• 대한예방한의학회지
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• 제13권3호
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• pp.87-99
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• 2009

Objectives : The study was to examine the empirical evidence concerning the effects of massage intervention for the laboring women and to investigate the effect sizes related to the characteristics of intervention. Methods : Meta analysis was performed. A total of 11 trials related to massage intervention between 2000 and 2007 were reviewed. Results : Massage intervention showed a beneficial effect on length of labor(1st stage : U=46.75, p=0.00, 2nd stage : U=6.13, p=0.01), perception of childbirth experience(U=12.57, p=0.00), intensity of uterine contraction at the active(U=6.34, p=0.01) and the transition phases(U=24.83, p=0.00), and interval of uterine contraction at the active phase(U=4.83, p=0.03). Massage decreased systolic(U=10.81, p=0.00) and diastolic blood pressure at the transition phase(U=10.60, p=0.00). However, massage had no effect on subjective and objective labor pain and anxiety. No differences were found in effectiveness of massage according to characteristics of intervention(massage material, massager, and massage site) except for anxiety(QB=4.82, p=0.03) and diastolic blood pressure at the active phase by massage site(QB=4.52, p=0.03). Conclusions :We found that massage intervention for the laboring women had an empirical evidence on improving perception of childbirth experience and shortening length of labor. These results should be interpreted with caution due to the lack of studies. More full-scale randomized clinical trials with reliable designs are recommended to further warrant the effectiveness of massage.

• Environmental Analysis Health and Toxicology
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• 제28권
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• pp.17.1-17.3
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• 2013

The fact that hazardous metals do not bio-degrade or bio-deteriorate translates to long-lasting environmental effects. In the context of evidently rapid global industrialization, this ought to warrant serious caution, particularly in developing countries. In the Republic of Fiji, a developing country in the South Pacific, several different environmental studies over the past 20 years have shown levels of lead, copper, zinc and iron in sediments of the Suva Harbor to be 6.2, 3.9, 3.3 and 2.1 times more than the accepted background reference levels, respectively. High levels of mercury have also been reported in lagoon shellfish. These data inevitably warrant thorough assessment of the waste practices of industries located upstream from the estuaries, but in addition, an exposure and health impact assessment has never been conducted. Relevant government departments are duty-bound, at least to the general public that reside in and consume seafood from the vicinities of the Suva Harbor, to investigate possible human effects of the elevated hazardous metal concentrations found consistently in 20 years of surface sediment analysis. Furthermore, pollution of the intermediate food web with hazardous metals should be investigated, regardless of whether human effects are eventually confirmed present or not.

• 대한한방종양학회지
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• 제5권1호
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• pp.19-32
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• 1999

To evaluate the antitumor activity and antimetastatic effects of Kamigumgusingihwan(KGSH) studies have ken done. The results were obtained as follows: 1. KGSH extracts exhibited a weak cytotoxicity against A549, SK-OV-3, B16-F10, and SK-MEL-2 cell lines. But exhibited potent cytotoxicity against P388 cell line in a dose-dependent manner. 2. The concentration inhibiting adhesion of A549, to complex extracellular matrix up to below 30% of control was recognized at $10^{-3}g/ml$ of KGSH 3. KGSH extracts showed a weak inhibitoty effect on DNA topo-isomerase I from calf thymus. 4. The T/C% was 137% in KGSH treated group in S-180 bearing ICR mice. 5. In pulmonary colonization assay, a number of colonies in the lungs were decreased significantly in KGSH treated group as compared with control group. 6. In hematological changes in B16-BL6 injected C57BL/6, numbers of WBC were decreased insignificantly in KGSH treated groups, and also those of platelet were increased insignificantly in KGSH treated groups as compared with control. 7. In CAM assay, KGSH extracts inhibited angiogenesis at $15{\mu}g/egg $concentration significantly as compared with control. Taken together these results, it is strongly demonstrated that KGSH significantly suppressed tumor metastasis by blocking cell adhesion to extracellular matrix. Therefore, KGSH is expected to be clinically a potent antimetastatic drug for the prevention and treatment of cancer.

