• 한국학교보건학회지
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• 제24권1호
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• pp.99-109
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• 2011

Purpose: The purpose of this study was to investigate factors influencing dysmenorrhea in middle school girls and to analyze the differences in dysmenorrhea according to personal factors of the subjects. Methods: This study was conducted from March 22 to April 2, 2010. The subjects of the study were 572 girls who attended three middle schools in Seoul and experienced dysmenorrheal. All were surveyed using the same questionnaire. Data were analyzed by the SPSS/WIN 12.0 program and included descriptive statistics, ANOVA and multiple regression analysis. Results: 1) The mean age of the subjects was 13.53 years, and the mean age of first menstruation (menarche) was 11.94 years. The number of days between the onset of menstrual cycles was 30.01 days. Most of the respondents had irregular menstrual cycles and menstrual periods lasting 3 to 7 days long. 2) Chief menstrual pains were lower abdominal and back pain. Subjects reported experiencing severe lower abdominal and/or back pain, most commonly on the second day of menstruation. The average score of menstrual discomfort was over 60 points (63%). The average score per 6 points of dysmenorrhea was as follows: fatigue (3.48), sensitivity (3.27), disability of movement (3.27), napping or lying down (2.98), mood swings (2.95), interference with studies (2.87). 3) Individual subject characteristics influencing the onset of dysmenorrhea were as follows: high stress levels, being in poor health, having an irregular diet, being younger and having longer menstrual periods than most other subjects. Conclusion: During puberty, girls with earlier menarche complained of physical and emotional discomfort, and irregular menstrual periods. Therefore, we need to explain overall menstrual characteristics and individual differences in the occurrence of dysmenorrhea, in health education programs.

• Safety and Health at Work
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• 제12권3호
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• pp.390-395
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• 2021

Background: Health-care providers typically undergo shift work and are subjected to increased stress. Night shift work may induce disturbed sleep cycles and circadian rhythm. The objective of this study was to explore if night shift workers (NSWs) show an increased risk of abnormal thyroid-stimulating hormone (TSH). Methods: We conducted a retrospective cohort study of 574 employees without thyroid disease and abnormal TSH at baseline who underwent annual check-ups between 2007 and 2016 in a medical center. NSWs were defined as those with working time schedules other than daytime hours. We calculated the incidence rate and estimated the adjusted hazard ratio (HR) for incident abnormal TSH and subclinical hypothyroidism compared with non-NSWs using a Cox regression model. Results: A total of 56 incident abnormal TSH cases and 39 subclinical hypothyroidism cases in NSWs were identified during 3000 person-years of follow-up. In models adjusted for age, sex, obesity, and working departments, we found no increased relative risk for incident abnormal TSH (HR: 0.72, 95% confidence interval: 0.33-1.60) or subclinical hypothyroidism (HR: 0.52, 95% confidence interval: 0.19-1.45) when comparing NSWs to non-NSWs; nor were incidence rates significantly different among exclusively medical employees after excluding administrative staff. Conclusion: In this hospital-based nine-year follow-up retrospective cohort study, NSWs were not associated with increased relative risk of incident abnormal TSH and subclinical hypothyroidism, in contrast to previous cross-sectional studies.

• 디지털융복합연구
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• 제19권5호
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• pp.469-477
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• 2021

