• 전기학회논문지P
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• 제66권3호
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• pp.117-122
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• 2017

Due to the aging and obesity population in Korea, degenerative musculoskeletal diseases and people suffering from degenerative arthritis are increasing day by day. So, it is necessary to develop rehabilitation treatment device. Conventional high-frequency treatment devices have disadvantages in that therapeutic range is narrow, cost is high, image is adversely affected, treatment time is long, and failure rate is high. This paper proposes a customized therapy device that is stable and effective in reducing treatment time and output to target body part using 2MHz switching frequency, feedback control technique, and joint insulation flexible multipolar electrode. The device can be a new concept high-frequency stimulator to accommodate the advantages of CET and RET.

• 한국정밀공학회지
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• 제31권11호
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• pp.1051-1058
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• 2014

In this study, we investigated the improvement effect of obesity by treatment with a developed low frequency electrical stimulation system. Thirty female in their 20's as an experiment subjects divided 3 groups(control, commercialized device, developed device) were treated with electrical stimulation on abdomen for 4 weeks. The body weight, body mass index(BMI), waist-hip ratio(WHR), muscle strength, muscle(transverse abdominis(TrA), internal obliquus abdominis(IO), external obliquus abdominis(EO)), fat thickness and abdominal surface temperature were measured by electromyogram(EMG), ultrasound and digital infrared thermal image(DITI). In the result, the body weight and BMI were decreased. Subcutaneous abdominal fat were significantly reduced after 4 weeks. The muscle strength and TrA muscle thickness was increased 13.2%(p<0.05), and 35.5%, respectively. The fat thickness showed decrease in abdomen (p<0.05). Infrared measurement on abdominal surface temperature as a parameter of improvement in blood circulation was significantly increased(p<0.05). Therefore, the low frequency stimulation showed positive effects on parameters of the obesity improvement.

• 대한의용생체공학회:의공학회지
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• 제45권1호
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• pp.43-48
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• 2024

The prevalence of obesity and its complications is steadily increasing worldwide. It is essential to understand cellular level metabolism and microenvironment to treat diseases related to lipid metabolism. Mechanical loading can activate signaling pathway by stimulating cells, especially vibration loading known to inhibit adipogenesis, so it has been studied as a treatment for obesity. Also, vibration loading can affect the inside of the human body non-invasively. Another clue to reducing adipose tissue is browning, which means that white adipocytes changes to brown adipocyte. In this study, we design and developed a device that that can control cell-cell contact, and vibration simulation device. Using these two devices, we investigated responses of cells to vibration loading. Protein expression associated with browning and adipogenesis were analyzed. In conclusion, vibration loading can be transmitted through cell contact and loading applied to the cells can induce browning and inhibit adipogenesis of preadipocytes. These results suggest the possibility that vibrations could be a treatment for obesity.

• 한국정보전자통신기술학회논문지
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• 제9권1호
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• pp.45-48
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• 2016

비만을 치료하기 위해 다양한 비만 치료기가 개발되어 왔으며, 초음파는 온열 및 진동작용으로 지방이 분해가 되기 쉬운 상태로 변하게 만든 후 혈액 및 림프액의 흐름을 촉진시켜 혈액으로 지방산 배출이 될 수 있도록 한다. 이러한 초음파 비만 치료기에 트랜스듀서 어레이가 사용되는데 트랜스듀서 어레이의 집속각도와 주파수는 지방을 분해하는데 중요한 영향을 미칠 수 있다. 본 논문에서는 트랜스듀서 어레이의 주파수를 설정하기 위해 27kHz, 1MHz, 3MHz의 주파수에 직경 5mm, 10mm, 16mm의 트랜스 듀서를 적용하여 파장과 근위장을 구하여 설정온도에 가장 짧은 시간에 도달하는 주파수를 설정하고, 3개 면이 닿는 트랜스듀서의 집속 각도를 설정하였다. 결과적으로 3MHz 주파수 일 때 설정온도에 도달하는 시간이 짧았으며, 집속각도는 $40^{\circ}$가 적정하였다.

