• Journal of Korean Neurosurgical Society
• /
• 제65권6호
• /
• pp.834-840
• /
• 2022

Objective : C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count are inflammatory markers used to evaluate postoperative infections. Although these markers are non-specific, understanding their normal kinetics after surgery may be helpful in the early detection of postoperative infections. To compliment the recent trend of reducing the duration of antibiotic use, this retrospective study investigated the inflammatory markers of patients who had received antibiotics within 24 hours after surgery according to the Health Insurance Review & Assessment Service guidelines and compared them with those of patients who had received antibiotics for 5 days, which was proven to be non-infectious. Methods : We enrolled 74 patients, divided into two groups. Patients underwent posterior lumbar interbody fusion (PLIF) at a single institution between 2019 and 2020. Group A included 37 patients who received antibiotics within 24 hours after the PLIF procedure, and group B comprised 37 patients who had used antibiotics for 5 days. A 1 : 1 nearest-neighbor propensity-matched analysis was used. The clinical variables included age, sex, medical history, body mass index, estimated blood loss, and operation time. Laboratory data included CRP, ESR, and WBC, which were measured preoperatively and on postoperative days (POD) 1, 3, 5, and 7. Results : CRP dynamics tended to decrease after peaking on POD 3, with a similar trend in both groups. The average CRP level in group B was slightly higher than that in group A; however, the difference was not statistically significant. Multiple linear regression analysis revealed operation time, number of fused levels, and estimated blood loss as significant predictors of a greater CRP peak value (r²=0.473, p<0.001) in patients. No trend (a tendency to decrease from the peak value) could be determined for ESR and WBC count on POD 7. Conclusion : Although slight differences were observed in numerical values and kinetics, sequential changes in inflammatory markers according to the duration of antibiotic administration showed similar patterns. Knowledge of CRP kinetics allows the assessment of the degree of difference between the clinical and expected values.

• 인간식물환경학회지
• /
• 제24권4호
• /
• pp.403-413
• /
• 2021

Background and objective: There is growing concern about the effects of modern society on mental health, coming with Covid-19-related caveats on depression, anxiety, and stress (DAS). This can be a subject to provide alternative methods which alleviate DAS. In line with this context, sensory gardens are widely acknowledged to stimulate the five major senses (sight, sound, taste, touch, and smell) and can have a significant (positive) impact on mental health. However, there is limited empirical evidence on the effect of these gardens with regard to alleviating DAS - particularly with respect to urban society This is a gab in knowledge how such limits can be addressed. Accordingly, this present study is clearly needed in order to verify if there are any correlations between sensory gardens and (positive) effects on DAS. The aim of this study was therefore to understand current levels of DAS in a high density building with a sensory garden in a courtyard and determine correlations between experiences in the sensory courtyard and levels of DAS. Methods: The Depression Anxiety and Stress Scale (DASS-21) was employed to test the level of DAS. Results: Additionally, 13 different factors associated with experiences in the building, including the stimulation of the five major senses in the sensory courtyard, were measured to reveal their contribution to mitigating depression, anxiety, and stress. It is noted that the average levels of DAS were 7.91, 7.77 and 9.01 respectively indicating that the mental health of participants requires mental health management. However, results show that factors associated with the sensory courtyard could improve mental health. For example, new social relationships, walking with colleagues, and the stimulation of each of the five major senses in the sensory garden could improve DAS. Conclusion: This illustrates that external experiences are more effective at mitigating depression, anxiety, and stress than internal ones. Factor analysis revealed four components: stimulating the five senses; internal and external facilities; internet-based device use; and new social relationships. There was a strong positive correlation between new social relationships and walking with colleagues. There were also strong positive correlations among the stimulation of each of the five senses. In conclusion, there are strong indications that sensory courtyards can help alleviate DAS and should therefore be promoted, particularly in the current Covid-19 situation wherein the physical and mental health of the public at large are threatened. Accordingly, courtyard design should be rethought in light of the relationship between the positive impact of sensory gardens and mental health.

