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Diagnostic Value of Fecal Calprotectin as a Screening Biomarker for Gastrointestinal Malignancies

  • Khoshbaten, Manouchehr;Pishahang, Parinaz;Nouri, Mohammad;Lashkari, Alireza;Alizadeh, Mahasti;Rostami-Nejad, Mohammad
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.4
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    • pp.1667-1670
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    • 2014
  • Background: Calprotectin in feces seems to be a more sensitive marker for gastrointestinal (GI) cancers than fecal occult blood, but its specificity may be too low for screening average risk populations. This study aims at evaluating the diagnostic value of fecal calprotectin as a screening biomarker for GI malignancies. Materials and Methods: In a case-control study, 100 patients with GI malignancies (50 patients with colorectal cancer and 50 patients with gastric cancer) and 50 controls were recruited in Tabriz Imam Reza and Sina hospitals during a 24-month period. One to two weeks after the last endoscopy/colonoscopy, fecal specimens were collected by the patients and examined by ELISA method for quantitative measurement of calprotectin content. The results were compared between the three groups. Results: The mean fecal calprotectin level was $109.1{\pm}105.3$ (2.3-454.3, median:74), $241.1{\pm}205.2$ (3.4-610.0, median:19.3) and $45.9{\pm}55.1{\mu}g/g$ (1.3-257.1, median:19.3) in gastric cancer, colorectal cancer and control group, respectively, the differences being significant (p<0.001) and remaining after adjustment for age. The optimal cut-off point for fecal calprotectin was ${\geq}75.8{\mu}g/g$ for distinguishing colorectal cancer from normal cases (sensitivity and specificity of 80% and 84%, respectively). This value was ${\geq}41.9{\mu}g/g$ for distinguishing gastric cancer from normal cases (sensitivity and specificity of 62%). Conclusions: Our results revealed that fecal calprotectin might be a useful and non-invasive biomarker for distinguishing colorectal cancer from non-malignant GI conditions. However, due to low sensitivity and specificity, this biomarker may not help physicians distinguishing gastric cancer cases from healthy subjects.

Validity assessment of VaR with Laplacian distribution (라플라스 분포 기반의 VaR 측정 방법의 적정성 평가)

  • Byun, Bu-Guen;Yoo, Do-Sik;Lim, Jongtae
    • Journal of the Korean Data and Information Science Society
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    • v.24 no.6
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    • pp.1263-1274
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    • 2013
  • VaR (value at risk), which represents the expectation of the worst loss that may occur over a period of time within a given level of confidence, is currently used by various financial institutions for the purpose of risk management. In the majority of previous studies, the probability of return has been modeled with normal distribution. Recently Chen et al. (2010) measured VaR with asymmetric Laplacian distribution. However, it is difficult to estimate the mode, the skewness, and the degree of variance that determine the shape of an asymmetric Laplacian distribution with limited data in the real-world market. In this paper, we show that the VaR estimated with (symmetric) Laplacian distribution model provides more accuracy than those with normal distribution model or asymmetric Laplacian distribution model with real world stock market data and with various statistical measures.

Adhesion Performance of Electromagnetic Induction Heating Pixture for the Integration with a Waterproof & Root Barrier Sheet and a Roof Green Unit System (방수·방근시트와 옥상녹화 박스유닛 시스템의 일체화를 위한 전자기 유도가열 융착 고정구의 부착성능)

  • Oh, Chang-Won
    • Journal of the Korea Institute of Building Construction
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    • v.18 no.5
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    • pp.463-469
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    • 2018
  • A currently used roof green system with multi layers has a low constructability. Therefore a new integrated waterproof & root barrier sheet and roof green box unit system was developed using steel plate fixture and cone type fixture by electromagnetic induction heating method. This study was proceeded to evaluate adhesion performance of two types of fixtures on Engineering PE, TPO, PVC sheet in a normal condition, repeated heating and cooling condition. As a result, adhesion load on Engineering PE sheet showed the highest value. The adhesion loads of steel plate fixture showed higher value as heating temperature was getting higher. However adhesion loads of cone type fixture showed opposite tendency. Regarding to the test conditions, test results of normal condition, repeated heating and cooling condition showed same value. The cone type fixture using butyl tape showed 7 times lower adhesion load than that of cone type fixture using electromagnetic heating and 28% lower adhesion load in a repeated heating and cooling condition than a usual condition.

