• Proceedings of the Korean Powder Metallurgy Institute Conference
• /
• 2006.09b
• /
• pp.729-730
• /
• 2006

The research involves the development of a powder metallurgical route for producing good quality TiAl targets for making physical vapour deposition (PVD) coatings. Mixtures of elemental titanium and aluminium powders were mechanically milled using a novel discus milling technique under various conditions. Hot isotropic pressing (HIP) was then employed for consolidation of the mechanically alloyed powders. A cathodic arc vapour deposition process was applied to produce a TiAlN coating. Microstructural examination was conducted on the target material and PVD coatings, using X-ray diffractometry (XRD), X-ray photoelectron spectrometry (XPS) and scanning electron microscopy (SEM). It has been found that combining mechanical alloying and HIP enable us to produce fairly good quality of TiAl based target. The PVD coatings obtained from the TiAl target showed very high microhardness values.

• Journal of Communications and Networks
• /
• v.15 no.1
• /
• pp.54-60
• /
• 2013

In this paper, a novel method called location-based delivery (LBD), which combines the short message service (SMS) and global position system (GPS), is proposed, and further, a realistic system for tracking a target's movement is developed. LBD reduces the number of short message transmissions while maintaining the location tracking accuracy within the acceptable range. The proposed approach, LBD, consists of three primary features: Short message format, location prediction, and dynamic threshold. The defined short message format is proprietary. Location prediction is performed by using the current location, moving speed, and bearing of the target to predict its next location. When the distance between the predicted location and the actual location exceeds a certain threshold, the target transmits a short message to the tracker to update its current location. The threshold is dynamically adjusted to maintain the location tracking accuracy and the number of short messages on the basis of the moving speed of the target. The experimental results show that LBD, indeed, outperforms other methods because it satisfactorily maintains the location tracking accuracy with relatively fewer messages.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.15 no.7
• /
• pp.2339-2355
• /
• 2021

In this paper, a joint probabilistic data association algorithm based on loss function (LJPDA) is proposed so that the computation load and accuracy of the multi-target tracking algorithm can be guaranteed simultaneously. Firstly, data association is divided in to three cases based on the relationship among validation gates and the number of measurements in the overlapping area for validation gates. Also the contribution coefficient is employed for evaluating the contribution of a measurement to a target, and the loss function, which reflects the cost of the new proposed data association algorithm, is defined. Moreover, the equation set of optimal contribution coefficient is given by minimizing the loss function, and the optimal contribution coefficient can be attained by using the Newton-Raphson method. In this way, the weighted value of each target can be achieved, and the data association among measurements and tracks can be realized. Finally, we compare performances of LJPDA proposed and joint probabilistic data association (JPDA) algorithm via numerical simulations, and much attention is paid on real-time performance and estimation error. Theoretical analysis and experimental results reveal that the LJPDA algorithm proposed exhibits small estimation error and low computation complexity.

• The Journal of the Acoustical Society of Korea
• /
• v.40 no.2
• /
• pp.109-120
• /
• 2021

This paper proposes the H∞ norm based data association gate method to apply robustly the data association gate of passive sonar automatic target tracking which is on non-linear targets in dense cluttered environment. For target tracking, data association method selects the measurements within validated gate, which means validated measuring extent, as candidates for the data association. If the extent of the validated gate in the data association is not proper or the data association executes under dense cluttered environment, it is difficult to maintain the robustness of target tracking due to interference of clutter measurements. To resolve this problem, this paper proposes a novel gating method which applies H∞ norm based bisection algorithm combined with 3-σ gate method under Gaussian distribution assumption and tracking error covariance. The proposed method leads to alleviate the interference of clutters and to track the non-linear maneuvering target robustly. Through analytic method and simulation to utilize simulated data of horizontal and vertical bearing measurements, improvement of data association robustness is confirmed contrary to the conventional method.

• Biomolecules & Therapeutics
• /
• v.23 no.1
• /
• pp.12-18
• /
• 2015

Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and identification of novel biomarkers for pathological cutaneous alteration is highly required. Here we will discuss if vascular endothelial growth factor (VEGF) has a potential as a biomarker for dermal impairment. Experimental and clinical evidences for induction of keratinocytic VEGF under pathological conditions will be reviewed.

