• Journal of Korean Neurosurgical Society
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• v.29 no.8
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• pp.1008-1018
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• 2000

Objective : Glutamate induced excitotoxicity is one of the leading causes of cell death under pathologic condition. However, there is controversy whether excitotoxicity may also participate in the neuronal death under low intensity insult such as simple hypoxia or hypoglycemia. To investigate the role of NMDA receptor in low intensity insult, we chose anoxia as the method of injury and used organotypically cultured hippocampal slice as the material of experiment. Materials & Methods : The hippocampal slices cultured for 2-3 weeks were exposed to 60 minutes of complete oxygen deprivation(anoxia). Neuronal death was assessed with Sytox stain. Corrected optical density of fluorescence in gray scale, used as cellular death indicator, was obtained from pictures taken at 24 and 48 hours following the insult. The well-known in vivo phenomenon of regional difference in susceptibility of hippocampal sub-fields to ischemic insult was reproduced in HOSC(hippocampal organotypic slice culture) by complete oxygen deprivation injury. Results : $CA_1$ was the most vulnerable to complete oxygen deprivation in hippocampus while $CA_3$ was resistant. Oxygen deprivation for 10 and 20 minutes with glucose(6.5g/l) present was insufficient to induce neuronal death in the cultured hippocampal slice. However, after 30 minutes exposure under anoxic condition, neuronal death was able to be detected in the center of $CA_1$ area. The intensity and area of fluorescence indicating cell death correlated with the duration of oxygen deprivation. NMDA receptor and non-NMDA receptor blocking with MK-801(30 & $60{\mu}M$) and CNQX($100{\mu}M$) did not provide cellular protection to HOSC against damage induced by oxygen deprivation, but increased intracellular calcium buffering capacity with BAPTA-AM($10{\mu}M$) was effective in preventing neuronal death (p=0.01, Student's t-test). Cycloheximide($1{\mu}g/ml$, $10{\mu}g/ml$) provided no protection to HOSC against insult of complete oxygen deprivation for 60 minutes and combined therapy of MK-801(30 & $60{\mu}M$) and cycloheximide(1 & $10{\mu}g/ml$) was also ineffective in preventing neuronal death. Conclusion : The results of this study show that the another mechanism not associated with glutamate receptor(NMDA & non NMDA) may play major role in cell death mechanisms induced by complete oxygen deprivation and increased intracellular calcium during anoxia may participate in the neuronal death mechanism of oxygen deprivation. Further investigation of the calcium entry channel activated during oxygen deprivation is necessary to understand the neuronal death of anoxia.

• Therapeutic Science for Rehabilitation
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• v.7 no.1
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• pp.37-50
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• 2018

Objective : The purpose of this study was to develop a competency indicators of occupational therapists for occupation-based intervention by conducting a Delphi survey to occupation-based intervention experts. Methods : After analyzing the data related to occupational therapists indicators in korea, the results of Delphi survey were collected three times from October to December 2016. Based on the results, we developed occupational therapists competency indicators for occupation-based intervention through expert panel's opinions. Results : Based on the eight competency elements, the competency indicators were examined by 133 primary and 133 secondary competency indicators. Finally, 131 competency indicators were developed based on 8 components as occupational therapist competence indicators for occupation-based intervention. The results of the third delphi showed a high level of content validity of .95, stability of .10, convergence of 0, and consensus of 1. Conclusion : The developed occupational therapist competence indicators for occupation-based intervention could be used in various clinical decision making such as occupation-based intervention, education training, education development and evaluation.