• 한국산학기술학회논문지
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• 제15권6호
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• pp.3714-3724
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• 2014

본 연구에서는 서울시내에 있는 S 사이버대학교 상담심리학과에 재학중인 대학생을 대상으로 단축형 집단 프로그램을 실시하고 그 효과를 살펴보았다. 본 연구에서 사용된 명상 프로그램은 마음챙김 인지치료와 자기-자비 프로그램을 혼합한 프로그램으로 구조화된 집단 프로그램 형식으로 구성되었으며 참가자들의 정서적 안녕감을 증진시키는 것을 목표로 하였다. 단축형 집단 프로그램에 참여한 참가자들은 4주간의 오프라인 집단 프로그램에 참여하였다. 전체 25명의 참가자들은 프로그램 사전과 사후에 우울, 심리적 안녕감, 긍정 및 부정적 정서, 마음챙김 및 자기 자비 측정치들을 실시하였다. 본 연구는 마음챙김 및 자기 자비 명상이 상담심리 대학생들의 심리적 안녕감에 미치는 긍정적인 영향을 살펴볼 수 있는 경험적 기초를 제공해주고 있다. 향후 심리학 전공 대학생 외에 여타의 다른 전공 대학생들을 대상으로 마음챙김과 자기 자비 명상을 접목한 프로그램을 실시하여 다양한 스트레스 상황에 노출되어 있는 대학생들의 정신 건강에 이 프로그램이 어떤 영향을 미치는지 반복 검증해보는 것이 필요할 것이다.

• 한국콘텐츠학회논문지
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• 제15권9호
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• pp.285-294
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• 2015

본 연구는 결핵환자의 스티그마, 가족지지 및 삶의 질과 이들의 상관관계를 파악하기 위한 서술적 조사연구이다. 연구 대상자는 일개 대학교 병원에서 결핵치료를 받는 환자 122명으로 구조화된 설문지를 이용하여 자료를 수집하였다. 수집된 자료는 기술통계, t-test, ANOVA, 및 Pearson's correlation으로 분석하였고, 연구결과는 다음과 같다. 스티그마 I(결핵에 대한 타인 관점에 대한 지각)은 $18.67{\pm}7.48$ 이었고, 스티그마 II(자신의 관점에 대한 지각)는 $14.84{\pm}6.93$ 이었다. 가족지지는 평균 $30.81{\pm}4.16$ 이었고, 삶의 질은 평균 $102.22{\pm}13.72$ 이었다. 스티그마 I과 스티그마 II 사이에는 높은 정적 상관성(r = .753, p <.001)을, 스티그마II와 삶의 질은 경도의 부적 상관성(r = -.250, p = .005)을, 가족지지와 삶의 질은 중정도의 정적 상관성(r = .314, p < .001)을 나타내었다. 본 연구결과가 보여준 가족지지와 삶의 질의 정적 상관관계를 기반으로, 결핵환자의 스티그마를 줄이고 삶의 질을 증진시키는 중재프로그램을 개발하고 그 효과를 평가하는 연구를 제언한다.

• 융합정보논문지
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• 제8권1호
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• pp.69-77
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• 2018

본 연구는 분만 후 산모의 자기효능감과 산후우울에 대한 남편의 도움의 융합적효과를 알아보기 위해 시행되었다. 남편은 3회의 산모와 아기돌봄 교육을 받고 분만 6주까지 이를 실천하였다. 실천정도는 분만 6주에, 자기효능감과 산후우울은 분만 1주와 6주에 각각 측정하여, 수집된 자료는 SPSS/WIN 20.0으로 분석하였다. 남편의 실천률은 80%였고, 자기효능감에의 영향요인은 분만력, 임신중입원 및 남편의 직업이었으며, 산후우울에의 영향요인은 산모의 교육정도, 월수입 및 임신중 우울이었다. 산후우울 유병률은 1주와 6주에 각각 33.3%와 1.7%이었고, 산후자기효능감증가 및 산후우울감소가 유의하였으며(p<.001), 두 변수 간 음의 상관관계가 있었다(r=-.62, p=.01). 남편의 도움은 산모의 자기효능감증가와 산후우울감소의 융합적 효과를 가져왔다. 이 결과는 대상자 수를 확대하여 반복연구 후 산모의 산후자기효능감과 산후우울관리를 위한 간호 중재개발 및 교육자료로 활용될 수 있다.

• 대한수의학회지
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• 제26권1호
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• pp.103-108
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• 1986

