 포름알데히드 노출 평가 (Exposure to Formaldehyde of Ambulatory Care Nurses in University Hospital)

  • 구동철;이채관;이재환;이수연;윤순영;한아름;김현주;박영범;정성욱;문찬석
    • 한국산업보건학회지
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    • 제24권4호
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    • pp.446-452
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    • 2014
  • Objective: This study aimed to evaluate the exposure status of formaldehyde(FA) among the nurses in ambulatory care departments of university hospital. Methods: Two university hospitals were surveyed. The FA concentration in air were measured to target 62 nurses in 8 ambulatory care departments(89 samples). Air sampling and analysis of FA were carried out according to the OSHA Method ID-205. The survey was conducted with questionnaire asking about how to control FA and whether the nurses use the formaldehyde protectors or not. Results: FA was detected in all samples. The maximum concentration of FA was 0.258 ppm and the geometric mean was 0.023 ppm. There was no sample that exceeded any of exposure standards by OSHA-TWA whereas there were 54 samples(60.7%) that exceeded the standards by NOISH-TWA. Among 62 nurses handling FA, 13 nurses(21.0%) used the protective gloves while nobody used a gas mask. It was assessed that any of 8 common ambulatory care departments did not use a safety cabinet for FA in which local exhaust ventilation was fixed. Conclusions: Nurses in ambulatory care departments were exposed to FA. Therefore, the environment management of a workplace, the health management of a nurses, FA handling education and installing a FA cabinet with a local exhaust ventilation were needed because FA as a carcinogen was able to cause any cancer to a human body if it was emitted in air for long time.

극저주파(Extremely Low Frequency : ELF) 대 전자기장(Electromagnatic field)의 생물학적 영향 (Biological effects of electromagnetic fields at extremely low frequencies)

  • 정해원
    • Journal of Radiation Protection and Research
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    • 제20권3호
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    • pp.187-200
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    • 1995
  • 본 연구는 극저주파대 전자기장(ELF)의 잠재적 건강위해를 문헌을 통해 고찰하였다. 최근의 연구는 주로 거주지 또는 직업적으로 전자기장에 노출된 사람의 암발생 및 출산결과 그리고 신경행동학적인 영향을 조사하기 위한 역학적 조사가 대부분이다. 또한, ELF의 생물학적 영향을 연구하기 위한 실험적 연구도 수행되고 있다. 현재까지의 연구결과를 보면 ELF가 암을 유발한다고 추정은 되지만 확정적으로 단정할 수 있는 증거가 부족하며 암 이외의 생물학적 영향도 추정은 되지만 암과의 연관성보다는 그 근거가 미약하다.

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Health and Economic Costs of Physical Inactivity

  • Kruk, Joanna
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권18호
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    • pp.7499-7503
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    • 2014
  • Physical inactivity has reached epidemic levels in developed countries and is being recognized as a serious public health problem. Recent evidence shows a high percentages of individuals worldwide who are physically inactive, i.e. do not achieve the WHO's present recommendation of 150 minutes of moderate to vigorous intensity per week in addition to usual activities. Living in sedentary lifestyle is one of the leading causes of deaths and a high risk factor for several chronic diseases, like cancer, cardiovascular disease, diabetes type 2, and osteoporosis. This article summarizes evidence for relative risk of the civilization diseases attributable to physical inactivity and the most important conclusions available from the recent investigations computing the economic costs specific to physical inactivity. The findings provide health and economic arguments needed for people to understand the meaning of a sedentary lifestyle. This may be also useful for public health policy in the creation of programmes for prevention of physical inactivity.

