• Journal of the Institute of Electronics Engineers of Korea SD
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• v.38 no.8
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• pp.1-12
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• 2001

The adaptive learning circuit is designed on the basis of modeling of MFSFET (Metal-Ferroelectric-Semiconductor FET) and the numerical results are analyzed. The output frequency of the adaptive learning circuit is inversely proportional to the source-drain resistance of MFSFET and the capacitance of the circuit. The saturated drain current with input pulse number is analogous to the ferroelectric polarization reversal. It indicates that the ferroelectric polarization plays an important role in the drain current control of MFSFET. The output frequency modulation of the adaptive learning circuit is investigated by analyzing the source-drain resistance of MFSFET as functions of input pulse numbers in the adaptive learning circuit and the dimensionality factor of the ferroelectric thin film. From the results, the frequency modulation characteristic of the adaptive learning circuit are confirmed. In other words, adaptive learning characteristics which means a gradual frequency change of output pulse with the progress of input pulse are confirmed. Consequently it is shown that our circuit can be used effectively in the neuron synapses of nueral networks.

• Archives of Plastic Surgery
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• v.36 no.2
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• pp.183-187
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• 2009

Purpose: Because of the volume of elective sterilizations performed in the world during the past decade, the vasectomy was a popular method for male sterilization in Korea and this, in turn, had been followed by an increase in the number of patient requiring vasectomy reversal with the high rate of subsequent divorce and remarriage. Recently, many authors have reported high success rates of vasovasostomy using microsurgical techniques and we performed modified two layer vasovasostomy with intravasal silicone tube to increase postoperative patency and pregnacy rate. Methods: Microscopic vasovasostomy was performed in 9 patients and their average age was $35.78{\pm}1.36years$(from 28 years to 44 years) from June 2006 to June 2008 at our department using modified two layer vasovasostomy with silicone tube insertion. Standard Guibor silicone tube, consisting of two 17.7 cm, 0.064 cm diameter, malleable, stainless steel probes connected by 29 cm of silicone tubing wedged onto disposable probes, were used in all cases. Results: Success rates were 88.8 % for patency and pregnancy 44.4 % for pregnancy in modified two layer vasovasostomy with silicone tube insertion. The patency rates were higher in cases of long postoperative day and in cases of short duration of vasectomy and vasovasostomy. Conclusion: We used a modified method to correspond the patency and pregnancy rate in microscopical modified two layer vasovasostomy using the intravasal silicone tube permanently. This method brings normal patency in microsurgical vasovasostomy because the silicone tube prevent obstruction of anastomosed site of the vas permanently.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.1
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• pp.61-66
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• 2014

Lung cancer is still the number one cause of death from cancer worldwide. The clinical effect of platinum-based chemotherapy for non-small cell lung cancer is constrained by the resistance to drug. To overcome chemo-resistance, various modified treatment including combination therapy has been used, but overall survival has not been improved yet. In this study, chemo-resistant lung cancer cells, A549/Cis and H460/Cis, were developed by long-term exposure of cells to cisplatin and the proliferative capability of these resistant cells was verified to be reduced. We found cytotoxic effect of epigallocatechin gallate (EGCG), a major catechin derived from green tea, on both the parental lung cancer cells, A549 and H460, and their cisplatin resistant cells, A549/Cis and H460/Cis. ELISA and Western blot analysis revealed that EGCG was able to increase interlukine-6 (IL-6) production per cell, whereas its downstream effector Signal transducers and activators of transcription 3 (STAT3) phosphorylation was not changed by EGCG, indicating that IL-6/STAT3 axis is not the critical signaling to be inhibited by EGCG. We next found that EGCG suppresses the expression of both Axl and Tyro 3 receptor tyrosine kinases at mRNA and protein level, explaining the cytotoxic effect of EGCG on lung cancer cells, especially, regardless of cisplatin resistance. Taken together, these data suggest that EGCG impedes proliferation of lung cancer cells including their chemo-resistant variants through downregulation of Axl and Tyro 3 expression.

