• Journal of muscle and joint health
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• v.7 no.2
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• pp.269-280
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• 2000

This study was conducted to clarify the effect of physical ability, pain, fatigue, depression, sexual satisfaction, and spouse criticism on the sexual intrusiveness of rheumatoid arthritis(RA)women. The subjects of the study were 89 RA outpatients who visited the department of rheumatology of Dong-A University Hospital in Pusan from March 2000 to April, 2000. Pain & Fatigue via graphic rating scale, depression via CES-D(Center for Epidemiologic Studies -Depression) scale and physical ability via the Health Assessment questionnaire(HAQ) were assessed. Also we used both Sexual satisfaction scale(Kim, et al, 1997) to measure sexual satisfaction and Spouse criticism scale(Kraaimaat et al. 1996) to measure spouse criticism. The Intrusiveness rating scale which was derived from Arthritis Impact Measurement Scale(AIMS) was used to measure illness intrusiveness in sexuality. The relationships between the variables such as pain, depression, fatigue, physical ability, spouse criticism, sexual satisfaction and illness intrusiveness on sexuality were analyzed by Pearson correlation. As a result, pain & depression were significantly positively related to illness intrusiveness and physical ability & sexual satisfaction was significantly negatively related to illness intrusiveness. But these variables were interrelated. So hierarchical regression was performed to examine the relative contribution of pain, depression, physical ability, and sexual satisfaction with regard to intrusiveness of RA on sexuality. It revealed that pain, depression & sexual satisfaction predicted significantly illness intrusiveness on sexuality. Therefore it is very important to reduce pain and depression and to increase sexual satisfaction for reducing illness intrusiveness.

• Journal of muscle and joint health
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• v.10 no.1
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• pp.7-18
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• 2003

This study was to investigate the effects(pain, discomfort, and range of motion) of heat therapy according to the application time among the elderly with osteoarthritis. Study participants were 27 elderly women, who were diagnosed as osteoarthritis, suffered from it for more than 6 months, and who were staying at a nursing home in Busan. The independent variable was heat therapy, which was applied for 20minutes, one time per week according to 3 timetable(before waking up, while in daily living, before going to bed) over 6 weeks. The dependent variables were pain and discomfort measured by 20 points visual analog scales, and range of extension and flexion measured by goniometery. The data were analyzed by descriptive statistics and repeated measures ANOVA. The results were as follows ; 1) There were significant differences for pain(F=9.77 p=.0001), discomfort(F=8.07 p=.001), range of extension(F=3.05 p=.05), and flexion(F=9.67 p=.0001) among heat therapy application times. 2) There were significant differences for pain(F=58.18 p=.0001), discomfort(F=63.68 p=.0001), range of extension(F=11.59 p=.001), and flexion(F=17.59 p=.0001) between before and after applying heat therapy. 3) There were not statistically significant differences for pain(F=.64 p=.531), discomfort(F=.18 p=.836), range of extension(F=1.33 p=.270), and fiexion(F=.26 p=.773) between before and after applying heat therapy according to the heat therapy application times. In conclusion, heat therapy was effective in reducing pain and discomfort, and in improving ROM for the elderly with osteoarthritis, but the effect of it was not different according to the time of application. We recommended further studies with larger sample size, longer and more repeatedly applied to investigate the effect of heat therapy according to the time of application.

• The Journal of Korean Medicine
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• v.26 no.1 s.61
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• pp.103-114
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• 2005

Objective; Childhood obesity has become one of the most common health problems facing children in the world. Although a number of regimens have been developed and distributed for the treatment of adult obesity, few studies have focused on therapeutic programs for obese children. The objective of this study was to develop and measure the effects of Taeumin childhood obesity by a sasang constitution­based education program. Methods ; A total of 14$(\%RBW\geq20)$ among 18 taeumin with childhood obesity from June to August 2003 participated in the constitution-based education program. It was designed to examine the effects of a constitution-based education program through anthropometric measurements, body composition indicates, biochemical indicates and serum level of taeumin childhood obesity. Results; The results of this study were as follows: 1. The anthropometric measurement of subscapular skinfold thickness was reduced after 4 weeks of the constitution-based education program. 2. The body composition indicates reduction in degree of obesity, percent body fat, and fat distribution. The other side increased in height, total body water, soft lean mass, and lean body mass. 3. For biochemical indicates, HDL-cholesterol was increased significantly after 4 weeks of the constitution-based education program. The other side decreased in AST and ALT. 4. There was a significant reduction in BMI and $\%RBW$ after the constitution-based education program. Conclusion : A constitution-based education program for weight control results in reduced degree of obesity among taeumin children.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.6
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• pp.687-694
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• 2017

