• 대한한방부인과학회지
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• 제24권3호
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• pp.98-108
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• 2011

Objectives: The purpose of this study is to investigate the relationship between granulocyte/lymphocyte ratio and dysmenorrhea, history of gynecological disease, heart rate varibility(HRV). Methods: From May 1st 2011 to July 10th 2011, a total of 40 female subjects (age 20-39) were recruited. We evaluated the menstruation condition by questionnaires including VAS(Visual Analog Scale), VRS(Verbal Rating Scale) and MVRS (Multidimensional Verbal Rating Scale), also measured subject's WBC differential count and HRV. Results: 1. There was no statistically significant difference in granulocyte/lymphocyte ratio according to menstruation cycle, duration, amount, color, and blood clot. 2. There was no statistically significant difference in VAS, VRS, MVRS mean scores between normal group and abnormal group according to granulocyte/ lymphocyte ratio. 3. The past prevalence of gynecological disease of abnormal group showed significantly higher compared with that of normal group($x^2$=6.578, p=0.010). 4. LF/HF ratio and granulocyte ratio significantly showed positive correlation ($r_s$=0.311 p=0.048) and LF/HF ratio and lymphocyte ratio significantly showed negative correlation($r_s$=-0.319 p=0.045). Conclusion: These findings suggest that the gynecologic diseases are related to disorder of autonomic nervous system, but not dysmenorrhea. And the balance state of sympathetic/parasympathetic nerve infered through granulocyte/lymphocyte ratio and HRV seems to be consistent. However, reconfirmation through further studies is needed.

• 대한한방부인과학회지
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• 제21권3호
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• pp.200-217
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• 2008

Purpose: The aim of this study is to review and analyze the status on the obstetric and gynecologic RCTs with acupuncture. Methods: Searching were performed in $7{\sim}14$ July, 2008. Search term used was "acupuncture" only. And we classified all the searched articles as diseases and related health problems. Then we also classified OBGY diseases and analyzed the trends of those parts. Results: We could search 666 articles, RCTs with acupuncture. Of them, we found 88 OBGY articles about nausea and vomiting in pregnancy, labor and postpartum. OBGY surgery, hot flashes and climacteric, ART, Disease with Pregnancy women and menstruation, fetal breech presentation, and breast disease etc. Conclusion: To improve traditional Korean OBGY research, it is needed activation of RCT research, study of meta analysis, development of clinical practice guidelines, variation of research subject, and co-works with conventional medicine.

• 동의생리병리학회지
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• 제20권3호
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• pp.740-747
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• 2006

This study was undertaken to clinically inspect the accuracy of DSOM-diagnosis System of Oriental Medicine, which were used for the object diagnosis of oriental medicine in the dept. of oriental OB&GY, oriental medical hospital of Dong-Eui University- about uterus myoma patients. We analyzed the prescription and consequence of diagnosis about 16 patients -who had uterus myoma, were treated more than one month, were improved in myoma size, dysmenorrhea, menorrhagia- in the oriental medical hospital of Dong-Eui University from January to December 2004. The calculation consequence of disease mechanism was as follows. The stagnation of Ki(氣滯), liver(肝), heart.(心) was 10 patients 71.4%, some deficiency(虛證), wet syndrome(濕), cold syndrome(寒) was 9 patients 64.3%, blood stasis(血奈) was 8 patients 57.1%. The agreement of consequence about DSOM and diagnosis was 13 patients, 92.9%.

• 대한한방부인과학회지
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• 제24권4호
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• pp.126-149
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• 2011

Purpose: KCDO-3(Korean Classification of Diseases(Oriental Medicine)-third edition) being used in January, 2010 accepted the KCD(Korean Classification of Diseases) and added disease pattern and syndrome of oriental medicine. But, the diagnoses of oriental medicine are too uncertain to express in A00-Z99(KCD). In this case, you should choose in U codes under the KCD use guidelines, but U codes are not capable of representing the symptoms too. So, we suggest the use criteria and consider the weakness of the U codes with medical records of patients who visited with amenorrhea or oligomenorrhea. Methods: We referred medical records of patients who visited oriental obstetrics and gynecology from January 1st to December 31st, 2010. From among them, we set up 122 patients who related with emmeniopathy as target group and searched codes distribution based on medical records. And we described that the process of choosing appropriate codes based on the medical records of 49 amenorrhea or oligomenorrhea patients. Results and Conclusions: The emmeniopathy is divided into menstrual disorder, amenorrhea and systemic disorders at the period of menstruation. And emmeniopathy is expressed in some codes such as N91, N92, N93, N94, U321, U77. When a patient visit hospital, a doctor should choose causal codes when there is confirmed diagnosis. Otherwise, a doctor chooses symptom codes. And if there are more than two diagnosis consistent with definition of chief condition, a doctor should code the first listed diagnosis as a chief condition. Because KCD-5 is classified according to western medical diagnosis, it is difficult to choose in KCD-5 when we diagnosed with disease pattern and syndrome of oriental medicine. But U codes are also deficient to express various condition of emmeniopathy. So we should add 'deficiency and detriment of the thoroughfare and conception vessels', 'prolonged menstruation' and various systemic disorders at the period of menstruation.