• Journal of Korean Medical classics
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• v.30 no.2
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• pp.113-131
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• 2017

Objectives : Dianji is a classic mental disorder in oriental medicine. Dian is often used as a name of disease together with Xian and Kuang. However, much confusion arises due to the usage of such words as Diankuang or Dianxian without the full comprehension of these terms' meanings. Dian, especially, is contained in both, so there is a need to clearly define its meaning. Therefore, the paper aims to study in what context Huangdineijing, the oldest classical medical text in oriental medicine, used Dian. Methods : All statements in Huangdineijing containing Dian were studied to create a number of categories. Based on this analysis, the paper attempted to understand Dianji's symptoms, mechanism, natures, and more. Then lastly, the relationship between the usage of Kuang and Xian was pondered upon. Conclusions & Results : The mechanism of pathology of the Dianji in Huangdineijing can be understood within the scope of upper excess and lower deficiency and the reversal of qi. Additionally, Dianji refers to a sickness in the head, and has a essence of spirit disease. Dian and Kuang were expressed as two types of relationship. One expression was a form of symptom that becomes visible during the occurrence phase of Dian, and the other expression was the cases where it was used as an independent sign. On the other hand, there was no case where Xian and Dian were explained in conjunction with each other. However, there still exist some similarities, mainly in that both diseases revolves around epilepsy.

• Steel and Composite Structures
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• v.28 no.3
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• pp.363-380
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• 2018

This paper presented an integral design procedure for demountable bolted composite frames with semi-rigid joints. Moment-rotation relationships of beam-to-column joints were predicted with analytical models aiming to provide accurate and reliable analytical solutions. Among this, initial stiffness of beam-to-column joints was derived on the basis of Timoshenko's plate theory, and moment capacity was derived in accordance with Eurocodes. The predictions were validated with relevant test results prior to further applications. Frame analysis was conducted by using Abaqus software with material and geometrical nonlinearity considered. Variable lateral loads incorporating wind actions and earthquake actions in accordance with Australian Standards were adopted to evaluate the flexural behaviour of the composite frames. Strength and serviceability limit state criteria were utilized to verify configurations of designed models. A wide range of frames with the varied number of storeys and bays were thereafter programmed to ascertain bending moment envelopes under various load combinations. The analytical results suggest that the proposed approach is capable of predicting the moment-rotation performance of the semi-rigid joints reasonably well. Outcomes of the frame analysis indicate that the load combination with dead loads and live loads only leads to maximum sagging and hogging moment magnitudes in beams. As for lateral loads, wind actions are more crucial to dominate the design of the demountable composite frames than earthquake actions. No hogging moment reversal is expected in the composite beams given that the frames are designed properly. The proposed analysis procedure is demonstrated to be a simple and efficient method, which can be applied into engineering practice.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.3
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• pp.275-285
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• 2003

A visualization study on the effect of forcing amplitude in tone-excited jet diffusion flames has been conducted. Visualization techniques are employed using optical schemes. which are a light scattering photography. Flame stability curve is attained according to Reynolds number and forcing amplitude at a fuel tube resonant frequency. Flame behavior is globally grouped into two from attached flame to blown-out flame according to forcing amplitude: one sticks the tradition flame behavior which has been observed in general jet diffusion flames and the other shows a variety of flame modes such as the flame of a feeble forcing amplitude where traditionally well-organized vortex motion evolves, a fat flame. an elongated flame. and an in-burning flame. Particular attention is focused on an elongation flame. which is associated with a turnabout phenomenon of vortex motion and on a reversal of the direction of vortex roll-up. It is found that the flame length with forcing amplitude is the direct outcome of the evolution process of the formed inner flow structure. Especially the negative part of the acoustic cycle under the influence of a strong negative pressure gradient causes the shapes of the fuel stem and fuel branch part and even the direction of vortex roll-up to dramatically change.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.3
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• pp.534-540
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• 2008

The adaptive learning circuit is designed on the basis of modeling of MFSFET (Metal-Ferroelectric-Semiconductor FET) and the numerical results is analyzed. The output frequency of the adaptive learning circuit is inversely proportional to the source-drain resistance of MFSFET and the capacitance of the circuit. The saturated drain current with input pulse number is analogous to the ferroelectric polarization reversal. It indicates that the ferroelectric polarization plays an important role in the drain current control of MFSFET. The output frequency modulation of the adaptive learning circuit is investigated by analyzing the source-drain resistance of MFSFET as functions of input pulse numbers in the adaptive learning circuit and the dimensionality factor of the ferroelectric thin film. From the results, adaptive learning characteristics which means a gradual frequency change of output pulse with the progress of input pulse, are confirmed. Consequently it is shown that our circuit can be used effectively in the neuron synapses of neural networks.