Alteration in Leukocyte Subsets and Expressions of FcγR and Complement Receptors among Female Ragpickers in Eastern India

  • Mondal, Nandan K.;Siddique, Shabana;Banerjee, Madhuchanda;Roychoudhury, Sanghita;Mukherjee, Sayali;Slaughter, Mark S.;Lahiri, Twisha;Ray, Manas R.
    • Safety and Health at Work
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    • 제8권2호
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    • pp.198-205
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    • 2017
  • Background: There are a million ragpickers in India who gather and trade recyclable municipal solid wastes materials for a living. The objective of this study was to examine whether their occupation adversely affects their immunity. Methods: Seventy-four women ragpickers (median age, 30 years) and 65 age-matched control housemaids were enrolled. Flow cytometry was used to measure leukocyte subsets, and leukocyte expressions of $Fc{\gamma}$ receptor I (CD64), $Fc{\gamma}RIII$ (CD16), complement receptor 1 (CD35) and CR3 (CD11b/CD18), and CD14. Serum total immunoglobulin-E was estimated with enzyme-linked immunosorbent assay. Results: Compared with the controls, ragpickers had significantly (p < 0.0001) higher levels of CD8-T-cytotoxic, CD16+CD56+natural killer, and CD4+CD45RO+memory T-cells, but depleted levels of CD19+B-cells. The percentage of CD4+T-helper-cells was lower than the control group (p < 0.0001), but their absolute number was relatively unchanged (p = 0.42) due to 11% higher lymphocyte counts in ragpickers. In ragpickers, the percentages of CD14+CD16+intermediate and CD14dim CD16+nonclassical monocyte subsets were elevated with a decline in CD14+CD16-classical monocytes. The expressions of CD64, CD16, CD35, and CD11b/CD18 on both monocytes and neutrophils, and CD14 on monocytes were significantly higher in ragpickers. In addition, ragpickers had 2.7-times more serum immunoglobulin-E than the controls (p < 0.0001). After controlling potential confounders, the profession of ragpicking was positively associated with the changes. Conclusion: Ragpicking is associated with alterations in both innate (neutrophils, monocytes, and natural killer cell numbers and expression of complement and $Fc{\gamma}$ receptors) and adaptive immunity (numbers of circulating B cells, helper, cytotoxic, and memory T cells).

Challenges in Cancer Control Services Provided by Family Physicians in Primary Care: A Qualitative and Quantitative Study From Karabuk Province in Turkey

  • Ozdemir, Raziye;Ural, Sevda;Karacali, Merve
    • Journal of Cancer Prevention
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    • 제23권4호
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    • pp.176-182
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    • 2018
  • Background: Family physicians (FPs) play an important role in cancer control. The aim of this study was to understand the functions of FPs in cancer control and to explore FPs' perceptions of their own roles and the difficulties they face in cancer control in Karabuk province, Turkey. Methods: The study consisted of two methodological parts. The qualitative part included a descriptive study in which data were collected from 87.5% (n=56) out of all FPs in Karabuk using a questionnaire. In the quantitative part, in-depth interviews with 15 FPs were conducted and analyzed through content analysis. Results: Half of the FPs (50.0%) provided cancer prevention information for their registered people, focusing on especially smoking cessation. In the last three months, the proportion of FPs who had not invited anyone to screenings was 37.5% for the pap test, 26.8% for the mammography, 19.0% for the fecal occult blood test and 34.5% for the colonoscopy. Only 16.1% of them reported that they made home visits for cancer patients. In the qualitative part of study, the following themes were highlighted: the perceived responsibilities of FPs regarding cancer control; the effect of geographically undefined working area of FPs; the issues with coordination between FPs and specialists; the effect of the number of primary care team members. Conclusions: Cancer control services provided by FPs have significant problems in terms of the FPs' approach to the services and their content, continuity and coordination.

암환자를 돌보는 가족원의 스트레스, 대처방식과 소진의 관계 (Relationships between Stress, Ways of Coping and Burnout of Family Caregivers of Cancer Patients)

  • 홍민주;태영숙;노미영
    • 종양간호연구
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    • 제12권1호
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    • pp.92-99
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    • 2012
  • Purpose: The study was to examine the relationships between stress, ways of coping and burnout among family caregivers of cancer patients. Methods: Data were collected by self-reported questionnaires from 207 family caregivers of cancer patients at one university hospital and one general hospital in Busan, Korea. The instruments included a Stress Scale, a Ways of Coping Scale and a Burnout Scale. The collected data were analyzed using frequency, percentage, t-test, ANOVA, Scheffe's test, and Pearson's correlation coefficients with the SPSS WIN 19.0 program. Results: Stress was found to have significant relationships with age, relation to the patient, education, monthly income, degree of care-giving, financial burden and activities of daily living of patient. In active coping, there were significant differences according to education and religion. Passive coping was significantly related to gender. In burnout, there were significant differences according to age, relation to the patient, education, occupational status, monthly income, degree of care-giving, financial burden and activities of daily living of patient. Stress and burnout showed a positive correlation, while there was a negative correlation between burnout and active coping. Conclusion: These results suggest that promoting active coping would better support family caregivers of cancer patients in managing burnout effectively.

