• Nuclear Engineering and Technology
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• v.53 no.5
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• pp.1519-1523
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• 2021

Radioactive iodine (¹³¹I) released from nuclear power plants has been a critical environmental concern for workers. The effective trapping of radioactive iodine isotopes from the off-gas stream generated from nuclear facilities is an important issue in radioactive waste treatment systems evaluation. Numerous studies on retaining methyl iodide (CH₃I¹³¹) by impregnated activated carbons under the high content of moisture have been extensively studied so far. But there have been no good results on how to remove methyl iodide at high humid conditions up to now. A new challenge is to introduce other promising impregnating chemical agents that are able to uptake enough radioactive methyl iodide under high humid conditions. In order to develop a good removal efficiency to control radioiodine gas generated from a high humid process, activated carbons (ACs) impregnated with triethylene diamine (TEDA) and qinuclidine (QUID) were prepared. In addition, the removal efficiencies of the activated carbons (ACs) under humid conditions up to 95% RH were evaluated by applying the standard method specified in ASTM-D3808. Quinuclidine impregnated activated carbon showed a much higher decontamination factor above 1,000, which is enough to meet the regulation index for the iodine filters in nuclear power plants (NPPs).

• Nuclear Engineering and Technology
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• v.56 no.9
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• pp.3933-3941
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• 2024

The paper concerns a room-temperature cross-bar H-mode (CH) drift tube linac (DTL) with KONUS (Kombinierte Null Grad Struktur) [1,2] beam dynamics. To make the acceleration in DTL cell more efficient, we studied the correlation between transit time factor (TTF) and structural coefficients, first. Furthermore, we developed a new code with Python to demonstrate the longitudinal dynamics more clearly. The code computationally generates clusters, bunch centers, and emittance growth in a single figure. Thus, the stabilization region and cluster evolution at various negative phases can be studied. Based on the above studies, we designed a 162.5 MHz CH-DTL to accelerate 10 mA D⁺ from 2.11 MeV to 3.25 MeV in continuous-wave (CW) mode. The proposed CH-DTL is a part of the Middle Energy Neutron Source (MENS). The dynamics and RF design were iterated to make the gap voltage error lower than 1 %. The initial beam is assumed to come from a Radio Frequency Quadrupole accelerator (RFQ). The geometries of the CH-DTL are optimized by using CST. Multiparticle tracking from LEBT to RFQ is performed with TraceWin and the transmission efficiency in the CH-DTL is 100 %.

• Proceedings of the Korean Nuclear Society Conference
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• 1995.05a
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• pp.509-516
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• 1995

The uncertainty analysis for the in-vessel steam explosion during severe accidents at a nuclear power plant is performed using a probabilistic approach. This approach consists of four steps; 1) screening, 2) quantification of uncertainty 3) propagation of uncertainty, and 4) output analysis. And the specific methods which satisfy the sub-objectives of each step are prepared and presented. Compared with existing ones, the unique feature of this approach is the improved estimation of uncertainties through quantification, which ensures the defensibility of the resultant failure probability distributions. Using the approach, the containment failure probability due to in-vessel steam explosion is calculated. The results of analysis show that 1) pour diameter is the most dominant factor and slug condensed phase fraction is the least and 2) fraction of core molten is the second most dominant factor, which is identified as distinct feature of this study as compared with previous studies.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.6
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• pp.1798-1809
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• 1996

The purpose of this paper is to develop new Z-Factors to evaluate the behavior of circumferential surface crack in ferritic steel piping including base metal and Submerged Arc Weld(SAW) metal in nuclear power plant. The Z-factor is a load multiplier to convert plastic load to elasto-plastic load. However the current Z-Factor is a load multiplier to convert plastic load to elasto-plastic load. However the current Z-Factor gives too conservative results. In this study, a J-estimation method, SC.TNP method, which is based on GE/EPRI expression, is used to develop new Z-Factors. The desirabilities of both the SC.TNP mehtod and the new Z-Factors are examined using the previous experimental results for the circumferential surface crack in ferritic steel pippings. The results are as follows ; (1) The SC.TNP mehtod is good for describing the circumferential surface crack behavior in farritic steel pipings, while the well-known R6 mehtod and DPFAD method give too conservative results. (2) The ASME-Z-Factor method using nwe Z-Factors well predicts the behavior of circumferential surface crack in ferritic steel pipings including base emtal and SAW metal.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.3_1spc
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• pp.518-524
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• 2013

Recently, probabilistic assessments of nuclear power plant components have generated interest in the nuclear industries, either for the efficient inspection and maintenance of older nuclear plants or for improving the safety and cost-effective design of newly constructed nuclear plants. In the present paper, the partial safety factor (PSF) of wall-thinned nuclear piping is evaluated based on a reliability index method, from which the effect of each statistical variable (assessment parameter) on a certain target probability is evaluated. In order to calculate the PSF of a wall-thinned pipe, a limit state function based on the load and resistance factor design (LRFD) concept is first constructed. As for the reliability assessment method, both the advanced first-order second moment (AFOSM) method and second-order reliability method (SORM) are employed to determine the PSF of each probabilistic variable. The present results can be used for developing maintenance strategies considering the priorities of input variables for structural integrity assessments of wall-thinned piping, and this PSF concept can also be applied to the optimal design of the components of newly constructed plants considering the target reliability levels.

