• Title/Summary/Keyword: Nuclear medicine study

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Pk/PD Study Using PET Biomarker

  • Yu, Kyung-Sang;Jang, In-Jin;Lim, Kyoung-Soo;Kwon, Jun-Soo;Jeong, Jae-Min;Lee, Jae-Sung;Kim, Jung-Ryul;Cho, Joo-Youn;Shin, Sang-Goo
    • 대한임상약리학회:학술대회논문집
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    • 2006.11a
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    • pp.141-142
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    • 2006
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The Study of Difference on Each System for Reliance Security in SUV of PET/CT Images : Initial Study (PET/CT 영상에서의 표준섭취계수(SUV)의 신뢰성 확보를 위한 시스템별 차이에 관한 연구 : 초기 연구)

  • Park, Hoon-Hee;Park, Min-Soo;Kim, Jung-Yul;Lee, Seung-Jae;Sheen, Hee-Soon;Lim, Han-Sang;Kim, Sei-Young;Jang, Hye-Won;Oh, Ki-Back;Kim, Jae-Sam;Lee, Chang-Ho
    • Korean Journal of Digital Imaging in Medicine
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    • v.10 no.1
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    • pp.5-6
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    • 2008
  • In this study, using an experiment, in certified an error between each system of SUV (standardized uptake value) that is one of the main analyses to diagnose a tumor in PET/CT, so, it would assure reliability and help to diagnose any lesions accurately. That is, a detailed analysis progressed. as all images reconstructed every setting time, then, clinical reliability between each system was expressed numerically at MBq/mL and SUV. Therefore, this study is considered that flexibility of follow-up using diverse system was insured, and it helps to offer accurate and beneficial information for diagnosis of various fields.

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A Case with Azygos System Demonstrated by Nuclear Angiography (핵의학적(核醫學的) 검사(檢査)로 관찰(觀察)된 기정맥계(奇靜脈系))

  • Cho, Suk-Shin;Kang, Chong-Myung
    • The Korean Journal of Nuclear Medicine
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    • v.19 no.2
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    • pp.101-103
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    • 1985
  • Azygos system, one of the main collateral vessels which communicates superior vena cava with inferior vena cava, is well visualized by Xray angiography. This system is rarely demonstrated by radioisotope study. We report a case whose azygos system was shown during $^{99m}Tc-DTPA$ renal scanning.

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The Effect of Contrast Agent on the Change of Hepatic Uptake of 99mTc-Mebrofenin in Patients with Liver Transplantation

  • Seung-Hun Yeom;Sang-Hyeong Kil;Yeong-Hyeon Lim;Gwang-Yeol Park;Gyeong-Nam Cho;Seong-Muk Cho;Ji-Ho Seong
    • The Korean Journal of Nuclear Medicine Technology
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    • v.28 no.1
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    • pp.23-29
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    • 2024
  • Purpose: 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) is an important and clinically useful diagnostic imaging study for detecting complications after liver transplantation. CT contrast agents due to their high atomic numbers, lead to a decrease in gamma ray count rates. This study investigated the impact of CT contrast agents on the uptake of 99mTc-mebrofenin in the liver. Materials and Methods: The quantitative HBS was performed on sixty-two liver transplantation patients (male:female=36:26), with a mean age of 59.4±6.4 years. Statistical comparison of hepatic uptake reduction ratio (HURR%) before and after the injection of CT contrast agents was performed using a paired t-test. Results: Hepatic uptake of the reduction ratio was 94.47±3.65% for the pre-CT contrast agents and 92.17±4.00% for the post-CT contrast agents. HURR% after CT contrast agent injection showed a statistically significant difference compared to before the injection (t=11.09, P<0.001). Conclusion: It will be necessary to pay attention when examining the HBS of patients with liver transplantation after the injection of CT contrast medium. It is advisable to schedule the examination on a different day to prevent residual contrast medium in the body from interfering with the quantitative evaluation of the nuclear medicine examination.

A Study on Exposure Dose from Injection Work and Elution Work for Radiation Workers and Frequent Workers in Nuclear Medicine (핵의학과 주사와 분배업무 작업종사자 및 수시출입자 피폭선량연구)