• Journal of Nutrition and Health
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• 제53권1호
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• pp.83-97
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• 2020

본 연구는 비만과 영양 관리가 필요한 30세 이상의 유방암 환자 43명을 대상으로 모바일 기기를 활용하여 영양관리를 통한 비만 및 식습관 개선 효과를 조사하였다. 중재 연구 이후 시험군의 체중은 통계적으로 유의하지는 않았으나 0.8 kg 감소하였으며, WHR은 0.75에서 0.71로 유의하게 감소하였다 (p = 0.012). 또한 영양지수가 61.3점에서 69.6점으로 유의적으로 높아졌으나 (p < 0.001) 대조군은 61.5점에서 59.0점으로 유의적으로 낮아졌으며 (p = 0.002) 중재 후 영양지수 변화를 두 군 간에 비교한 결과에서도 유의적인 차이가 있는 것으로 나타났다 (p < 0.001). 식품섭취빈도 조사 결과에서 과일, 우유 및 유제품, 콩 및 콩제품, 생선 및 조개류, 육류 및 육가공품, 가금류, 견과류 섭취빈도의 경우 시험군에서만 유의적으로 증가하였으며, 과자 및 달거나 기름진 빵, 라면류, 외식 또는 배달음식의 섭취빈도는 시험군에서만 유의적으로 감소하였다. 식이기록법 결과에서도 비타민C, 칼륨, 철분 섭취량이 유의적으로 증가하여 시험군의 식습관이 전체적으로 개선된 것을 확인할 수 있었다. 그러나 본 연구는 중재기간이 4주밖에 되지 않아 신체활동과 삶의 질의 경우 시험군과 대조군을 비교하였을 때 뚜렷한 효과가 관찰되지 않았다. 따라서 이러한 연구 결과를 활용하여 유방암환자들을 위한 비만 관리 프로그램의 기초자료로 활용할 수 있을 것으로 사료된다.

• Clinical and Experimental Reproductive Medicine
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• 제2권2호
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• pp.41-46
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• 1975

Careful scruting of the data indicate that malnutrition actually limits fertility. Spermatogenesis may likewise be impaired by inadequate diet, particularly one that is very poor in protein. For those who are underweight, increased caloric intake stressing high protein content is recommended. Included are supplementary vitamins, particularly B complex, which stimulate the appetite. Injudicious dieting by the woman to conform to current standards of beauty may also result in malnutrition. This contributes to faulty oogenesis and, in extreme dieting, may produce a long-standing amenorrhea. Obsity may also reduce fertility. Since most cases of obesity are due to over-eating, the full cooperation of the patient must be enlisted. And no device is effective for breaking up fatty deposits. Instead, a program of exercise is recommended. The treatment of both malnutrition and obesity is directed toward general dietary habits either weight gain or weight reduction, with a well balanced high protein diet.

• Journal of Acupuncture Research
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• 제27권6호
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• pp.43-57
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• 2010

Objectives : To investigate the effects of electroacupuncture on parameters related to obesity in adults with abdominal obesity. Methods : A three arm randomized single blind pilot study was conducted from Jan 4 to March 25, 2010 in Kyung Hee Oriental Medical Hospital. The subjects were 39 adults with abdominal obesity and were randomly divided by computer generated random table into 3 groups; EA(electroacupuncture), sham EA(sham electroacupuncture) and waitlist groups. Acupuncture points located at abdomen($CV_{12}$, $CV_6$, $ST_{25}$, $SP_{15}$, $SP_{14}$) and extremities($LI_4$, $LI_{11}$, $ST_{36}$, $ST_{44}$) were inserted by disposable stainless steel needles and were stimulated 30 minutes with 24Hz, 0.27~1.3mA(tolerable strength), asymmetric biphasic continuous pulse wave form by STN-111 Stratek device in EA group. Two treatment sessions per week for 5 weeks(10 sessions in total) were done in EA and sham EA groups. The primary outcome measurement was WC(waist circumference), and the secondary outcome measurements included WHR(waist hip ratio), ASF(thickness of abdominal subcutaneous fat), and inbody measurements of BW(body weight), BMI(body mass index), BFR(body fat ratio) and VFA(visceral fat area), and also scores of BULIT-R(bulimia test revised), KoQoL(Korean obesity of QoL) and BSQ(body shape questionnaire). Results : All of 39 subjects were included in ITT(intention-to-treat) analysis. There were significant reductions in WC, WHR and ASF after 5-week electroacupuncture treatments and the percentage reductions were significantly greater than sham EA or waitlist group. There were no significant differences between groups in percentage reductions of other parameters(BW, BMI, BFR, VFA, BULIT-R, KoQoL and BSQ). But, there were continuous reductions in BW, BMI, BFR and VFA at 3 weeks after the end of treatment and there was significant reduction in BW compared with the baseline value in EA group. No seriously adverse effects were reported during the period. Conclusions : Electroacupuncture was more effective than sham electroacupuncture or no intervention on the reduction of WC, WHR and ASF in adults with abdominal obesity.