• Journal of the Korean Magnetics Society
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• v.8 no.1
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• pp.34-41
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• 1998

We have theoretically investigated torque curve shapes of simple uniaxial magnetic materials by considering conditions for round peaks to exist. These conditions are functions of an applied field, anisotropy field, ans lowest critical field $h_0$ for a domain wall to move or nucleate. The peak having a height of 2h appears when h is lower than h$_1$, the peak having a height of 1 appears when h is higher than h$_2$, ans two peaks having heights of 1 and -1 appear when h is higher than h$_3$. It was found that torque curves of simple uniaxial magnetic materials could be classified into 8 distinct types depending on the existence of hysteresis, the number of the round peaks, and the reversal mechanisms. Simple uniaxial magnetic materials also found to be classifed into the 5 groups depending on $h_0$.

• Nutrition Research and Practice
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• v.5 no.4
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• pp.294-300
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• 2011

Takju is a Korean alcoholic beverage made from rice, and is brewed with the yeast Saccharomyces cerevisiae. This study was conducted to evaluate the effects of exercise training and moderate Takju consumption on learning ability in 6-week old Sprague-Dawley male rats. The rats were treated with exercise and alcohol for 4 weeks in six separate groups as follows: non-exercised control (CC), exercised control (EC), non-exercised consuming ethanol (CA), exercised consuming ethanol (EA), non-exercised consuming Takju (CT), and exercised consuming Takju (ET). An AIN-93M diet was provided ad libitum. Exercise training was performed at a speed of 10 m/min for 15 minutes per day. Ethanol and Takju were administered daily for 6-7 hours to achieve an intake of about 10 ml after 12 hours of deprivation, and, thereafter, the animals were allowed free access to deionized water. A Y-shaped water maze was used from the third week to understand the effects of exercise and alcohol consumption on learning and memory. After sacrifice, brain acetylcholinesterase (AChE) activity was analyzed. Total caloric intake and body weight changes during the experiment were not significantly different among the groups. AChE activity was not significantly different among the groups. The number of errors for position reversal training in the maze was significantly smaller in the EA group than that in the CA and ET groups, and latency times were shorter in the EA group than those in the CC, EC, CT, and ET groups. The latency difference from the first to the fifth day was shortest in the ET group. The exercised groups showed more errors and latency than those of the non-exercised groups on the first day, but the data became equivalent from the second day. The results indicate that moderate exercise can increase memory and learning and that the combination of exercise and Takju ingestion may enhance learning ability.

• The Journal of Korean Academy of Sensory Integration
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• v.12 no.2
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• pp.25-36
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• 2014

Objective : The purpose of this study is learning the characteristics of literature applying single subject researches in the field of sensory integration therapy of Korean occupational therapy and evaluating the quality level of them. Methods : Analyzed the characteristics of 17 single subject research papers (independent variable, study design, study subject, total number of session, study period, intervention time, intervention place, dependent variable, measuring tool and result) published between 2002 and 2013 using the document delivery service of Korean Society of Occupational Therapy, National Discovery for Science Leaders (NDSL), Nuri Media (DBpia), Research Information Sharing Service (RISS), Korean Studies Information Service System (KISS) and National Assembly Library and evaluated the literatures using quality evaluation scale. Results : According to the analysis result on the literature characteristics, reversal design was the most used study method. Total number of session was 10 sessions to 34 sessions. Study period was 4 weeks to 16 weeks. Intervention time was 8 minutes to 70 minutes and most interventions were done in occupational therapy room or sensory integration therapy room. According to the result of quality level evaluation, 4 papers out of 17 papers were on high level and remaining papers were on intermediate level. However, there was no study which included intervention blind. Conclusion : Suggested standards that need to be supplemented and discussions on qualitative improvement including repetitive research on the mediation effect during the application of the single subject research methodology, the securement of adequate data sections, and processing of a mediation blind. It is expected to be used as basic data for conducting a better qualitative research in the future.