• Korean Journal of Acupuncture
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• v.30 no.1
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• pp.27-36
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• 2013

Objectives : The focus of the analysis was laid on changes in research pertaining to bee venom in regards to time progression. Methods : We collected 365 articles on Bee venom study result from OASIS system using the Keyword 'bee venom, apitoxin, apitherapy, bee sting'. We figured out number and percentage of theses according to year, study method, journal, subject. Results : Bee venom papers published in the journal of korean medicine from 1976. The classification of papers associated with bee venom, clinical studies outnumbered the other study types by a ratio of 1.3 to 1, followed by 138 for experimental papers, and 22 for literature studies. Proportion of Experimental Papers Classified According to the Theme, 16 for pain-killing, 14 papers concentrated on apoptosis anticancer, 13 for anti inflammatory, 11 for arthritis, and other disorders were followed. Type analysis of papers associated with bee venom in clinical trials, lumbar disorders comprised 38 out of 205 papers, 35 papers concentrated on upper limb disorders, 34 papers concentrated on systemic disease, followed by the effect on body. Conclusions : Bee venom is a treatment method based on the unique theory of Korean traditional medicine. Its effort and academical approach on bee venom are expected to receive positive evaluation through numerous research works.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.33 no.4
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• pp.114-125
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• 2020

Objectives : The aim of this study is to review the topical anesthetic effect of herbal medicine. Methods : Using domestic database(OASIS, RISS) and foreign database(Pubmed, Embase, Cochrane library, CNKI), clinical studies about efficacy of herbal medicine as topical anesthetics were searched. Only randomized controlled trials(RCT) were selected and analyzed. Results : Total 647 studies were searched. After screening process, 5 articles were selected. 2 were from Chinese database and 3 were from English database. Articles were about clinical use of herbal medicine as topical anesthetics and compare their efficacy with conventional topical anesthetics. Out of 5 articles, 4 articles used pain rating scales recorded by subjects as outcome measurement. All studies showed lower pain score in herbal medicine using groups. 4 studies showed that there was no statistically significant difference in pain score between herbal medicine using group and conventional topical anesthetics using group. Conclusions : The results suggest that topical anesthetics using herbal medicine is as effective as or maybe even more effective than conventional topical anesthetics. However, experimental design and composition of intervention were all different, which provides inaccuracy when comparing the experimental results. Also, sample sizes were small and the number of RCTs were insufficient to identify full list of herbs that have potentials to be used topical anesthetics. Further studies need to be conducted to find out potentials of herbal medicine as topical anesthetics.

• Herbal Formula Science
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• v.28 no.2
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• pp.199-209
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• 2020

Objectives : The purpose of this systematic review is to confirm whether Gwibitang is beneficial in chronic fatigue syndrome (CFS). Methods : Clinical trials were searched from databases including Pubmed, Embase, Central Cochrane, CNKI, Wanfang, CQVIP, CiNii, OASIS, Koreamed, and NDSL. The eligible study design was limited into randomized controlled trial, quasi-randomized controlled trial and controlled clinical trial. The outcomes included general effectiveness as nominal scale, and fatigue severity, insomnia severity and quality of life as interval or ratio scale. The meta-analysis and assessment of risk of bias was performed based on the data extracted from the selected trials. Results : The results of eight randomized controlled trials (n=596) were included in the meta-analysis. The results of the synthesis showed Gwibitang is beneficial substantially for relieving and managing the general symptoms, and its heterogeneity was not in important level (RR 0.26 [95% CI 0.17, 0.39], Z=6.47, P<0.00001, I²=0%). Gwibitang was beneficial for alleviating fatigue (SMD -0.78 [95% CI -1.27, -0.30], Z=3.17, P=0.002), but its certainty was low. In case of insomnia, too few trials had been found and their risk of bias was substantial, so no conclusions had been brought to. Conclusions : We found an evidence that Gwibitang could be beneficial for managing and alleviating main symptoms in CFS patients.