  • Ju, Yong-Jin;Dong, Kyung-Rae;Choi, Eun-Jin;Kwak, Jong-Gil;Ryu, Jae-Kwang;Chung, Woon-Kwan
    • Journal of Radiation Industry
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    • v.11 no.1
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    • pp.47-54
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    • 2017
  • Compared to other occupations, there is a greater risk of exposure to radiation due to the use of radioisotopes in nuclear medicine for diagnostic evaluations and therapy. To consider ways to reduce exposure dose for those in nuclear medicine involved in injection work and elution work among radiation workers as well as for sanitation workers and trainees among frequent workers an investigation into exposure dose and situational analysis from changes in yearly exposure dose evaluations, changes in work environment and changes in forms of inspection were conducted. Exposure dose measurements were taken by using EPD MK2 worn during working hours for one injection worker, one elution worker, two sanitation workers, and one trainee at a general hospital in the Seoul area for three days from July 18th to 20th 2016. Radiation from radioisotopes which are a part of nuclear medicine can significantly affect not only radiation workers who deal with radioisotopes directly but also frequency works as well. According to this study the annual dose limit for elution workers and injection workers were considered safe as the amount of exposure was not large enough to have a significant effect. The limits of this study consist in the duration of this study and the quantity of participants. Also there was a limitation of the measurement device involving accumulated exposure, where the EPD MK2 cannot check the changes in exposure according to a particular activity.

Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes

  • Hewage, Susara Ruwan Kumara Madduma;Piao, Mei Jing;Kang, Kyoung Ah;Ryu, Yea Seong;Fernando, Pattage Madushan Dilhara Jayatissa;Oh, Min Chang;Park, Jeong Eon;Shilnikova, Kristina;Moon, Yu Jin;Shin, Dae O;Hyun, Jin Won
    • Biomolecules & Therapeutics
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    • v.25 no.4
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    • pp.427-433
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    • 2017
  • Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved in synthesis of reduced glutathione (GSH), and investigated the associated upstream signaling cascades. By activating nuclear factor-erythroid 2-related factor (Nrf2), galangin treatment significantly increased expression of glutamate-cysteine ligase catalytic subunit (GCLC) and glutathione synthetase (GSS). This activation of Nrf2 depended on extracellular signal-regulated kinases (ERKs) and protein kinase B (AKT) signaling. Inhibition of GSH in galangin-treated cells attenuated the protective effect of galangin against the deleterious effects of UVB. Our results reveal that galangin protects human keratinocytes by activating ERK/AKT-Nrf2, leading to elevated expression of GSH-synthesizing enzymes.

Study on Blood Cortisol in Patients treated with Oral Corticosteroid Drugs (경구 Corticosteroid계 약물 치료한 환자에 있어서 혈중 cortisol에 관한 연구)

  • Park, J.H.;Kim, K.W.;Yoo, H.S.;Lee, J.T.;Park, C.Y.;Ryu, K.J.
    • The Korean Journal of Nuclear Medicine
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    • v.14 no.1
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    • pp.23-28
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    • 1980
  • This is an analysis of 32 patients who received long continuous corticosteroid drug due to some diseases. Patients were collected from June 1976 to March 1980. Blood cortisol level, variation of diurnal rhythm and side effects were studied. The Result as follows: 1. Side effects were observed in 24 patients(75%) and most common complaint was obesity. 2. Diurnal rhythm analysed by Doe's method shows abnormal diurnal rhythm is 21 out of 32(66%). 3. Mean durations or therapy of abnormal diurnal rhythm and normal diurnal rhythm were $55.7{\pm}4.4$ months and $43.9{\pm}7.0$ months respectively which shows statistically significant difference. 4. Mean cortisol value of steroid treated patients were lower than normal. 5. Reverse diurnal rhythm was 4 out of 21 patients. 6. 8 A.M. cortisol value is lower than 2 times of 8 P.M. in all patients who showed abnormal diurnal rhythm except one.

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Substituent Effect on the Structure and Biological Property of 99mTc-Labeled Diphosphonates: Theoretical Studies

  • Qiu, Ling;Lin, Jian-Guo;Gong, Xue-Dong;Cheng, Wen;Luo, Shi-Neng
    • Bulletin of the Korean Chemical Society
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    • v.33 no.12
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    • pp.4084-4092
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    • 2012
  • Theoretical calculations based on density functional theory (DFT) were performed to study the substituent effect on the geometric and electronic structures as well as the biological behavior of technetium-99m-labeled diphosphonate complexes. Optimized structures of these complexes are surrounded by six ligands in an octahedral environment with three unpaired 4d electrons ($d^3$ state) and the optimized geometry of $^{99m}Tc$-MDP agrees with experimental data. With the increase of electron-donating substituent or tether between phosphate groups, the energy gap between frontier orbitals increases and the probability of non-radiative deactivation via d-d electron transfer decreases. The charge distribution reflects a significant ligand-to-metal electron donation. Based on the calculated geometric and electronic structures and biologic properties of $^{99m}Tc$-diphosphonate complexes, several structure-activity relationships (SARs) were established. These results may be instructive for the design and synthesis of novel $^{99m}Tc$-diphosphonate bone imaging agent and other $^{99m}Tc$-based radiopharmaceuticals.