• International Journal of Computer Science & Network Security
• /
• 제22권9호
• /
• pp.35-42
• /
• 2022

The article deals with the role of extra-curricular work by means of multimedia technologies in order to improve the quality of training of future specialists. An important condition for achieving high results in training specialists is the optimal combination of classroom and independent extra-curricular work of students by means of multimedia technologies. Very significant is the development of student independence, the formation of skills of independent search activity, the ability to take responsibility, independently solve a problem, find constructive solutions, a way out of a crisis situation, and so on. Extra-curricular work forms students' ability to master the techniques of analysis, synthesis, generalization, comparison; develops flexibility of thinking; opens up opportunities for the development and stabilization of positive learning motives to activate the process of mastering knowledge by means of multimedia technologies as a means of forming the personality of a highly qualified specialist. The concept of multimedia as one of the priority areas of Information Technology, which plays a particularly important role in the process of informatization of education, is revealed, and its advantages in education are shown. The advent of multimedia systems optimizes transformations in education, in many areas of professional activity, science, art, etc. The necessity of distance learning to improve the quality of training of future specialists using multimedia technologies in extra-curricular work is justified. The effectiveness of pedagogical support in the process of distance learning is achieved by the following conditions, which is revealed in the article. Various forms and types of extra-curricular work of students that are used in the modern practice of the educational environment of a higher education institution are described. Scientific and informational activity is considered a key area of information activity. The analysis of scientific and information activities in the field of education allows us to identify its main functions, which emphasize the growing role of scientific information in the education system, in particular, extra-curricular work using multimedia technologies. Operational, complete, accurate, targeted information that meets objective and subjective needs becomes an important link between the field of management, science and practice.

• 대한후두음성언어의학회지
• /
• 제33권3호
• /
• pp.172-178
• /
• 2022

Background and Objectives Injection laryngoplasty is a common method for treatment of unilateral vocal fold paralysis. Unilateral vocal fold paralysis has various causes, including idiopathic, infection, stroke, neurologic condition, surgery and nerve invasion by cancer. To the knowledge of the authors, there was no study on the relationship between the causes of vocal cord paralysis and the outcome of injection laryngoplasty. Therefore, we tried to investigate the difference in the outcomes of injection laryngoplasty between vocal cord paralysis after surgery group and nerve invasion by cancer group. Materials and Method A retrospective analysis was performed for 24 patients who underwent vocal cord injection due to unilateral vocal cord paralysis caused by surgery or nerve invasion by cancer. The objective quality of the voice was assessed by acoustic voice analysis with the Multi-Dimensional Voice Program. Results Both group showed an improvement of fundamental frequemcy (F0), jitter percent, shimmer (percent), and noise to hearmonic ratio (NHR) after injection laryngoplasty. The vocal cord paralysis due to nerve invasion group showed more improvement in both the mean and median value of F0, shimmer percent and NHR than the vocal cord paralysis due to surgery group, but there was not statistically significant. Conclusion Our study did not show a statistically significant difference in outcome between vocal cord paralysis due to cancer invasion group and surgery group, but statistically tendency was suggested. The vocal cord paralysis due to nerve invasion group showed more improvement in both the mean and median value of acoustic voice analysis than surgery group.

• 디자인융복합연구
• /
• 제14권2호
• /
• pp.1-16
• /
• 2015

오늘날 아동 비만의 위험성과 영양불균형이 사회적 문제로 떠오르면서 국내에서도 식생활 및 영양정보를 다루는 교육용 콘텐츠·자료 개발이 다양한 형태로 시도되고 있으며 그 중요도가 높아지고 있다. 이에 본 연구에서는 초등학교 저학년 학생을 대상으로 아동이 학교에서 이루어지는 영양교육과 연계하여 자기 주도적으로 학습하고, 습득한 지식을 실생활에 적용하여 올바르고 균형 있는 식생활을 할 수 있도록 하기 위한 맞춤형 영양교육 학습 자료를 디자인 방향을 설정하고자 하였다. 이를 위해 선행연구 및 문헌조사 등을 바탕으로 초등학교 저학년 영양교육에 대한 이론적 고찰을 시행하고, 의료·교육·디자인계 전문가 자문을 통해 저학년 아동을 대상으로 실행될 설문조사를 위한 문항 요소를 도출하여 서울시와 경남 창원시 소재의 초등학교 2곳의 1, 2학년 어린이 110명을 대상으로 설문조사를 실시하였다. 평가 결과, 저학년 아동은 영양교육에 대해 긍정적인 반응을 보였으며, 멀티미디어 기반의 컨텐츠를 활용한 학습 유형과 퀴즈활동을 선호하고, 칼로리 조절 식사에 관하여 학습하고자 하는 의향이 있었다. 학습 자료 디자인 요소에 대해서는 주황, 초록 계열의 색과 고딕류 서체를 선호하였으며, 영양에 대한 정보 표현법으로는 실제의 모습과 흡사한 그림체와 수치측량법 사용에 긍정적인 의견을 나타냈다. 이를 바탕으로 초등학교 저학년인 1,2학년 학생들의 눈높이에 맞춘 자기주도학습 영양교육자료 디자인의 방향성을 설정하였다.