• The Journal of Korean Medicine
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• v.38 no.3
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• pp.13-29
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• 2017

Objectives: The objective of this review is to investigate the use of conventional Western medicine (WM) and complementary and alternative medicine (CAM) on leg cramps. Leg cramps are the occurrence of muscular spasm in the leg muscles which occur frequently in the elderly and are frequently observed in the clinical field. Methods: Relevant clinical studies were searched from five medical databases including PubMed, KISS, RISS, OASIS, and J-STAGE. Systematic review, clinical studies, and clinical practice guideline were included in this review. Results: In total, 27 clinical studies, 9 systematic review and meta-analysis, and 1 clinical practice guideline met the inclusion criteria. Included studies were classified and analyzed according to the type of intervention. Studies on quinine and magnesium have been most studied in WM and CAM, respectively. Although quinine shows some clinical effects on leg cramps, however, the risk of side effects are suggested. In addition, magnesium failed to improve the clinically significant effects in most studies. Five case reports using Oriental herbal medicine (OHM) were included and OHMs were effective in improving leg cramps without side effects, however, the quality of evidence was low. Clinical studies on other interventions were lacking. Conclusions: The results of this study indicate that there is no definite treatment standard for leg cramps until now, and there are limitations such as low level of evidence and side effects for each treatment. OHM can be an effective alternative to conventional intervention on leg cramps, therefore, related clinical studies are needed.

• Journal of Acupuncture Research
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• v.29 no.3
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• pp.19-28
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• 2012

Objectives : The aim of this study is to evaluate present clinical evidence of oriental medical treatment for cancer in Korea. Method : A search was performed in the Korean Studies Information, Korea Institute of Science and Technology Information, KoreaMed, Oriental Medicine Advanced Searching Integrated System, National Assembly Library, RISS4u, DBPIA, and Oasis using the keyword 'cancer', 'leukemia', 'malignant tumor', 'lymphoma', 'multiple myeloma', 'melanoma'. The search period spanned between Jan 1, 1980~June 30, 2011 and the results were analyzed and evaluated according to the publication date, journal, method of treatment, type of study, and the primary outcome. Randomized clinical trials (RCTs) and Non randomized clinical trial(NRCT) were reviewed separately. Result : The results yielded 133 trials during the period of Jan 1, 1980~June 30, 2011. Most of the trials were concerned with lung cancer and 94 of the trials were simple case studies or case series studies. 61 trials used herbal Formula/herbal medicine as the primary method of treatment. A total of 4 RCTs existed compared to only one NRCT. Conclusion : The use of oriental medicine for the treatment of cancer is gaining popularity in the field of medical scientific research. However most of the studies that have been published up to date are mostly case studies or case series studies, and RCT/NRCT are rare. In order to provide appropriate evidence regarding the effectiveness of oriental medicine in the treatment of cancer, more rigorous and well-designed studies are warranted.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.13 no.1
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• pp.55-68
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• 2018

Objectives: The objective of this study was to review the trends of Korean medicine-based treatment for thoracic outlet syndrome(TOS). Methods: Korean and foreign on-line databases(Pubmed, Cochran Library, CNKI, NDSL KISS and OASIS) were researched for articles discussing Korean medicine-based treatment for TOS. Repeated articles, review articles, commentaries, and those not relevant to the topic of study were excluded. Results: The total number of studies selected was 26, which included 18 case reports and 8 randomized controlled trials(RCT). In these studies, acupuncture, pharmacopuncture, acupotomy, and warm acupuncture were used as interventions for TOS.Chuna therapy was found to be the most commonly used combination treatment. Despite the high prevalence of TOS, only 3 case reports of the 26 studies selected in this review were published in Korean academic journals. Conclusions: In this study, we analyzed the trends of traditional Korean medicine-based treatment for TOS. The results showed that Korean medicine-based treatment could be an effective method for treating TOS.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.1
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• pp.61.1-61.1
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• 2011

NGC5929는 북동방향으로 0.5' 떨어진 NGC5930의 기조력 영향을 받는 활동성은하이다. 우리는 NGC5930이 NGC5929와의 상호작용에 따라 NGC5929의 활동성을 어떻게 유발하는지 수치실험을 알아보고자 한다. NGC5929의 적경, 적위는 (15h 26m, $41^{\circ}$40')이고, 크기는 $1'.14{\times}$ 0'.89이다. 지구로부터 거리는 36.5Mpc(적색편이는 $0.00836{\pm}0.00007km/s$)이다. 관측 자료에서 보인 NGC5929는 원반 모양의 은하 오른쪽 위쪽의 가스는 접근성, 왼쪽 아래 부분은 멀어지는 운동학적 특성이 보인다. 호스트 은하 원반이 기울어져 장축 방향이 $PA=85^{\circ}$, 단축이 $PA=45^{\circ}$ 은하의 구조임을 알 수 있다. 이 연구를 위해 우리는 하와이 CFHT 3.6m의 OASIS로 관측한 NGC5929의 중심부를 MR1, MR2로 관측한 영상을 참고하여, 이 영상에서 보이는 활동성 즉, 15*12 arcsec의 OASIS field 영역의 관측 자료에 나타난 $H{\beta}$영상이나, [O III]에 나타난 제트 형태와 방출방향에 대해 조사하였다. CFHT OASIS의 분석으로 우리는 continuum, [O III], $H{\beta}$ 선을 통한 영상을 조사하였고, 특히 [O III]영상에서 에서 강한 활동은하의 성격이 보인다. 이 방출선의 특성이 별의 UV, 행성상 성운 주변, 블랙홀 주위, 충격파 중 어느 영향이 가장 강한지 조사하였고, [O III]이미지에서 보인 제트의 형성조건에 동반은하 NGC5930의 영향이 어떠한 역할을 하였는지 조사하고, $H{\beta}$영상에 나타난 starburs지역도 살펴보고자 한다. 우리는 관측 자료에서 보인 활동성의 근원을 알기 위해 Gadget, Magalie를 사용하여 두 은하의 운동학적 및 은하의 구조에 대해 조사하려고 한다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.1
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• pp.43-73
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• 2017