본 연구 목적은 임부의 임신 스트레스, 자아존중감 및 우울 정도를 조사하고 그 변수들 사이의 관계를 규명하여, 임부의 우울에 영향을 미치는 요인을 파악하는 데 있다. 본 연구는 154명의 임부를 대상으로 자료를 수집하고, 분석은 t-test, ANOVA, Scheffe's test, Stepwise Regression Analysis, Pearson's correlation coefficient를 이용하였다. 대상자의 임신 스트레스는 평균 61.17±13.84점(범위:27~135)으로, 계획된 임신인지에 따라 유의한 차이를 있는 것으로 나타났다. 대상자의 자아존중감은 평균 30.94±4.76점(범위:10~40)으로, 종교, 직업, 임신주수에 따라 유의한 차이를 보였다. 대상자의 우울은 평균 6.89±5.04점(범위:0~63)으로, 계획된 임신인지에 따라 유의한 차이를 보였다. 대상자의 우울은 임신 스트레스와 통계적으로 유의한 양적 상관관계를 나타냈고, 자아존중감과는 통계적으로 유의한 음적 상관관계가 있는 것으로 나타났으며, 임신 스트레스는 자아존중감과 통계적으로 유의한 음의 상관관계가 있는 것으로 나타났다. 임부의 우울에 영향을 주는 요인은 자아존중감, 계획된 임신 여부, 임신 스트레스 순이었다. 본 연구결과는 산전 관리 시 임부의 임신 스트레스, 자아존중감 및 우울 등 정서적 요인 정도를 사정하고, 임부의 정서적 측면을 지지하기 위한 간호 중재 프로그램 개발 및 적용의 필요성을 제시한다.

• 한국융합학회논문지
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• 제12권12호
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• pp.529-538
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• 2021

본 연구의 목적은 FoMO에 대한 개념분석을 통해 개념의 속성을 규명하고, 암 환자에서의 FoMO 개념을 통해 암 환자의 FoMO에 대한 중재에 기초자료를 제공하기 위함이다. Walker & Avant(2010)의 개념분석 방법을 적용하여 개념속성, 선행요인, 결과요인을 확인하기 위해, 2004년부터 2021년까지 발표한 국내외 선행연구 중 최종 82편을 분석하였다. 개념속성은 상대적 박탈감, 사회적 배제, 소속감의 결핍, 타인과 상호작용의 부재, 부정적인 감정이었으며, 선행요인은 흐름을 놓치거나 자신이 포함되지 않은 것에 대한 소외감, 타인과 지속적으로 연결되고 싶은 욕구였다. 이에 대한 결과는 정신적 고통이 증가하고, 우울, 불안 등 부정 정서가 촉발되며, 삶의 만족감과 자존감이 저하된다. 암 환자에서도 이러한 FoMO의 속성이 확인되었다. 이를 바탕으로 암 환자의 FoMO를 개선하기 위한 효과적인 중재 프로그램의 개발이 필요하다.

• 분석과학
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• 제31권6호
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• pp.232-239
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• 2018

Human breast milk (HBM) provides neonates with indispensable nutrition. The present study evaluated the anti-cancer activity of diluted and pasteurized early HBM (< 6 weeks' lactation) on human breast cancer cell lines. The cell lines MCF7 and MDA-MB231 were exposed to 1 % HBM from the 1st, 3rd, and 6th weeks of lactation and exhibited reduced proliferation rates. As controls, breast cell lines (293T and MCF-10A), breast cancer cell lines (MCF-7 and MDA-MB-231), and $CD133^{hi}CXCR4^{hi}ALDH1^{hi}$ patient-derived human cancer stem-like cells (KU-CSLCs) were treated with prominent milk proteins ${\beta}$-casein, ${\kappa}$-casein, and lactoferrin at varying doses (10, 50, and $100{\mu}g$) for 24 or 48 hrs. The impact of these proteins on cell proliferation was investigated. Breast cancer cell lines treated with ${\kappa}$-casein and lactoferrin exhibited significantly reduced viability, in both a dose- and time-dependent manner. Interestingly, ${\kappa}$-casein selectively impacted only cancer (but not normal breast) cell lines, particularly the more malignant cell line. However, ${\beta}$-casein-exposed human breast cancer cell lines exhibited a significantly higher proliferation rate. Thus, ${\kappa}$-casein and lactoferrin appear to exert selective anti-cancer activities. Further studies are warranted to determine the mechanisms underlying ${\kappa}$-casein- and lactoferrin-mediated cancer cell-selective cytotoxic effects.