• Applied Chemistry for Engineering
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• v.16 no.3
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• pp.372-378
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• 2005

Calcium Carbonate Saturation Index (LI: Langelier Index), an indicator of $CaCO_3(s)$ saturation, indicates corrosiveness of drinking water and it has been used to monitor drinking water conditions in USA, E.U, and Japan. The objective of this research was to measure LI parameters including water temperature, pH, total alkalinity, calcium ion concentration, and electric conductivity, and to evaluate possibility of using LI in domestic system. Results showed that water temperature varied from 2.0 to $26^{\circ}C$ during 15 months, indicating an average annual temperature of $23.9^{\circ}C$. Total alkalinity was from 20 to 45 mg/L. The concentration difference between total alkalinity and $HCO_3{^-}$ value was hardly observed; the concentration of total alkalinity can be replaced by that of $HCO_3{^-}$. Tap water had a medium corrosiveness since LI values were from 2.0 to 0.5. To reduce the corrosiveness and to increase LI values of drinking water, the results of this study showed that chemicals such as $Ca(OH)_2$, $CaCO_3$, NaOH, or $NaHCO_3$ should be added to water treatment plants.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.5
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• pp.640-649
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• 2018

This study analyzed the consumer awareness of cycling wear using web mining, one of the big data analysis methods. For this, the texts of postings and comments related to cycling wear from 2006 to 2017 at Naver cafe, 'people who commute by bicycle' were collected and analyzed using R packages. A total of 15,321 documents were used for data analysis. The keywords of cycling wear were extracted using a Korean morphological analyzer (KoNLP) and converted to TDM (Term Document Matrix) and co-occurrence matrix to calculate the frequency of the keywords. The most frequent keyword in cycling wear was 'tights', including the opinion that they feel embarrassed because they are too tight. When they purchase cycling wear, they appeared to consider 'price', 'size', and 'brand'. Recently 'low price' and 'cost effectiveness' have become more frequent since 2016 than before, which indicates that consumers tend to prefer practical products. Moreover, the findings showed that it is necessary to improve not only the design and wearability, but also the material functionality, such as sweat-absorbance and quick drying, and the function of pad. These showed similar results to previous studies using a questionnaire. Therefore, it is expected to be used as an objective indicator that can be reflected in product development by real-time analysis of the opinions and requirements of consumers using web mining.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.2
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• pp.245-251
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• 2018

Objective: This study was conducted to determine the effects of dietary maifanite supplementation and fecal collection method on the apparent total tract digestibility (ATTD) of calcium (Ca) and phosphorus (P) and blood parameters in growing pigs. Methods: Thirty-six growing barrows (Duroc${\times}$Landrace${\times}$Yorkshire; $27.0{\pm}2.6kg$) were allotted to six dietary treatments with 6 pigs per treatment according to body weight in a completely randomized design. The experimental treatments were: i) Low Ca+cornstarch (2.25%), ii) Low Ca+maifanite (2.25%), iii) Medium Ca+cornstarch (1.42%), iv) Medium Ca+maifanite (1.42%), v) High Ca+cornstarch (0.64%), and vi) High Ca+maifanite (0.64%). Feces were collected by the total collection (TC) and indicator method (IM). At the beginning and the end of the experiment, blood samples were collected from each pig. Results: For the TC method, there were no difference in Ca intake, fecal Ca output, Ca retention and the ATTD of Ca between cornstarch and maifanite diets at the same dietary Ca level. However, urinary Ca excretion was lower (p = 0.01) in pigs fed low Ca diets without maifanite supplementation compared with other dietary treatments. Dietary maifanite supplementation had no effect on the P metabolism in growing pigs. For the IM method, there was no difference in Ca digestibility between cornstarch and maifanite diets at the same dietary Ca level. The ATTD of P was greater (p<0.01) in pigs fed the high Ca diet with maifanite supplementation compared with the high Ca diet with cornstarch treatment. Dietary inclusion of maifanite had no effect on blood parameters in growing pigs. Conclusion: Dietary maifanite supplementation had no effect on the ATTD of Ca and P and serum parameters in growing pigs. The IM resulted in lower digestibility values than the TC method.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.11
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• pp.724-731
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• 2016