• Nutrition Research and Practice
• /
• 제17권4호
• /
• pp.682-697
• /
• 2023

BACKGROUND/OBJECTIVES: Tibetan tea is a kind of dark tea, due to the inherent complexity of natural products, the chemical composition and beneficial effects of Tibetan tea are not fully understood. The objective of this study was to unravel the composition of Tibetan tea using knowledge-guided multilayer network (KGMN) techniques and explore its potential antioxidant and hypolipidemic mechanisms in mice. MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH2O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method. RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism. CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.

• Tuberculosis and Respiratory Diseases
• /
• 제86권4호
• /
• pp.284-293
• /
• 2023

Background: Attitudes towards smoking, lung cancer screening, and perceived risk of lung cancer have not been widely studied in Malaysia. The primary objective of this study was to describe the factors affecting the willingness of high-risk current smokers and ex-smokers to undergo low-dose computed tomography (LDCT) screening for lung cancer. Methods: A prospective, cross-sectional questionnaire study was conducted in current smokers or ex-smokers aged between 55 and 80 years at three hospitals in Kota Kinabalu, Sabah, Malaysia. The questionnaire recorded the following parameters: perceived lung cancer risk; Prostate Lung Colon Ovarian Cancer 2012 risk prediction model excluding race and ethnicity predictor (PLCO_m2012norace); demographic characteristics; psychosocial characteristics; and attitudes towards lung cancer and lung cancer screening. Results: A vast majority of the 95 respondents (94.7%) indicated their willingness to undergo screening. Stigma of lung cancer, low levels of knowledge about lung cancer symptoms, concerns about financial constraints, and a preference for traditional medication were still prevalent among the respondents, and they may represent potential barriers to lung cancer screening uptake. A desire to have an early diagnosis (odds ratio [OR], 11.33; 95% confidence interval [CI], 1.53 to 84.05; p=0.02), perceived time constraints (OR, 3.94; 95% CI, 1.32 to 11.73; p=0.01), and proximity of LDCT screening facilities (OR, 14.33; 95% CI, 1.84 to 111.4; p=0.01) had significantly higher odds of willingness to undergo screening. Conclusion: Although high-risk current smokers and ex-smokers are likely to undergo screening for lung cancer, several psychosocial barriers persist. The results of this study may guide the policymakers and clinicians regarding the need to improve lung cancer awareness in our population.

• Animal Bioscience
• /
• 제37권4호
• /
• pp.609-621
• /
• 2024

Objective: Hair follicle stem cells (HFSCs) differentiation is a critical physiological progress in skin hair follicle (HF) formation. Goat HFSCs differentiation is one of the essential processes of superior-quality brush hair (SQBH) synthesis. However, knowledge regarding the functions and roles of miR-133a-3p and miR-145-5p in differentiated goat HFSCs is limited. Methods: To examine the significance of chi-miR-133a-3p and chi-miR-145-5p in differentiated HFSCs, overexpression and knockdown experiments of miR-133a-3p and miR-145-5p (Mimics and Inhibitors) separately or combined were performed. NANOG, SOX9, and stem cell differentiated markers (β-catenin, C-myc, Keratin 6 [KRT6]) expression levels were detected and analyzed by using real-time quantitative polymerase chain reaction, western blotting, and immunofluorescence assays in differentiated goat HFSCs. Results: miR-133a-3p and miR-145-5p inhibit NANOG (a gene recognized in keeping and maintaining the totipotency of embryonic stem cells) expression and promote SOX9 (an important stem cell transcription factor) expression in differentiated stem cells. Functional studies showed that miR-133a-3p and miR-145-5p individually or together overexpression can facilitate goat HFSCs differentiation, whereas suppressing miR-133a-3p and miR-145-5p or both inhibiting can inhibit goat HFSCs differentiation. Conclusion: These findings could more completely explain the modulatory function of miR-133a-3p and miR-145-5p in goat HFSCs growth, which also provide more understandings for further investigating goat hair follicle development.