3차 의료기관에서 진단된 원발성 폐암의 임상적 특성 (Clinical Charicteristics of Primary Lung Cancer Patients in a Tertiary Hospital)

  • 류정선;이훈재;임종한;김루시아;이경희;조재화;윤용한;곽승민;이홍렬;김광호;노준규;정수경
    • Tuberculosis and Respiratory Diseases
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    • 제60권3호
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    • pp.321-329
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    • 2006
  • 연구 배경: 폐암은 2000년에 들어와 우리나라 암 사망 원인 질환 중 1위가 되었으며, 아직 뚜렷한 생존기간의 향상이 없는 예후가 불량한 암이다. 최근 표적 치료제 개발에 따른 후속 연구 및 흡연이 폐암 발병에 미치는 영향에 대한 연구들에서 인종 간 유전적 특성의 차이, 생활환경이 미치는 영향 등이 부각되기도 하였다. 우리나라 폐암 환자의 임상적 특성에 대한 연구는 아직 미흡한 실정이다. 저자 등은 단일 3차 의료기관에서 지난 9년간 확진된 폐암 환자의 임상적 특성을 알아보고자 한다. 방 법: 1996년 9월부터 2005년 8월까지 9년간 본원에 입원하여 폐암으로 진단을 받았던 1655예의 환자를 대상으로 연구하였다. 모든 대상 환자에 있어서 연령, 성별, 세포형, 임상적 병기를 분석하였다. 폐암 진단 당시 설문에 응답하였던 941예의 환자를 대상으로 폐암 가족력, 직업, 흡연력, 임상 증상, 체중감소, 수행상태 등을 조사하였다. 진단 당시 동반 질환으로 당뇨, 고혈압을 포함한 심장혈관질환, 만성폐쇄성폐질환, 특발성 폐섬유화증 및 활동성 폐결핵 등을 조사하였다. 결 과:전체 연구대상 폐암 환자의 남여 성비는 3.6:1 이었다. 세포형은 편평상피세포암이 제일 흔하였고, 여자에서는 선암이 흔한 세포형이었다. 흡연력이 있었던 경우가 80.1%이었고 비흡연자는 19.9%이었다. 여자 72.3%가 비흡연자 이었다. 비흡연자에서는 남여 모두 선암이 제일 흔한 세포형이었고, 흡연력이 있는 환자에서는 편평상피세포암이 흔하였다. 1996년부터 2000년까지와 2001년부터 2005년까지 두 단위 기간으로 나누어 보았을 때, 비소세포폐암 중 선암이 차지하는 빈도의 증가(29.5%에서 33.7%로)추세와 편평상피세포암의 감소(49.9%에서 41.8%로) 추세를 확인할 수 있었다. 환자 중 무증상은 6.2%에서 관찰되었고 흔한 증상으로는 기침, 객담, 호흡곤란 등 순 이었다. 동반 질환으로 만성폐쇄성폐질환, 심장 혈관 질환, 당뇨, 결핵, 특발성 폐섬유화증은 각각 44.1%, 22.2%, 10.7%, 3.9%, 1.6%에서 관찰되었다. 부모, 형제, 자매 중 폐암 가족력이 있었던 환자는 4.4% 이었고, 환자 직업력이 폐암 발병과 관련성이 있을 것으로 추정된 경우는 12.2%이었다. 결 론: 우리나라 폐암 환자에서 높은 흡연율이 관찰되었고 아직 편평상피세포암이 제일 흔한 세포형 이었다. 향후 우리나라 폐암 환자의 임상적 특성에 대한 보다 세밀한 조사가 필요하겠다.