Plumbagin, a hydroxy 1,4-naphthoquinone compound from plant metabolites, exhibits anticancer, antibacterial, and antifungal activities via modulating various signaling molecules. However, its effects on vascular functions are rarely studied except in pulmonary and coronary arteries where NADPH oxidase (NOX) inhibition was suggested as a mechanism. Here we investigate the effects of plumbagin on the contractility of skeletal artery (deep femoral artery, DFA), mesenteric artery (MA) and renal artery (RA) in rats. Although plumbagin alone had no effect on the isometric tone of DFA, $1{\mu}M$ phenylephrine (PhE)-induced partial contraction was largely augmented by plumbagin (${\Delta}T_{Plum}$, 125% of 80 mM KCl-induced contraction at $1{\mu}M$). With relatively higher concentrations (>$5{\mu}M$), plumbagin induced a transient contraction followed by tonic relaxation of DFA. Similar biphasic augmentation of the PhE-induced contraction was observed in MA and RA. VAS2870 and GKT137831, specific NOX4 inhibitors, neither mimicked nor inhibited ${\Delta}T_{Plum}$ in DFA. Also, pretreatment with tiron or catalase did not affect ${\Delta}T_{Plum}$ of DFA. Under the inhibition of PhE-contraction with L-type $Ca^{2+}$ channel blocker (nifedipine, $1{\mu}M$), plumbagin still induced tonic contraction, suggesting $Ca^{2+}$-sensitization mechanism of smooth muscle. Although ${\Delta}T_{Plum}$ was consistently observed under pretreatment with Rho A-kinase inhibitor (Y27632, $1{\mu}M$), a PKC inhibitor (GF 109203X, $10{\mu}M$) largely suppressed ${\Delta}T_{Plum}$. Taken together, it is suggested that plumbagin facilitates the PKC activation in the presence of vasoactive agonists in skeletal arteries. The biphasic contractile effects on the systemic arteries should be considered in the pharmacological studies of plumbagin and 1,4-naphthoquinones.

• Environmental Analysis Health and Toxicology
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• v.21 no.1 s.52
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• pp.27-34
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• 2006

Numerous studies reported the significant association between genetic polymorphisms in the vitamin D receptor (VDR) gene and various bone phenotypes such as bone mineral density (BMD) and bone quality, although conflicting results were produced. The objective of this study was to investigate the association between a TaqI RFLP in the VDR gene and calcaneal BMD in Korean vegetarian men, and its interaction with nutrition status as an environmental factor. BUA (broadband ultrasound attenuation), SOS (sound of speed) and stiffness index of the calcaneus were measured using an ultrasound bone densitometer in 266 Korean men (age: $mean{\pm}SD;\;50.9{\pm}12.0$ year), and a TaqI RFLP in the VDR gene analysed by PCR-RFLP method. In total subjects, the distribution of TT, Tt and tt genotypes occurred with frequencies of 90.8%, 8.8% and 0.4%, respectively. There were no significant associations between this polymorphism and osteopenia-osteoporosis or several bone phenotypes in our subjects irrespectively of nutrition status (P>0.05). Therefore, our results suggest that a TaqI RFLP in the vitamin D receptor gene does not contribute to the susceptibility to the calcaneal BMD in Korean men.

• Korean Journal of Ichthyology
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• v.26 no.4
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• pp.274-280
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• 2014

The spermatozoa of Platichthys stellatus is relatively simple cells composed of a spherical head, a short midpiece, and a tail, as in most Pleuronectiformes. The ultrastructure is characterized by the following features: a round nucleus with a deep nuclear fossa, the centriolar complex located at a right angle to each other, a short midpiece, a tail with paired lateral ribbon and no acrosome. However there are some minor morphological differences, including the appearance and number of the mitochondria, the shape and size of the nuclear fossa and the structure of the basal body. Especially the basal body structure consisting of a basal foot, a rootlet and nine alar sheets structures varies considerably in different species. It can be used as indicator of relationships in Pleuronectiformes because minute morphological differences might have functional and evolutionary significance. In conclusion, the spermatozoa of P. stellatus show a certain structural homogeneity and provide support for the concept that ultrastructural features of spermatozoa can be useful in taxonomic studies of Pleuronectiformes.