• 한국학교보건학회지
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• 제31권3호
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• pp.203-213
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• 2018

Purpose: This study provides information for the development of educational programs for improving awareness of support to the elderly among adolescents. Methods: The 350 students of high schools located in Seoul were selected as subjects and surveyed using structured questionnaires during 11th~15th of April in 2014. The 327 subjects were used for analysis and the response rate was 93.4%. SPSS/WIN18.0 program was performed for t-test, ANOVA and regression analysis. Results: First, adolescents with parents aged over 50 compared to those with parents younger than 40 showed high level of awareness of support to the elderly. The high level of cognitive factors including image and perception towards the elderly (t=3.07, p=.01) were significant factors of awareness of support to the elderly. In experiential factors, adolescents with extensive influence of media and experiences with cohabitation with grandparents, and experiences with voluntary service activities were statistically significant with the high level of awareness of support to the elderly. Second, in regression analysis, adolescents' economic support awareness was higher with the stronger influence in the elderly-related media (${\beta}=.221$, p=.032). The emotional support awareness was higher among the eldest sons (${\beta}=.220$, p=.017) and perception (${\beta}=.352$, p=.001) to elderly (${\beta}=.221$, p=.032). Physical support awareness was higher when the positive image for the elderly (${\beta}=.223$, p=.016) and the high perception towards the elderly (${\beta}=.293$, p=.007). Conclusion: The awareness of support to the elderly should be constantly strengthened to the adolescents. Despite the rapid increase of the elderly, studies are not sufficient. Further research will be necessary.

• 의학교육논단
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• 제21권1호
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• pp.41-50
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• 2019

The aim of this study is to analyze the current status and performance evaluation systems of faculty in Korean medical colleges and professional graduate medical schools (called medical schools). We developed a research tool based on previous studies and distributed it to 40 medical schools from July to October 2017. The response rate was 100%. We calculated the number of faculty members and analyzed the faculty evaluation systems and awareness according to national and private medical schools. As of 2017, the number of medical faculty in Korea was 11,111 (4,973 faculty were employed by their alma mater, which is 44.76% of the total), with non-medical doctor faculty accounting for 754 of the total. The medical schools reflect research achievements as most important for re-appointment and screening to promote faculty, and the area of education is secondary excepting clinical faculty of private medical schools. However, important issues in the faculty evaluation deal with the relevance of research achievement and the need for qualitative assessment. Some medical schools revised or have been revising the faculty evaluation system in areas such as minimum standards of education for promotion and separation of promotion and tenure review. Opening non-tenure track lines for faculty show positive effects such as increasing the number of positions for hire and easing the financial burdens of medical schools. Downfalls include inconsistencies between the responsibilities and actual practices of tenure not being available and the instability of faculty's status. In conclusion, medical schools need to prepare a faculty evaluation system that fits the position of faculty members and attempt to establish a reasonable compensation system.

• The Korean Journal of Physiology and Pharmacology
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• 제23권5호
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• pp.403-409
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• 2019

Free fatty acid (FFA) intake regulates blood pressure and vascular reactivity but its direct effect on contractility of systemic arteries is not well understood. We investigated the effects of saturated fatty acid (SFA, palmitic acid), polyunsaturated fatty acid (PUFA, linoleic acid), and monounsaturated fatty acid (MUFA, oleic acid) on the contractility of isolated mesenteric (MA) and deep femoral arteries (DFA) of Sprague-Dawley rats. Isolated MA and DFA were mounted on a dual wire myograph and phenylephrine (PhE, $1-10{\mu}M$) concentration-dependent contraction was obtained with or without FFAs. Incubation with $100{\mu}M$ of palmitic acid significantly increased PhE-induced contraction in both arteries. In MA, treatment with $100{\mu}M$ of linoleic acid decreased $1{\mu}M$ PhE-induced contraction while increasing the response to higher PhE concentrations. In DFA, linoleic acid slightly decreased PhE-induced contraction while $200{\mu}M$ oleic acid significantly decreased it. In MA, oleic acid reduced contraction at low PhE concentration (1 and $2{\mu}M$) while increasing it at $10{\mu}M$ PhE. Perplexingly, depolarization by 40 mM KCl-induced contraction of MA was commonly enhanced by the three fatty acids. The 40 mM KCl-contraction of DFA was also augmented by linoleic and oleic acids while not affected by palmitic acid. SFA persistently increased alpha-adrenergic contraction of systemic arteries whereas PUFA and MUFA attenuated PhE-induced contraction of skeletal arteries. PUFA and MUFA concentration-dependent dual effects on MA suggest differential mechanisms depending on the types of arteries. Further studies are needed to elucidate underlying mechanisms of the various effects of FFA on systemic arteries.

