• Geosciences Journal
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• v.23 no.1
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• pp.1-20
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• 2019

We present data from the Mesozoic Keumkang, Palbong, and Baekhwa granites in Garorim Bay, in the southwestern part of the Gyeonggi massif, South Korea. Using major and trace element concentrations, Sr-Nd-Pb isotopic compositions, and sensitive high-resolution ion microprobe (SHRIMP) zircon U-Pb ages, we aim to constrain the petrogenesis of the granites and explain their origin within a broader regional geological context. SHRIMP U-Pb zircon ages of $232.8{\pm}3.2$, $175.9{\pm}1.2$, and $176.8{\pm}9.8$ Ma were obtained from the Keumkang, Palbong and Baekhwa granites, respectively. The Late Triassic Keumkang granites belong to the shoshonite series and show an overall enrichment in large ion lithophile elements (LILE), a depletion in high field strength elements (HFSE) relative to primitive mantle, compared with neighboring elements in the primitive mantle-normalized incompatible trace element diagram with notable high Ba and Sr contents, and negligible Eu anomalies. The Keumkang granites are typified by highly radiogenic Sr and unradiogenic Nd and Pb isotopic compositions: $(^{87}Sr/^{86}Sr)_i=0.70931-0.70959$, $(^{143}Nd/^{144}Nd)_i=0.511472-0.511484$ [$({\varepsilon}_{Nd})_i=-17.0$ to -16.7], and $(^{206}Pb/^{204}Pb)=17.26-17.27$. The Middle Jurassic Palbong and Baekhwa granites belong to the medium- to high-K calc-alkaline series, and show LILE enrichment and HFSE depletion similar to the Keumkang granites, but exhibit significant negative anomalies in Ba, Sr, and Eu. Furthermore, they have elevated Y and Yb contents at any given $SiO_2$ content compared with other Jurassic granitoids from the Gyeonggi massif. The Palbong and Baekhwa granites have slightly less radiogenic Sr and more radiogenic Nd and Pb isotopic compositions [$(^{87}Sr/^{86}Sr)_i=0.70396-0.70908$, $(^{143}Nd/^{144}Nd)_i=0.511622-0.511660$, $({\varepsilon}_{Nd})_i=-15.4$ to -14.7, $(^{206}Pb/^{204}Pb)=17.56-17.76$] relative to the Keumkang granites. The Keumkang granites are considered to have formed in a post-collisional environment following the Permo-Triassic Songrim orogeny that records continent-continent collision between the North and South China blocks, and may have formed by fractional crystallization of metasomatized lithospheric mantle-derived mafic melts. The Palbong and Baekhwa granites may have been produced from a gabbroic assemblage at pressures of less than ~15 kbar, associated with subduction of the paleo-Pacific (Izanagi) plate at the Eurasian continental margin. Elevated ${\varepsilon}_{Nd}(t)$ values in the granitoids from the southwestern part of the Gyeonggi massif relative to those of the central and northern parts, together with the comparatively shallow depth of origin, imply the presence of an exotic block in the Korean lithosphere.

• Analytical Science and Technology
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• v.10 no.6
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• pp.403-407
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• 1997

Separation factor for $^6Li$ and $^7Li$ have been determined using ion exchange resin having 1,7,13-trioxa-4,10,16-triazacyclooctadecane($N_3O_3$) as an anchor group. The lighter isotope, $^6Li$ is concentrated in the solution phase, while the heavior isotope, $^7Li$ is enriched in the resin phase. By Ccolumnl chromatography[0.9cm(I.D)${\times}$20cm(height)] using 2.0M ammonium chloride solution as an eluent, single separation factor, ${\alpha}$, 1.009. i.e.$(^7Li/^6Li)_{resin}$/$(^7Li/^6Li)_{solution}$ was obtained by the Glueckauf theory from the elution curve and isotope ratios.

• Economic and Environmental Geology
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• v.46 no.2
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• pp.179-198
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• 2013