• Journal of Microbiology and Biotechnology
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• v.28 no.8
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• pp.1270-1281
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• 2018

Periodontal disease is triggered by the host immune response to pathogens in the microbial biofilm. Worsening of periodontal disease destroys the tooth-supporting tissues and alveolar bone. As oral inflammation can induce systemic diseases in humans, it is important to prevent periodontal disease. In this study, we demonstrated that Curcuma xanthorrhiza supercritical extract (CXS) and its active compound, xanthorrhizol (XAN), exhibit anti-inflammatory effects on lipopolysaccharide (LPS)-treated human gingival fibroblast-1 cells and anti-osteoclastic effects on receptor activator of nuclear factor kappa B ligand (RANKL)-treated RAW264.7 cells. LPS-upregulated inflammatory factors, such as nuclear factor kappa B p65 and $interleukin-1{\beta}$, were prominently reduced by CXS and XAN. In addition, RANKL-induced osteoclastic factors, such as nuclear factor of activated T-cells c1, tartrate-resistant acid phosphatase, and cathepsin K, were decreased in the presence of CXS and XAN. CXS and XAN inhibited the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway. Collectively, these results provide evidence that CXS and XAN suppress LPS-induced inflammation and RANKL-induced osteoclastogenesis by suppressing the MAPK/AP-1 pathway.

• Biomedical Science Letters
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• v.29 no.3
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• pp.137-143
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• 2023

Inflammation plays an important role in immune system's response to tissue injury and biological stimuli. However, excessive inflammation can cause tissue damage. Therefore, the development of naturally derived anti-inflammatory agents have received broad attention. In this study, we investigated the anti-inflammatory mechanism of Rubi Fructus (RF) extract on the mast cell-mediated inflammatory response. To determine the regulatory mechanism of RF in inflammatory reaction, we evaluated the effects of RF on secretion of interleukin (IL)-8, IL-6 and tumor necrosis factor (TNF)-α and activation of nuclear factor-κB (NF-κB) and caspase-1 in activated human mast cells-1 (HMC-1). The results showed that RF attenuated IL-8, IL-6 and TNF-α secretion in a concentration-dependent manner. Moreover, RF significantly attenuated caspase-1and NF-κB activation in activated HMC-1. Conclusively, the present results provide evidence that RF may be a promising agent for anti-inflammatory therapy.

• Journal of The Korean Society of Integrative Medicine
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• v.7 no.4
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• pp.61-69
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• 2019

Purpose : Human gingival fibroblast cell is one of the the main cell types in periodontal tissue, which they can show anti-inflammatory activity through the production of numerous lines of inflammatory mediators such as inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and interleukins. Porphyromonas gingivalis, one of the oral pathogens, has reported to play a critical role in the development of periodontal diseases. This study aimed to investigate anti-inflammatory and antioxidative activities of Gracilaria textorii ethanol extract (GTEE) in P. gingivalis derived lipopolysaccharide (LPS-PG) stimulated human gingival fibroblast (HGF)-1 cell line. Methods : In order to analyze anti-inflammatory and antioxidative activities of GTEE in HGF-1 cell line, NOS enzyme activity, expression levels of iNOS, COX-2, NAD(P)H quinone dehydrogenase (NQO)1 and their transcription factors were estimated by Griess reaction and western hybridization. Results : LPS-PG induced overexpression of iNOS and COX-2, which was significantly attenuated by GTEE treatment in a dose-dependent manner without any cytotoxicity. In addition, intracellular NOS activity was in accordance with the result of iNOS expression. Due to important role in the regulation of inflammatory responses, phosphorylated status of p65 and c-jun, each subunit of nuclear factor (NF)-κB and activator protein (AP)-1, was also dose-dependently ameliorated by GTEE treatment. One of phase II enzymes, NQO1, and its transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), were analyzed since elevated phase II enzyme expression inhibited inflammatory response, which was significantly elevated by GTEE treatment in HGF-1 cell line. Conclusion : In conclusion, GTEE mitigated LPS-PG-stimulated inflammatory responses by attenuating NF-κB and AP-1 activation as well as accelerating NQO1 and Nrf2 expression in HGF-1 cell line. These results indicate that GTEE might be utilized a promising strategy for potential anti-inflammatory agent in periodontal diseases.

• Proceedings of the Korean Nuclear Society Conference
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• 2001.05a
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• pp.331.1-331
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• 2001

• Proceedings of the Korean Nuclear Society Conference
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• 1998.10a
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• pp.47.1-47
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• 1998