The purpose of this study was to determine what rules or patterns exist when people gaze at a villa savoye, which is probably Le Corbusier's best known building, using eye-movement tracking techniques. Villa savoye was designed, addressing his emblematic "Five Points", such as pilotis, functional roofs, free floor plans, long horizontal windows, and freely-designed facades. This study examined how the villa savoye's facade image is formed in an objective manner. This study selected a total of 56 test subjects, and showed them an image of a villa savoye. Using eye-movement tracking tools, this study recorded where they mostly gazed at when seeing the building. In addition, an experiment was carried out to test the different points of view, relating to visual attention, between the two groups with different levels of knowledge in architecture. To analyze the data, the Gaze Frequency was used as the key indicator. The results showed that the subjects have a higher degree of attention to either the door or window in general than in former studies. The architecture major group showed that they gazed the experiment image more evenly.

• Journal of Korean Society of Rural Planning
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• v.21 no.2
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• pp.79-90
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• 2015

In empirical studies on rural development projects, differentiation tends to be considered a strategy aimed at increasing the number of visitors. Rural development projects include the improvement of living environment, and the discussion about project goals and evaluation of project results are often focused on the aspect of rural tourism. Thus, subjective benefits of such projects for residents are omitted. This study examines the meaning of differentiation from the perspective of residents and explores the validity of the number of visitors and the possibility of reflecting residents' subjective score as evaluation indicators for a project. To achieve such an objective, this study uses survey data collected from 153 people in 38 comprehensive development projects in areas of Eup and Myeon, Korea. The results of this study show that differentiation is viewed as a by-product of positive improvement from a rural development project, from the perspective of residents. The effects of rural development are classified into two dimensions: socioeconomic effects and living environmental effects. Landscape improvement is included in the dimension of living environmental effects and an increase in the number of visitors is included in the dimension of socioeconomic effects. As such, they are confirmed to be the factors that determine the level of differentiation. For example, the increase in the number of visitors is confirmed to be a valid indicator of project success, in which two-dimensional characters are reflected. The level of differentiation evaluated by residents is a result of the workings of the above two factors. Unlike in previous studies, the possibility of evaluation based on the perception of residents is confirmed in the evaluation of results. When the level of differentiation is interpreted as the direct result of a project, the number of visitors has an impact on socioeconomic effects, and the project content of landscape improvement has an impact on living environmental effects. The goal of policy and residents is the same in terms of the effort residents may make in maximizing results of a project by themselves; thus, the government's goal is achieved even when a project is carried out under the autonomy of residents. Ultimately, the government should focus on providing conditions in which active citizen participation can not only occur but help to establish a policy direction, which subsequently strengthens the substantial rights of residents.

• Journal of Sasang Constitutional Medicine
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• v.23 no.3
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• pp.275-284
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• 2011

1. Objective: This literary review investigates Lee Jema's clinical experiences with Soyang-type patients and their influence on his conceptualization of the Soyang physiology and pathology. 2. Methods: 1) The case reports in "Soyang constitutional type: Spleen Cold-based Exterior-Cold disease" were compared before and after the Sinchuk revision to explore the temporal change in the Sasang medical concepts. 2) The texts in Donguisusebowon (Gabo edition) and Donguisusebowon (Sasangchobongwon) were analyzed to investigate the pathological concepts appearing before the completion of the Donguisusebowon (Gabo edition). 3) The texts in Donguisusebowon (Sinchuk edition) was analyzed to investigate the pathological concepts formed between the Gabo and Sinchuk editions of Donguisusebowon. 3. Results and Conclusions: 1) Gabo edition : The Gabo edition divided the External-origin Exterior disease into Cold-dominant (Heat-moderate) and Heat-dominant (Cold-moderate) patterns and differentiated the severity of Exterior-based Exterior disease and Interior-based Interior disease into mild, moderate, severe, and critical conditions. Cold-damage Delirium disease pattern was categorized as an Interior-based Interior disease, and the treatment protocol using Baekho-tang (Baihu-tang) was established. The stool condition and bowel movement reflecting the patient's defecation habits, the prime indicator of health in the Soyang constitutional type, were emphasized on their importance. 2) Sinchuk edition: The Delirium disease pattern was moved into the Exterior-cold disease, and the treatment protocol applying Jihwangbaekho-tang (Dihuangbaihu-tang) and Hyeongbangsabaek-san (Jingfangxiebai-san), with variational usage of Gypsum, was newly established. The Seong-Jeong and basal disease patterns were suggested as important factors in treating the patients. Also, it was proposed that the symptoms and signs reflecting the condition of the life-preserving energy be assessed to understand the patient's current condition. The importance of post-acute rehabilitation and aftercare as well as the most appropriate acute-stage treatment were emphasized.