The Boziguoer A-type granitoids in Baicheng County, Xinjiang, belong to the northern margin of the Tarim platform as well as the neighboring EW-oriented alkaline intrusive rocks. The rocks comprise an aegirine or arfvedsonite quartz alkali feldspar syenite, an aegirine or arfvedsonite alkali feldspar granite, and a biotite alkali feldspar syenite. The major rock-forming minerals are albite, K-feldspar, quartz, arfvedsonite, aegirine, and siderophyllite. The accessory minerals are mainly zircon, pyrochlore, thorite, fluorite, monazite, bastnaesite, xenotime, and astrophyllite. The chemical composition of the alkaline granitoids show that $SiO_2$ varies from 64.55% to 72.29% with a mean value of 67.32%, $Na_2O+K_2O$ is high (9.85~11.87%) with a mean of 11.14%, $K_2O$ is 2.39%~5.47% (mean = 4.73%), the $K_2O/Na_2O$ ratios are 0.31~0.96, $Al_2O_3$ ranges from 12.58% to 15.44%, and total $FeO^T$ is between 2.35% and 5.65%. CaO, MgO, MnO, and $TiO_2$ are low. The REE content is high and the total ${\sum}REE$ is $(263{\sim}1219){\times}10^{-6}$ (mean = $776{\times}10^{-6}$), showing LREE enrichment HREE depletion with strong negative Eu anomalies. In addition, the chondrite-normalized REE patterns of the alkaline granitoids belong to the "seagull" pattern of the right-type. The Zr content is $(113{\sim}1246){\times}10^{-6}$ (mean = $594{\times}10^{-6}$), Zr+Nb+Ce+Y is between $(478{\sim}2203){\times}10^{-6}$ with a mean of $1362{\times}10^{-6}$. Furthermore, the alkaline granitoids have high HFSE (Ga, Nb, Ta, Zr, and Hf) content and low LILE (Ba, K, and Sr) content. The Nb/Ta ratio varies from 7.23 to 32.59 (mean = 16.59) and the Zr/Hf ratio is 16.69~58.04 (mean = 36.80). The zircons are depleted in LREE and enriched in HREE. The chondrite-normalized REE patterns of the zircons are of the "seagull" pattern of the left-inclined type with strong negative Eu anomaly and without a Ce anomaly. The Boziguoer A-type granitoids share similar features with A1-type granites. The average temperature of the granitic magma was estimated at $832{\sim}839^{\circ}C$. The Boziguoer A-type granitoids show crust-mantle mixing and may have formed in an anorogenic intraplate tectonic setting under high-temperature, anhydrous, and low oxygen fugacity conditions.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10513-10524
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• 2015

Background: Metastasis is a major reason for poor prognosis in patients with cancer, including hepatocellular carcinoma (HCC). A salient feature is the ability of cancer cells to colonize different organs. Long non-coding RNAs (lncRNAs) play important roles in numerous cellular processes, including metastasis. Materials and Methods: In this study, the lncRNA expression profiles of two HCC cell lines, one with high potential for metastasis to the lung (HCCLM3) and the other to lymph nodes (HCCLYM-H2) were assessed using the Arraystar Human LncRNA Array v2.0, which contains 33,045 lncRNAs and 30,215 mRNAs. Coding-non-coding gene co-expression (CNC) networks were constructed and gene set enrichment analysis (GSEA) was performed to identify lncRNAs with potential functions in organ-specific metastasis. Levels of two representative lncRNAs and one representative mRNA, RP5-1014O16.1, lincRNA-TSPAN8 and TSPAN8, were further detected in HCC cell lines with differing metastasis potential by qRT-PCR. Results: Using microarray data, we identified 1,482 lncRNAs and 1,629 mRNAs that were differentially expressed (${\geq}1.5$ fold-change) between the two HCC cell lines. The most upregulated lncRNAs in H2 were RP11-672F9.1, RP5-1014O16.1, and RP11-501G6.1, while the most downregulated ones were lincRNA-TSPAN8, lincRNA-CALCA, C14orf132, NCRNA00173, and CR613944. The most upregulated mRNAs in H2 were C15orf48, PSG2, and PSG8, while the most downregulated ones were CALCB, CD81, CD24, TSPAN8, and SOST. Among them, lincRNA-TSPAN8 and TSPAN8 were found highly expressed in high lung metastatic potential HCC cells, while lowly expressed in no or low lung metastatic potential HCC cells. RP5-1014O16.1 was highly expressed in high lymphatic metastatic potential HCC cell lines, while lowly expressed in no lymphatic metastatic potential HCC cell lines. Conclusions: We provide the first detailed description of lncRNA expression profiles related to organ-specific metastasis in HCC. We demonstrated that a large number of lncRNAs may play important roles in driving HCC cells to metastasize to different sites; these lncRNAs may provide novel molecular biomarkers and offer a new basis for combating metastasis in HCC cases.

• The Journal of the Petrological Society of Korea
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• v.13 no.2
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• pp.47-63
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• 2004

This study focuses on the petrography and petrochemical characteristics of the volcanic and plutonic rocks in Gadeog island, Busan, Korea. Based on textural and mineralogical characteristics, intermediate volcanic rocks can be divided into andesitic lava flows (porphyritic and massive andesites) and andesitic pyroclastics. Felsic volcanic rocks are composed of rhyolite, rhyolitic welded tuff, and tuff breccia. Plutonic rocks are intruded rhyolite and andesitic rocks, and composed of hornblende granodiorite which contains lots of mafic magma enclaves. Volcanic rocks are composed of andesite, dacite and rhyolite having a range in SiO$_2$ from 59 to 78wt.%. The volcanic rocks belong to the calc-alkaline rock series. Plutonic rocks have a range in SiO$_2$ from 63 to 69wt.%. This compositional variations correspond to those of Cretaceous volcanic and plutonic rocks in the southeastern Gyeongsang basin. The trace element composition and rare earth element patterns of the volcanics, which are characterized by high LREE/HFSE ratios and enrichment in LREE, suggest that they are typical of calc-alkaline volcanic rocks produced in the subduction environment around continental arc. We concluded that volcanic and plutonic rocks in Gadeog Island were evolved from orogenic andesitic magma which was produced by partial melting of the mantle wedge in the subduction environment.