Objectives : Because fungal disease is common and easy to recur, there is need to develop treatment in Korean medical academy. For more intensified study about fungal disease, this article summarized and analyzed tendency of ones in Korean medical journal. Methods : We found 74 articles about fungus in journal of Korean medicine by using 15 Korean keywords and 19 English keywords at internet reference site as follows ; http://oasis.kiom.re.kr, http://www.riss.kr, http://www.dbpia.co.kr, http://www.ndsl.kr, http://kiss.kstudy.com, http://www.naver.com, http://www.google.com. Results : There were 12 articles(16.2%), ranked highest in 2005. Korean Journal of Oriental Physiology & Pathology ranked highest(41.9%). 3 persons ranked highest(23.0%) in number of author. There was 1 descriptive report in original article category. There were 52 In vitro articles and 8 In vivo & In vitro articles in experimental study item. Candida species ranked highest in strain category. There were 4 case reports. Conclusions : There were many experimental studies about fungal diseases, but more clinical research and case reports are necessary to give practical application to patients.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.4
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• pp.62-74
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• 2017

Objectives : The purpose of this study is to investigate the effect of laser therapy for diabetic ulcer by using methods of systematic review. Methods : In this review, PubMed, Cochrane library, Web of Science, CNKI, CiNii, J-STAGE, NDSL and OASIS were used as the search engines. The search period is from the start date of the search engine to October 3, 2016. Randomized controlled trials(RCTs) using laser therapy for diabetic ulcer were searched and extracted by two independent researchers. Risk of bias(RoB) of Cochrane was used to assess methodological quality of studies. Results : Finally, five RCTs were selected. The follow-up period ranged from 15 days to 20 weeks. InGaAlP laser, GaAlAs laser and light emitting diode(LED) were used to treat diabetic ulcer. The clinical trials used sham laser irradiation or standard treatment as control in comparison to laser therapy. The endpoints included ulcer size, rate of healing and time to healing with follow-up period. The RCTs demonstrated therapeutic outcomes with no adverse effect. Most items of RoB were unclear and methodological quality was low. Conclusions : Our analysis suggests that laser therapy has therapeutic effects for diabetic ulcer. However, more systematic and stringent clinical trials will be required.

• Journal of Society of Preventive Korean Medicine
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• v.16 no.3
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• pp.53-73
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• 2012

Objectives : The inclusion of Korean Medicine in the national health care system led to the need of a serious discussion on its modernization. This paper looked at how these discussions were progressed. Especially, a difference in the meaning of 'science' in the 1950s and the 1990s was observed. Methods : Articles related to the medical dispute between Korean and Western Medicine in "EE LIM", especially the ones from the 1950s, were selected, classified and analyzed. Research papers on Evidence-Based Medicine were also analyzed. Evidence-Based Medicine was a new medical research methodology in the 1990s. Articles on Evidence-Based Medicine were searched and selected from journal databases: DBpia, KISS, RISS, and OASIS. Results : The problem of establishment of modernity of Korean Medicine in the recent times was addressed in the context of scientification and systematization. Accordingly, the academic societies of Korean Medicine aimed for scientification. But efforts to secure the identity of Korean Medicine opposed to western science were also made. Meanwhile, Evidence-Based Medicine established in 1992 presented a different concept of science. This led to a new means of acknowledgement of Korean Medicine in the modern society. Conclusions : The modernization process of Korean Medicine up to now was a course of scientification. But as this process did not fully reflect its characteristics, the modernization of Korean Medicine still remains a pending question. A modern study methodology that fully reflects the identity of Korean Medicine needs to be established.