• Journal of Periodontal and Implant Science
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• 제32권3호
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• pp.489-500
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• 2002

The purpose of this study was to evaluate newly fabricated tricalcium phosphate(TCP)/chitosan microgranuls as bone substitutes. TCP/chitosan microgranules were fabricated by dropping TCP-chitosan suspension into the NaOH/ethanol solution. The size of microgranules could be controllable via airflow rate. PDGF-BB was loaded into the fabricated granules via freeze-drying methods(300 ng/20 mg). To evaluate cell proliferation, cultured osteoblasts cell lines(MC3T3-El) was dropped on the BioOss(R), chitosan microgranules, TCP/chitosan microgranules and cultured for 1, 7 , 14, and 28 days. Scanning electron microscopic observation was done after 7 days of culture and light microscopic examination was done after 28 days of culture. PDGF-BB release from the microgranules was tested. Rabbit calvarial defects(8 mm in diameter) were formed and chitosan, TCP/chitosan, PDGF-TCP/chitosan microgranules, and BioGran(R) were grafted to test the ability of new bone formation. At SEM view, the size of prepared microgranules was 250-1000 um and TCP powders were observed at the surface of TCP/chitosan microgranules. TCP powders gave roughness to the granules and this might help the attachment of osteoblasts. The pores formed between microgranules might be able to allow new bone ingrowth and vascularization. There were no significant differences in cell number among BioOss(R) and two microgranules at 28 day. Light and scanning electron microscopic examination showed that seeded osteoblastic cells were well attached to TCP/chitosan microgranules and proliferated in a multi-layer. PDGF-BB released from TCP/chitosan microgranules was at therapeutic concentration for at least 1 week. In rabbit calvarial defect models, PDGF-TCP/chitosan microgranules grafted sites showed thicker bone trabeculae pattern and faster bone maturation than others. These results suggested that the TCP/chitosan microgranules showed the potential as bone substitutes.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제39권6호
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• pp.274-282
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• 2013

Objectives: The posterior maxillary region often provides a limited bone volume for dental implants. Maxillary sinus elevation via inserting a bone graft through a window opened in the lateral sinus wall has become the most common surgical procedure for increasing the alveolar bone height in place of dental implants in the posterior maxillary region. The purpose of this article is to assess the change of bone volume and the clinical effects of dental implant placement in sites with maxillary sinus floor elevation and autogenous bone graft through the lateral window approach. Materials and Methods: In this article, the analysis data were collected from 64 dental implants that were placed in 24 patients with 29 lacks of the bone volume posterior maxillary region from June 2004 to April 2011, at the Department of Oral and Maxillofacial Surgery, Inha University Hospital. Panoramic views were taken before the surgery, after the surgery, 6 months after the surgery, and at the time of the final follow-up. The influence of the factors on the grafted bone material resorption rate was evaluated according to the patient characteristics (age and gender), graft material, implant installation stage, implant size, implant placement region, local infection, surgical complication, and residual alveolar bone height. Results: The bone graft resorption rate of male patients at the final follow-up was significantly higher than the rate of female patients. The single autogenous bone-grafted site was significantly more resorbed than the autogenous bone combined with the Bio-Oss grafted site. The implant installation stage and residual alveolar height showed a significant correlation with the resorption rate of maxillary sinus bone graft material. The success rate and survival rate of the implant were 92.2% and 100%, respectively. Conclusion: Maxillary sinus elevation procedure with autogenous bone graft or autogenous bone in combination with Bio-Oss is a predictable treatment method for implant rehabilitation.

• Journal of Periodontal and Implant Science
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• 제36권4호
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• pp.797-808
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• 2006

Objective : The purpose of this study was to evaluate the physicochemical properties and cytocompatibility of microporous, spherical biphasic calcium phosphate(BCP) ceramics with a 60/40 $hydroxyapatite/{\beta}$ -tricalcium phosphate weight ratio for application as a bone graft substitute. Materials and Methods : Microporous, spherical BCP granules(MGSB) were prepared and their basic characteristics were compared with commercially available BCP(MBCP; Biomatlante, France) and deproteinized bovine bone mineral(Bio-Oss; GBistlich-Pharma, Switzerland, BBP; Oscotec. Korea), Their physicochemical properties were evaluated by scanning electron microscopy, X-ray diffractometry, Fourier-transform infrared spectroscopy, inductively coupled plasma atomic emission spectrometer, and Brunauer-Emmett-Teller method. Cell viability and proliferation of MC3T3-El cells on different graft materials were evaluated. Results : MGSB granules showed a chemical composition and crystallinity similar with those in MBCP, they showed surface structure characteristic of three dimensionally, well-interconnected micropores. The results of MTT assay showed increases in cell viablity with increasing incubation times. At 4d of incubation, MGSB, MBCP and BBP showed similar values in optical density, but Bio-Oss exhibited significantly lower optical density compared to other bone substitutes(p <0,05). MGSB showed significantly greater cell number compared to other bone substitutes at 3, 5, and 7d of incubation(p <0,05), which were similar with those in polystyrene culture plates. Conclusion: These results indicated the suitable physicochemical properties of MGSB granules for application as an effective bone graft substitute. which provided compatible environment for osteoblast cell growth. However, further detailed studies are needed to confirm its biological effects on bone formation in vivo.