• Economic and Environmental Geology
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• v.19 no.spc
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• pp.163-173
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• 1986

Black and graphite slates from the Okcheon metamorphic belt contain enriched values of uranium (average 200~250ppm) and molybdenum (average 150~200ppm). Uranium mineralization is closely associated with quartz and sulfide veinlets which are formed diagenetically in graphite slate. The uranium minerals were concentrated in outer part of graphite nodules. The ${\delta}^{13}C$ values of organic carbon from the metasediments including uranium bearing graphite slate range from -15.2 to -26.1‰ with a mean of -23.5‰. Meanwhile, ${\delta}^{13}C$ values of coal and coaly shale from some Paleozoic coal fields of South Korea vary from -19.4 to -23.9‰ with an average of -22.5‰. Isotopic compositions of vein calcite in uranium bearing slate range from -13.4 to -15.4‰ in ${\delta}^{13}C$ and +11.3 to +15.1‰ in ${\delta}^{18}O$ could indicate a reduced organic carbon source isotopically exchanged with a graphite of biogenic origin. Metamorphic temperature determined by a calcite-graphite isotope geothermometer was 383~$433^{\circ}C$ which corresponded to greenschist facies by Miyashiro (1973) and is consistent with metamorphic facies estimated by mineral assemblages (Lee, et al., 1981, and Kim, 1971). The fixation of uranyl species by carbonaceous matter in marine epicontinental environment, and remobilization of organouranium by diagenetic processes have attributed to the enrichment of uranium and heavy metals in the graphite slate of Okcheon metamorphic belt.

• Microbiology and Biotechnology Letters
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• v.19 no.2
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• pp.140-146
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• 1991

Mutation experiments were performed to select the mutant of Aspergillus niger 55, which had lost almost all the ability to produce transglucosidases but retained that of high productivity of raw meal saccharifying enzyme, by means of successive induction with N-methyl-N'-nitro-N-nitrosoguanidine(MNNG), ultraviolet(UV) light, and ${\gamma}$-rays. Also, we used the mutant enrichment techniques, such as liquid culture-filtration procedure and differential heat sensitivity of conidia, in order to increase the possibility of obtaining a mutant. The glucoamylase productivity of mutant PFST-38 was 11 times higher than that of the parent strain. The mutant PFST-38 was morphologically identical to the parent strain, except for the size of conidia, the tendency to form conidia and the lenght of conidiophore. Asp. niger mutant PFST-38 apeared to be useful for the submerged production of the raw corn meal saccharifying enzyme.

• 한국균학회소식:학술대회논문집
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• 2016.05a
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• pp.17-17
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• 2016

Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal pathogen Cryptococcus neoformans. Herein, we identified and characterized calcineurin substrates in C. neoformans by employing phosphoproteomic $TiO_2$ enrichment and quantitative mass spectrometry. The identified targets include the zinc finger transcription factor Crz1 and proteins whose functions are linked to P-bodies/stress granules (PBs/SGs) and mRNA translation and decay, such as Pbp1 and Puf4. We show that Crz1 is a bona fide calcineurin substrate, and localization and transcriptional activity of Crz1 are controlled by calcineurin. Several of the calcineurin targets localized to PBs/SGs, including Puf4 and Pbp1, and are required for survival at high temperature and for virulence. Genetic epistasis analysis revealed that Crz1 and the novel targets Lhp1, Puf4, and Pbp1 function in a branched calcineurin pathway that orchestrates stress survival and virulence. These findings propose that calcineurin controls thermal stress and virulence at the transcriptional level via Crz1 and post-transcriptionally by regulating target factors involved in mRNA metabolism.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.2
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• pp.32.3-32.3
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• 2018

We use the synthetic light-cone from the cosmological hydrodynamical simulation Horizon-AGN to produce a mock photometric galaxy catalogue on the redshift range 0

• Economic and Environmental Geology
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• v.19 no.spc
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• pp.53-71
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• 1986

Detailed studies of regional geology and geochemistry of the tungsten mineralisation of Ogbang mine were carried out; in particular geochemical trends of major and trace elements of different lithological units, in comparison with those of the Sangdong area, together with igneous plutons in the area. The Ogbang deposit is in a pegmatitic association localised only in amphibolites whilst pegmatites in adjacent schists and gneisses are barren. The tungsten is geochemically accompanied by increase of $K_2O$, $Na_2O$ and Rb, and depletion of Sr. The trend of Rb/Sr ratio to the type of mineralisation, in commonly seen in the mineralised granites of the world, suggests that the tungsten in the Ogbang pegmatites was supplied by hydrothermal processes which at the same time caused Rb enrichment and Sr depletion. These trend could be of use in the search for new ore bodies in common with those of mineralised granitic or pegmatitic host rocks. There is no evidence that the granites in the area have any genetic influence spacially and temporarily on the initial scheelite formation.