• Clinical Endoscopy
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• 제57권3호
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• pp.309-316
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• 2024

The treatment of obesity and its comorbidities ranges from clinical management involving lifestyle changes and medications to bariatric and metabolic surgery. Various endoscopic bariatric and metabolic therapies recently emerged to address an important therapeutic gap by offering a less invasive alternative to surgery that is more effective than conservative therapies. This article comprehensively reviews the technical aspects, mechanism of action, outcomes, and future perspectives of one of the most promising endoscopic bariatric and metabolic therapies, named duodenojejunal bypass liner. The duodenojejunal bypass liner mimics the mechanism of Roux-en-Y gastric bypass by preventing food contact with the duodenum and proximal jejunum, thereby initiating a series of hormonal changes that lead to delayed gastric emptying and malabsorptive effects. These physiological changes result in significant weight loss and improved metabolic control, leading to better glycemic levels, preventing dyslipidemia and non-alcoholic fatty liver disease, and mitigating cardiovascular risk. However, concern exists regarding the safety profile of this device due to the reported high rates of severe adverse events, particularly liver abscesses. Ongoing technical changes aiming to reduce adverse events are being evaluated in clinical trials and may provide more reliable data to support its routine use in clinical practice.

• 한국방사선학회논문지
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• 제9권7호
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• pp.473-478
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• 2015

사회 인구학적 특성을 보정 하였을 때 대사 증후군의 예측에 가장 높은 연관이 남녀 모두에서 비만-복부 비만군이라고 보고되고 있으며, 의료기기의 발전과 더불어 방사선에 대한 피폭선량이 증가하고 있는 추세이다. 이에 흉부 X선 검사에서 복부의 비만정도를 가정하여 흉부팬텀에서 앞쪽방향(forward)으로 각도를 부여한 후 기준영상과 비교하여 입사표면선량과 영상의 왜곡 정도를 평가하였다. 흉부팬텀의 각도가 앞쪽방향으로 $5^{\circ}$ 증가할 때 마다 폐의 가로직경은 1.22%, 세로직경은 0.44% 증가하였다. 심장직경은 앞쪽방향으로 $5^{\circ}$ 증가할 때 마다 1.01% 증가, CTR은 0.27% 감소가 관찰되었다. 그 중 폐의 가로직경이 가장 큰 증가, 폐의 세로직경이 가장 작은 증가를 보였고 CTR은 작은 감소를 보였다. 그러나 팬텀에 입사하는 표면선량 측정의 경우, 흉부팬텀의 각도가 앞쪽방향으로 $5^{\circ}$ 증가할 때 마다 6.12%의 비교적 큰 증가를 보였다. 임상에서 흉부 X-선 후전방향촬영을 시행하는 경우, 복부비만 등으로 인해 흉부의 각도가 기울어짐에 따라 영상의 왜곡뿐만 아니라 환자에게 노출되는 선량이 증가되고 재촬영으로 추가적인 방사선 피폭이 발생될 수 있으므로 올바른 위치잡이에 주의를 기울여 환자의 방사선피폭 감소에 노력을 해야 할 것이다.

• 셀메드
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• 제1권1호
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• pp.7.1-7.9
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• 2011

Bioelectric impedance measurements have been reported to show significant variation between individuals. Different physiological conditions like thickened skin, obesity, and fluid retention can affect the impedance measurement. Therefore, it is important to learn what other factors can affect the measurements of impedance even in healthy individuals. Such information is a prerequisite for understanding the changes in impedance associated with acupuncture treatment. This study investigated the bio-impedance properties of tissue segments in the arms of a number of healthy subjects, so as to define the factors that might influence the variation of the bio-impedance data in acupuncture meridians studies. 51 healthy subjects were recruited through Liverpool Hospital, Sydney. Demographic data was collected from each subject including the age, sex, BMI, and time since most recent meal. Electrodes were applied to the forearms of each test subject. Measurements were done by a purpose-built Bio-Impedance Research Device (BIRD-I) which allowed the determination of core resistance (Rc) and core reactance (Xc) of each of the three meridian tissue segments on the anterior surface of the forearm. No significant difference was found in the core resistance attributable to age group, gender, BMI or meal intake. However, a statistically significant trend in increasing resistance from the radial to ulnar aspect of the forearm (p < 0.001) was found. No significant difference was found in the core resistance of test tissue segments among the 51 healthy subjects measured in this study. However, the trend of increasing core resistance from the radial to ulnar aspects of the arm deserves further investigation.