• Journal of Korean Neurosurgical Society
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• v.50 no.4
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• pp.370-376
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• 2011

Objective : Posttraumatic cerebral infarction (PTCI), an infarction in well-defined arterial distributions after head trauma, is a known complication in patients with severe head trauma. The primary aims of this study were to evaluate the clinical and radiographic characteristics of PTCI, and to assess the effect on outcome of decompressive hemicraniectomy (DHC) in patients with PTCI. Methods : We present a retrospective analysis of 20 patients with PTCI who were treated between January 2003 and August 2005. Twelve patients among them showed malignant PTCI, which is defined as PTCI including the territory of Middle Cerebral Artery (MCA). Medical records and radiologic imaging studies of patients were reviewed. Results : Infarction of posterior cerebral artery distribution was the most common site of PTCI. Fourteen patients underwent DHC an average of 16 hours after trauma. The overall mortality rate was 75%. Glasgow outcome scale (GOS) of survivors showed that one patient was remained in a persistent vegetative state, two patients were severely disabled and only two patients were moderately disabled at the time of discharge. Despite aggressive treatments, all patients with malignant PTCI had died. Malignant PTCI was the indicator of poor clinical outcome. Furthermore, Glasgow coma scale (GCS) at the admission was the most valuable prognostic factor. Significant correlation was observed between a GCS less than 5 on admission and high mortality (p<0.05). Conclusion : In patients who developed non-malignant PTCI and GCS higher than 5 after head injury, early DHC and duroplasty should be considered, before occurrence of irreversible ischemic brain damage. High mortality rate was observed in patients with malignant PTCI or PTCI with a GCS of 3-5 at the admission. A large prospective randomized controlled study will be required to justify for aggressive treatments including DHC and medical treatment in these patients.

• Journal of the Korean Geographical Society
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• v.50 no.5
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• pp.485-503
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• 2015

This study aims at evaluating geomorphological classification systems to predict the occurrence of landslides in mountainous region in Korea. Geomorphological classification systems used in this study are Catena, TPI, and Geomorphons. Study sites are Gapyeong-gun, Hoengseong-gun, Gimcheon-si, Yeoju-si/Yicheon-si in which landslide occurrence data were collected by local governments from 2001-2014. Catena method has objective classification standard to compare among regions objectively and understand the result intuitively. However, its procedure is complicated and hard to be automated for the general public to use it. Both TPI and Geomorphons have simple procedure and GIS-extension, therefore it has high accessibility. However, the results of both systems are highly dependent on the scale, and have low relevance to geomorphological formation process because focusing on shape of terrain. Three systems have low compatibility, therefore unified concept are required for broad use of landform classification. To assess the effectiveness of prediction on landslide by each geomorphological classification system, 50% of geomorphological classes with higher landslide occurrence are selected and the total landslide occurrence in selected classes are calculated and defined as 'predictive ability'. The ratio of terrain categorized by 'predictive ability' to whole region is defined as 'vulnerable area ratio'. An indicator to compare three systems which is predictive ability divided by vulnerable area ratio was developed to make a comprehensive judgment. As a result, Catena ranked the highest in suitability.