• Nutrition Research and Practice
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• 제13권5호
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• pp.399-409
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• 2019

BACKGROUND/OBJECTIVES: This study was designed to provide scientific evidence on the effectiveness of worksite-based dietary intervention to reduce obesity among overweight/obese employees. MATERIALS/METHODS: Electronic search was performed using Ovid Medline, Embase, Cochrane Library, and CINAHL databases. The keywords used were "obesity," "nutrition therapy," and "worksite." The internal validity of the randomized controlled trials (RCTs) was assessed using the Cochrane's Risk of Bias. Meta-analysis of selected studies was performed using Review Manager 5.3. RESULTS: A total of seven RCTs with 2,854 participants were identified. The effectiveness of dietary interventions was analyzed in terms of changes in weight, body mass index (BMI), total cholesterol, and blood pressure. The results showed that weight decreased with weighted mean difference (WMD) of -4.37 (95% confidence interval (CI): -6.54 to -2.20), but the effectiveness was statistically significant only in short-term programs < 6 months (P = 0.001). BMI also decreased with WMD of -1.26 (95% CI: -1.98 to -0.55), but the effectiveness was statistically significant only in short-term programs < 6 months (P = 0.001). Total cholesterol decreased with WMD of -5.57 (95% CI: -9.07 to -2.07) mg/dL, demonstrating significant effectiveness (P = 0.002). Both systolic (WMD: -4.90 mmHg) and diastolic (WMD: -2.88 mmHg) blood pressure decreased, demonstrating effectiveness, but with no statistical significance. CONCLUSIONS: The worksite-based dietary interventions for overweight/obese employees showed modest short-term effects. These interventions can be considered successful because weight loss was below approximately 5-10 kg of the initial body weight, which is the threshold for the management of obesity recommended by the Scottish Intercollegiate Guideline Network (SIGN).

• Nutrition Research and Practice
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• 제13권3호
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• pp.263-267
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• 2019

BACKGROUD/OBJECTIVES: Obesity is globally a major public health issue. Evidence suggests that elevated ferritin levels are associated with obesity, dyslipidemia, insulin resistance, and metabolic syndrome. This study was undertaken to examine the relationship between the serum ferritin level and depression in Korean male adults with respect to classification of the prevailing obesity. SUBJECTS/METHODS: This was a case-control study; subjects were classified into obese group (${\geq}25.0kg/m^2$, 28 subjects) and normal group ($18.5-22.9kg/m^2$, 27 subjects). A survey was conducted to assess the depression levels as per the guidelines suggested by the Center program for Epidemiological Studies-Depression (CES-D). Blood was collected from each group for assessing biomarkers, and isolated plasma was evaluated for fasting glucose, insulin, quantitative insulin sensitivity check index, and ferritin levels. Data were analyzed, and groups were compared with respect to Body Mass Index (BMI), depression scale and biomarkers. RESULTS: The average depression score of the obesity group was 16.86, which was higher than the normal group (12.56). Subjects scoring more than 16 points comprised 53.6% of the population in the obese group, which was more than double that in the normal group, as assessed by the CES-D program. Furthermore, the serum ferritin level of the obesity group was 207.12 ng/mL, which was higher than that of the normal group (132.66 ng/mL). Lastly, the BMI appeared to be significantly correlated with both depression (r = 0.320, P = 0.017) and elevated ferritin levels (r = 0.352, P = 0.008). CONCLUSION: This study provides evidence of existing correlation between ferritin and depression with obesity.