• 유통과학연구
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• 제13권1호
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• pp.57-70
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• 2015

Purpose - Open source software has high utilization in most of the server market. The utilization of open source software is a global trend. Particularly, Internet infrastructure and platform software open source software development has increased rapidly. Since 2003, the Korean government has published open source software promotion policies and a supply promotion policy. The dynamism of the open source software market, the lack of relevant expertise, and the market transformation due to reasons such as changes in the relevant technology occur slowly in relation to adoption. Therefore, this study proposes an assessment model of services provided in an open source software service company. In this study, the service level of open source software companies is classified into an enterprise-level assessment area, the service level assessment area, and service area. The assessment model is developed from an on-site driven evaluation index and proposed evaluation framework; the evaluation procedures and evaluation methods are used to achieve the research objective, involving an impartial evaluation model implemented after pilot testing and validation. Research Design, data, and methodology - This study adopted an iteration development model to accommodate various requirements, and presented and validated the assessment model to address the situation of the open source software service company. Phase 1 - Theoretical background and literature review Phase 2 - Research on an evaluation index based on the open source software service company Phase 3 - Index improvement through expert validation Phase 4 - Finalizing an evaluation model reflecting additional requirements Based on the open source software adoption case study and latest technology trends, we developed an open source software service concept definition and classification of public service activities for open source software service companies. We also presented open source software service company service level measures by developing a service level factor analysis assessment. The Behavior-Structure-Evolution Evaluation Model (BSEM) proposed in this study consisted of a rating methodology for calculating the level that can be granted through the assessment and evaluation of an enterprise-level data model. An open source software service company's service comprises the service area and service domain, while the technology acceptance model comprises the service area, technical domain, technical sub-domain, and open source software name. Finally, the evaluation index comprises the evaluation group, category, and items. Results - Utilization of an open source software service level evaluation model For the development of an open source software service level evaluation model, common service providers need to standardize the quality of the service, so that surveys and expert workshops performed in open source software service companies can establish the evaluation criteria according to their qualitative differences. Conclusion - Based on this evaluation model's systematic evaluation process and monitoring, an open source software service adoption company can acquire reliable information for open source software adoption. Inducing the growth of open source software service companies will facilitate the development of the open source software industry.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.2097-2100
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• 2003

Many studies have been done on secure operating system using secure kernel that has various access control policies for system security. Secure kernel can protect user or system data from unauthorized and/or illegal accesses by applying various access control policies like DAC(Discretionary Access Control), MAC(Mandatory Access Control), RBAC(Role Based Access Control), and so on. But, even if secure operating system is running under various access control policies, network traffic among these secure operating systems can be captured and exposed easily by network monitoring tools like packet sniffer if there is no protection policy for network traffic among secure operating systems. For this reason, protection for data within network traffic is as important as protection for data within local system. In this paper, we propose a secure operating system trusted channel, SOSTC, as a prototype of a simple secure network protocol that can protect network traffic among secure operating systems and can transfer security information of the subject. It is significant that SOSTC can be used to extend a security range of secure operating system to the network environment.

• 대한치과보철학회지
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• 제36권4호
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• pp.581-586
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• 1998

무치악환자의 Implant보철수복 방법은 식립된 Implan의 수에 따라 다양하다. 많은 수의 Implant가 식립된 경우에는 고정성 보철물로 수복이 가능하지만 시술이나 기공상의 복잡성, 고가의 치료비, 보철물과 잔존치조제사이의 빈 공간으로 인한 비심미성, 발음의 어려움과 같은 여러 가지 문제점이 존재한다. 적은 수의 Implant가 식립된 경우는 Bar Retained Overdenture를 사용하지만 역시 기공과정이 복잡하며, Bar와 잔존치조제사이의 공간으로 인한 점막지지 면적의 감소와 보수가 어려운 단점이 있다. 여기에 비해서 O-ring Attachment를 이용하면 기공과정이 쉽고, 잔존치조제와 보철물 사이에 공간이 없으므로 점막지지 면적을 많이 얻을 수 있다. 또한 Implant식립의 수도 최소화할 수 있어 경제적이며, 문제가 발생한 경우에 쉽게 대처할 수 있는 장점을 지니고 있다. 본 증례들은 Steri-Oss Implant System의 O-ring Attachment를 이용하여 무치악환자를 보철 수복한 예로서 술후 기능적, 심미적으로 만족할 만한 결과를 얻었기에 문헌고찰과 더불어 발표하는 바이다.