• 대한한방부인과학회지
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• 제19권1호
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• pp.202-218
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• 2006

Purpose : Because girls at puberty· are lack in sex ability, temporary menstruation disorder can be occured. This disorder is considered that will be disappeared as growing, so people used to leave the disease untreated and just watched. But clinically I frequently experience not to disappear. So I have carried out this study to investigate the actual condition of young girls's menstrual disorders. Methods : I researched 440 high school girls in Pusan by Menstruation Diary which I made about menstrual cycle, duration, amount and pain. The results were managed by the ststistics. Results :1. Menstrual cycle 1) In disorder of menstrual cycle, persons who have Bate menstruation are more than persons who have premature menstruation. 2) Persons who have normal menstrual cycle are in 124 persons(28.51%), the others who have severe premature menstruation or late menstruation more than one time for 4-7 months are in 311 Persons.(71.49%) 2. Menstrual duration and amount 1) Persons who have normal menstrual amount we in 66-89%, hypermenorrhea is in 1-11%, hypomenorrhea is in 5-21%. 2) In the study of menstrual duration, persons more than one thirds are irregular in thier menstrual amount every menstruation. 3) In the study of MMQ, persons who are irregular in thier menstrual amount every menstruation are in 125persons.(29.76%) 3. Menstrual pain 1) Persons who have slight menstrual pain are in 289 persons(65.98%), the middle is in 86 persons(19.63%) the severe is in 34 persons(7.76%) by MMP. 2) Persons who are irregular in thier menstrual pain every menstruation are in 145 persons.(33.11%) Conclusion : In menstrual cycle, there are more persons who have irregular menstrual cycle than normal.(71.49%) In menstrual duration and amount, more persons have normal menstrual amount.(66-89%) In menstrual pain, persons who have slight menstrual pain are the most.(65.98%)

• 대한한방부인과학회지
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• 제34권3호
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• pp.114-136
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• 2021

Objectives: The purpose of this study is to analyze the effectiveness and safety of herbal medicine treatment for treating hyperthyroidism. Methods: We searched for randomized controlled trials of Hyperthyroidism treated with herbal medicine, published from January 2016 to May 2021, through electronic database such as Pubmed, EMBASE, China Academic Journal (CAJ). Interventions and results of the selected clinical studies were analyzed. Results: The 25 randomized controlled trials were finally included according to the inclusion and exclusion criteria. Treatment group was treated with herbal medicine alone in 2 studies, and with herbal medicine and conventional medicine in 23 studies. Control group was treated with conventional medicine. Outcome measures are total efficacy rate, thyroid function test, Traditional Chinese medicine (TCM) syndrome scores, liver function test, recurrence rate, etc. Prunellae Spica (夏枯草) (60%) was the most frequently used herb in herbal medicine treatment. In all of 25 studies, treatment group was more effective and safer for hyperthyroidism than the control group. Conclusions: This study indicates that herbal medicine treatment alone or combined with conventional medicine treatment could be helpful in improving the therapeutic effect on hyperthyroidism and reducing side effects as well.

• 대한한방부인과학회지
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• 제34권4호
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• pp.12-29
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• 2021

Objective: This study was performed to investigate the inhibitory effect of Cheongpochukeo-tang (CCT) on lipopolysaccharide (LPS)-induced inflammation model. Methods: RAW 264.7 cells were pre-treated with CCT and incubated with LPS (500 ng/ml) after 1 hour. Cell viability was measured by MTT assay to figure out cytotoxicity of CCT. The production of nitric oxide and mRNA expression of pro-inflammatory cytokine were measured. And the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB) were examined to figure out molecular mechanisms of CCT's anti-inflammatory effects. In addition, mice survival rate and cytokine levels of serum were observed after treated with CCT. And mice liver tissues were observed and their cytokines levels in liver tissue were measured. Results: CCT did not have cytotoxic effect in RAW 264.7 cells. It inhibited LPS-induced nitric oxide (NO) production, but showed an increase in NO by itself at 2 mg/ml concentration. CCT inhibited mRNA expression of IL-1β, IL-6, TNF-α in a dose dependant and the activaton of MAPKs and NF-κB. In addition, CCT reduced mortality in the LPS-induced mouse model and inhibited production of cytokines in mouse serum and liver tissue. Conclusion: The results suggest that CCT could reduce LPS-induced inflammation by inhibiting MAPKs and NF-κB activaton, NO production, and pro-inflammatory cytokines secretion. Thereby, CCT could be effective medicine for the inflammatory disease.

