Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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The Distribution of TaqI RFLP in the Vitamin D Receptor Gene in Korean Vegetarian Men and its Association with Calcaneal Bone Mineral Density

한국인 채식 남성에서 비타민 D 수용체 유전자의 TaqI 다형성의 분포 및 종골의 골밀도와의 관련성

  • Kang Byung-Yong (Research Institute for Life Science, Sahmyook University) ;
  • Kim So-Yeon (Department of Health and Social Welfare, Sahmyook Nursing and Health College) ;
  • Lee Sang-Jin (Department of Animal Science, Sahmyook College) ;
  • Kim Hyun-Hee (Department of Life Science, Sahmyook University)
  • 강병용 (삼육대학교 생명과학연구소) ;
  • 김소연 (삼육간호보건대학 사회복지학과) ;
  • 이상진 (삼육의명대학 동물자원학과) ;
  • 김현희 (삼육대학교 생명과학과)
  • Published : 2006.03.01
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Abstract

Numerous studies reported the significant association between genetic polymorphisms in the vitamin D receptor (VDR) gene and various bone phenotypes such as bone mineral density (BMD) and bone quality, although conflicting results were produced. The objective of this study was to investigate the association between a TaqI RFLP in the VDR gene and calcaneal BMD in Korean vegetarian men, and its interaction with nutrition status as an environmental factor. BUA (broadband ultrasound attenuation), SOS (sound of speed) and stiffness index of the calcaneus were measured using an ultrasound bone densitometer in 266 Korean men (age: $mean{\pm}SD;\;50.9{\pm}12.0$ year), and a TaqI RFLP in the VDR gene analysed by PCR-RFLP method. In total subjects, the distribution of TT, Tt and tt genotypes occurred with frequencies of 90.8%, 8.8% and 0.4%, respectively. There were no significant associations between this polymorphism and osteopenia-osteoporosis or several bone phenotypes in our subjects irrespectively of nutrition status (P>0.05). Therefore, our results suggest that a TaqI RFLP in the vitamin D receptor gene does not contribute to the susceptibility to the calcaneal BMD in Korean men.

Keywords

References

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