• 대기
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• 제27권3호
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• pp.345-358
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• 2017

The decadal change in rainfall for Changma period over the South Korea in early-2000s is detected in this study. The Changma rainfall in P1 (1992~2002) decade is remarkably less than in P2 (2003~2013) decade. The much rainfall in P2 decade is associated with the increase of rainy day frequency during Changma period, including the frequent occurrences of rainy day with a intensity of 30 mm/day or more in P2 decade. This decadal change in the Changma rainfall is due to the decadal change of atmospheric circulation around the Korean Peninsula which affects the intensity and location of Changma rainfall. During P2 decade, the anomalous anti-cyclone over the south of the Korean Peninsula, which represents the expansion of the North Pacific high with warm and wet air mass toward East Asia, is stronger than in P1 decade. In addition, the upper level zonal wind and meridional gradient of low-level equivalent potential temperature in P2 decade is relatively strengthened over the northern part of the Korean Peninsula than in P1 decade, which corresponds with the intensification of meridional gradient between air mass related to the East Asian summer monsoon nearby the Korean Peninsula in P2 decade. The enhanced meridional gradient of atir mass during P2 decade is favorable condition for the intensification of Changma rainfall band and more Changma rainfall. The atmospheric conditions related to enhanced Changma rainfall during P2 decade is likely to be influenced by the teleconnection linked to the suppressed convection anomaly over the southern part of China and South China Sea in P2 decade.

• 대기
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• 제27권3호
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• pp.277-290
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• 2017

Characteristics of precipitation in South Korea during the 2016 Changma period (6/18~7/30) are analyzed in great details. El $Ni{\tilde{n}}o$-induced tropical Indian Ocean (IO) basin-wide warming lasts from spring to early summer and induces the western North Pacific subtropical high (WNPSH) circulation anomaly through an equatorial Kelvin wave during the 2016 Changma period. Along the northern edge of the WNPSH, strong precipitation occurred, in particular, over eastern China and southern Japan. During the Changma period, South Korea had the near-normal mean precipitation amount (~332 mm). However, about 226 mm of rain fell in South Korea during 1 July to 6 July, which amounts to 67% of total Changma precipitation in that year. Upper-level synoptic migratory lows and low-level moisture transport played an essential role, especially from 1 July to 3 July, in triggering an abrupt development of fronts over the Korean Peninsula and the eastern continent China. The front over the eastern China migrates progressively eastward, which results in heavy rainfall over the Korean peninsula from 1 to 3 July. In contrast, from 4 to 6 July, the typhoon (NEPARTAK) affected an abrupt northward advance of the North Pacific subtropical high (NPSH). The northward extension of the NPSH strengthens the Changma front and induces the southerly flows toward the Korean peninsula, giving rise to an increase in heavy rainfall. The NEPARTAK is generated due to interaction of the Madden-Julian Oscillation (MJO), equatorial Rossby wave and Kelvin waves.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2879-2881
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• 2015

There is paucity of data on non Hodgkin's lymphoma (NHL) from our population in North-East India. In this retrospective study, patients were consecutively followed-up to see the clinic-pathological pattern of NHL, various responses, and pattern of relapses to first line treatment with chemotherapy. All patients in the present study received standard regimen of cyclophosphamde, doxorubicin, vincristine, prednisolone (CHOP) with or without rituximab (R-CHOP) as per our institutional protocol as first line therapy. Our study has shown that, in our adult population, the majority of NHL cases present with stage II and stage III disease and extra nodal involvement, B-cell lymphomas and diffuse large cell lymphomas being the most common subtypes. International prognostic index was a significant factor for varied responses to treatment. The majority of relapses after complete remission occurred in the first year.

• 해양환경안전학회지
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• 제22권1호
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• pp.145-151
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• 2016

수온과 기후 지수 자료를 이용하여 한국주변해 상층부의 수온변동과 북태평양 기후체제와의 관계를 분석하였다. 1970, 1980 그리고 1990년대 후반에 발생한 기후체제전환은 해양생태계의 구조 변화에 중요한 영향을 끼쳤다. 북서태평양 대륙주변부에 위치한 우리나라 주변해역 또한, 10년 이상의 장주기적인 변화의 영향을 받지만, 해역별 반응은 다르다. 동해, 서해, 남해 상층부(10 m)의 경우 1988년의 기후체제전환은 3개 해역의 상층부 수온변화에서 동시에 나타난다. 반면, 1998년은 동해남부해역과 서해, 1976년의 기후체제전환은 전 해역의 겨울철 수온변화에서만 그 영향이 나타난다. 1998년 기후체제전환 이후, 서해, 동중국해, 동해 남부의 수온은 점차 감소하지만, 동해 북부해역은 1988년 기후체제전환 이후 증가하는 형태이다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3795-3802
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• 2012