• Korean Medical Education Review
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• v.10 no.2
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• pp.25-44
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• 2008

Objectives: Through using of the strong research method like a Randomized Controlled Trial: RCT, we have to heighten quality of Medical Education study. I'd like to introduce "CONSORT", which stands for Consolidated Standards of Reporting Trials. Contents: Preventive Service Task Force(200l) in USA proposed Levels of evidence for enlarging evidence-based Practice: EBP. And the CONSORT was introduced, which encompasses various initiatives developed by the CONSORT Group to alleviate the problems arising from inadequate reporting of randomized controlled trials (RCTs). the CONSORT has 13 guides like these: 1. How participants were allocated to interventions 2. Scientific background and explanation of rationale 3. Eligibility criteria for participants. The settings and locations where the data were collected. 4. Precise details of the interventions intended for each group and how and when they were actually administered 5. Specific objectives and hypotheses 6. Clearly defined primary and secondary outcome measures, When applicable. any methods to enhance the quality of measurements (e.g., multiple observations, training of assessors) 7. How sample size was determined. When applicable, explanation of any interim analyses and stopping rules 8. Method used to generate the random allocation sequence, Details of any restriction [of randomization] 9. Method used to implement the random allocation sequence 10. Who generated the allocation sequence, who enrolled participants. and who assigned participants to their groups 11. Whether or not participants, those administering the interventions, and those assessing the outcomes were blinded to group assignment. If done, how the success of blinding was evaluated 12. Statistical methods used to compare groups for primary outcome(s), Methods for additional analyses, such as subgroup analyses and adjusted analyses 13. Flow of participants through each stage (a diagram is strongly recommended) Specifically, for each group report the numbers of participants randomly assigned. receiving intended treatment, completing the study protocol. and analyzed for the primary outcome. Results and Conclusion: Randomized Controlled Trial: RCT guided of CONSORT will contribute to do stronger evidence-based medical studies.

• Journal of Digital Convergence
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• v.16 no.7
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• pp.493-509
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• 2018

This study was performed to compare the effects of health behaviors, dietary habits, and psychological health on metabolic syndrome (MS) between young adults living in one-person households (OPHs) and multiple-person households (MPHs). The data from the Korean National Health and Nutrition Examination Survey (KNHANES), which was conducted in 2014 and 2016 were used. The subjects were 2,682, who were 20 to 39 years old. The data were analyzed using complex sample Rao-Scott ${\chi}^2-tests$, t-tests, and multiple logistic regression using SPSS 23.0 software. Sex, age, obesity, and subjective health status were associated with MS in young adults living in either OPHs or MPHs. Breakfast consumption frequency, eating alone, food label use, stress, and depression were associated with MS only in young adults living in OPHs. Thus, these differentiated risk factors of MS should be considered, when health promotion strategies and interventions are planned for young adults living in OPHs. Also, further studies are needed to evaluate the effectiveness of the strategies or interventions.

• Journal of Digital Convergence
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• v.18 no.4
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• pp.263-272
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• 2020

The purpose of this study was to identify the relationships between sleep time and depression and suicidal ideation in middle aged women. The subjects of this study were 1,617 women aged 40-64 years who participated in the Seventh Korea National Health and Nutrition Examination Survey (KNHANES VII-2), 2017. Data were downloaded from the KNHANES website and were analysed through complex sampling design data analysis using IBM SPSS 21.0 program. Suicidal ideation is 3.65 times higher in women who sleeps for five hours or less in weekend than in women who sleeps more than seven hours and less than nine hours in weekend. These result indicate that suicide prevention program for middle aged women should include strategies for maintaining proper sleep times and women who sleeps for five hours or less should be considered as a priority intervention case. In additions, further studies on the relationship between sleep times and depression of middle aged women should be conducted.

• Journal of Korean Society of Forest Science
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• v.106 no.1
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• pp.87-99
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• 2017

The first purpose of this study is the verification of hypothesis on Abies holophylla planted as a guardian for Japanese. Second, the purpose of this study is on Abies holophylla planted in the historic sites for anti-Japan fighter. Japan planted Abies holophylla to honor the god of Suwataisha that took care of the Jingu-Kogo's Conquest of Samhan(Three Kingdoms). The fact that Abies holophylla was planted in the historic sites for anti-Japan fighter such as General Gwon Yul, Yi Sun-Shin was investigated. The hypothesis that Abies holophylla was planted as a guardian for Japanese was verified through survey on the pictures of Abies holophylla in Japanese temple, public sites, company of nursing the saplings, commemorative tree of governor and the judgment of Abies holophylla damage incident. Further studies should focus on the intention of planting Abies holophylla by Japan. Researcher should discuss Abies holophylla planted in the historic sites for anti-Japan fighter because old big trees will be respected.