• 대한한방부인과학회지
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• 제22권2호
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• pp.172-188
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• 2009

Purpose: For mothers just delivered of a child, sanhupung(産後風) is a critical disease which can threaten their health. The symptoms of sanhupung were diverse and divided into pain symptoms, general symptoms, and neuropsychiatric symptoms. We tried to search for the relationship between sanhupung and somatization of postpartum depression. Methods: Analysis was carried out with materials concerning the postpartum depression and sanhupung. For the analysis, materials related with the issue of this study were searched at the Korea Education & Research Information Service, and Oriental medicine advanced searching. Results: 1. The range of period and symptoms of sanhupung has been broaden. The symptoms of sanhupung were divided into pain syndrome, general symptoms, and neuropsychiatric symptoms. 2. As the symptoms of postpartum depression might indicate not only physical symptoms but also mental disorder, more attention should be placed on wether the symptoms were involved in somatization of postpartum depression. Conclusion: The authors conclude that obstinate sanhupung that do not healed up and improve in symptoms have a relation to somatization of postpartum depression.

• Journal of Acupuncture Research
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• 제22권6호
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• pp.75-84
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• 2005

Objectives : Research on the effect and satisfaction between Acupuncture Treatment, Physical Treatment and contemporary Treatments of Acupuncture and Physical of lumbago patients Methods : We separated lumbago patients into three groups. A group with only Acupuncture Treatment and a group with only Physical Treatment and a group with contemporary treatments of Acupuncture and Physical. Questionnaire survey and score of Visual Analog Scale(VAS) and Oswestry Disability Index(ODI) were examined for comparison. Results & Conclusion : 1. Of the 54 patients Acupuncture Teatment group had 17 patients with similar ratio of gender and the average age was 39.5 years old. For the Physical Treatment group the ratio of male was 75% of the 8 patients and had the youngest average age which was 29.1 years old and the group with contemporary Treatments the ratio of female was 62% of 29 patients and had the oldest average age which was 46.7 years old. 2. The Acupuncture Treatment group had the shortest treatment period because of many acute stage caused by lumber sprain and the improvement score was the best. The group of contemporary treatments had the longest history day and treatment period by serious disease like HIVD and spinal stenosis but the improvement score of VAS and ODI was good similar to the Acupuncture Treatment group. For the Physical Treatment group there was many patients with degenerative change but not severe pain. The VAS, ODI and the improvement score was the lowest before and after the treatment.

• 대한한방부인과학회지
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• 제20권1호
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• pp.32-49
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• 2007

Purpose: Breast cancer is the most common disease in Korean women. Despite remarkable improvements in treatment strategies against various cancer during the past 40 years, breast cancer still remains as one of the main causes of cancer mortality among women in the whole world. This study was carried out to investigate antioxidative and anti-proliferative effects on MCF-7 human breast cancer cells of Ikiyangyoung-Tang extract. Methods: We measured a content of polyphenol and flavonoid in the Ikiyangyoung-Tang extract, eliminative ability of DPPH radical, ABTS free radical and hydrogen peroxide, antioxidative effects of linoleic acid, cytotoxicity on MCF-7 human breast cancer cells. MCF-7 cells were cultured in Dulbecco's modified Eagle's medium/F12(DMEM/F12) supplemented with 10 % fetal bovine serum(FBS; Gibco) and antibiotics. Results : The extract of Ikiyangyoung-Tang contains polyphenol of 168.3${\pm}$12.8 ${\mu}$g/mg and flavonoid of 84.3${\pm}$3.4 ${\mu}$g/mg. Above results show profitable abilities of elimination of ${\alpha}$-${\alpha}$-Diphenyl-${\beta}$-picrylhydrazyl(DPPH) radical, ABTS free radical and hydrogen peroxide. Also, the extract of Ikiyangyoung-Tang strongly inhibits the proliferation of MCF-7 cells in a dose ependent manner. And. it has cytotoxicity on NIH3T3 cells. Conclusion : It can be concluded that Ikiyangyoung-Tang extract has an antioxidative effect and antiproliferative effect on MCF-7 human breast cancer cells.