Determining Obesity Frequency of Rural Children by Skinfold Thickness, Analyzing Their KAP Related ti Obesity and Obesity Camp Strategy (농촌아동의 피부두겹두께 의한 비만도, 이에 따른 비만관련 KAP 비교 및 비만캠프 전략)

  • 박영숙;전혜자;송병국
    • Korean Journal of Community Nutrition
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    • v.5 no.3
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    • pp.502-512
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    • 2000
  • A survey was conducted on 222 students in two elementary schools in rural areas, one was a rural small city and the other was in the countryside. By measuring their skin-foldness in 4 spots by caliper, the body fatness of 5 grades(BFGr) of the subjects was resulted as follows ; 28.0% of boys and 6.7% of girls were classified as obese the and 34.1% of boys and 31.1% of girls as overweight. Comparing by region, children in the small city seemed to be fatter than the ones in the countryside(21.7% vs. 17.2% as obesity). Comparing by gender, boys were fatter than girls(28.0% vs. 6.7% as obesity). When recategorizing body fatness from 5 grades(BFGr) into 3 groups(BFGp) as overweight group(obesity+overweight), normal and underweight group(underweight+severe-underweight), we observed no significant difference in childrens dietary habits and food intake frequencies by BFGp. Overweight and underweight groups enjoyed snacking before dinner more frequently than the normal group(42.1-59.3% vs. 31.5%). The subjects showed poor nutrition knowledge score with relatively high attitude score about weight control and dietary behavior score was a little lower than the attitude score. Nutrition education programs, like camps, should stress on childrens nutrition knowledge. BFGp related to obesity attitude positive, a very low level and the latter related to diet, exercise and fasting attitudes at positive levels. Therefore overweight children seemed to be motivated easily. Also the higher the in exercise-value score, the more increased was shown in exercise attitude at positive, very low level. Emphasizing exercise-value in camp programs might make childrens exercise attitude more positive. As strategies for a rural obesity camp program are being developed by obese and non-obese children. The camp would be held over summer vacation for 3 days(2 nights) at the participants expence not exceeding 50,000 won. Contents of the program cover nutrition knowledge, and exercise-value as well as cooking lessons, exercise practice, and self-esteem enhencement.

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X-ray Image Processing for the Korea Red Ginseng Inner Hole Detection (II) - Results of inner hole detection - (홍삼 내공검출을 위한 X-선 영상처리기술 (II) - 내공검출결과 -)

  • 손재룡;최규홍;이강진;최동수;김기영
    • Journal of Biosystems Engineering
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    • v.28 no.1
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    • pp.45-52
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    • 2003
  • Red ginsengs are inspected manually by examining those in the dark room with back light illumination. Manual inspection is often influenced by physical condition of inspectors. Sometimes. the best grade, heaven. has some inner holes though it was inspected by a specialist. In order to resolve this problem, this study was performed to develop image processing algorithm to detect the inner holes in the x-ray image of ginseng. Because of little gray value difference between background and ginseng in the image. simple thresholding method was not appropriate. Modified watershed algorithm was used to differentiate the inner holes from background and normal ginseng body. Inner hole edge region detected by watershed algorithm consists of many number of blobs including normal portions. With line profile analysis with scanning one line at a time beginning the starting point. it shelved two peaks both ends representing extracting each blobs. in which setting threshold value as of lower peak value enabled us to obtain inner hole image. Once this procedure has to be done till the finishing point it is completing inner hole detection for one blob. Thus. conducting ail blobs by this procedure is completing inner detection of one whole ginseng. Detection results of the inner holes fer various size of red ginsengs were good even though there was small detection variation. 6.2%. according to position of x-rat tube.

Studies on Status and hematological Values of Reproductive Disorders in Dairy Cattle of Jeonnam Area (전남지방(全南地方) 유우(乳牛)에 있어서 번식장해(繁殖障害)의 실태(實態) 및 그 혈액치(血液値)에 관(關)한 조사연구(調査硏究))

  • Park, Young Jun
    • Korean Journal of Veterinary Research
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    • v.14 no.2
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    • pp.253-268
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    • 1974
  • A total of 331 dairy cattle in Jeonnam area were examined for the breeding status and hematological values during the period from June to August. 1971 and 1974. The data obtained were analysed according to the status of breeding and the type of farm management. The results obtained in this work were summarized as follows: 1. 331 dairy cows were grouped as pregnant (63.81%) anestrus after parturition (12.45%), pregnancy unknown (11.48%), repeat breeder (10.32%), and others (1.94%). 2. The summery of reproductive histories and clinical examination were as follows. Average of calving interval was 16.5 months, interval from parturition to first breeding 97 days and postpartum interval to first estrus 72 days. Services per conception was 1.6 rate of postpartum estrus (60 days) 12.0%, and the rate of repent breeder 10.3%. 3. Generally, the blood values of RBC, Hb, serum total protein and A/G ratio were lower than those normal values, especially, the cows which showed abnormal values belonged to the repeat breeder and the unknown to conception group. The mean value for serum inorganic phosphorus was the normal value or hyperphosphatemia, on the other hand, the mean value for serum calcium of the repeat breeder group was the lowest than the other group. 4. Follow-up evaluations on the results of the laboratory tests strongly suggest that the problems of repeat breeder had a tendency to occur more frequently in the large herd (A and B type farm), and the Ca/P ratio of almost all the cows showed abnormal values.