The oil emulsion and alhydrogel pilli vaccines were prepared from a strain(O9: K35, K99, F41) of enterotoxigenic Escherichia coli isolated from calves with diarrhea and their immunogenicity was tested in guinea-pigs, pregnant goats and cows. Serum antibody responses to K99 and F41 antigens in guinea-pigs given experimental oil and gel vaccines peaked at 4 and 6 weeks after vaccinations. At that time, the mean hemagglutination inhibition titers to K99 and F41 antigens in guinea-pigs given oil vaccine were 1:25 and 1:1, 218 and those given gel vaccine were 1:54 and 1:724 respectively. Agglutinin titers in pregnant goats given the oil vaccine were significantly higher(mean 1:2,347) compared to those of control group(mean 1:160). Less than 12.5% of goatlings from vaccinated goats developed scours compared to nearly 100% in control group after oral challenge with enterotoxigenic Escherichia coil within 24 hours after birth. The highest agglutinin titers of cow serum and colostrum and of the serum of calves 48 hours after birth from cows given oil vaccine were 1:256, 1:512 and 1:64 respectively. On the other hand, those titers of serum and colostrum and of the serum of nursing calves from nonvaccinated cows were 1:8, 1:16 and 1:20 respectively. The protective efficacy of the oil emulsion vaccine was 72.1% under field conditions. These results strongly indicated that the vaccine could be applied for protection of diarrhea caused by enterotoxigenic Escherichia coli in calves.

• 한국약용작물학회지
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• 제24권1호
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• pp.7-13
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• 2016

Background : Ginger has been extensively used in foods and traditional medicines in Asian countries. Despite its frequent consumption in daily life, the mechanism of potential interactions between ginger components-drug has not been examined. To elucidate the mechanism of governing the effects of 6-shogaol, a primary constituent of dried ginger, on human cytochrome P450 (CYP) isoenzymes an incubation studies were carried out using pooled human liver microsome (HLM). Methods and Results : CYP isoenzyme specific substrate was incubated with multiple concentrations of inhibitor, HLM and cofactors. 6-shogaol showed a potent inhibitory effect on CYP2C9, CYP1A2 and CYP2C19 with half maximal inhibitory concentration ($IC_{50}$) values of 29.20, 20.68 and $18.78{\mu}M$ respectively. To estimate the value of the inhibition constant ($K_i$) and the mode of inhibition, an incubation study with varying concentrations of each CYP isoenzyme-specific probe was performed. 6-shogaol inhibited CYP2C9 and CYP2C19 noncompetitively ($K_i=29.02$ and $19.26{\mu}M$ respectively), in contrast, the inhibition of CYP1A2 was best explained by competitive inhibition ($K_i=6.33{\mu}M$). Conclusions : These findings suggest that 6-shogaol may possess inhibitory effects on metabolic activities mediated by CYP1A2, CYP2C9 and CYP2C19 in humans.

• Journal of Acupuncture Research
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• 제33권1호
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• pp.95-101
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• 2016

Objectives : The aim of this report was to investigate the effects of Korean medical treatment on facial nerve paralysis with sensorineural hearing loss and tinnitus caused by traumatic temporal bone fracture. Methods : We treated a patient with acupuncture, herbal medicine and physiotherapy. The effect of these treatments was evaluated by House-Brackmann facial grading scale, Yanagihara's unweighted grading system and by Digital Infrared Thermographic Image. Results : After 21 days of Korean medical treatment, House-Brackmann facial grading scale changed from III to II and Yanagihara's unweighted grading score increased from 14 to 27. Digital Infrared Thermographic Image also improved. Conclusions : These results suggest that Korean medical treatments were effective in treating facial nerve paralysis with sensorineural hearing loss and tinnitus caused by traumatic temporal bone fracture. We hope that a more efficient application of this treatment will be the result of clinical data accumulated in future studies.

• Journal of Acupuncture Research
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• 제35권2호
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• pp.95-100
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• 2018

Background: The aim of this study is to assess the feasibility of acupuncture treatment for the management of subacute and chronic post-thoracotomy pain in patients with traumatic multiple rib fractures. Methods: A total of 30 participants who have undergone thoracotomy after traumatic multiple rib fractures will be recruited. Participants will be invited and equally randomised into acupuncture plus usual care and usual care alone groups. A computer-generated random number sequence will be used and concealed using opaque, sealed, sequentially numbered envelopes. Twelve sessions of manual and electrical acupuncture performed by Korean medicine doctors will be provided over a span of 3 months to participants allocated to the acupuncture group. Participants in the usual care group will continue pain medication, exercise and physical therapy as required. Study feasibility will be measured based on the proportion of patients who complete the measurement of pain at 12 or 24 weeks after baseline. The clinical outcomes will include; the average pain intensity over the recent week at rest, movement and cough, quality of life, patient's global assessment of recovery, respiratory function measured by the pulmonary function test and use of pain medication at 4, 8, 12 and 24 weeks after enrolment. Adverse events will be recorded for all participants. Written informed consent will be obtained from all participants. The local ethics committee has approved the study. This pilot trial will inform further studies investigating the potential role of acupuncture for subacute and chronic post-thoracotomy pain in patients with traumatic multiple rib fractures.