• 심성연구
• /
• 제35권1호
• /
• pp.1-65
• /
• 2020

Bonny Method of Guided Imagery and Music(BMGIM)은 음악에 의해 떠오른 심상경험을 통해 자기인식에 이르는 것을 목적으로 하는 개인 심리치료법이다. BMGIM에서는 심상을 다룰 때 내담자의 통찰에 중점을 두지만, 내담자들이 때로는 심상경험의 의미를 이해하지 못해 혼란스러워하는 경우도 있다. 또한 치료사와 내담자들은 BMGIM의 경험을 인과적-환원적 관점에서 보는 경향이 있다. 이 논문은 BMGIM 심상경험의 의미를 이해하기 위해 심상을 상징으로 보고, 목적의미를 중시하는 융 학파의 관점에서 심상경험을 해석해 본 것이다. 먼저 BMGIM의 정의와 절차를 다루어 보았고, 그 다음에 BMGIM의 구성 요소로서의 음악과 심상을, 그리고 마지막으로 두 여성 내담자의 BMGIM 심상의 상징적 의미를 살펴보았다. 치료사와 내담자 모두 심상경험을 보다 깊이 살펴봄으로써 심상의 상징적 의미뿐 아니라 내담자의 상처와 고통의 목적의미를 새롭게 인식할 수 있었고, 특히 다음 세 가지 사실을 확인할 수 있었다. 첫째로, BMGIM도 꿈이나 적극적 명상과 마찬가지로 정신의 자발적 내용을 다룬다는 것이다. 둘째로, BMGIM에서도 인격의 발전, 치유와 전체성을 지향하는 객체정신의 자율성이 나타난다는 것이다. 마지막으로, 융 학파의 관점이 심상경험의 의미를 보다 깊고 풍부하게 이해하는데 도움이 된다는 것이다. 이런 점에서 BMGIM도 꿈 분석이나 적극적 명상처럼 무의식을 다루는, 유용한 치료적 도구가 될 수 있으리라 여겨진다.

• 경영정보학연구
• /
• 제25권1호
• /
• pp.233-255
• /
• 2023

코로나19로 인한 팬데믹 상황에서도 여전히 여행에 대한 욕구와 수요가 시장에 존재하고 있다. 이러한 상황에서 정보기술(IT)의 발달로 인해 온라인에 대한 접근성과 유용성 및 디지털 기기의 활용도 함께 증가하였고, 비대면으로도 새로운 경험을 얻을 수 있는 '온라인 체험(Online Experience)' 시장이 급격하게 성장하였다. 본 연구는 AirBnB 온라인 체험 서비스에서 서비스제공자(Provider-oriented)와 서비스이용자(User-oriented)에 의해 생성된 정형 및 비정형 데이터가 고객만족에 미치는 영향에 대해 분석하였다. 분석에 사용된 데이터는 파이썬 웹크롤러로 수집되었으며, 주요 변수인 비정형 데이터는 전처리와 감성분석을 거쳐 회귀분석에 사용되었다. 분석 결과, 주요변수인 호스트가 생성한 체험 소개글, 호스트 소개글과 같은 비정형 데이터는 텍스트의 생성 목적에 따라 주관도(Subjectivity)가 다르게 나타나며, 체험 소개글은 주관적일수록, 호스트 소개글은 객관적일수록 고객 만족에 유의한 정의 영향을 미치는 것을 확인하였다. 또한, 에어비앤비 온라인 체험에 참여한 게스트가 생성한 정형 데이터는 다른 게스트의 만족에 긍정적인 영향을 미치는 것을 확인하였다. 본 연구 결과는 온라인 공유경제 플랫폼 이해관계자 및 온라인 체험 지식경영에 관심을 갖는 연구자에게 다양한 시사점을 제공할 것으로 기대한다.