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An Empirical Study of Employee's Deviant Behavior for Improving Efficiency of Information Security Governance (정보보호 거버넌스 효율성 제고를 위한 조직원의 정보보호 행위에 관한 실증 연구)

  • Kim, Hye Jung;Ahn, Joong Ho
    • The Journal of Society for e-Business Studies
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    • v.18 no.1
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    • pp.147-164
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    • 2013
  • For the continuous information security governance, we have to focus on not just technical aspects like access control and DRM, but informal level management like information security(IS) behavior, culture, and personal value. But there are few informal level studies, while many formal level studies of IS governance or technical means. This study is an empirical test that how IS culture, normal beliefs, personal behavior and value affect employee's deviant behavior. And we define a lack of an awareness of value and importance on IS regulations in organizations as "Information Security Anomie" with the concept of anomie, a viewpoint on social organization.

Long Memory Properties in the Volatility of Australian Financial Markets: A VaR Approach (호주 금융시장 변동성의 장기기억 특성: VaR 접근법)

  • Kang, Sang-Hoon;Yoon, Seong-Min
    • International Area Studies Review
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    • v.12 no.2
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    • pp.3-26
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    • 2008
  • This article investigates the usefulness of the skewed Student-t distribution in modeling the long memory volatility property that might be present in the daily returns of two Australian financial series; the ASX200 stock index and AUD/USD exchange rate. For this purpose we assess the performance of FIGARCH and FIAPARCH Value-at-Risk (VaR) models based on the normal, Student-t, and skewed Student-t distribution innovations. Our results support the argument that the skewed Student-t distribution models produce more accurate VaR estimates of Australian financial markets than the normal and Student-t distribution models. Thus, consideration of skewness and excess kurtosis in asset return distributions provides appropriate criteria for model selection in the context of long memory volatility models in Australian stock and foreign exchange markets.

Understanding on TDS Creep Phenomena of Reverse Osmosis Membranes in Water Purifiers (역삼투막 정수기에서 발생하는 총용존고형물 크리프 현상의 이해)

  • Kang, Sanghyeon;Yun, Sunghan
    • Membrane Journal
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    • v.32 no.2
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    • pp.126-132
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    • 2022
  • Water purifiers have a quite different characteristic in comparison with general membrane water treatment processes in which the running and resting are repeated dozens of times a day. In the case of water purifiers using reverse osmosis membranes, this characteristic makes a phenomenon that the total dissolved solids (TDS) of permeate in water purifiers at the beginning of running shows a higher value than a normal value (TDS reduction is lower than a normal value). It is called "TDS creep". The effects of resting times and feed concentrations on the TDS creep were investigated. The feed flushing, the volume increase in permeate side and the flushing with purified water were applied to reduce TDS creep and the effectiveness were observed. Among these trials, the minimization of concentration between feed and permeate side of reverse osmosis membrane like the flushing with purified water can be an ultimate solution to reduce the TDS creep.

A Study on the Reliability and Validity of the Five-Visceral Weak Children Questionnaire for Children with Anorexia (식욕부진 소아 대상 오장허약아 설문지의 신뢰도 및 타당도 연구)

  • Ko Mi Mi;Lee Sun Haeng;Chang Gyu Tae;Lee Boram
    • The Journal of Pediatrics of Korean Medicine
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    • v.38 no.2
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    • pp.1-10
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    • 2024
  • Objectives This study aimed to assess the reliability and validity of the Five-Visceral Weak Children Questionnaire (FWCQ) in childhood anorexia and to propose optimal cutoff values. Methods We conducted two surveys, spaced one month apart, targeting the parents of 366 children aged 2-9 years who had been diagnosed with anorexia for at least one month. To evaluate the reliability of the FWCQ, we calculated Cronbach's alpha coefficient and employed the test-retest method. Additionally, correlation analysis was performed between the FWCQ and each visceral question, and discriminant validity was assessed by comparing responses from the anorexic and normal groups. Furthermore, we determined the cutoff value of the spleen weak score, which is closely associated with appetite, for the anorexic group. Results The first survey yielded responses from 336 participants, followed by 171 responses in the second survey conducted one month later. The FWCQ demonstrated high internal consistency (Cronbach's alpha = 0.776), and test-retest results were consistent. The correlation coefficients between the FWCQ and each visceral question were all statistically significant. Moreover, significant discriminant validity was observed between the anorexic and normal groups in the FWCQ score and the heart, spleen, and kidney weak scores. The optimal cutoff value for the spleen weak score in the anorexic group was found to be 5.5 points (with a sensitivity of 73.44% and specificity of 66.47%). Conclusions The FWCQ exhibited strong reliability and validity in children with anorexia.