• IMMUNE NETWORK
• /
• v.13 no.5
• /
• pp.222-226
• /
• 2013

Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation of Runt-related transcription factor 1 (RUNX1) target genes. Nineteen RUNX1 translocational partner genes, at least, have been identified, but not Homeobox A (HOXA) genes so far. We report a novel translocation of RUNX1 into the HOXA gene cluster in a 57-year-old female AML patient who had been diagnosed with myelofibrosis 39 months ahead. G-banding showed 46,XX,t(7;21)(p15;q22). The involvement of RUNX1 and HOXA genes was confirmed by fluorescence in situ hybridization.

• BMB Reports
• /
• v.49 no.11
• /
• pp.623-628
• /
• 2016

GPR78 is an orphan G-protein coupled receptor (GPCR) that is predominantly expressed in human brain tissues. Currently, the function of GPR78 is unknown. This study revealed that GPR78 was expressed in lung cancer cells and functioned as a novel regulator of lung cancer cell migration and metastasis. We found that knockdown of GPR78 in lung cancer cells suppressed cell migration. Moreover, GPR78 modulated the formation of actin stress fibers in A549 cells, in a RhoA- and Rac1-dependent manner. At the molecular level, GPR78 regulated cell motility through the activation of $G{\alpha}q$-RhoA/Rac1 pathway. We further demonstrated that in vivo, the knockdown of GPR78 inhibited lung cancer cell metastasis. These findings suggest that GPR78 is a novel regulator for lung cancer metastasis and may serve as a potential drug target against metastatic human lung cancer.

• Journal of Korea Technical Association of The Pulp and Paper Industry
• /
• v.34 no.4
• /
• pp.1-6
• /
• 2002

In order to simulate the actual wet-end process in papermachine, RDA, a novel handsheet former, was used and following results were obtained. While the addition of polyelectrolytes gives significant effect on fiber flocculation, increase of stock consistency influenced on the formation of RDA sheets greatly. In particular, the consistency increase from 0.3 % to 0.4% abruptly increased floe size of RDA sheet and it results in severe deterioration of paper strength. Stock consistency, therefore, should be regarded as the most important factor in the formation simulation with RDA and should be controlled as the first sequence of tuning the operating conditions of RDA to simulate correctly the target machine paper's formation.

• Proceedings of the Korean Society of Plant Pathology Conference
• /
• 1998.06a
• /
• pp.50-69
• /
• 1998

Dimethomorph is a novel fungicide with a high level of activity against diseases induced by certain Oomycetes, including fungal populations that are resistant to other products. In several ways, this fungicide illustrates the opportunities and challenges presented by many modern pesticides. The specific mode of action, which affects cell wall formation, is associated with a very high level of performance and low dose rates under field conditions. These low dose rates, combined with a low level of toxicity to non-target organisms present an outstanding safety profile. This same highly-specific mode of action, however, limits the spectrum of activity and suggests the need for a resistance management plan, both of which must be addressed in new product development. In addition, the biological and physiochemical properties of this, and other new products are not adequately described by the traditional classification of fungicides into“protectant”and“systemic”types. These unique profiles provide novel and useful products for disease control.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2014.02a
• /
• pp.113.1-113.1
• /
• 2014

Surface-enhanced Raman scattering (SERS) has long been projected as a powerful analytical technique for chemical and biological sensing applications. Pairing with portable Raman spectrometers makes the technique extremely appealing as real-time sensors for field application. However, the lack of reliable, uniform, low cost and ease-of-use SERS enhancement structures has prevented the wide adoption of this technique for general applications. We have discovered a novel hybrid structure based on the high-density and uniform arrays of gold nanofingers over a large surface area for SERS applications. The nanofingers are flexible and their tips can be brought together to trap molecules to mimic the biological system. We report here a rapid, simple, low-cost, and sensitive method of detecting trace level of food contaminants by using nanofinger chips based on portable SERS technique. We also present here the characterization of surface reaction of target molecules with our gold nanofinger substrates and the effect of nanofinger closing towards SERS performance. This new type of nano-structures can potentially revolutionize the medical and biologic research by providing a novel way to capture, localize, manipulate, and interrogate biological molecules with unprecedented capabilities.