• 대한치과보철학회지
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• 제38권3호
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• pp.291-309
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• 2000

Statement of problem. There were several studies on the effects of irradiation to peri-implant bone tissue. However, no clear biological effect of irradiation on peri-implant bone tissue was reported yet. Purpose. This study compared the effect of irradiation on the surrounding tissue of a HA-coated implant fixture with controls. Material and methods. 6 Steri-Oss implants were implanted into the femur of 6 mongrels. The implanted dogs were divided into three groups and received irradiation. After 1 month, 2months and 4 months healing period, the histologic examination and mobility test and digital radiographic imaging analyses were performed to compare the control and experimental group respectively. Results. The irradiated group showed slower healing than control group in light microscopic observations. The mobility test demonstrated significant less number (Periotest) in control group than that of irradiated groups. The digital radiographic imaging analysis showed that the bone density of irradiated group was higher than control group. Conclusion. Generally, control group showed favorable biological response and less mobility than irradiated group. The conflict result of bone density value were measured by the digital radiographic imaging analysis. The digital radiographic imaging analysis needs more research in future.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권3호
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• pp.209-214
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• 2012

This case report assessed the three-year follow-up results after autogenous and xenogenic bone grafts of the jaw. Autogenous particulated bone with osteogenesis and osteoinductive properties and xenogenic Bio-Oss$^{(R)}$ (Geistlich Pharma AG, Wolhusen, Switzerland) graft materials with osteoconductive propertes were grafted into cystic cavities that remained after multiple cystic enucleation in the right upper posterior maxilla and the left lower posterior mandible. Six months later, increased radiopacity in the grafted area was seen. Three-year follow-up results with clinical and panoramic radiography after autogenous and xenogenic bony mixtures in jaw are reviewed and discussed.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제38권
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• pp.26.1-26.6
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• 2016

Background: Xenologous or synthetic graft materials are commonly used as an alternative for autografts for guided bone regeneration. The purpose of this study was to evaluate effectiveness of carbonate apatite on the critical-size bone defect of rat's calvarium. Methods: Thirty-six critical-size defects were created on 18 adult male Sprague-Dawley rat calvaria under general anesthesia. Calvarial bones were grinded with 8 mm in daimeter bilaterally and then filled with (1) no grafts (control, n = 10 defects), (2) bovine bone mineral (Bio-$Oss^{(R)}$, Geistlich Pharma Ag. Swiss, n = 11 defects), and (3) hydroxyapatite ($Bongros^{(R)}$, Bio@ Inc., Seongnam, Korea, n = 15 defects). At 4 and 8 weeks after surgery, the rats were sacrificed and all samples were processed for histological and histomorphometric analysis. Results: At 4 weeks after surgery, group 3 ($42.90{\pm}9.33%$) showed a significant difference (p < 0.05) compared to the control ($30.50{\pm}6.05%$) and group 2 ($28.53{\pm}8.62%$). At 8 weeks after surgery, group 1 ($50.21{\pm}6.23%$), group 2 ($54.12{\pm}10.54%$), and group 3 ($50.92{\pm}6.05%$) showed no significant difference in the new bone formation. Conclusions: $Bongros^{(R)}$-HA was thought to be the available material for regenerating the new bone formation.

• 대한치과보철학회지
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• 제38권5호
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• pp.631-639
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• 2000

Root-form endosseous implants which are in use today have a variety of materials, designs and surface characteristics. Among them, pure titanium surface implants and titanium matrix coated with HA are popular as well as are available in many studies. Rate of clinical success is obviously lower in jaw with cancellous bone than dense bone. In order to increase the rate of success in poor bone quality. More advanced techniques of implant surgery and surface treatment of implant fixture body have been developed. As a successful result, the installation of HA coated implant in bone quality type III or IV became highly successful. Since most clinical studies were performed without knowing the characteristics of HA coated implants, it has been impossible to come up with proper clinical data. Therefore the characterization of HA coated implants is essential to understand long term clinical performance and the predictability of HA coated implant system Our results showed that HA coated implants had the success rate at 93.7% in bone quality type III, IV for 3.8 years, and the fixture of Steri-Oss showed more stability with time.