Cochinchina momordica seeds (CMS) have been widely used due to antitumor activity by Mongolian tribes of China. However, the details of the underlying mechanisms remain unknown. In the present study, we found that an EtOAc (ethyl ester) extract of CMS (CMSEE) induced differentiation and caused growth inhibition of melanoma B16 F1 cells. CMSEE at the concentration of $5-200{\mu}g/ml$ exhibited strongest anti-proliferative effects on B16 F1 cells among other CMS fractions (water or petroleum ether). Moreover, CMSEE induced melanoma B16 F1 cell differentiation, characterized by dendrite-like outgrowth, increasing melanogenesis production, as well as enhancing tyrosinase activity. Western blot analysis showed that sustained phosphorylation of p38 MAP accompanied by decrease in ERK1/2 and JNK dephosphorylation were involved in CMSEE-induced B16 F1 cell differentiation. Notably, 6 compounds that were isolated and identified may be responsible for inducing differentiation of CMSEE. These results indicated that CMSEE contributes to the differentiation of B16 F1 cells through modulating MAPKs activity, which may throw some light on the development of potentially therapeutic strategies for melanoma treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6955-6959
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• 2013

The incidence of hepatocellular carcinoma (HCC) is relatively high in Southeast Asia. Globally, HCC has a high fatality rate and short survival. The objectives of this retrospective cohort study were to review the epidemiology and survival of HCC patients at a tertiary centre in north-east of Peninsular Malaysia. Subjects were adult HCC patients diagnosed by histopathology or radio-imaging. Secondary liver carcinoma was excluded. Kaplan Meier and multiple Cox proportional hazard survival analyses were used. Only 210 HCC cases from years 1987-2008, were included in the final analysis. The number of cases was increasing annually. The mean age was 55.0 (SD 13.9) years with male:female ratio of 3.7:1. Approximately 57.6% had positive hepatitis B virus, 2.4% hepatitis C virus, 20% liver cirrhosis and 8.1% chronic liver disease. Only 2.9% had family history and 9.0% had frequently consumed alcohol. Most patients presented with abdominal pain or discomfort and had hepatomegaly, 47.9% had an elevated ${\alpha}$-fetoprotein level of 800 IU/ml or more, 51.9% had multiple tumors and 44.8% involved multiple liver lobes. Approximately 63.3% were in stage 3 and 23.4% in stage 4, and 82.9% did not receive any treatment. The overall median survival time was 1.9 months (95% confidence interval (CI): 1.5, 2.3). The 1-month, 6-month, 1-year and 2-year survival rates were 71.8%, 23.3%, 13.0% and 7.3% respectively. Significant prognostic factors were Malay ethnicity [Adjusted hazard ratio (AHR) 1.6; 95%CI: 1.0, 2.5; p=0.030], no chemotherapy [AHR 1.7; 95%CI: 1.1, 2.5; p=0.017] and Child-Pugh class C [AHR 2.6; 95%CI: 1.4, 4.9; p=0.002]. HCC in our study affected a wide age range, mostly male, in advanced stage of disease, with no treatment and very low survival rates. Primary prevention should be advocated in view of late presentation and difficulty of treatment. Vaccination of hepatitis virus and avoidance of liver toxins are to be encouraged.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4527-4531
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• 2016

Background: PTEN protein is one of the most important tumour suppressor factors which is detectable by immunohistochemistry. The goal of the present study was to investigate the prognostic role of PTEN gene expression in breast cancer patients. Materials and Methods: This descriptive-analytical study was conducted on 100 breast cancer patients referred to Sabzevar hospitals in the north-east of Iran between 2010 and 2011, who were followed up to 2015. PTEN gene expression in tissue samples was determined using specific monoclonal antibodies and data were analyzed using Chi-square test and Fisher's exact test. Patient survival was analyzed after 4 years of follow-up using the Cox regression model. Results: PTEN gene expression was evident in 70 of 100 cnacer samples but was found at high levels in all non-cancer samples. There was an inverse significant relationship between PTEN gene expression and tumour stage or tumour grade (p<0.001). The expression of PTEN in invasive ductal tumours was lower than in non-invasive tumours. There was also an inverse significant relationship between the hazard of death and PTEN gene expression (p<0.001). In addition, there was an inverse significant relationship between tumour stage and hazard of death (p<0.001). Conclusion: These findings indicate that lack of PTEN gene expression can be a sign of a worse prognosis and poor survival in breast cancer cases.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6141-6147
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• 2015

Background: Cancer is a leading cause of death worldwide. A large proportion of cancer deaths are preventable through early detection but there are a range of social, emotional, cultural and financial dimensions that hinder the effectiveness of cancer prevention and treatment efforts. Cancer stigma is one such barrier and is increasingly recognized as an important factor influencing health awareness and promotion, and hence, disease prevention and control. The impact and extent of stigma on the cancer early detection and care continuum is poorly understood in India. Objectives: To evaluate cancer awareness and stigma from multiple stakeholder perspectives in North India, including men and women from the general population, health care professionals and educators, and cancer survivors. Materials and Methods: A qualitative study was conducted with in-depth interviews (IDIs) and focus group discussions (FGDs) among 39 individuals over a period of 3 months in 2014. Three groups of participants were chosen purposively - 1) men and women who attended cancer screening camps held by the Indian Cancer Society, Delhi; 2) health care providers and 3) cancer survivors. Results: Most participants were unaware of what cancers are in general, their causes and ways of prevention. Attitudes of families towards cancer patients were observed to be positive and caring. Nevertheless, stigma and its impact emerged as a cross cutting theme across all groups. Cost of treatment, lack of awarenes and beliefs in alternate medicines were identified as some of the major barriers to seeking care. Conclusions: This study suggests a need for spreading awareness, knowledge about cancers and assessing associated impact among the people. Also Future research is recommended to help eradicate stigma from the society and reduce cancer-related stigma in the Indian context.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3361-3366
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• 2012

Background & Objectives: The most northern and northwestern regions of Iran are at a high risk for gastric cancer. The aim of this study was to assess the general population's awareness about risk factors, symptoms and signs, preventive methods and management of gastric carcinoma in a high prevalence city in the North of Iran. Methods: A cross-sectional population-based telephone survey which was conducted on 3,457 residents of Rasht, the capital city of Guilan Province, to assess their awareness regarding gastric carcinoma. The questionnaires contained demographic data and statements on respondents' knowledge about risk factors, symptoms and signs, prevention and management of gastric cancer which were filled by general practitioners after asking the subjects. Data were analyzed in SPSS14. P<0.05 was considered significant. Results: The mean knowledge score of the respondents was $5.05{\pm}1.37$ regarding risk factors of gastric carcinoma, $4.39{\pm}1.99$ regarding symptoms and signs, $6.0{\pm}1.22$ regarding preventive strategies, and $1.6{\pm}1.16$ regarding management. Totally the mean knowledge level of the respondents toward gastric carcinoma would be $17.1{\pm}3.97$ from the maximum grade of 29. The age group of 45-55 y/o, bachelor degree and higher, physicians and nurses, those who had cancer history in friends or had the history of gastrointestinal diseases showed significantly higher knowledge scores (P=0.001). Conclusion: There is a general lack of awareness of cancer risk factors, symptoms and signs, methods of prevention, and importance of early diagnosis and treatment. Educational programs should be developed to promote adherence to recommended screening guidelines.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3305-3311
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• 2012

Background: The present study aimed to find the prognostic implications of two polymorphisms in TP53 (p.R72P, PIN3 Ins16bp) and one in CCR5 ($CCR5{\Delta}32$) in sporadic breast cancer patients. Methods: DNA samples of 80 breast cancer patients and 80 age and gender matched unrelated healthy control individuals from Punjab, North West India were analyzed. Results: For p.R72P, the genotype frequency was 13.8% (RR), 58.8% (RP), 27.5% (PP) in patients and 33.9% (RR), 40.0% (RP), 26.5% (PP) in controls. For PIN3 Ins16bp, the genotype frequencies were 53.75% (A1A1), 37.5% (A1A2), 8.75% (A2A2) in patients and 66.3% (A1A1), 31.3% (A1A2), 2.5% (A2A2) in controls. Only 4 (5%) breast cancer patients were heterozygous for $CCR5{\Delta}32$ deletion. Common RR-A1A1-WT/WT genotype was lower while RP-A1A2-WT/WT genotype was higher in patients as compared to controls. RP-A1A1-WT/WT genotype was significantly higher in patients as compared to control individuals (p = 0.008). Conclusion: Though a clear association of any particular genotype with sporadic breast cancer or stage was not apparent, the results of present study were suggestive that sporadic breast cancer patients with RR-A1A1-WT/WT genotype might have a better response to chemotherapy, thus improving their chances of survival.